Detailed information for compound 1058980

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.395 | Formula: C21H20N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOC(=O)c1ccc2c(c1)c1CC(=O)Nc3c(c1[nH]2)cccc3
  • InChi: 1S/C21H20N2O3/c1-2-3-10-26-21(25)13-8-9-18-15(11-13)16-12-19(24)22-17-7-5-4-6-14(17)20(16)23-18/h4-9,11,23H,2-3,10,12H2,1H3,(H,22,24)
  • InChiKey: BPIAKNZODYMQSE-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin B1 References
Homo sapiens malate dehydrogenase 2, NAD (mitochondrial) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Trypanosoma cruzi malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to S. cerevisiae MDH3 (YDL078C) peroxisomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans similar to S. cerevisiae MDH3 (YDL078C) peroxisomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania major glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania braziliensis malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania major mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma mansoni malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense mitochondrial malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Candida albicans similar to S. cerevisiae MDH1 (YKL085W) mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Candida albicans similar to S. cerevisiae MDH1 (YKL085W) mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania mexicana malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Candida albicans similar to all three S. cerevisiae malate dehydrogenases (YKL085W, YDL078C, YOL126C) Get druggable targets OG5_127145 All targets in OG5_127145
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi glycosomal malate dehydrogenase, putative Get druggable targets OG5_127145 All targets in OG5_127145
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K00026 malate dehydrogenase [EC1.1.1.37B], putative Get druggable targets OG5_127145 All targets in OG5_127145
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana glycosomal malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis mitochondrial malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus malate dehydrogenase Get druggable targets OG5_127145 All targets in OG5_127145
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Plasmodium falciparum L-lactate dehydrogenase malate dehydrogenase 2, NAD (mitochondrial) 296 aa 319 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0136 0.0167
Schistosoma mansoni inositol monophosphatase 0.0043 0.0474 0.1488
Schistosoma mansoni DNA polymerase eta 0.002 0.0136 0.0233
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0136 0.0167
Toxoplasma gondii ABC1 family protein 0.0109 0.1436 1
Echinococcus granulosus malate dehydrogenase 0.0043 0.0475 0.1491
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1906 0.679
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Toxoplasma gondii lactate dehydrogenase LDH1 0.0022 0.0161 0.0647
Loa Loa (eye worm) hypothetical protein 0.0147 0.1989 0.5079
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.1436 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0613 0.3416
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0022 0.0161 0.0647
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1436 0.8625
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.1436 0.1319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0316 0.09
Trichomonas vaginalis cyclin B, putative 0.0016 0.0073 0.0204
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0699 0.2319
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0136 0.0557
Giardia lamblia Hypothetical protein 0.0064 0.0782 0.4486
Trichomonas vaginalis cyclin B, putative 0.0124 0.1654 0.4639
Trypanosoma cruzi cyclin, putative 0.0124 0.1654 1
Echinococcus granulosus cyclins 0.0064 0.0782 0.2627
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0613 0.1719
Giardia lamblia Cyclin A 0.0064 0.0782 0.4486
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0406 0.1234
Leishmania major DNA polymerase eta, putative 0.002 0.0136 0.0398
Echinococcus granulosus L lactate dehydrogenase B chain 0.0022 0.0161 0.0327
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0699 0.2319
Onchocerca volvulus 0.0124 0.1654 0.4527
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Trichomonas vaginalis cyclin B, putative 0.0016 0.0073 0.0204
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1436 0.4029
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0022 0.0161 0.0558
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0474 0.2604
Loa Loa (eye worm) hypothetical protein 0.0109 0.1436 0.3614
Brugia malayi Pre-SET motif family protein 0.0032 0.0316 0.0644
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.2735 0.9861
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0136 0.0233
Trypanosoma brucei unspecified product 0.002 0.0136 0.0557
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0316 0.09
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0073 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1906 0.679
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0699 0.4592
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.2735 0.7057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1906 0.679
Echinococcus multilocularis cyclins 0.0064 0.0782 0.2627
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0613 0.3416
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 0.0398
Entamoeba histolytica cyclin, putative 0.0064 0.0782 0.4486
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.1436 0.5051
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1906 0.4859
Plasmodium vivax hypothetical protein, conserved 0.0109 0.1436 1
Trichomonas vaginalis cyclin B, putative 0.0124 0.1654 0.4639
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0316 0.09
Loa Loa (eye worm) hypothetical protein 0.0032 0.0316 0.0644
Schistosoma mansoni inositol monophosphatase 0.0043 0.0474 0.1488
Echinococcus granulosus cyclin b3 0.0064 0.0782 0.2627
Trypanosoma brucei cyclin 9 0.0016 0.0073 0.0165
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0022 0.0161 0.0327
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0484 0.3019
Echinococcus granulosus lactate dehydrogenase a 0.0022 0.0161 0.0327
Mycobacterium tuberculosis Conserved protein 0.0109 0.1436 0.1319
Trichomonas vaginalis set domain proteins, putative 0.0256 0.3565 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.1654 0.419
Entamoeba histolytica cyclin family protein 0.0064 0.0782 0.4486
Leishmania major hypothetical protein, conserved 0.0109 0.1436 0.8625
Brugia malayi Pre-SET motif family protein 0.0225 0.3113 0.806
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1436 0.4029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.1436 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.1436 0.3614
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Echinococcus multilocularis cyclins 0.0064 0.0782 0.2627
Trypanosoma cruzi malate dehydrogenase, putative 0.0022 0.0161 0.0558
Loa Loa (eye worm) hypothetical protein 0.0109 0.1436 0.3614
Echinococcus granulosus cyclins 0.0064 0.0782 0.2627
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0474 0.254
Trichomonas vaginalis cyclins, putative 0.0124 0.1654 0.4639
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0136 0.0381
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0613 0.3416
Leishmania major cytosolic malate dehydrogenase 0.0022 0.0161 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.1436 0.1319
Loa Loa (eye worm) hypothetical protein 0.0124 0.1654 0.419
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0699 0.196
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0699 0.3961
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0782 0.2193
Loa Loa (eye worm) malate dehydrogenase 0.0043 0.0475 0.1067
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0613 0.2
Echinococcus multilocularis cyclins 0.0064 0.0782 0.2627
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0613 0.2
Brugia malayi follicle stimulating hormone receptor 0.0275 0.3846 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1906 0.679
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0613 0.3525
Plasmodium falciparum L-lactate dehydrogenase 0.0022 0.0161 0.1244
Echinococcus granulosus geminin 0.0201 0.2773 1
Plasmodium falciparum malate dehydrogenase 0.0022 0.0161 0.1244
Echinococcus multilocularis cyclins 0.0064 0.0782 0.2627
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0613 0.3416
Echinococcus multilocularis cyclins 0.0064 0.0782 0.2627
Echinococcus multilocularis cyclins 0.0064 0.0782 0.2627
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0474 0.1331
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0699 0.2319
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.1436 0.5051
Echinococcus granulosus protein kinase shaggy 0.0059 0.0699 0.2319
Trichomonas vaginalis cyclin A, putative 0.0016 0.0073 0.0204
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0699 0.2319
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0474 0.1488
Entamoeba histolytica cyclin, putative 0.0124 0.1654 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0613 0.1431
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0409 0.0277
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0022 0.0161 0.0451
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0022 0.0161 0.0327
Entamoeba histolytica hypothetical protein 0.0038 0.0406 0.2107
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.2735 0.9861
Loa Loa (eye worm) hypothetical protein 0.0052 0.0597 0.1388
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0699 0.3961
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0613 0.3416
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0613 0.3416
Plasmodium falciparum cyclin 0.0064 0.0782 1
Echinococcus multilocularis cyclin B 0.0124 0.1654 0.5856
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0136 0.0233
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0613 0.3416
Loa Loa (eye worm) hypothetical protein 0.006 0.0719 0.1713
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0124 0.1654 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0613 0.2
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0136 0.0398
Toxoplasma gondii lactate dehydrogenase LDH2 0.0022 0.0161 0.0647
Echinococcus multilocularis geminin 0.0201 0.2773 1
Trypanosoma brucei protein kinase, putative 0.0059 0.0699 0.406
Trichomonas vaginalis cyclins, putative 0.0124 0.1654 0.4639
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0022 0.0161 0.0451
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.2014 0.7191
Trichomonas vaginalis cyclins, putative 0.0075 0.0945 0.265
Schistosoma mansoni cyclin B 0.0124 0.1654 0.5856
Echinococcus granulosus cyclins 0.0064 0.0782 0.2627
Plasmodium falciparum protein kinase 5 0.0053 0.0613 0.7615
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0474 0.1331
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0613 0.3525
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0136 0.0398
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0484 0.1359
Toxoplasma gondii hypothetical protein 0.0049 0.0556 0.3547
Entamoeba histolytica hypothetical protein 0.0038 0.0406 0.2107
Trypanosoma brucei malate dehydrogenase-related 0.0022 0.0161 0.0714
Plasmodium falciparum lactate dehydrogenase, putative 0.0022 0.0161 0.1244
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0484 0.1525
Schistosoma mansoni L-lactate dehydrogenase 0.0022 0.0161 0.0327
Brugia malayi intracellular kinase 0.0059 0.0699 0.166
Trypanosoma cruzi CYC2-like cyclin, putative 0.0124 0.1654 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.1436 0.1319
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0699 0.3961
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0613 0.396
Trypanosoma brucei mitotic cyclin 6 0.0124 0.1654 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0136 0.0398
Trichomonas vaginalis cyclin B3, putative 0.0016 0.0073 0.0204
Mycobacterium ulcerans malate dehydrogenase 0.0022 0.0161 0.0194
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0043 0.0475 0.1067
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0431 0.2268
Toxoplasma gondii malate dehydrogenase MDH 0.0022 0.0161 0.0647
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0613 0.2
Trichomonas vaginalis cyclins, putative 0.0064 0.0782 0.2193
Entamoeba histolytica malate dehydrogenase, putative 0.0022 0.0161 0.0558
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0043 0.0475 0.2547
Trypanosoma brucei cyclin 3 0.0016 0.0073 0.0165
Echinococcus multilocularis cyclin B3 1 0.0064 0.0782 0.2627
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Schistosoma mansoni malate dehydrogenase 0.0022 0.0161 0.0327
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1953 0.6966
Trichomonas vaginalis cyclin D, putative 0.0016 0.0073 0.0204
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 0.0398
Trypanosoma brucei mitotic cyclin 0.0016 0.0073 0.0165
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0022 0.0161 0.0327
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.1654 0.419
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0699 0.166
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0613 0.1719
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1436 0.5051
Echinococcus granulosus cyclin B3 1 0.0064 0.0782 0.2627
Giardia lamblia G2/mitotic-specific cyclin B 0.0124 0.1654 1
Echinococcus multilocularis malate dehydrogenase 0.0043 0.0475 0.1491
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.1436 0.8648
Giardia lamblia DINP protein human, muc B family 0.002 0.0136 0.0398
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0316 0.09
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0474 0.254
Loa Loa (eye worm) hypothetical protein 0.0124 0.1654 0.419
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0699 0.8829
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0699 0.3961
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Echinococcus granulosus lactate dehydrogenase protein 0.0022 0.0161 0.0327
Loa Loa (eye worm) malate dehydrogenase 0.0022 0.0161 0.0234
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0474 0.1488
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.2014 0.5145
Trichomonas vaginalis cyclin D, putative 0.0064 0.0782 0.2193
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0484 0.3019
Trichomonas vaginalis cyclin B, putative 0.0124 0.1654 0.4639
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0136 0.0233
Echinococcus granulosus dna polymerase kappa 0.002 0.0136 0.0233
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0043 0.0475 0.2547
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.2014 0.7191
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Leishmania major glycosomal malate dehydrogenase 0.0043 0.0475 0.2547
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0613 0.3416
Loa Loa (eye worm) hypothetical protein 0.0022 0.0161 0.0234
Echinococcus multilocularis lactate dehydrogenase a 0.0022 0.0161 0.0327
Schistosoma mansoni malate dehydrogenase 0.0022 0.0161 0.0327
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0484 0.3019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1906 0.679
Echinococcus granulosus malate dehydrogenase 0.0043 0.0475 0.1491
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0022 0.0161 0.0026
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0275 0.3846 1
Echinococcus granulosus cyclins 0.0064 0.0782 0.2627
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.1436 0.1319
Trichomonas vaginalis esterase, putative 0.0109 0.1436 0.4029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0474 0.254
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0043 0.0475 0.2547
Trichomonas vaginalis cyclins, putative 0.0016 0.0073 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0073 0.0204
Entamoeba histolytica hypothetical protein 0.0038 0.0406 0.2107
Brugia malayi beta-lactamase family protein 0.0109 0.1436 0.3614
Loa Loa (eye worm) inositol-1 0.0043 0.0474 0.1064
Echinococcus multilocularis cyclin b3 0.0064 0.0782 0.2627
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0474 0.2664
Mycobacterium tuberculosis Conserved protein 0.0109 0.1436 0.1319
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1906 0.4859
Trypanosoma cruzi cyclin 6, putative 0.0124 0.1654 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0613 0.1431
Schistosoma mansoni malate dehydrogenase 0.0043 0.0475 0.1491
Echinococcus multilocularis lactate dehydrogenase protein 0.0022 0.0161 0.0327
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0613 0.2
Plasmodium vivax SET domain protein, putative 0.0032 0.0316 0.1782
Trichomonas vaginalis cyclin B, putative 0.0064 0.0782 0.2193
Schistosoma mansoni cyclin B3 0.0199 0.2735 0.9861
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0136 0.0557
Echinococcus multilocularis lactate dehydrogenase a 0.0022 0.0161 0.0327
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1436 0.4029
Echinococcus granulosus cytosolic malate dehydrogenase 0.0022 0.0161 0.0327
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0431 0.2268
Onchocerca volvulus 0.0059 0.0699 0.1793
Echinococcus multilocularis dna polymerase kappa 0.002 0.0136 0.0233
Trypanosoma brucei cytosolic malate dehydrogenase 0.0022 0.0161 0.0714
Schistosoma mansoni malate dehydrogenase 0.0022 0.0161 0.0327
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1436 0.8625
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0316 0.09
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1906 0.679
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0699 0.3961
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0406 0.1234
Trichomonas vaginalis cyclin B3, putative 0.0064 0.0782 0.2193
Trypanosoma brucei glycosomal malate dehydrogenase 0.0043 0.0475 0.267
Entamoeba histolytica protein kinase, putative 0.0059 0.0699 0.3961
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0484 0.1359
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 0.0398
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0613 0.1431
Echinococcus granulosus cytosolic malate dehydrogenase 0.0022 0.0161 0.0327
Trichomonas vaginalis cyclin D, putative 0.0064 0.0782 0.2193
Echinococcus granulosus cyclin B 0.0124 0.1654 0.5856
Leishmania major malate dehydrogenase 0.0043 0.0475 0.2547
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.1436 0.3614
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0613 0.3416
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0316 0.1782
Onchocerca volvulus 0.0109 0.1436 0.3905
Trichomonas vaginalis cyclin B, putative 0.0124 0.1654 0.4639
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0699 0.3961
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0613 0.3416
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0409 0.1942
Schistosoma mansoni cyclins 0.0064 0.0782 0.2627
Echinococcus granulosus lactate dehydrogenase a 0.0022 0.0161 0.0327
Echinococcus multilocularis cyclins 0.0064 0.0782 0.2627
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0136 0.0557
Mycobacterium ulcerans beta-lactamase 0.0109 0.1436 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0474 0.1331
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.1436 0.3614
Giardia lamblia Malate dehydrogenase 0.0022 0.0161 0.0558
Leishmania major malate dehydrogenase, putative 0.0022 0.0161 0.0558
Brugia malayi hypothetical protein 0.0147 0.1989 0.5079
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Onchocerca volvulus 0.0256 0.3565 1
Brugia malayi hypothetical protein 0.0038 0.0406 0.0883
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0474 0.254
Brugia malayi Inositol-1 0.0043 0.0474 0.1064
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.2735 0.7057
Trichomonas vaginalis cyclins, putative 0.0124 0.1654 0.4639
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0022 0.0161 0.0451
Mycobacterium ulcerans hypothetical protein 0.0109 0.1436 1
Onchocerca volvulus 0.0109 0.1436 0.3905
Trichomonas vaginalis cyclin A, putative 0.0124 0.1654 0.4639
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0699 0.196
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0073 0.0204
Schistosoma mansoni hypothetical protein 0.0201 0.2773 1
Echinococcus multilocularis dna polymerase eta 0.002 0.0136 0.0233
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1436 0.5051
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0474 0.2945
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0022 0.0161 0.0451
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0699 0.4592
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0136 0.0167
Onchocerca volvulus 0.0032 0.0316 0.0696
Schistosoma mansoni hypothetical protein 0.0201 0.2773 1
Entamoeba histolytica malate dehydrogenase, putative 0.0022 0.0161 0.0558
Leishmania major cyclin 0.0124 0.1654 1
Entamoeba histolytica cyclin family protein 0.0064 0.0782 0.4486
Leishmania major malate dehydrogenase, putative 0.0022 0.0161 0.0558
Plasmodium vivax malate dehydrogenase, putative 0.0022 0.0161 0.0647
Mycobacterium ulcerans lipase LipD 0.0109 0.1436 1
Onchocerca volvulus 0.0109 0.1436 0.3905
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1436 0.4029
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0022 0.0161 0.0558
Loa Loa (eye worm) beta-lactamase 0.0109 0.1436 0.3614
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0431 0.5056
Brugia malayi Protein kinase domain containing protein 0.0053 0.0613 0.1431
Echinococcus granulosus cyclins 0.0064 0.0782 0.2627
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0016 0.0073 0.0165
Brugia malayi beta-lactamase family protein 0.0109 0.1436 0.3614
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0316 0.09
Echinococcus granulosus dna polymerase eta 0.002 0.0136 0.0233
Schistosoma mansoni L-lactate dehydrogenase 0.0022 0.0161 0.0327
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0406 0.1234
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0136 0.0557
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0136 0.0233
Entamoeba histolytica hypothetical protein 0.0038 0.0406 0.2107
Loa Loa (eye worm) acetyltransferase 0.0149 0.2014 0.5145
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.1436 0.1319
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Trichomonas vaginalis cyclins, putative 0.0016 0.0073 0.0204
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1436 0.4029
Brugia malayi lactate dehydrogenase. 0.0022 0.0161 0.0234
Trichomonas vaginalis cyclins, putative 0.0124 0.1654 0.4639
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.1436 0.1319
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0043 0.0475 0.267
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0613 0.2
Loa Loa (eye worm) hypothetical protein 0.0109 0.1436 0.3614
Leishmania major DNA polymerase kappa, putative 0.002 0.0136 0.0398
Leishmania major mitochondrial malate dehydrogenase 0.0043 0.0475 0.2547
Brugia malayi cell division control protein 2 homolog 0.0053 0.0613 0.1431
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0613 0.2
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0136 0.0381
Echinococcus multilocularis lactate dehydrogenase a 0.0022 0.0161 0.0327
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.3113 0.806
Mycobacterium tuberculosis Conserved protein 0.0109 0.1436 0.1319
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0613 0.2
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 0.0398
Chlamydia trachomatis malate dehydrogenase 0.0022 0.0161 0.5
Loa Loa (eye worm) hypothetical protein 0.0109 0.1436 0.3614
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0073 0.0204
Onchocerca volvulus 0.0147 0.1989 0.5488
Mycobacterium leprae Probable lipase LipE 0.0109 0.1436 1
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0022 0.0161 0.0558
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0316 0.09
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0613 0.2
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0474 1
Brugia malayi beta-lactamase 0.0109 0.1436 0.3614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1906 0.679
Echinococcus multilocularis malate dehydrogenase 0.0043 0.0475 0.1491
Loa Loa (eye worm) hypothetical protein 0.0109 0.1436 0.3614
Mycobacterium leprae conserved hypothetical protein 0.0109 0.1436 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0699 0.166
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0557
Trichomonas vaginalis cyclin B3, putative 0.0016 0.0073 0.0204
Trichomonas vaginalis malate dehydrogenase, putative 0.0022 0.0161 0.0451
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0613 0.2
Plasmodium vivax lactate dehydrogenase 0.0022 0.0161 0.0647
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0298 0.0836
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0613 0.1719
Trypanosoma cruzi cyclin, putative 0.0124 0.1654 1
Schistosoma mansoni hypothetical protein 0.0038 0.0406 0.1234
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0022 0.0161 0.0234
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.1436 0.1319
Plasmodium vivax protein kinase Crk2 0.0053 0.0613 0.396
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0167
Trypanosoma cruzi malate dehydrogenase, putative 0.0043 0.0475 0.2547

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9.9 microM Inhibition of mitochondrial malate dehydrogenase by spectrophotometry ChEMBL. 19906467
IC50 (binding) > 10 microM Inhibition of CDK1/cyclin B ChEMBL. 19906467
IC50 (binding) > 10 microM Inhibition of GSK3-beta ChEMBL. 19906467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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