Detailed information for compound 1051316

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.228 | Formula: C15H19BrN2O
  • H donors: 1 H acceptors: 1 LogP: 3.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NCc1coc(n1)c1ccccc1Br)CC
  • InChi: 1S/C15H19BrN2O/c1-3-11(4-2)17-9-12-10-19-15(18-12)13-7-5-6-8-14(13)16/h5-8,10-11,17H,3-4,9H2,1-2H3
  • InChiKey: JHQDAJSLMJBXHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0168 0.0122
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0098 0.0133
Schistosoma mansoni hypothetical protein 0.0094 0.0546 0.1287
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0125 0.0749 0.0719
Trypanosoma brucei protein kinase, putative 0.005 0.0257 0.8553
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.0109
Loa Loa (eye worm) macrophage migration inhibitory factor 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0081
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1594 0.3988
Trypanosoma cruzi ISWI complex protein 0.003 0.0124 0.3693
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0202 0.0156
Echinococcus multilocularis geminin 0.0172 0.1059 0.2609
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0257 0.0212
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.009 0.0043
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.0045
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0038 0.0173 0.0127
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.009 0.0043
Echinococcus granulosus lamin 0.0054 0.0283 0.0336
Loa Loa (eye worm) hypothetical protein 0.0297 0.1885 0.1847
Echinococcus granulosus roundabout 2 0.0035 0.0155 0.0154
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0168 0.0122
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0257 0.0299
Leishmania major hypothetical protein, conserved 0.0025 0.009 0.0043
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0168 0.0313
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0035 0.0155 0.0154
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0283 0.0238
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0257 0.0212
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.009 0.0043
Leishmania major macrophage migration inhibitory factor-like protein 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0301 0.0255
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0168 0.5583
Brugia malayi Importin beta-1 subunit 0.0057 0.0301 0.027
Echinococcus multilocularis snurportin 1 0.0608 0.3928 1
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1508 0.2073
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0301 0.0655
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0202 0.022
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0257 0.0543
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0143 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0843 0.08
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.0109
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0257 0.0212
Schistosoma mansoni hypothetical protein 0.0094 0.0546 0.1287
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0257 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0081
Loa Loa (eye worm) hypothetical protein 0.0084 0.0479 0.0434
Schistosoma mansoni lamin 0.0054 0.0283 0.0609
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0094 0.0546 0.1287
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1594 0.3988
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0094 0.0546 0.0709
Trypanosoma cruzi ISWI complex protein 0.003 0.0124 0.3693
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0202 0.6712
Brugia malayi latrophilin 2 splice variant baaae 0.0203 0.1265 0.1238
Entamoeba histolytica Ran family GTPase 0.0042 0.0202 0.0156
Onchocerca volvulus 0.0125 0.0749 0.5805
Schistosoma mansoni hypothetical protein 0.0049 0.0249 0.0521
Echinococcus granulosus lamin dm0 0.0054 0.0283 0.0336
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0047 0.155
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0257 0.8553
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0202 0.0156
Brugia malayi hypothetical protein 0.024 0.1508 0.148
Loa Loa (eye worm) hypothetical protein 0.018 0.111 0.1068
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0249 0.0218
Loa Loa (eye worm) hypothetical protein 0.008 0.0454 0.041
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0257 0.0212
Brugia malayi follicle stimulating hormone receptor 0.0229 0.1432 0.1405
Onchocerca volvulus 0.0054 0.0283 0.04
Echinococcus granulosus geminin 0.0172 0.1059 0.1437
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.009 0.0043
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0098 0.0073
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0202 0.0156
Schistosoma mansoni zinc finger protein 0.003 0.0124 0.0201
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0392 0.049
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0147 0.0259
Brugia malayi N-terminal motif family protein 0.018 0.111 0.1081
Loa Loa (eye worm) TAR-binding protein 0.0253 0.1594 0.1555
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0118 0.07 0.1684
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0168 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1594 0.3988
Loa Loa (eye worm) hypothetical protein 0.0203 0.1265 0.1224
Echinococcus granulosus defective proboscis extension response 0.003 0.0127 0.0114
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0127 0.0095
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0202 0.0171
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0168 0.0122
Plasmodium falciparum importin beta, putative 0.0057 0.0301 0.0255
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.009 0.2044
Onchocerca volvulus 0.0125 0.0749 0.5805
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1508 0.3764
Echinococcus multilocularis musashi 0.0054 0.0283 0.0609
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0168 1
Schistosoma mansoni hypothetical protein 0.0608 0.3928 1
Plasmodium vivax importin-beta 2, putative 0.0057 0.0301 0.0255
Schistosoma mansoni zinc finger protein 0.0039 0.018 0.0343
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0147 0.0259
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0168 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0283 0.0238
Schistosoma mansoni vesicular amine transporter 0.003 0.0127 0.0207
Echinococcus multilocularis tar DNA binding protein 0.0253 0.1594 0.3988
Brugia malayi Bromodomain containing protein 0.0148 0.0899 0.087
Loa Loa (eye worm) hypothetical protein 0.0053 0.0277 0.0231
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0194 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0081
Brugia malayi secreted modular calcium-binding protein 1 0.0125 0.0749 0.0719
Brugia malayi hypothetical protein 0.003 0.0127 0.0095
Echinococcus multilocularis GPCR, family 2 0.0094 0.0546 0.1287
Echinococcus granulosus neuroglian 0.003 0.0127 0.0114
Loa Loa (eye worm) latrophilin receptor protein 2 0.0094 0.0546 0.0502
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0257 0.0212
Schistosoma mansoni hypothetical protein 0.0172 0.1059 0.2609
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0257 0.0212
Plasmodium falciparum macrophage migration inhibitory factor 0.153 1 1
Trypanosoma brucei ISWI complex protein 0.003 0.0124 0.4136
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0168 0.5759
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0147 0.0143
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0202 0.0156
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0297 0.1885 0.1859
Echinococcus granulosus Immunoglobulin 0.003 0.0127 0.0114
Schistosoma mansoni Neurotrimin precursor (hNT) 0.003 0.0127 0.0207
Brugia malayi hypothetical protein 0.0025 0.009 0.0058
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0094 0.0546 0.0709
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0608 0.3928 0.3899
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.009 0.2981
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.153 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0094 0.0546 0.1287
Echinococcus granulosus GPCR family 2 0.0094 0.0546 0.0709
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0168 0.0122
Leishmania major macrophage migration inhibitory factor-like protein 0.153 1 1
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0125 0.0749 0.0719
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.0218 0.0443
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0147 0.0259
Schistosoma mansoni hypothetical protein 0.0203 0.1265 0.314
Loa Loa (eye worm) hypothetical protein 0.0125 0.0749 0.0705
Loa Loa (eye worm) hypothetical protein 0.0124 0.0745 0.0702
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.0109
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0392 0.089
Brugia malayi RNA, U transporter 1 0.0162 0.0992 0.0963
Leishmania major importin beta-1 subunit, putative 0.0046 0.023 0.0184
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.153 1 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.0218 0.0244
Echinococcus multilocularis roundabout 2 0.0035 0.0155 0.0279
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.1432 0.1392
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.009 0.2044
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0147 0.0259
Brugia malayi TAR-binding protein 0.0253 0.1594 0.1568
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0202 0.0156
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0301 0.0255
Onchocerca volvulus 0.0054 0.0283 0.04
Schistosoma mansoni bromodomain containing protein 0.0125 0.0747 0.1804
Brugia malayi Inositol-1 0.0037 0.0168 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0081
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0047 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0283 0.0252
Echinococcus granulosus snurportin 1 0.0608 0.3928 0.5508
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0257 0.0543
Brugia malayi Bromodomain containing protein 0.0075 0.0423 0.0392
Echinococcus multilocularis Immunoglobulin 0.003 0.0127 0.0207
Brugia malayi PHD-finger family protein 0.0049 0.0249 0.0218
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0735 0.4767 0.4743
Loa Loa (eye worm) hypothetical protein 0.0125 0.0749 0.0705
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0735 0.4767 0.4743
Onchocerca volvulus 0.0125 0.0749 0.5805
Leishmania major GTP-binding protein, putative 0.0042 0.0202 0.0156
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0257 0.0212
Echinococcus multilocularis Immunoglobulin 0.003 0.0127 0.0207
Schistosoma mansoni survival motor neuron protein 0.0049 0.0249 0.0521
Echinococcus granulosus twitchin 0.0031 0.013 0.0118
Echinococcus multilocularis lamin 0.0054 0.0283 0.0609
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0147 0.0259
Brugia malayi Calcitonin receptor-like protein seb-1 0.0297 0.1885 0.1859
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0257 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0168 0.0313
Schistosoma mansoni hypothetical protein 0.0094 0.0546 0.1287
Brugia malayi hypothetical protein 0.0124 0.0745 0.0716
Echinococcus granulosus zinc finger protein 0.0039 0.018 0.0189
Loa Loa (eye worm) hypothetical protein 0.0076 0.0424 0.0379
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0257 0.0299
Trichomonas vaginalis ran, putative 0.0042 0.0202 0.0156
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0297 0.1885 0.1847
Loa Loa (eye worm) hypothetical protein 0.0125 0.0749 0.0705
Brugia malayi MAP kinase sur-1 0.005 0.0257 0.0226
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.0045
Echinococcus granulosus tar DNA binding protein 0.0253 0.1594 0.2197
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0283 0.0238
Echinococcus granulosus importin subunit beta 1 0.0057 0.0301 0.0361
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0168 0.5759
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0147 0.0259
Plasmodium vivax macrophage migration inhibitory factor, putative 0.153 1 1
Echinococcus granulosus intermediate filament protein 0.0054 0.0283 0.0336
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0081
Loa Loa (eye worm) RNA binding protein 0.0253 0.1594 0.1555
Brugia malayi Fibronectin type III domain containing protein 0.003 0.0127 0.0095
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0202 0.737
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.0218 0.0443
Schistosoma mansoni ran 0.0042 0.0202 0.04
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1594 0.3988
Schistosoma mansoni hypothetical protein 0.0094 0.0546 0.1287
Loa Loa (eye worm) hypothetical protein 0.0094 0.0546 0.0502
Schistosoma mansoni tar DNA-binding protein 0.0253 0.1594 0.3988
Onchocerca volvulus 0.0125 0.0749 0.5805
Schistosoma mansoni cell adhesion molecule 0.0035 0.0155 0.0279
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0257 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0745 0.0702
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0125 0.0749 0.0705
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0301 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.003 0.0127 0.0207
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0094 0.0546 0.0516
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.023 0.0184
Echinococcus multilocularis zinc finger protein 0.0039 0.018 0.0343
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.111 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0202 0.04
Echinococcus multilocularis basement membrane specific heparan sulfate 0.003 0.0127 0.0207
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0257 0.0212
Loa Loa (eye worm) inositol-1 0.0037 0.0168 0.0122
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1088 0.7092 1
Trichomonas vaginalis importin beta-1, putative 0.0046 0.023 0.0184
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0155 0.0109
Schistosoma mansoni lamin 0.0054 0.0283 0.0609
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0168 0.0172
Brugia malayi RNA recognition motif domain containing protein 0.0253 0.1594 0.1568
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0047 0.0015
Schistosoma mansoni importin beta-1 0.0057 0.0301 0.0655
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0117 0.0071
Schistosoma mansoni inositol monophosphatase 0.0037 0.0168 0.0313
Brugia malayi RNA binding protein 0.0253 0.1594 0.1568
Brugia malayi intermediate filament protein 0.0054 0.0283 0.0252
Loa Loa (eye worm) hypothetical protein 0.0125 0.0749 0.0705
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0257 1
Loa Loa (eye worm) hypothetical protein 0.024 0.1508 0.1468
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.023 0.0184
Entamoeba histolytica hypothetical protein 0.0046 0.023 0.0184
Brugia malayi Latrophilin receptor protein 2 0.0094 0.0546 0.0516
Schistosoma mansoni hypothetical protein 0.0172 0.1059 0.2609
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0081
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.023 0.8702
Echinococcus multilocularis lamin dm0 0.0054 0.0283 0.0609
Schistosoma mansoni hypothetical protein 0.003 0.0124 0.0201
Schistosoma mansoni ran 0.0042 0.0202 0.04
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0043
Echinococcus multilocularis neuroglian 0.003 0.0127 0.0207
Schistosoma mansoni intermediate filament proteins 0.0054 0.0283 0.0609
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0202 0.737
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0117 0.0086
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0101
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0143 0.5
Onchocerca volvulus Huntingtin homolog 0.0124 0.0745 0.5769
Brugia malayi Thyroglobulin type-1 repeat family protein 0.0125 0.0749 0.0719
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0118 0.07 0.0928
Loa Loa (eye worm) thyroglobulin type-1 repeat family protein 0.0125 0.0749 0.0705
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0253 0.1594 0.1555
Onchocerca volvulus Huntingtin homolog 0.0124 0.0745 0.5769
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0147 0.0143
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0173 0.0142
Schistosoma mansoni nephrin 0.003 0.0127 0.0207
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0257 0.0212
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0257 0.0543
Schistosoma mansoni hypothetical protein 0.0041 0.0194 0.0379
Giardia lamblia Macrophage migration inhibitory factor 0.153 1 1
Leishmania major hypothetical protein, conserved 0.003 0.0124 0.0078

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 9 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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