Detailed information for compound 105345

Basic information

Technical information
  • TDR Targets ID: 105345
  • Name: (3S,6S,9S,12R)-3,6-dibenzyl-9-[6-(oxiran-2-yl )-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0] pentadecane-2,5,8,11-tetrone
  • MW: 588.694 | Formula: C33H40N4O6
  • H donors: 3 H acceptors: 5 LogP: 3.06 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2[C@@H](C(=O)N[C@@H]1CCCCCC(=O)C1CO1)CCC2
  • InChi: 1S/C33H40N4O6/c38-28(29-21-43-29)17-9-3-8-15-24-30(39)35-25(19-22-11-4-1-5-12-22)31(40)36-26(20-23-13-6-2-7-14-23)33(42)37-18-10-16-27(37)32(41)34-24/h1-2,4-7,11-14,24-27,29H,3,8-10,15-21H2,(H,34,41)(H,35,39)(H,36,40)/t24-,25-,26-,27+,29?/m0/s1
  • InChiKey: LLOKIGWPNVSDGJ-LATQDQCYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S,6S,9S,12R)-3,6-dibenzyl-9-[6-(oxiran-2-yl)-6-oxo-hexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • (3S,6S,9S,12R)-3,6-dibenzyl-9-[6-(2-oxiranyl)-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • (3S,6S,9S,12R)-9-[6-(oxiran-2-yl)-6-oxo-hexyl]-3,6-bis(phenylmethyl)-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • (3S,6S,9S,12R)-3,6-dibenzyl-9-[6-keto-6-(oxiran-2-yl)hexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-diquinone
  • (3S,6S,9S,12R)-9-[6-(oxiran-2-yl)-6-oxohexyl]-3,6-bis(phenylmethyl)-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • (3S,6S,9S,12R)-9-[6-(2-oxiranyl)-6-oxohexyl]-3,6-bis(phenylmethyl)-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • (3S,6S,9S,12R)-3,6-bis(benzyl)-9-[6-keto-6-(oxiran-2-yl)hexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-diquinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Brugia malayi hypothetical protein 0.01 0.0368 0.1899
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0311 0.0308
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi nuclear receptor NHR-67 0.0089 0.0321 0.1653
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0088
Entamoeba histolytica protein kinase, putative 0.0087 0.0311 0.1731
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0007 0.0017
Leishmania major DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Echinococcus multilocularis histone deacetylase 6 0.0452 0.192 0.2086
Brugia malayi hypothetical protein 0.0036 0.0085 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0189 0.0761 0.0757
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0158 0.0802
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0187 0.0199
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0114 0.0431 0.0427
Loa Loa (eye worm) hypothetical protein 0.0071 0.0238 0.1224
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.0761 0.3948
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Mycobacterium ulcerans hypothetical protein 0.0023 0.003 0.0237
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0202 0.1035
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0089 0.0321 0.0317
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Brugia malayi serine/threonine-protein kinase plk-2 0.0186 0.0747 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0042 0.0111 0.0497
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Leishmania major hypothetical protein, conserved 0.0042 0.0111 0.0561
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.0761 0.3948
Toxoplasma gondii peptidase, M28 family protein 0.0042 0.0111 0.0561
Schistosoma mansoni polycystin 1-related 0.0079 0.0275 0.0272
Mycobacterium ulcerans hydrolase 0.0139 0.0541 0.4924
Trypanosoma cruzi histone deacetylase, putative 0.0197 0.0797 0.4139
Brugia malayi photoreceptor-specific nuclear receptor 0.0189 0.0761 0.3948
Echinococcus granulosus nAChR subunit 0.0059 0.0188 0.0201
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.003 0.0237
Schistosoma mansoni hypothetical protein 0.0023 0.0031 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0189 0.0761 0.3948
Schistosoma mansoni acetylcholine receptor subunit beta 0.0023 0.0028 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0063 0.0204 0.1043
Schistosoma mansoni histone deacetylase 4 5 0.0452 0.192 0.1917
Brugia malayi hypothetical protein 0.0034 0.0076 0.0377
Schistosoma mansoni retinoid-x-receptor (RXR) 0.01 0.0368 0.0364
Onchocerca volvulus 0.0042 0.0111 0.0402
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Entamoeba histolytica serine/threonine protein kinase, putative 0.0186 0.0747 0.421
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.0211
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Brugia malayi nuclear hormone receptor family member odr-7 0.0089 0.0321 0.1653
Entamoeba histolytica hypothetical protein 0.0025 0.0037 0.0168
Trypanosoma cruzi glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0059 0.0188 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0017
Leishmania major glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0166 0.0658 0.0654
Brugia malayi tailless protein 0.0089 0.0321 0.1653
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0303 0.4084
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0059 0.0188 0.0963
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0089 0.0321 0.0345
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Brugia malayi Steroid receptor seven-up type 2 0.0189 0.0761 0.3948
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.0747 0.3878
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0202 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0201
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0189 0.0761 0.0757
Schistosoma mansoni hypothetical protein 0.0162 0.0641 0.0638
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.023
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Brugia malayi nicalin 0.0042 0.0111 0.0561
Trypanosoma brucei histone deacetylase, putative 0.0452 0.192 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0185 0.0742 0.3852
Echinococcus granulosus histone deacetylase 8 0.0197 0.0797 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0189 0.0761 0.3948
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0125 0.048 0.2486
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) GABA receptor subunit 0.0036 0.0088 0.0441
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0189 0.0761 0.0824
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0303 0.5345
Loa Loa (eye worm) histone deacetylase 1 0.0417 0.1765 0.9188
Toxoplasma gondii histone deacetylase HDAC1 0.0452 0.192 1
Echinococcus granulosus tumor protein p63 0.033 0.1383 0.1501
Plasmodium falciparum flap endonuclease 1 0.0028 0.0053 0.0257
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.003 0.0237
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0345 0.4648
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0188 0.0963
Toxoplasma gondii histone deacetylase HDAC2 0.0417 0.1765 0.9188
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Mycobacterium ulcerans hypothetical protein 0.0042 0.0111 0.0983
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0382 0.1974
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trichomonas vaginalis glutaminase, putative 0.0265 0.1094 0.5183
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Onchocerca volvulus 0.0114 0.0431 0.1942
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0004 0.0002
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0028 0.0024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0303 0.4084
Entamoeba histolytica hypothetical protein 0.0087 0.0311 0.1731
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0187 0.0955
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0072 0.0354
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0303 0.4084
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0189 0.0761 0.3948
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0139 0.0541 0.2802
Echinococcus granulosus histone deacetylase 1 0.0417 0.1765 0.1917
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0188 0.0201
Echinococcus granulosus histone deacetylase 3 0.0417 0.1765 0.1917
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.01 0.0368 0.0364
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0094 0.0098
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0148 0.0578 0.2998
Schistosoma mansoni nAChR subunit 0.0023 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0417 0.1765 0.9188
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0072 0.0354
Brugia malayi eukaryotic initiation factor 4A 0.0185 0.0742 0.3852
Mycobacterium leprae PROBABLE HYDROLASE 0.0139 0.0541 1
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0189 0.0761 0.3948
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0059 0.0188 0.0201
Schistosoma mansoni hypothetical protein 0.0164 0.0651 0.0647
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0296 0.1233 0.6413
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0036 0.0088 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.003 0.013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0189 0.0761 0.3948
Brugia malayi FXNA 0.0042 0.0111 0.0561
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0188 0.0201
Brugia malayi histone deacetylase 3 (HD3) 0.0417 0.1765 0.9188
Onchocerca volvulus 0.0059 0.0188 0.0773
Plasmodium falciparum histone deacetylase, putative 0.0452 0.192 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0021 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0004 0.5
Brugia malayi MH2 domain containing protein 0.013 0.0502 0.2599
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Echinococcus multilocularis nAChR subunit 0.0059 0.0188 0.0201
Toxoplasma gondii thioredoxin reductase 0.0037 0.0092 0.0462
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0189 0.0761 0.0757
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Trypanosoma brucei trypanothione reductase 0.0037 0.0092 0.0462
Toxoplasma gondii histone deacetylase HDAC4 0.0197 0.0797 0.4139
Leishmania major histone deacetylase, putative 0.0452 0.192 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Echinococcus multilocularis geminin 0.0164 0.0651 0.0704
Brugia malayi Flap endonuclease-1 0.0028 0.0053 0.0257
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0158 0.0802
Plasmodium vivax glutathione reductase, putative 0.0037 0.0092 0.0462
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Echinococcus granulosus histone deacetylase 7 0.0452 0.192 0.2086
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0004
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Brugia malayi nuclear receptor RXR 0.01 0.0368 0.1899
Schistosoma mansoni retinoic acid receptor RXR 0.0189 0.0761 0.0757
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0028 0.0024
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0189 0.0761 0.3529
Onchocerca volvulus 0.0089 0.0321 0.141
Echinococcus multilocularis muscleblind protein 0.0163 0.0646 0.0699
Onchocerca volvulus Putative nachr subunit 0.0059 0.0188 0.0773
Onchocerca volvulus 0.0062 0.0202 0.0839
Trypanosoma cruzi glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0021 0.0092
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0089 0.0321 0.0345
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0382 0.1974
Echinococcus granulosus eukaryotic initiation factor 4A 0.0185 0.0742 0.0804
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0089 0.0321 0.1653
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Echinococcus granulosus nuclear receptor nhr 48 0.0089 0.0321 0.0345
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0089 0.0321 0.0345
Trichomonas vaginalis set domain proteins, putative 0.0494 0.2104 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0095 0.0099
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0023 0.0028 0.0125
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus multilocularis global transcription activator snf2l2 0.0073 0.0251 0.0269
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0021 0.0088
Brugia malayi RNA binding protein 0.0123 0.0471 0.2436
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0189 0.0761 0.0824
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Echinococcus granulosus histone deacetylase 6 0.046 0.1953 0.2122
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0007 0.0003
Echinococcus granulosus thyroid hormone receptor alpha 0.0089 0.0321 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0188 0.0963
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Plasmodium falciparum thioredoxin reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0187 0.0183
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0152
Schistosoma mansoni helicase 0.0073 0.0251 0.0247
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Echinococcus granulosus dual specificity 0.0087 0.0311 0.0335
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Trypanosoma brucei polo-like protein kinase 0.0186 0.0747 0.3878
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Plasmodium vivax RNA helicase-1, putative 0.0185 0.0742 0.3852
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.0321 0.0345
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0345 0.4648
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0092 0.0462
Brugia malayi BRM protein 0.0073 0.0251 0.1289
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0262 0.1081 0.1077
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0202 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Onchocerca volvulus 0.0059 0.0188 0.0773
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi leucyl aminopeptidase 0.0042 0.0111 0.0561
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0085 0.0089
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0471 0.2436
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0023 0.0028 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Schistosoma mansoni microtubule-associated protein tau 0.2103 0.919 0.919
Schistosoma mansoni histone deacetylase 4 5 0.0452 0.192 0.1917
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0004 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0502 0.2599
Plasmodium falciparum histone deacetylase 2 0.0452 0.192 1
Loa Loa (eye worm) RNA binding protein 0.0123 0.0471 0.2436
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0036 0.0088 0.0441
Schistosoma mansoni thyroid hormone receptor 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.1059 0.5505
Schistosoma mansoni histone deacetylase 1 2 3 0.0197 0.0797 0.0793
Onchocerca volvulus 0.0036 0.0088 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Brugia malayi Nuclear hormone receptor E75 0.0089 0.0321 0.1653
Giardia lamblia Histone deacetylase 0.0417 0.1765 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0037 0.0171
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Toxoplasma gondii histone deacetylase HDAC3 0.0417 0.1765 0.9188
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0037 0.0171
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0037 0.0033
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0059 0.0188 0.0963
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0189 0.0761 0.0824
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0023 0.0028 0.0026
Plasmodium vivax SET domain protein, putative 0.0062 0.0202 0.1035
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus multilocularis ecdysone induced protein 78C 0.0189 0.0761 0.0824
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Schistosoma mansoni hypothetical protein 0.0036 0.0085 0.0082
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0037 0.0171
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Onchocerca volvulus Matrilysin homolog 0.0114 0.0431 0.1942
Trypanosoma brucei histone deacetylase 1 0.0417 0.1765 0.9188
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0188 0.0201
Loa Loa (eye worm) matrix metalloproteinase 0.0114 0.0431 0.223
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0189 0.0761 0.3948
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0088 0.0441
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0092 0.0462
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Brugia malayi orphan nuclear receptor NR2E1 0.0089 0.0321 0.1653
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0053 0.0257
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.2206 0.2397
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0158 0.0802
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0334 0.1561
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0158 0.0802
Leishmania major eukaryotic initiation factor 4a, putative 0.0185 0.0742 0.3852
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0262 0.1081 0.1172
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0059 0.0188 0.0201
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0215 0.1101
Schistosoma mansoni DNA polymerase eta 0.0021 0.0021 0.0017
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Echinococcus granulosus GPCR family 2 0.0033 0.0072 0.0074
Onchocerca volvulus 0.0023 0.003 0.001
Brugia malayi Protein kinase domain containing protein 0.0087 0.0311 0.1604
Echinococcus granulosus dna polymerase eta 0.0021 0.0021 0.0018
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Echinococcus granulosus dna polymerase kappa 0.0021 0.0021 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0186 0.0747 0.3878
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0188 0.0201
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0215 0.1101
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma brucei histone deacetylase 3 0.0452 0.192 1
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi hypothetical protein 0.0089 0.0321 0.1653
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0042 0.0111 0.0107
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0053 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0334 0.1561
Brugia malayi ecdysteroid receptor 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus granulosus global transcription activator snf2l2 0.0073 0.0251 0.0269
Loa Loa (eye worm) BRM protein 0.0038 0.0095 0.0475
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Loa Loa (eye worm) acetylcholine receptor protein 0.0023 0.0028 0.0125
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0158 0.0802
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Brugia malayi Histone deacetylase family protein 0.0452 0.192 1
Loa Loa (eye worm) DR-78 0.0089 0.0321 0.1653
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0059 0.0188 0.0963
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0189 0.0761 0.0757
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0189 0.0761 0.0757
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0187 0.0183
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.071 0.3351
Giardia lamblia Kinase, PLK 0.0186 0.0747 0.421
Brugia malayi nuclear hormone receptor 0.0089 0.0321 0.1653
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.067 0.3092
Brugia malayi glutathione reductase 0.0037 0.0092 0.0462
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0037 0.0171
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0262 0.1081 0.5618
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Schistosoma mansoni RAR-like nuclear receptor 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0471 0.2436
Loa Loa (eye worm) matrixin family protein 0.0253 0.1044 0.5428
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0036 0.0088 0.0085
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.01 0.0368 0.0396
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.0747 0.3878
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0092 0.1245
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0188 0.0201
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0188 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.0761 0.3948
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0108 0.0404 0.04
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0059 0.0188 0.0963
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0139 0.0541 0.2802
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0053 0.0262
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.003 0.013
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0007 0.0017
Brugia malayi Pre-SET motif family protein 0.0434 0.184 0.9581
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus multilocularis GPCR, family 2 0.0033 0.0072 0.0074
Schistosoma mansoni glutaminase 0.0265 0.1094 0.1091
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.0321 0.141
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0185 0.0742 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0088 0.0441
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.003 0.0237
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0303 0.4084
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0059 0.0188 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0189 0.0761 0.3948
Schistosoma mansoni nuclear hormone receptor 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.158
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0189 0.0761 0.0824
Plasmodium vivax histone deacetylase 1, putative 0.0417 0.1765 0.9188
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0185 0.0742 0.4181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0189 0.0761 0.3948
Loa Loa (eye worm) glutathione reductase 0.0037 0.0092 0.0462
Onchocerca volvulus Serine\/threonine kinase homolog 0.0186 0.0747 0.3464
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.071 0.3351
Echinococcus granulosus muscleblind protein 0.0163 0.0646 0.0699
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0072 0.0074
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0189 0.0761 0.0824
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0059 0.0188 0.0963
Onchocerca volvulus Matrilysin homolog 0.0253 0.1044 0.4894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.0761 0.3948
Onchocerca volvulus 0.0162 0.0641 0.2955
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0059 0.0188 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis histone deacetylase 3 0.0417 0.1765 0.1917
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Brugia malayi steroid hormone receptor 0.0189 0.0761 0.3948
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0189 0.0761 0.3948
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0201
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Schistosoma mansoni nicalin (M28 family) 0.0042 0.0111 0.0107
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0017
Schistosoma mansoni nuclear receptor 0.0089 0.0321 0.0317
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0053 0.0262
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0238 0.1224
Onchocerca volvulus 0.0059 0.0188 0.0773
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.0761 0.3948
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0087 0.0311 0.1604
Onchocerca volvulus Protein ultraspiracle homolog 0.0189 0.0761 0.3529
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0004 0.0056
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.01 0.0368 0.0396
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0187 0.2519
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.2206 0.2397
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0192 0.0205
Loa Loa (eye worm) matrixin family protein 0.0276 0.1145 0.5953
Loa Loa (eye worm) hypothetical protein 0.0163 0.0646 0.3352
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0023 0.0028 0.0026
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0303 0.4084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Treponema pallidum ATP-dependent RNA helicase 0.0185 0.0742 0.5
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0042 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Onchocerca volvulus 0.0189 0.0761 0.3529
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0354
Schistosoma mansoni histone deacetylase hda2 0.046 0.1953 0.195
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0031 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Onchocerca volvulus 0.0059 0.0188 0.0773
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi hypothetical protein 0.0052 0.0158 0.0802
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0036 0.0088 0.0441
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0185 0.0742 0.3439
Plasmodium falciparum eukaryotic initiation factor 4A 0.0185 0.0742 0.3852
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0028 0.0125
Echinococcus multilocularis thyroid hormone receptor alpha 0.0189 0.0761 0.0824
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0141 0.0137
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0103 0.0382 0.1974
Brugia malayi Matrixin family protein 0.0276 0.1145 0.5953
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0189 0.0761 0.0824
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0023 0.0028 0.0125
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Onchocerca volvulus 0.0148 0.0578 0.2651
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Onchocerca volvulus Matrix metalloproteinase homolog 0.0253 0.1044 0.4894
Schistosoma mansoni Fxna peptidase (M28 family) 0.0042 0.0111 0.0107
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0188 0.0201
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.003 0.0404
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0345 0.4648
Onchocerca volvulus Histone deacetylase 10 homolog 0.0197 0.0797 0.3704
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0021 0.0279
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Schistosoma mansoni neurotransmitter gated ion channel 0.0036 0.0088 0.0085
Echinococcus granulosus FTZ F1 alpha 0.0189 0.0761 0.0824
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Loa Loa (eye worm) histone deacetylase 3 0.0417 0.1765 0.9188
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Loa Loa (eye worm) histone deacetylase 7A 0.0452 0.192 1
Mycobacterium ulcerans glutaminase 0.0265 0.1094 1
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0502 0.2599
Echinococcus multilocularis histone deacetylase 6 0.046 0.1953 0.2122
Loa Loa (eye worm) nuclear receptor NHR-67 0.0089 0.0321 0.1653
Brugia malayi hypothetical protein 0.0089 0.0321 0.1653
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0416 0.1758 0.1909
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Brugia malayi Muscleblind-like protein 0.0163 0.0646 0.3352
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis histone deacetylase 8 0.0197 0.0797 0.0863
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0382 0.1974
Onchocerca volvulus Bile acid receptor homolog 0.0189 0.0761 0.3529
Brugia malayi glutaminase DH11.1 0.0265 0.1094 0.5688
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0037 0.0036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0189 0.0761 0.0757
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0202 0.0216
Loa Loa (eye worm) glutaminase 0.0265 0.1094 0.5688
Leishmania major histone deacetylase, putative 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0031 0.0029
Trypanosoma brucei histone deacetylase 2 0.0197 0.0797 0.4139
Schistosoma mansoni kinase 0.0095 0.0345 0.0341
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0186 0.0747 0.0809
Brugia malayi nuclear receptor NHR-88 0.0089 0.0321 0.1653
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Loa Loa (eye worm) hypothetical protein 0.0062 0.0202 0.1035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Trypanosoma cruzi histone deacetylase 1, putative 0.0417 0.1765 0.9188
Trypanosoma brucei unspecified product 0.0021 0.0021 0.0088
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0021 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi Hemopexin family protein 0.0162 0.0641 0.3327
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Echinococcus multilocularis histone deacetylase 6 0.0452 0.192 0.2086
Brugia malayi conserved hypotetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0189 0.0761 0.3948
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Loa Loa (eye worm) LGC-31 protein 0.0059 0.0188 0.0963
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Loa Loa (eye worm) hypothetical protein 0.0263 0.1084 0.5636
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Leishmania major trypanothione reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) hypothetical protein 0.0185 0.0742 0.3852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0189 0.0761 0.3948
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0007 0.0003
Brugia malayi Nuclear hormone receptor E75 0.0089 0.0321 0.1653
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0059 0.0188 0.0963
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0028 0.0026
Onchocerca volvulus 0.0059 0.0188 0.0773
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.0747 0.0744
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0092
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.003 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0072 0.0074
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Echinococcus granulosus ecdysone induced protein 78C 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Echinococcus multilocularis nAChR subunit 0.0036 0.0088 0.0092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Mycobacterium tuberculosis Probable reductase 0.0085 0.0303 0.4084
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0085 0.0082
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0471 0.0508
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Schistosoma mansoni histone deacetylase 0.0417 0.1765 0.1762
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0111 0.15
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0053 0.0219
Loa Loa (eye worm) histone deacetylase 0.0452 0.192 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Brugia malayi histone deacetylase 1 (HD1) 0.0417 0.1765 0.9188
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) histone deacetylase 11 0.0197 0.0797 0.4139
Plasmodium vivax histone deacetylase 2, putative 0.0452 0.192 1
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.1059 0.5505
Brugia malayi nuclear receptor RXR 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni nuclear receptor 0.0089 0.0321 0.0317
Leishmania major histone deacetylase, putative 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0021 0.0279
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Brugia malayi hypothetical protein 0.01 0.0368 0.1899
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.0321 0.141
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0089 0.0321 0.1653
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0092 0.0462
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0187 0.0955
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0898 0.388 0.5
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0185 0.0742 0.0738
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Echinococcus granulosus neuropeptide s receptor 0.0517 0.2206 0.2397
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi Thioredoxin reductase 0.0037 0.0092 0.0462
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0021 0.0017
Brugia malayi Pre-SET motif family protein 0.0062 0.0202 0.1035
Echinococcus granulosus nAChR subunit 0.0036 0.0088 0.0092
Plasmodium falciparum histone deacetylase 1 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Schistosoma mansoni zinc finger protein 0.0089 0.0321 0.0317
Trypanosoma cruzi histone deacetylase, putative 0.0197 0.0797 0.4139
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0215 0.1182
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0053 0.0054
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0202 0.0216
Echinococcus granulosus histone deacetylase 6 0.0452 0.192 0.2086
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0059 0.0188 0.0963
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0085 0.0089
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0059 0.0188 0.0201
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0042 0.0111 0.0983
Entamoeba histolytica histone deacetylase, putative 0.0417 0.1765 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Onchocerca volvulus Glutaminyl cyclase homolog 0.0262 0.1081 0.507
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0197 0.0797 0.4139
Brugia malayi Peptidase family M28 containing protein 0.0262 0.1081 0.5618
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0094 0.0098
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0188 0.0201
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0018
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0095 0.0099
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Echinococcus multilocularis dual specificity 0.0087 0.0311 0.0335
Entamoeba histolytica protein kinase, putative 0.0087 0.0311 0.1731
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0321 0.0317
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.003 0.0237
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0042 0.0111 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0059 0.0188 0.0201
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0048 0.0141 0.0714
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0187 0.0199
Leishmania major hypothetical protein, conserved 0.0052 0.0158 0.0802
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0053 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Echinococcus granulosus tar DNA binding protein 0.0123 0.0471 0.0508
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0471 0.2436
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0028 0.0026
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0087 0.0311 0.1604
Echinococcus multilocularis nuclear receptor nhr 48 0.0089 0.0321 0.0345
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0017
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.0311 0.1731
Schistosoma mansoni acetylcholine receptor-related 0.0023 0.0028 0.0024
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0188 0.0201
Brugia malayi Histone deacetylase family protein 0.0452 0.192 1
Onchocerca volvulus 0.0059 0.0188 0.0773
Schistosoma mansoni nAChR subunit 0.0023 0.0028 0.0024
Echinococcus multilocularis histone deacetylase 1 0.0417 0.1765 0.1917
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0646 0.0699
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0017
Trypanosoma brucei histone deacetylase 4 0.0452 0.192 1
Plasmodium vivax histone deacetylase, putative 0.0197 0.0797 0.4139
Brugia malayi hypothetical protein 0.0148 0.0578 0.2998
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Plasmodium falciparum glutathione reductase 0.0037 0.0092 0.0462
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0345 0.6164
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Onchocerca volvulus 0.0089 0.0321 0.141
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Schistosoma mansoni histone deacetylase hda2 0.0197 0.0797 0.0793
Loa Loa (eye worm) BRM protein 0.0047 0.0134 0.068
Loa Loa (eye worm) hypothetical protein 0.0255 0.1051 0.5465
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Brugia malayi Histone deacetylase 1 0.0417 0.1765 0.9188
Brugia malayi excitatory GABA receptor EXP-1A 0.0059 0.0188 0.0963
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Schistosoma mansoni nuclear receptor nhr-48 0.0089 0.0321 0.0317
Trypanosoma cruzi histone deacetylase 1, putative 0.0417 0.1765 0.9188
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0072 0.0074
Echinococcus multilocularis microtubule associated protein 2 0.2103 0.919 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0646 0.3352
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.023
Schistosoma mansoni flap endonuclease-1 0.0026 0.0041 0.0037
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0189 0.0761 0.3948
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0185 0.0742 1
Echinococcus multilocularis histone deacetylase 7 0.0452 0.192 0.2086
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0007 0.0017
Echinococcus multilocularis dna polymerase eta 0.0021 0.0021 0.0018
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.1101
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0072 0.0354
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus multilocularis tumor protein p63 0.033 0.1383 0.1501
Trypanosoma brucei glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0262 0.1081 0.1172
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0072 0.0074
Loa Loa (eye worm) glutaminase 2 0.0265 0.1094 0.5688
Plasmodium vivax histone deacetylase, putative 0.0452 0.192 1
Onchocerca volvulus 0.0494 0.2104 1
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0188 0.0201
Brugia malayi nuclear hormone receptor family member nhr-6 0.0089 0.0321 0.1653
Echinococcus granulosus histone deacetylase 0.0452 0.192 0.2086
Loa Loa (eye worm) hypothetical protein 0.0234 0.0956 0.4969
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.0321 0.0345
Echinococcus multilocularis FTZ F1 alpha 0.0189 0.0761 0.0824
Echinococcus granulosus histone deacetylase 6 0.0452 0.192 0.2086
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0185 0.0742 0.0804
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0185 0.0742 0.3852
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0021 0.0077
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Brugia malayi nuclear receptor NHR-88 0.0189 0.0761 0.3948
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0189 0.0761 0.0824
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0037 0.0036
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Brugia malayi histone deacetylase 11 0.0197 0.0797 0.4139
Schistosoma mansoni steroid hormone receptor ad4bp 0.0189 0.0761 0.0757
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0059 0.0188 0.0185
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0321 0.0317
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0059 0.0188 0.0963
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0021 0.0018
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0186 0.0747 0.3878
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.003 0.0404
Schistosoma mansoni hypothetical protein 0.0164 0.0651 0.0647
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0021 0.0017
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0434 0.184 0.9581
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0186 0.0747 0.0809
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0185 0.0742 0.4181
Loa Loa (eye worm) leucyl aminopeptidase 0.0042 0.0111 0.0561
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0017
Schistosoma mansoni coup transcription factor 0.0189 0.0761 0.0757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0037 0.0141
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0059 0.0188 0.0963
Leishmania major histone deacetylase, putative 0.0452 0.192 1
Onchocerca volvulus 0.0036 0.0088 0.0292
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Giardia lamblia DINP protein human, muc B family 0.0021 0.0021 0.0077
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0139 0.0541 0.7289
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.2206 0.2397
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0017
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0185 0.0742 0.0804
Onchocerca volvulus 0.0048 0.0141 0.0544
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Schistosoma mansoni histone deacetylase 0.0417 0.1765 0.1762
Brugia malayi ecdysone receptor 0.0089 0.0321 0.1653
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0416 0.1758 0.1909
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Schistosoma mansoni hypothetical protein 0.0071 0.0238 0.0235
Echinococcus granulosus flap endonuclease 1 0.0028 0.0053 0.0054
Brugia malayi nuclear hormone receptor 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.158
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Echinococcus granulosus microtubule associated protein 2 0.2103 0.919 1
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0042 0.0111 0.15
Leishmania major DNA polymerase eta, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Loa Loa (eye worm) steroid hormone receptor 0.0189 0.0761 0.3948
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0185 0.0742 0.0804
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) nuclear hormone receptor 0.0089 0.0321 0.1653
Toxoplasma gondii hypothetical protein 0.0042 0.0111 0.0561
Echinococcus multilocularis histone deacetylase 0.0452 0.192 0.2086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Echinococcus granulosus geminin 0.0164 0.0651 0.0704
Brugia malayi TAR-binding protein 0.0123 0.0471 0.2436
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Toxoplasma gondii histone deacetylase HDAC5 0.0197 0.0797 0.4139

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.01 uM Inhibitory concentration against histone deacetylase activity ChEMBL. 11405644
IC50 (binding) = 0.01 uM Inhibitory concentration against maize histone deacetylase 2 ChEMBL. 15857140

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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