Detailed information for compound 105065

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 317.125 | Formula: C12H10Cl2N2O4
  • H donors: 4 H acceptors: 4 LogP: 2.18 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)c1[nH]c2c(c1CCC(=O)O)c(Cl)cc(c2)Cl
  • InChi: 1S/C12H10Cl2N2O4/c13-5-3-7(14)10-6(1-2-9(17)18)11(12(19)16-20)15-8(10)4-5/h3-4,15,20H,1-2H2,(H,16,19)(H,17,18)
  • InChiKey: MOJICEXBFDXLFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0734 1
Echinococcus multilocularis musashi 0.0031 0.0249 0.0247
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0091 0.0901 0.1286
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0117 0.1187 0.1186
Echinococcus granulosus Diacylglycerol kinase theta 0.0031 0.0252 0.0358
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0054
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0088 0.0867 1
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0189 0.2564
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0039 0.0054
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0204 0.029
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0039 0.0121
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0404 0.0575
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0348 0.4732
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0046 0.0416 0.5659
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0204 0.5
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0249 0.0354
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0002 0.0001
Echinococcus multilocularis Diacylglycerol kinase theta 0.0031 0.0252 0.0251
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0025 0.0189 0.0269
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0072 0.0693 0.2215
Schistosoma mansoni coup transcription factor 0.0012 0.0039 0.0054
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0044 0.0388 0.1237
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0025 0.0189 0.0269
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0734 1
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0025 0.0189 0.0606
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0044 0.0388 0.2931
Onchocerca volvulus 0.0095 0.0947 0.4584
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0734 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0246 0.035
Schistosoma mansoni sphingosine kinase A B 0.0652 0.6999 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0039 0.0121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0002 0.0001
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0295 0.3126 1
Toxoplasma gondii NAC domain-containing protein 0.004 0.0348 0.2925
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0025 0.0189 0.0188
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2021 0.6466
Brugia malayi LBP/BPI 0.0031 0.0246 0.0784
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0164 0.0631
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0144 0.1479 0.2112
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0669 0.0954
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0734 0.2346
Brugia malayi intermediate filament protein 0.0031 0.0249 0.0792
Loa Loa (eye worm) hypothetical protein 0.0041 0.0361 0.0513
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0204 0.2767
Onchocerca volvulus 0.0031 0.0249 0.1058
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0669 0.5626
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0416 0.0593
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0022 0.0067
Brugia malayi Protein kinase domain containing protein 0.0009 0.0008 0.002
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0044 0.0388 0.1241
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0039 0.0054
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0669 0.0954
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0025 0.0189 0.2564
Toxoplasma gondii Alpha-galactosidase 0.0017 0.0094 0.0778
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0039 0.0038
Onchocerca volvulus 0.0072 0.0693 0.3302
Loa Loa (eye worm) hypothetical protein 0.0045 0.0404 0.0575
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0039 0.0054
Schistosoma mansoni thyroid hormone receptor 0.0156 0.1605 0.2292
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0072 0.0693 0.2215
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0249 0.0354
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0669 0.0954
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0046 0.0416 0.0593
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0348 0.4732
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.1187 0.1695
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0044 0.0388 0.0387
Schistosoma mansoni hypothetical protein 0.0144 0.1479 0.2112
Onchocerca volvulus 0.0033 0.0271 0.1168
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0046 0.0416 0.5659
Trypanosoma cruzi diacylglycerol kinase, putative 0.0025 0.0189 0.2564
Plasmodium falciparum LCCL domain-containing protein 0.0045 0.0404 0.3167
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0416 0.0415
Loa Loa (eye worm) doublecortin family protein 0.0045 0.0404 0.0575
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0039 0.0121
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0046 0.0416 0.3498
Schistosoma mansoni hypothetical protein 0.0045 0.0404 0.0575
Echinococcus granulosus intermediate filament protein 0.0031 0.0249 0.0354
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0044 0.0388 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0039 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.3126 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0046 0.0416 0.0593
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0947 0.0946
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0046 0.0409 0.0582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0652 0.6999 1
Entamoeba histolytica hypothetical protein 0.004 0.0348 0.0487
Onchocerca volvulus 0.0072 0.0693 0.3302
Onchocerca volvulus 0.0045 0.0404 0.184
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0039 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.2135 0.6829
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0016 0.0083 0.0117
Echinococcus granulosus Protein kinase C brain isozyme 0.0016 0.0083 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0008 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2021 0.6466
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0144 0.1479 0.1478
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0669 0.0667
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0189 0.2564
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0763 0.1088
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0039 0.0054
Loa Loa (eye worm) AGC/PKA protein kinase 0.0046 0.0416 0.0593
Schistosoma mansoni hypothetical protein 0.0025 0.0189 0.0269
Echinococcus multilocularis transcription factor btf3 0.004 0.0348 0.0347
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0072 0.0693 0.2215
Mycobacterium ulcerans endonuclease IV 0.0088 0.0867 0.1237
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0669 0.0954
Onchocerca volvulus 0.0031 0.0249 0.1058
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0025 0.0189 0.0606
Trypanosoma brucei Sphingosine kinase 0.0025 0.0189 0.2564
Echinococcus granulosus cpg binding protein 0.0035 0.0291 0.0414
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0009 0.0008 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0039 0.0054
Echinococcus multilocularis thyroid hormone receptor alpha 0.0156 0.1605 0.1604
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0039 0.0054
Loa Loa (eye worm) diacylglycerol kinase 2 0.0025 0.0189 0.0269
Chlamydia trachomatis endonuclease IV 0.0088 0.0867 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0039 0.0054
Onchocerca volvulus Ceramide kinase 1 homolog 0.0025 0.0189 0.0758
Leishmania major protein kinase A catalytic subunit 0.0046 0.0416 0.5659
Echinococcus granulosus protein kinase C gamma type 0.001 0.0021 0.0028
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0039 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0039 0.0038
Brugia malayi Ceramide kinase 0.0025 0.0189 0.0602
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0078 0.0763 0.2441
Trichomonas vaginalis sphingosine kinase, putative 0.0025 0.0189 0.0606
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0039 0.0054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0039 0.0121
Leishmania major diacylglycerol kinase-like protein 0.0025 0.0189 0.2564
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0204 0.022
Schistosoma mansoni polycystin 1-related 0.0045 0.0404 0.0575
Trypanosoma brucei diacylglycerol kinase, putative 0.0025 0.0189 0.2564
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0009 0.0008 0.0006
Echinococcus multilocularis sphingosine kinase 1 0.0652 0.6999 0.6999
Toxoplasma gondii AGC kinase 0.0009 0.0008 0.0053
Brugia malayi nuclear hormone receptor 0.0012 0.0039 0.0121
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0046 0.0416 0.0593
Echinococcus multilocularis lamin dm0 0.0031 0.0249 0.0247
Echinococcus multilocularis RUN 0.0045 0.0404 0.0403
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0088 0.0867 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0117 0.1187 0.1186
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0044 0.0388 0.5272
Loa Loa (eye worm) histone methyltransferase 0.001 0.0024 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0054
Trypanosoma cruzi Sphingosine kinase 0.0025 0.0189 0.2564
Schistosoma mansoni rab6-interacting 0.0045 0.0404 0.0575
Loa Loa (eye worm) hypothetical protein 0.0031 0.0252 0.0358
Echinococcus multilocularis serine:threonine protein kinase 38 0.0009 0.0008 0.0006
Brugia malayi Diacylglycerol kinase protein 2 0.0025 0.0189 0.0602
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0039 0.0054
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0164 0.0232
Leishmania major hypothetical protein, conserved 0.0025 0.0189 0.2564
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0416 0.0584
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0295 0.3126 0.4465
Loa Loa (eye worm) hypothetical protein 0.0031 0.0252 0.0358
Toxoplasma gondii endonuclease IV APN 0.0088 0.0867 0.7296
Mycobacterium tuberculosis Diacylglycerol kinase 0.0025 0.0189 0.0269
Onchocerca volvulus 0.0072 0.0693 0.3302
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0039 0.0054
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0164 0.0232
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0008 0.0009
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0025 0.0189 0.0188
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0348 0.1114
Mycobacterium ulcerans diacylglycerol kinase 0.0025 0.0189 0.0269
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0404 0.0403
Trichomonas vaginalis diacylglycerol kinase, putative 0.0025 0.0189 0.0606
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0106
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0669 0.0954
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0009 0.0008 0.0006
Leishmania major basic transcription factor 3a, putative 0.004 0.0348 0.4732
Loa Loa (eye worm) hypothetical protein 0.0041 0.0361 0.0513
Schistosoma mansoni cpg binding protein 0.0035 0.0291 0.0414
Echinococcus multilocularis serine threonine protein kinase 0.001 0.0021 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0039 0.0054
Loa Loa (eye worm) ceramide kinase 0.0025 0.0189 0.0269
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0039 0.0054
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0164 0.0232
Trichomonas vaginalis sphingosine kinase, putative 0.0025 0.0189 0.0606
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0671 0.0957
Plasmodium vivax multidomain scavenger receptor, putative 0.0045 0.0404 0.3167
Onchocerca volvulus 0.0025 0.0189 0.0758
Mycobacterium tuberculosis Conserved protein 0.0652 0.6999 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0009
Brugia malayi nuclear receptor NHR-88 0.0012 0.0039 0.0121
Brugia malayi hypothetical protein 0.0041 0.0361 0.115
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0734 0.1039
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.0361 0.115
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0008 0.0009
Entamoeba histolytica diacylglycerol kinase, putative 0.0025 0.0189 0.026
Loa Loa (eye worm) hypothetical protein 0.0088 0.0867 0.1237
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0044 0.0388 0.5272
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0025 0.0189 0.0269
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.3126 1
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Brugia malayi p70 ribosomal S6 kinase beta 0.0009 0.0008 0.002
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.0083 0.0117
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0046 0.0416 0.5659
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0046 0.0416 0.5659
Schistosoma mansoni rab6-interacting 0.0045 0.0404 0.0575
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0009 0.0008 0.0006
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0044 0.0388 0.0552
Brugia malayi diacylglycerol kinase 0.0031 0.0252 0.0802
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0039 0.0054
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Trypanosoma cruzi diacylglycerol kinase, putative 0.0025 0.0189 0.2564
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0025 0.0189 0.1585
Echinococcus granulosus dnaJ subfamily B 0.0468 0.5001 0.7145
Brugia malayi beta-NAC-like protein 0.004 0.0348 0.111
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0083 0.0117
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0039 0.0038
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0008 0.0006
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0734 0.1048
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0093 0.0131
Echinococcus granulosus lamin dm0 0.0031 0.0249 0.0354
Loa Loa (eye worm) hypothetical protein 0.003 0.0243 0.0345
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0041 0.0361 0.0513
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.3126 1
Schistosoma mansoni cpg binding protein 0.0033 0.0271 0.0385
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0097
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0348 0.0487
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0054
Echinococcus granulosus geminin 0.0194 0.2021 0.2886
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0054
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.1187 0.1695
Leishmania major protein kinase A catalytic subunit isoform 2 0.0046 0.0416 0.5659
Onchocerca volvulus 0.0072 0.0693 0.3302
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0009 0.0008 0.0009
Trypanosoma cruzi Sphingosine kinase 0.0025 0.0189 0.2564
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0044 0.0388 0.2931
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.3126 1
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0416 0.1331
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0025 0.0189 0.0269
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0025 0.0189 0.2564
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0117 0.1187 0.1695
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0039 0.0038
Echinococcus granulosus Polycystic kidney disease protein 0.0045 0.0404 0.0575
Echinococcus multilocularis geminin 0.0194 0.2021 0.202
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.3126 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0039 0.0121
Brugia malayi hypothetical protein 0.0031 0.0246 0.0784
Schistosoma mansoni cpg binding protein 0.0035 0.0291 0.0414
Trichomonas vaginalis bmru protein, putative 0.0025 0.0189 0.0606
Loa Loa (eye worm) AGC/PKN protein kinase 0.0009 0.0008 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0075 0.0074
Brugia malayi Melibiase family protein 0.0078 0.0763 0.2438
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0044 0.0388 0.3259
Onchocerca volvulus 0.0072 0.0693 0.3302
Loa Loa (eye worm) AGC/NDR protein kinase 0.0009 0.0008 0.0009
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.0083 0.0082
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0416 0.0584
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.3126 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0039 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0039 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0024 0.0022
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0416 0.0415
Loa Loa (eye worm) hypothetical protein 0.0095 0.0947 0.1352
Brugia malayi protein kinase C II. 0.0016 0.0083 0.0262
Schistosoma mansoni thyroid hormone receptor 0.0156 0.1605 0.2292
Schistosoma mansoni transcription factor btf3 0.004 0.0348 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0348 0.1114
Entamoeba histolytica hypothetical protein, conserved 0.0652 0.6999 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0025 0.0189 0.0606
Loa Loa (eye worm) hypothetical protein 0.0031 0.0246 0.035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0039 0.0121
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0204 0.2767
Brugia malayi Hr1 repeat family protein 0.0009 0.0008 0.002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0039 0.0038
Trichomonas vaginalis bmru protein, putative 0.0025 0.0189 0.0606
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0046 0.0409 0.0407
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0204 0.029
Schistosoma mansoni atypical protein kinase C 0.0099 0.0988 0.1409
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0054
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0947 0.3028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0249 0.0354
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0416 0.0415
Giardia lamblia Kinase, AGC PKA 0.0046 0.0416 0.5
Schistosoma mansoni lamin 0.0031 0.0249 0.0354
Schistosoma mansoni hypothetical protein 0.0194 0.2021 0.2886
Onchocerca volvulus 0.0045 0.0404 0.184
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0088 0.0867 0.277
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0271 0.0385
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0046 0.0416 0.3349
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0046 0.0416 0.1328
Loa Loa (eye worm) hypothetical protein 0.0041 0.0361 0.0513
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0204 0.5
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0389 0.0553
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0198 0.2067 0.2952
Onchocerca volvulus 0.0072 0.0693 0.3302
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0044 0.0388 0.0552
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0734 0.0733
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0164 0.0521
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.2135 0.6829
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0075 0.0106
Schistosoma mansoni diacylglycerol kinase theta 0.0031 0.0252 0.0358
Toxoplasma gondii AGC kinase 0.0046 0.0416 0.3498
Echinococcus multilocularis ceramide kinase 0.0025 0.0189 0.0188
Schistosoma mansoni serine/threonine kinase 0.0009 0.0008 0.0009
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.0361 0.115
Loa Loa (eye worm) ICD-1 protein 0.004 0.0348 0.0496
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0204 0.2344
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0046 0.0416 0.3349
Toxoplasma gondii diacylglycerol kinase, putative 0.0031 0.0252 0.2113
Echinococcus granulosus lamin 0.0031 0.0249 0.0354
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0054
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0198 0.2067 0.2066
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0046 0.0416 0.5659
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.1187 0.1695
Loa Loa (eye worm) AGC/AKT protein kinase 0.0009 0.0008 0.0009
Entamoeba histolytica hypothetical protein 0.0027 0.0204 0.0281
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0039 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Loa Loa (eye worm) AGC/PKA protein kinase 0.0046 0.0416 0.0593
Schistosoma mansoni lipoxygenase 0.0117 0.1184 0.169
Brugia malayi hypothetical protein 0.0025 0.0189 0.0602
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0041 0.0361 0.0513
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0734 0.1048
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0204 0.171
Echinococcus granulosus protein kinase c iota type 0.0093 0.0925 0.132
Mycobacterium ulcerans hypothetical protein 0.0652 0.6999 1
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0046 0.0416 0.5659
Brugia malayi hypothetical protein 0.0045 0.0404 0.1288
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0416 0.0415
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0009 0.0008 0.0009
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0016 0.0083 0.0082
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0763 0.1088
Schistosoma mansoni loxhd1 0.0045 0.0404 0.0575
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0044 0.0388 0.1237
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0204 0.029
Mycobacterium ulcerans epimerase 0.0023 0.0164 0.0232
Echinococcus multilocularis protein kinase c iota type 0.0093 0.0925 0.0924
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0008 0.0006
Onchocerca volvulus Glucosylceramidase homolog 0.0194 0.2021 1
Trichomonas vaginalis diacylglycerol kinase, putative 0.0025 0.0189 0.0606
Brugia malayi Doublecortin family protein 0.0045 0.0404 0.1288
Echinococcus granulosus RUN 0.0045 0.0404 0.0575
Entamoeba histolytica diacylglycerol kinase, putative 0.0031 0.0252 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0348 0.1114
Echinococcus granulosus serine:threonine protein kinase N2 0.0009 0.0008 0.0009
Onchocerca volvulus 0.0041 0.0361 0.1622
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0404 0.0575
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0039 0.0054
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0039 0.0054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0039 0.0121
Schistosoma mansoni diacylglycerol kinase theta 0.0031 0.0252 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0039 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0083 0.0117
Schistosoma mansoni sphingoid long chain base kinase 0.0652 0.6999 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0039 0.0121
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0204 0.022
Echinococcus granulosus sphingosine kinase 1 0.0652 0.6999 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0009 0.0008 0.0009
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0249 0.0792
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0947 0.1352
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0416 0.0593
Schistosoma mansoni intermediate filament proteins 0.0031 0.0249 0.0354
Leishmania major diacylglycerol kinase, putative 0.0025 0.0189 0.2564
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0404 0.0403
Mycobacterium ulcerans hypothetical protein 0.0023 0.0164 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0039 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0072 0.0693 0.0989
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0039 0.0121
Brugia malayi protein kinase C3,putative 0.0085 0.0838 0.2679
Toxoplasma gondii AGC kinase 0.0046 0.0416 0.3498
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0009 0.0008 0.0009
Brugia malayi diacylglycerol kinase 0.0031 0.0252 0.0802
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0039 0.0121
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0039 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0008 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0164 0.188
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0025 0.0189 0.0269
Loa Loa (eye worm) hypothetical protein 0.0031 0.0246 0.035
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0025 0.0189 0.2564
Brugia malayi hypothetical protein 0.0045 0.0404 0.1288
Schistosoma mansoni lamin 0.0031 0.0249 0.0354
Leishmania major protein kinase A catalytic subunit isoform 1 0.0046 0.0416 0.5659
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0669 0.0954
Leishmania major hypothetical protein, conserved 0.0025 0.0189 0.2564
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0094 0.0132
Onchocerca volvulus 0.0072 0.0693 0.3302
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2021 0.6466
Brugia malayi steroid hormone receptor 0.0012 0.0039 0.0121
Echinococcus multilocularis lamin 0.0031 0.0249 0.0247
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0046 0.0416 0.5659
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Echinococcus multilocularis cpg binding protein 0.0035 0.0291 0.029
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0416 0.0593
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0734 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0024 0.0032
Schistosoma mansoni lipoxygenase 0.0198 0.2067 0.2952
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.1187 0.1695
Leishmania major sphingosine kinase A, B, putative 0.0025 0.0189 0.2564
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0044 0.0388 0.5272
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0348 0.2346
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0044 0.0388 0.5272
Entamoeba histolytica diacylglycerol kinase, putative 0.0025 0.0189 0.026
Brugia malayi Protein kinase domain containing protein 0.0009 0.0008 0.002
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0044 0.0388 0.1241
Toxoplasma gondii melibiase subfamily protein 0.0117 0.1187 1
Echinococcus granulosus Diacylglycerol kinase zeta 0.0025 0.0189 0.0269
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0947 0.1352
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0734 0.1048
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0025 0.0189 0.1585
Brugia malayi ecdysteroid receptor 0.0012 0.0039 0.0121
Echinococcus multilocularis dnaJ subfamily B 0.0468 0.5001 0.5
Brugia malayi CXXC zinc finger family protein 0.0033 0.0271 0.0862
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0039 0.0054
Echinococcus granulosus NDR protein kinase 0.0009 0.0008 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0083 0.0117
Loa Loa (eye worm) hypothetical protein 0.0078 0.0763 0.1088
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0389 0.0387
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0044 0.0388 0.0552
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0669 0.0954
Onchocerca volvulus 0.0072 0.0693 0.3302
Loa Loa (eye worm) hypothetical protein 0.0041 0.0361 0.0513
Brugia malayi Protein kinase domain containing protein 0.0009 0.0008 0.002
Brugia malayi Eye-specific diacylglycerol kinase 0.0025 0.0189 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0189 0.0606
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0088 0.0867 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0097
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0348 0.2346
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2021 0.6466
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2021 0.6466
Echinococcus granulosus transcription factor btf3 0.004 0.0348 0.0496
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0039 0.0054
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0072 0.0693 0.0989
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0008 0.0024
Brugia malayi hypothetical protein 0.0041 0.0361 0.115
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0009 0.0008 0.0009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0039 0.0054
Schistosoma mansoni hypothetical protein 0.0194 0.2021 0.2886
Echinococcus multilocularis Polycystic kidney disease protein 0.0045 0.0404 0.0403
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0009 0.0008 0.0009
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0039 0.0054
Onchocerca volvulus 0.0041 0.0361 0.1622
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0002 0.0001
Echinococcus granulosus ceramide kinase 0.0025 0.0189 0.0269
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0046 0.0416 0.0593
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0093 0.0293
Loa Loa (eye worm) hypothetical protein 0.0045 0.0404 0.0575
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2021 0.6466
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0044 0.0388 0.0552
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0204 0.171
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.0361 0.115
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2021 0.6466
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0088 0.0867 0.1237
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0039 0.0054
Schistosoma mansoni hypothetical protein 0.0468 0.5001 0.7145
Entamoeba histolytica diacylglycerol kinase, putative 0.0031 0.0252 0.0349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0039 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.0031 0.0246 0.035
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0348 0.4732
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.059 0.4964
Onchocerca volvulus 0.0031 0.0246 0.1045
Trypanosoma brucei rac serine-threonine kinase, putative 0.0009 0.0008 0.0086
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0041 0.0361 0.0513
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0669 0.9102
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0246 0.0788
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0025 0.0189 0.2564

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) >> 10 uM Inhibitory activity against Fructose-1,6-bisphosphatase (F16BPase) in human liver ChEMBL. 12781194

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.