Detailed information for compound 1069028

Basic information

Technical information
  • TDR Targets ID: 1069028
  • Name: 4-(phenylamino)-6-(propan-2-ylamino)-1,3,5-tr iazine-2-carbonitrile
  • MW: 254.29 | Formula: C13H14N6
  • H donors: 2 H acceptors: 4 LogP: 3.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1nc(Nc2ccccc2)nc(n1)NC(C)C
  • InChi: 1S/C13H14N6/c1-9(2)15-12-17-11(8-14)18-13(19-12)16-10-6-4-3-5-7-10/h3-7,9H,1-2H3,(H2,15,16,17,18,19)
  • InChiKey: SBCCNMDXOPPQRI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-(isopropylamino)-6-(phenylamino)-1,3,5-triazine-2-carbonitrile
  • 4-(isopropylamino)-6-(phenylamino)-s-triazine-2-carbonitrile
  • Oprea1_790994
  • ZINC00499751

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Carica papaya Papain Starlite/ChEMBL No references
Homo sapiens cathepsin K Starlite/ChEMBL References
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Cathepsin L homolog Papain   345 aa 317 aa 33.8 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Papain   345 aa 313 aa 29.7 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 318 aa 22.3 %
Giardia lamblia Dipeptidyl-peptidase I precursor Papain   345 aa 281 aa 26.0 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 302 aa 24.8 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 392 aa 23.0 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium vivax vivapain-1 Papain   345 aa 360 aa 30.0 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Plasmodium yoelii cysteine proteinase precursor Papain   345 aa 346 aa 30.6 %
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Papain   345 aa 320 aa 28.4 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 343 aa 25.4 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 361 aa 24.9 %
Brugia malayi cathepsin B-like cysteine proteinase Papain   345 aa 306 aa 26.1 %
Echinococcus multilocularis cathepsin L Papain   345 aa 352 aa 36.4 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 357 aa 26.9 %
Plasmodium vivax vivapain-3 Papain   345 aa 340 aa 33.2 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Papain   345 aa 328 aa 33.5 %
Brugia malayi Papain family cysteine protease containing protein Papain   345 aa 308 aa 27.6 %
Trypanosoma cruzi cysteine protease, putative Papain   345 aa 344 aa 30.8 %
Trypanosoma cruzi cysteine proteinase, putative Papain   345 aa 298 aa 29.2 %
Onchocerca volvulus Papain   345 aa 344 aa 23.3 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Papain   345 aa 328 aa 33.5 %
Theileria parva cysteine proteinase, putative Papain   345 aa 324 aa 32.1 %
Plasmodium vivax unspecified product Papain   345 aa 358 aa 30.2 %
Trypanosoma cruzi cysteine proteinase, putative Papain   345 aa 299 aa 30.1 %
Plasmodium knowlesi knowpain-1 Papain   345 aa 396 aa 29.8 %
Onchocerca volvulus Papain   345 aa 326 aa 31.9 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Papain   345 aa 342 aa 30.7 %
Echinococcus granulosus cathepsin L Papain   345 aa 316 aa 29.1 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Papain   345 aa 324 aa 35.2 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 351 aa 25.1 %
Giardia lamblia Dipeptidyl-peptidase I precursor Papain   345 aa 280 aa 29.6 %
Dictyostelium discoideum cathepsin L-like proteinase Papain   345 aa 330 aa 37.3 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 291 aa 24.1 %
Onchocerca volvulus Protein MCM10 homolog Papain   345 aa 294 aa 34.7 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 321 aa 29.3 %
Theileria parva cysteine proteinase, putative Papain   345 aa 350 aa 29.4 %
Plasmodium berghei berghepain-1 Papain   345 aa 345 aa 29.9 %
Echinococcus multilocularis cathepsin L Papain   345 aa 355 aa 27.3 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Papain   345 aa 323 aa 26.3 %
Onchocerca volvulus Papain   345 aa 307 aa 35.5 %
Entamoeba histolytica cysteine protease, putative Papain   345 aa 373 aa 27.3 %
Echinococcus granulosus cathepsin b Papain   345 aa 321 aa 25.9 %
Onchocerca volvulus Papain   345 aa 312 aa 35.6 %
Plasmodium falciparum cysteine proteinase falcipain 1 Papain   345 aa 376 aa 30.6 %
Babesia bovis papain family cysteine protease containing protein Papain   345 aa 342 aa 31.0 %
Neospora caninum hypothetical protein Papain   345 aa 297 aa 23.2 %
Echinococcus granulosus cathepsin L Papain   345 aa 356 aa 36.0 %
Theileria parva cysteine proteinase, putative Papain   345 aa 307 aa 29.0 %
Onchocerca volvulus Papain   345 aa 324 aa 32.1 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Papain   345 aa 355 aa 30.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.1231 1
Schistosoma mansoni hypothetical protein 0.0181 0.1865 0.4441
Brugia malayi mbt repeat family protein 0.0051 0.0213 0.0507
Toxoplasma gondii Alpha-amylase AMY3, putative 0.009 0.0707 0.0537
Trichomonas vaginalis alpha-amylase, putative 0.009 0.0707 0.0659
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.2116 0.504
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0074 0.0508 0.046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0508 0.046
Leishmania major cathepsin L-like protease 0.0131 0.1231 1
Brugia malayi Alpha amylase, catalytic domain containing protein 0.009 0.0707 0.1683
Loa Loa (eye worm) hypothetical protein 0.0051 0.0213 0.0507
Trichomonas vaginalis alpha-amylase, putative 0.0731 0.8859 0.8853
Entamoeba histolytica alpha-amylase family protein 0.009 0.0707 0.0659
Entamoeba histolytica oligo-1,6-glucosidase, putative 0.009 0.0707 0.0659
Brugia malayi Muscleblind-like protein 0.0159 0.1593 0.3793
Schistosoma mansoni alpha-amylase 0.009 0.0707 0.1683
Loa Loa (eye worm) hypothetical protein 0.0058 0.0302 0.072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0508 0.046
Brugia malayi Cathepsin L-like cysteine proteinase 0.005 0.0197 0.0469
Trypanosoma cruzi cruzipain precursor, putative 0.0131 0.1231 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Brugia malayi 1,4-alpha-glucan branching enzyme 0.0364 0.4199 1
Echinococcus granulosus cathepsin L cysteine protease 0.0038 0.0051 0.0122
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0213 0.0507
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0543 0.1293
Onchocerca volvulus 0.0074 0.0508 0.1163
Echinococcus granulosus cathepsin l1 0.0074 0.0508 0.1211
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0213 0.0507
Onchocerca volvulus 0.0074 0.0508 0.1163
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0051 0.0122
Echinococcus multilocularis glucan (1,4 alpha), branching enzyme 1 0.0364 0.4199 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.2116 0.504
Onchocerca volvulus 0.026 0.2876 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0197 0.0469
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0543 0.1293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0939 0.2236
Onchocerca volvulus 0.0051 0.022 0.0087
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.1231 1
Trichomonas vaginalis amylase, putative 0.0364 0.4199 0.4169
Loa Loa (eye worm) hypothetical protein 0.0074 0.0504 0.1201
Schistosoma mansoni cathepsin F (C01 family) 0.0074 0.0508 0.1211
Trichomonas vaginalis alpha-amylase, putative 0.009 0.0707 0.0659
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.0508 0.046
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0302 0.072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0508 0.046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0543 0.1293
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.2474 0.5893
Onchocerca volvulus 0.0074 0.0508 0.1163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Entamoeba histolytica cysteine protease, putative 0.0074 0.0508 0.046
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0051 0.0122
Toxoplasma gondii alpha amylase, catalytic domain-containing protein 0.0364 0.4199 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0074 0.0508 0.1211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Echinococcus granulosus geminin 0.0181 0.1865 0.4441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0508 0.046
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0197 0.0146
Schistosoma mansoni cathepsin F (C01 family) 0.0074 0.0508 0.1211
Loa Loa (eye worm) hypothetical protein 0.005 0.0197 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Loa Loa (eye worm) alpha amylase 0.009 0.0707 0.1683
Brugia malayi mbt repeat family protein 0.0051 0.0213 0.0507
Trichomonas vaginalis alpha-amylase, putative 0.009 0.0707 0.0659
Echinococcus granulosus glucan 14 alpha branching enzyme 1 0.0364 0.4199 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Schistosoma mansoni hypothetical protein 0.0181 0.1865 0.4441
Brugia malayi hypothetical protein 0.0252 0.2774 0.6607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0508 0.046
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.1231 1
Entamoeba histolytica hypothetical protein 0.0077 0.0543 0.0494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Echinococcus granulosus muscleblind protein 0.0159 0.1593 0.3793
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0074 0.0508 0.1211
Entamoeba histolytica beta/alpha-amylase precursor, putative 0.009 0.0707 0.0659
Schistosoma mansoni alpha-amylase 0.009 0.0707 0.1683
Loa Loa (eye worm) hypothetical protein 0.0074 0.0508 0.1211
Chlamydia trachomatis 1,4-alpha-glucan branching enzyme 0.0364 0.4199 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0213 0.0507
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0074 0.0508 1
Plasmodium vivax vivapain-2 0.0074 0.0508 1
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.0508 0.046
Loa Loa (eye worm) hypothetical protein 0.0364 0.4199 1
Schistosoma mansoni alpha-amylase 0.009 0.0707 0.1683
Trichomonas vaginalis starch branching enzyme II, putative 0.0364 0.4199 0.4169
Schistosoma mansoni starch branching enzyme II 0.0364 0.4199 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0074 0.0508 0.1211
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0074 0.0508 0.1211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Brugia malayi Papain family cysteine protease containing protein 0.0074 0.0508 0.1211
Toxoplasma gondii glycosyltransferase 0.0364 0.4199 1
Echinococcus granulosus cathepsin L 0.0038 0.0051 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0707 0.0659
Trichomonas vaginalis alpha-amylase, putative 0.009 0.0707 0.0659
Schistosoma mansoni alpha-amylase 0.009 0.0707 0.1683
Entamoeba histolytica alpha-amylase, putative 0.009 0.0707 0.0659
Brugia malayi Alpha amylase, catalytic domain containing protein 0.009 0.0707 0.1683
Onchocerca volvulus Cathepsin L homolog 0.0074 0.0508 0.1163
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0302 0.072
Loa Loa (eye worm) hypothetical protein 0.0159 0.1593 0.3793
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0213 0.0507
Loa Loa (eye worm) MBCTL1 0.0058 0.0302 0.072
Loa Loa (eye worm) cysteine protease 0.0074 0.0508 0.1211
Schistosoma mansoni hypothetical protein 0.0077 0.0543 0.1293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0508 0.046
Onchocerca volvulus Cathepsin F homolog 0.0074 0.0508 0.1163
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0074 0.0508 0.1211
Echinococcus multilocularis trehalose 6 phosphate hydrolase 0.009 0.0707 0.1683
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0197 0.0469
Echinococcus granulosus cathepsin L cysteine proteinase 0.0074 0.0508 0.1211
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0364 0.4199 0.4169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0197 0.0146
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0213 0.0507
Brugia malayi Cathepsin L-like precursor 0.0074 0.0508 0.1211
Entamoeba histolytica hypothetical protein 0.0077 0.0543 0.0494
Echinococcus multilocularis geminin 0.0181 0.1865 0.4441
Trichomonas vaginalis alpha-amylase, putative 0.009 0.0707 0.0659
Loa Loa (eye worm) fibroinase 0.0074 0.0508 0.1211
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.2774 0.6607
Trichomonas vaginalis alpha-amylase, putative 0.009 0.0707 0.0659
Trichomonas vaginalis alpha-amylase, putative 0.009 0.0707 0.0659
Echinococcus granulosus trehalose 6 phosphate hydrolase 0.009 0.0707 0.1683
Onchocerca volvulus 0.0074 0.0508 0.1163
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0504 0.1201
Brugia malayi Cathepsin L-like precursor 0.005 0.0197 0.0469
Trichomonas vaginalis set domain proteins, putative 0.026 0.2876 0.284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Onchocerca volvulus 0.0074 0.0508 0.1163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Echinococcus multilocularis cathepsin L 0.0038 0.0051 0.0122
Brugia malayi Cathepsin L-like precursor 0.005 0.0197 0.0469
Schistosoma mansoni alpha-amylase 0.009 0.0707 0.1683
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0364 0.4199 0.4169
Echinococcus multilocularis muscleblind protein 0.0159 0.1593 0.3793
Entamoeba histolytica alpha-amylase family protein 0.009 0.0707 0.0659
Schistosoma mansoni hypothetical protein 0.0051 0.022 0.0524
Entamoeba histolytica hypothetical protein 0.0077 0.0543 0.0494
Plasmodium falciparum cysteine proteinase falcipain 3 0.0074 0.0508 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0213 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0051 0.0122
Echinococcus multilocularis cysteine protease 0.0074 0.0508 0.1211
Loa Loa (eye worm) hypothetical protein 0.0159 0.1593 0.3793
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0508 0.046
Loa Loa (eye worm) alpha amylase 0.009 0.0707 0.1683
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0197 0.0146
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0939 0.2236
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0302 0.072
Trichomonas vaginalis alpha-amylase, putative 0.009 0.0707 0.0659
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0213 0.0507
Entamoeba histolytica hypothetical protein 0.0077 0.0543 0.0494
Brugia malayi Cathepsin L-like precursor 0.0074 0.0508 0.1211
Giardia lamblia 1,4-alpha-glucan branching enzyme 0.0364 0.4199 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0508 0.3875
Onchocerca volvulus 0.0051 0.0213 0.006
Brugia malayi Cathepsin L-like precursor 0.0074 0.0508 0.1211
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0074 0.0508 0.046
Brugia malayi cathepsin L-like precursor 0.005 0.0197 0.0469
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0074 0.0508 0.1211
Echinococcus multilocularis cysteine protease 0.0074 0.0508 0.1211
Brugia malayi Cathepsin L-like precursor 0.0074 0.0508 0.1211
Trichomonas vaginalis amylase, putative 0.009 0.0707 0.0659
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0508 0.046
Toxoplasma gondii 1,4-alpha-glucan-branching enzyme 0.0364 0.4199 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0051 0.0122
Onchocerca volvulus Cathepsin L homolog 0.0074 0.0508 0.1163
Mycobacterium tuberculosis 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) 0.0364 0.4199 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Brugia malayi Cathepsin L-like precursor 0.0074 0.0508 0.1211
Mycobacterium ulcerans glycogen branching protein 0.0364 0.4199 1
Entamoeba histolytica hypothetical protein 0.009 0.0707 0.0659
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0302 0.072
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0038 0.0051 0.0122
Echinococcus multilocularis cathepsin L cysteine protease 0.0074 0.0508 0.1211
Schistosoma mansoni hypothetical protein 0.009 0.0707 0.1683
Brugia malayi hypothetical protein 0.0077 0.0543 0.1293
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0213 0.0507
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0302 0.072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Leishmania major cathepsin L-like protease 0.0131 0.1231 1
Loa Loa (eye worm) hypothetical protein 0.0252 0.2774 0.6607
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0213 0.0507
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.1231 1
Entamoeba histolytica alpha-amylase, putative 0.009 0.0707 0.0659
Trichomonas vaginalis alpha-amylase, putative 0.009 0.0707 0.0659
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0074 0.0508 1
Schistosoma mansoni hypothetical protein 0.0074 0.0504 0.1201
Plasmodium vivax vivapain-2 0.0074 0.0508 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Loa Loa (eye worm) ctsf protein 0.0074 0.0508 0.1211
Leishmania major cathepsin L-like protease 0.0131 0.1231 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0074 0.0508 0.046
Onchocerca volvulus 0.0074 0.0508 0.1163
Echinococcus granulosus cathepsin l1 0.005 0.0197 0.0469
Loa Loa (eye worm) hypothetical protein 0.005 0.0197 0.0469
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.2774 0.6607
Echinococcus multilocularis alpha glucosidase 0.009 0.0707 0.1683
Echinococcus granulosus alpha glucosidase 0.009 0.0707 0.1683
Brugia malayi Cathepsin L-like precursor 0.0074 0.0508 0.1211
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.0462 0.3483
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0939 0.2236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Echinococcus granulosus cysteine protease 0.0038 0.0051 0.0122
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0106 0.0919 0.7358
Brugia malayi Pre-SET motif family protein 0.0229 0.2474 0.5893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0302 0.072
Loa Loa (eye worm) hypothetical protein 0.0108 0.0939 0.2236
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.022 0.0524
Schistosoma mansoni survival motor neuron protein 0.0051 0.022 0.0524
Echinococcus multilocularis muscleblind protein 1 0.0159 0.1593 0.3793
Schistosoma mansoni hypothetical protein 0.0309 0.35 0.8336
Mycobacterium leprae Putative uncharacterized protein ML2045 0.009 0.0707 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0508 0.046
Onchocerca volvulus 0.0074 0.0508 0.1163

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.2 uM Inhibition of human recombinant His-tagged cathepsin K using Cbz-Phe-Arg-AMC as substrate incubated for 30 mins prior to substrate addition by FRET assay ChEMBL. 23350811
IC50 (binding) = 0.89 uM Inhibition of Trypanosoma cruzi cruzain after 15 mins ChEMBL. 19908842
Inhibition (binding) Covalent reversible inhibition of human recombinant His-tagged cathepsin K using Cbz-Phe-Arg-AMC as substrate at 333-fold IC50 incubated for 30 mins prior to substrate addition followed by 333-fold dilution measured up to 60 mins by rapid dilution assay ChEMBL. 23350811
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay. (Class of assay: confirmatory) [Related pubchem assays: 1476 (Cruzain without detergent), 1478 (Cruzain with detergent)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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