Detailed information for compound 1060879

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 264.282 | Formula: C15H12N4O
  • H donors: 1 H acceptors: 2 LogP: 3.16 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1nc2ccccc2n2c1ncc2c1cocc1
  • InChi: 1S/C15H12N4O/c1-16-14-15-17-8-13(10-6-7-20-9-10)19(15)12-5-3-2-4-11(12)18-14/h2-9H,1H3,(H,16,18)
  • InChiKey: VIVJRTXHYAOKNN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0447 0.5307 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0157 0.0142
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0111 0.3681
Echinococcus granulosus frizzled 0.0015 0.0027 0.0011
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0121 0.1323 0.131
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.1874 0.227
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0595 0.058
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0595 0.0715
Brugia malayi hypothetical protein 0.0447 0.5307 0.6444
Schistosoma mansoni cpg binding protein 0.0062 0.0593 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2908 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0025 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1352 0.1338
Schistosoma mansoni lamin 0.0026 0.0157 0.0142
Schistosoma mansoni ap endonuclease 0.0022 0.0111 0.0096
Brugia malayi Cytochrome P450 family protein 0.0019 0.0069 0.0076
Schistosoma mansoni ap endonuclease 0.0022 0.0111 0.0096
Schistosoma mansoni cpg binding protein 0.0062 0.0593 0.0578
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0346 0.2336
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1852 0.637
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.058
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.029 0.0998
Schistosoma mansoni hypothetical protein 0.0033 0.0242 0.0226
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0111 0.3681
Schistosoma mansoni cpg binding protein 0.0058 0.0552 0.0537
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0269 0.0254
Loa Loa (eye worm) hypothetical protein 0.0447 0.5307 0.6444
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0304 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0447 0.5307 0.6444
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0346 0.2336
Schistosoma mansoni lamin 0.0026 0.0157 0.0142
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0111 0.0382
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1852 0.637
Echinococcus multilocularis lamin dm0 0.0026 0.0157 0.0142
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0552 0.0663
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.029 0.0345
Schistosoma mansoni Smad4 0.0016 0.0036 0.002
Brugia malayi MH1 domain containing protein 0.0016 0.0036 0.0036
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0081 0.0828 0.2849
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0069 0.2209
Loa Loa (eye worm) hypothetical protein 0.0153 0.1714 0.2076
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0111 0.0382
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0595 0.0715
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.058
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0036 0.0036
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.029 0.0275
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0242 0.0286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.105 0.1268
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0111 0.0127
Trypanosoma brucei glucosidase, putative 0.0037 0.029 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.029 0.9536
Echinococcus granulosus frizzled 0.0015 0.0027 0.0011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.101 0.122
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.058
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0036 0.002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0157 0.0183
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0269 0.0254
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0023
Schistosoma mansoni alpha-glucosidase 0.0143 0.1591 0.1578
Onchocerca volvulus 0.0058 0.0552 0.1029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0157 0.0183
Leishmania major cytochrome p450-like protein 0.0019 0.0069 0.1014
Brugia malayi MH2 domain containing protein 0.0237 0.274 0.3323
Echinococcus granulosus tar DNA binding protein 0.0062 0.0595 0.058
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1517 0.1504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.105 0.1036
Echinococcus granulosus frizzled 0.0015 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0152 0.0176
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0428 0.0513
Loa Loa (eye worm) hypothetical protein 0.0048 0.0428 0.0513
Brugia malayi hypothetical protein 0.0035 0.0269 0.0319
Brugia malayi MH1 domain containing protein 0.0016 0.0036 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.105 0.1036
Schistosoma mansoni hypothetical protein 0.0096 0.101 0.0996
Schistosoma mansoni frizzled-like receptor 0.0015 0.0027 0.0011
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0069 0.0076
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0036 0.002
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0304 1
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.1852 0.3482
Onchocerca volvulus 0.0096 0.101 0.1893
Toxoplasma gondii exonuclease III APE 0.0022 0.0111 0.049
Schistosoma mansoni smad 0.0016 0.0036 0.002
Echinococcus multilocularis Protein lozenge 0.0056 0.0524 0.051
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0081 0.0828 0.0814
Brugia malayi CXXC zinc finger family protein 0.0058 0.0552 0.0663
Entamoeba histolytica hypothetical protein 0.0035 0.0269 0.8823
Schistosoma mansoni hypothetical protein 0.083 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0009
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.2908 0.3527
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0036 0.002
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0007 0.0023
Loa Loa (eye worm) Smad1 0.0016 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2908 1
Brugia malayi Hint module family protein 0.0153 0.1714 0.2076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.105 0.1036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.105 0.1036
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0059 0.0064
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.029 0.0998
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0346 0.0331
Echinococcus granulosus intermediate filament protein 0.0026 0.0157 0.0142
Entamoeba histolytica hypothetical protein 0.0035 0.0269 0.8823
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0111 0.0752
Echinococcus granulosus Smad4 0.0016 0.0036 0.002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0111 0.0096
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0111 0.5
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.2908 0.3527
Loa Loa (eye worm) acetyltransferase 0.0141 0.1565 0.1895
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0036 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0269 0.0254
Loa Loa (eye worm) hypothetical protein 0.0033 0.0242 0.0286
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0007 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0624 0.061
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0469 0.5582 0.6777
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.029 0.0998
Brugia malayi Cytochrome P450 family protein 0.0019 0.0069 0.0076
Loa Loa (eye worm) hypothetical protein 0.0335 0.3938 0.4778
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2908 1
Schistosoma mansoni alpha-glucosidase 0.0143 0.1591 0.1578
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.029 0.9536
Echinococcus multilocularis musashi 0.0026 0.0157 0.0142
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0624 0.061
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0121 0.1323 0.131
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0015 0.0027 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0624 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0595 0.0715
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0121 0.1323 0.131
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0111 0.0096
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0428 0.0513
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0009 0.0003
Echinococcus multilocularis smad 0.0016 0.0036 0.002
Onchocerca volvulus 0.0026 0.0157 0.0285
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0059 0.0044
Schistosoma mansoni lozenge 0.0056 0.0524 0.051
Schistosoma mansoni hypothetical protein 0.0035 0.0269 0.0254
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0624 1
Schistosoma mansoni frizzled 0.0015 0.0027 0.0011
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0624 1
Brugia malayi Melibiase family protein 0.0081 0.0828 0.0999
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0059 0.0044
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0346 0.1191
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.105 0.1268
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.029 0.0998
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0069 0.2209
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.029 0.1896
Echinococcus multilocularis frizzled 0.0015 0.0027 0.0011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0025 0.0009
Echinococcus granulosus lamin 0.0026 0.0157 0.0142
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.029 0.0275
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.029 0.0998
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.274 0.3323
Onchocerca volvulus 0.0096 0.1016 0.1904
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1565 0.1552
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0048 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0624 0.061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0111 0.3681
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0428 0.0513
Echinococcus granulosus cpg binding protein 0.0062 0.0593 0.0578
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0036 0.002
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.058
Loa Loa (eye worm) hypothetical protein 0.0081 0.0828 0.0999
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.029 0.0998
Echinococcus granulosus frizzled 5 0.0015 0.0027 0.0011
Brugia malayi TAR-binding protein 0.0062 0.0595 0.0715
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1874 0.1862
Echinococcus multilocularis frizzled 5 0.0015 0.0027 0.0011
Echinococcus multilocularis GPCR, family 2 0.0015 0.0025 0.0009
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1565 0.1552
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.105 0.1036
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0056 0.006
Brugia malayi hypothetical protein 0.0469 0.5582 0.6777
Echinococcus granulosus smoothened 0.0342 0.4024 0.4015
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0069 0.0076
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1565 0.1895
Echinococcus granulosus lamin dm0 0.0026 0.0157 0.0142
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0036 0.0036
Brugia malayi MH2 domain containing protein 0.0016 0.0036 0.0036
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0624 0.4517
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.029 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0081 0.0828 0.0814
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0595 0.0715
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1852 0.637
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0009
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0304 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.105 0.1036
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0111 0.351
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.029 0.0345
Echinococcus granulosus GPCR family 2 0.0015 0.0025 0.0009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0624 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1852 0.637
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.029 0.0998
Schistosoma mansoni hypothetical protein 0.0411 0.4868 0.486
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0111 0.169
Schistosoma mansoni alpha glucosidase 0.0037 0.029 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.058
Echinococcus multilocularis frizzled 0.0015 0.0027 0.0011
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.1874 0.1862
Brugia malayi MH2 domain containing protein 0.0016 0.0036 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0025 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0111 0.5
Brugia malayi RNA binding protein 0.0062 0.0595 0.0715
Schistosoma mansoni smad1 5 8 and 0.0016 0.0036 0.002
Onchocerca volvulus 0.0026 0.0157 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1961 0.6743
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0121 0.1323 0.131
Schistosoma mansoni smad1 5 8 and 0.0016 0.0036 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1852 0.637
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2908 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.029 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1852 0.637
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.105 0.1036
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1232 0.9289
Loa Loa (eye worm) hypothetical protein 0.0153 0.1714 0.2076
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0157 0.0183
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0023
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.029 0.0998
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2908 1
Brugia malayi Smad1 0.0016 0.0036 0.0036
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0346 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0121 0.1323 0.131
Toxoplasma gondii melibiase subfamily protein 0.0121 0.1323 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0121 0.1323 0.131
Echinococcus granulosus frizzled 4 0.0015 0.0027 0.0011
Echinococcus multilocularis hedgehog 0.0564 0.6744 0.6739
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.029 0.0998
Echinococcus multilocularis frizzled 10 0.0015 0.0027 0.0011
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0009 0.0003
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0015 0.0027 0.0025
Echinococcus multilocularis Smad4 0.0016 0.0036 0.002
Loa Loa (eye worm) runx1 0.0056 0.0524 0.0629
Brugia malayi intermediate filament protein 0.0026 0.0157 0.0183
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0346 0.1191
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0069 0.2209
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0015 0.0027 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0111 0.0127
Echinococcus granulosus smad 0.0016 0.0036 0.002
Schistosoma mansoni frizzled-like receptor 0.0015 0.0027 0.0011
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.274 0.3323
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0025 0.0009
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0157 0.0183
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0624 0.061
Entamoeba histolytica hypothetical protein 0.0035 0.0269 0.8823
Schistosoma mansoni survival motor neuron protein 0.0096 0.101 0.0996
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0025 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1961 0.6743
Entamoeba histolytica hypothetical protein 0.0035 0.0269 0.8823
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1852 0.637
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0685 0.8233 1
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.2908 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.1874 0.227
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0624 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1874 0.1862
Echinococcus granulosus Desert hedgehog protein 0.0564 0.6744 0.6739
Brugia malayi Hint module family protein 0.0153 0.1714 0.2076
Schistosoma mansoni smad1 5 8 and 0.0016 0.0036 0.002
Echinococcus multilocularis frizzled 4 0.0015 0.0027 0.0011
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0015 0.0027 0.0025
Echinococcus granulosus survival motor neuron protein 1 0.0469 0.5582 0.5575
Echinococcus multilocularis cpg binding protein 0.0062 0.0593 0.0578
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.029 0.459
Echinococcus multilocularis smoothened 0.0342 0.4024 0.4015
Echinococcus multilocularis lamin 0.0026 0.0157 0.0142
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0023
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0121 0.1323 0.131
Brugia malayi follicle stimulating hormone receptor 0.0685 0.8233 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0025 0.0022
Echinococcus multilocularis survival motor neuron protein 1 0.0469 0.5582 0.5575
Echinococcus multilocularis dnaJ subfamily B 0.083 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0007 0.0023
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0069 0.0076

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 74.1 uM Cytotoxicity against human A375 cells after 96 hrs by MTT assay ChEMBL. 19278757

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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