Detailed information for compound 1092841

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 561.67 | Formula: C35H35N3O4
  • H donors: 2 H acceptors: 4 LogP: 5.83 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CC[C@@H](C(=O)N1CCN(CC1)c1cccc(c1)C)NC(=O)c1cc(cc(c1)c1ccccc1)c1ccccc1
  • InChi: 1S/C35H35N3O4/c1-25-9-8-14-31(21-25)37-17-19-38(20-18-37)35(42)32(15-16-33(39)40)36-34(41)30-23-28(26-10-4-2-5-11-26)22-29(24-30)27-12-6-3-7-13-27/h2-14,21-24,32H,15-20H2,1H3,(H,36,41)(H,39,40)/t32-/m0/s1
  • InChiKey: HRHFPPMGKJJEKB-YTTGMZPUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2Y, G-protein coupled, 12 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0642
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0148 0.2386
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.03 0.1064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.0622 0.2209
Echinococcus multilocularis GPCR, family 2 0.0036 0.0144 0.0144
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0041 0.018
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0041 0.0144
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0153 0.0959
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0055 0.0055
Echinococcus multilocularis expressed conserved protein 0.009 0.0483 0.0483
Schistosoma mansoni spingomyelin synthetase-related 0.0024 0.0073 0.0324
Schistosoma mansoni hypothetical protein 0.0036 0.0144 0.0639
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.031 0.1377
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0028 0.0125
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0094 0.0333
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0144 0.0144
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0173 0.0173
Onchocerca volvulus 0.0015 0.0013 0.019
Leishmania major pantothenate kinase subunit, putative 0.0013 0.0004 0.0012
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0028 0.0872
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0642
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.176 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0018
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0061 0.03 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0039 0.0137
Brugia malayi hypothetical protein 0.0466 0.2818 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0519 0.0519
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0153 0.0858
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.03 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0028 0.0148
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0792 0.4493
Onchocerca volvulus 0.0019 0.0041 0.0606
Brugia malayi jmjC domain containing protein 0.0017 0.0028 0.01
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1179
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0005 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0173 0.0614
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.176 1
Trypanosoma brucei inositol phosphorylceramide synthase 0.0024 0.0073 0.0402
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0041 0.018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0508 0.3213
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0181 0.1136
Loa Loa (eye worm) hypothetical protein 0.012 0.067 0.2377
Echinococcus multilocularis muscleblind protein 1 0.015 0.0857 0.0857
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0291 0.1733 0.615
Schistosoma mansoni cpg binding protein 0.0031 0.0115 0.0513
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0293 0.1301
Echinococcus multilocularis lamin dm0 0.0028 0.0094 0.0094
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0028 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0181 0.1017
Echinococcus granulosus lamin 0.0028 0.0094 0.0333
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.03 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0144 0.0144
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.03 0.4846
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0041 0.0144
Toxoplasma gondii exonuclease III APE 0.0061 0.03 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0173 0.0769
Schistosoma mansoni ap endonuclease 0.0061 0.03 0.1333
Schistosoma mansoni thyroid hormone receptor 0.004 0.0173 0.0769
Echinococcus multilocularis survival motor neuron protein 1 0.0466 0.2818 0.2818
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.03 0.1693
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0028 0.0148
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0397 0.1409
Brugia malayi steroid hormone receptor 0.004 0.0173 0.0614
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0073 0.2375
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0268 0.8944
Onchocerca volvulus 0.0042 0.0181 0.2701
Toxoplasma gondii thioredoxin reductase 0.0037 0.0153 0.5069
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.03 0.1693
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0181 0.0181
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0041 0.0144
Onchocerca volvulus Huntingtin homolog 0.012 0.067 1
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1179
Brugia malayi Fli-1 protein 0.0232 0.1364 0.4841
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.176 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0028 0.0872
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0148 0.4886
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0181 0.2013
Mycobacterium ulcerans lipase LipD 0.0042 0.0181 0.2013
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0073 0.0402
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0614
Schistosoma mansoni hypothetical protein 0.0036 0.0144 0.0639
Onchocerca volvulus 0.0042 0.0181 0.2701
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0041 0.0144
Brugia malayi hypothetical protein 0.0019 0.0041 0.0144
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.176 1
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0028 0.0028
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0028 0.01
Schistosoma mansoni hypothetical protein 0.0112 0.0619 0.275
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0449 0.2839
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0614
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0181 0.1015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0291 0.1733 0.1733
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0291 0.1733 0.615
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0073 0.2432
Mycobacterium tuberculosis Conserved protein 0.0042 0.0181 0.1136
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0066 0.0718
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0024 0.0137
Mycobacterium leprae Probable lipase LipE 0.0042 0.0181 0.2603
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1179
Brugia malayi ecdysone receptor 0.0019 0.0041 0.0144
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0148 0.0827
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0055 0.0243
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0173 0.0173
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0173 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0173 0.0614
Brugia malayi nuclear receptor RXR 0.0021 0.0055 0.0194
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0259
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.03 0.1064
Brugia malayi beta-lactamase family protein 0.0042 0.0181 0.0642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0173 0.0614
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0041 0.018
Echinococcus multilocularis muscleblind protein 0.015 0.0857 0.0857
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0181 0.0642
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0293 0.3272
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0073 0.0402
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0234
Brugia malayi hypothetical protein 0.012 0.067 0.2377
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0181 0.1136
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0073 0.2432
Schistosoma mansoni hypothetical protein 0.004 0.0169 0.0752
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0173 0.0614
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0259
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0181 0.1017
Toxoplasma gondii hypothetical protein 0.0024 0.0073 0.2375
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0519 0.8395
Schistosoma mansoni ap endonuclease 0.0061 0.03 0.1333
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Brugia malayi jmjC domain containing protein 0.0017 0.0028 0.01
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0055 0.0194
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0124 0.0774
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0173 0.0769
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0173 0.0614
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.01
Schistosoma mansoni hypothetical protein 0.0095 0.0513 0.228
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0173 0.0614
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.0622 0.2209
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0148 0.0827
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0173 0.0614
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0041 0.0144
Loa Loa (eye worm) hypothetical protein 0.0096 0.0519 0.1843
Echinococcus granulosus lamin dm0 0.0028 0.0094 0.0333
Schistosoma mansoni ets-related 0.0232 0.1364 0.6063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0173 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0073 0.2432
Entamoeba histolytica hypothetical protein 0.0112 0.0619 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0066 0.1067
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0173 0.0173
Brugia malayi conserved hypotetical protein 0.0019 0.0041 0.0144
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0173 0.0769
Echinococcus granulosus GPCR family 2 0.0036 0.0144 0.051
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0041 0.0144
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0024 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0194
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0028 0.0125
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0002 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.1733 0.7703
Brugia malayi hypothetical protein 0.0021 0.0055 0.0194
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0449 0.8669
Schistosoma mansoni survival motor neuron protein 0.0095 0.0513 0.228
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0181 0.0642
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0181 0.6036
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0293 0.1039
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0002 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0181 0.6036
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0173 0.2584
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.089 0.5646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0173 0.0614
Loa Loa (eye worm) hypothetical protein 0.0065 0.0328 0.1165
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0718
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0792 0.4493
Brugia malayi jmjC domain containing protein 0.0017 0.0028 0.01
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0041 0.0041
Echinococcus multilocularis protein patched 0.0041 0.0178 0.0178
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0028 0.0872
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0173 0.2584
Brugia malayi nuclear hormone receptor 0.0019 0.0041 0.0144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0066 0.0718
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0073 0.0402
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0194
Loa Loa (eye worm) DR-78 0.0019 0.0041 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0173 0.0614
Schistosoma mansoni hypothetical protein 0.004 0.0169 0.0752
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0181 0.6036
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.03 0.3351
Brugia malayi beta-lactamase 0.0042 0.0181 0.0642
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0148 0.4886
Echinococcus granulosus phd:f box containing protein 0.0017 0.0028 0.01
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0173 0.0769
Schistosoma mansoni inositol monophosphatase 0.0036 0.0148 0.0656
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0291 0.1733 0.1733
Onchocerca volvulus 0.0042 0.0181 0.2701
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0024 0.0137
Brugia malayi Ets-domain containing protein 0.0076 0.0397 0.1409
Brugia malayi Ets-domain containing protein 0.0076 0.0397 0.1409
Schistosoma mansoni intermediate filament proteins 0.0028 0.0094 0.0417
Loa Loa (eye worm) hypothetical protein 0.0051 0.0236 0.0838
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0055 0.0194
Entamoeba histolytica hypothetical protein 0.0112 0.0619 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0449 0.2839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0173 0.0614
Leishmania major trypanothione reductase 0.0037 0.0153 0.0858
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0073 0.0259
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0067 0.0238
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0041 0.0606
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0105
Loa Loa (eye worm) glutathione reductase 0.0037 0.0153 0.0543
Loa Loa (eye worm) hypothetical protein 0.0036 0.0144 0.051
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0066 0.1067
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0173 0.0614
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0153 0.0543
Echinococcus granulosus FTZ F1 alpha 0.004 0.0173 0.0614
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0041 0.0144
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0153 0.5069
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.03 1
Mycobacterium ulcerans hypothetical protein 0.0156 0.089 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0024 0.0137
Brugia malayi jmjC domain containing protein 0.0017 0.0028 0.01
Brugia malayi CHE-14 protein 0.0041 0.0178 0.0633
Brugia malayi intermediate filament protein 0.0028 0.0094 0.0333
Mycobacterium ulcerans beta-lactamase 0.0042 0.0181 0.2013
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0519 0.1843
Schistosoma mansoni cpg binding protein 0.0029 0.0105 0.0466
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0397 0.1409
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.03 0.1693
Schistosoma mansoni coup transcription factor 0.004 0.0173 0.0769
Echinococcus granulosus expressed conserved protein 0.009 0.0483 0.1714
Brugia malayi jmjC domain containing protein 0.0066 0.033 0.1171
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0073 0.0402
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0028 0.0148
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.01
Echinococcus multilocularis musashi 0.0028 0.0094 0.0094
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.03 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0181 0.1136
Loa Loa (eye worm) hypothetical protein 0.015 0.0857 0.3039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0144 0.051
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0293 0.9764
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0148 0.4924
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Echinococcus multilocularis lamin 0.0028 0.0094 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0173 0.0614
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0234
Loa Loa (eye worm) hypothetical protein 0.0077 0.0401 0.1422
Schistosoma mansoni hypothetical protein 0.0036 0.0144 0.0639
Brugia malayi CXXC zinc finger family protein 0.0029 0.0105 0.0372
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0041 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0173 0.0614
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0041 0.0041
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0024 0.0073 0.0259
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0041 0.0144
Plasmodium vivax sphingomyelin synthase 1, putative 0.0024 0.0073 0.2375
Brugia malayi nuclear receptor RXR 0.0019 0.0041 0.0144
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0094 0.0333
Leishmania major hypothetical protein, conserved 0.0042 0.0181 0.1017
Brugia malayi tailless protein 0.0019 0.0041 0.0144
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0293 0.3272
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0041 0.018
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.032 0.032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0024 0.0137
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0508 1
Schistosoma mansoni lamin 0.0028 0.0094 0.0417
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0259
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0024 0.0073 0.2375
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0614
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0291 0.1733 0.615
Schistosoma mansoni nuclear hormone receptor 0.004 0.0173 0.0769
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0148 0.1637
Echinococcus granulosus cpg binding protein 0.0031 0.0115 0.0409
Onchocerca volvulus 0.0029 0.0105 0.1566
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0144 0.051
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0234
Onchocerca volvulus 0.0028 0.0094 0.14
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0041 0.018
Loa Loa (eye worm) fli-1 protein 0.0232 0.1364 0.4841
Schistosoma mansoni hypothetical protein 0.004 0.0169 0.0752
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0614
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0041 0.0144
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0144 0.051
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1179
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0194
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0173 0.0614
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0148 0.4924
Plasmodium vivax glutathione reductase, putative 0.0037 0.0153 0.5069
Schistosoma mansoni lamin 0.0028 0.0094 0.0417
Brugia malayi nuclear receptor NHR-67 0.0019 0.0041 0.0144
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0181 0.1017
Schistosoma mansoni thyroid hormone receptor 0.004 0.0173 0.0769
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0041 0.0144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0619 0.0619
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0173 0.0614
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0181 0.1015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0007
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0028 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.033 0.1466
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0792 0.4493
Trichomonas vaginalis esterase, putative 0.0042 0.0181 0.6036
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0776 0.2752
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0181 0.6036
Brugia malayi hypothetical protein 0.0021 0.0055 0.0194
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0173 0.0614
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0194
Brugia malayi nuclear hormone receptor 0.004 0.0173 0.0614
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0293 0.3272
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0013 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0374 0.225 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0173 0.0173
Schistosoma mansoni inositol monophosphatase 0.0036 0.0148 0.0656
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0173 0.0614
Brugia malayi Cytochrome P450 family protein 0.0023 0.0067 0.0238
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0028 0.0125
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0519 0.1843
Leishmania major hypothetical protein, conserved 0.0017 0.0028 0.0148
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0234
Toxoplasma gondii ABC1 family protein 0.0042 0.0181 0.6006
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0173 0.0614
Mycobacterium tuberculosis Conserved protein 0.0042 0.0181 0.1136
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0259
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0014 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0718
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0449 0.2839
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0041 0.0144
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0173 0.0173
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0144 0.051
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0066 0.0718
Mycobacterium ulcerans hypothetical protein 0.0023 0.0066 0.0718
Echinococcus multilocularis cpg binding protein 0.0031 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0173 0.0769
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Onchocerca volvulus 0.0028 0.0094 0.14
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0642
Loa Loa (eye worm) hypothetical protein 0.012 0.067 0.2377
Schistosoma mansoni jumonji domain containing protein 0.0064 0.032 0.142
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0173 0.0614
Mycobacterium tuberculosis Probable reductase 0.0085 0.0449 0.2839
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0181 0.6036
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0181 0.0642
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0173 0.0173
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0178 0.0633
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0181 0.1015
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0041 0.0041
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0449 0.2839
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0073 0.2375
Brugia malayi Thioredoxin reductase 0.0037 0.0153 0.0543
Mycobacterium tuberculosis Conserved protein 0.0042 0.0181 0.1136
Echinococcus granulosus sphingomyelin synthase protein 1 0.0024 0.0073 0.0259
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.003 0.0174
Schistosoma mansoni nuclear receptor 0.0019 0.0041 0.018
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0449 0.2839
Brugia malayi beta-lactamase family protein 0.0042 0.0181 0.0642
Echinococcus multilocularis geminin 0.0374 0.225 0.225
Onchocerca volvulus 0.0023 0.0066 0.0985
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.032 0.1134
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0124 0.1313
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0066 0.0718
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0642
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0178 0.0633
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0178 0.0178
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0156 0.0554
Loa Loa (eye worm) hypothetical protein 0.0466 0.2818 1
Loa Loa (eye worm) inositol-1 0.0036 0.0148 0.0524
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0181 0.2603
Schistosoma mansoni patched 1 0.0041 0.0178 0.0793
Mycobacterium ulcerans hypothetical protein 0.0042 0.0181 0.2013
Onchocerca volvulus 0.0019 0.0041 0.0606
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0073 0.2432
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.003 0.0309
Brugia malayi hypothetical protein 0.0019 0.0041 0.0144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0173 0.0614
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0055 0.0194
Plasmodium falciparum glutathione reductase 0.0037 0.0153 0.5069
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0055 0.0194
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0181 0.0804
Plasmodium falciparum thioredoxin reductase 0.0037 0.0153 0.5069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0066 0.0406
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.01
Loa Loa (eye worm) hypothetical protein 0.0113 0.0622 0.2209
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0014 0.005
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0041 0.0041
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.03 0.03
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0148 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0178 0.5953
Brugia malayi Muscleblind-like protein 0.015 0.0857 0.3039
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0105 0.0372
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0181 0.1015
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0041 0.0041
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0619 0.275
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0181 0.2013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.1733 0.7703
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0028 0.01
Brugia malayi jmjC domain containing protein 0.0064 0.032 0.1134
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0776 0.0776
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0041 0.0144
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.033 0.1466
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0002 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0173 0.0614
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0173 0.2584
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0293 0.0293
Brugia malayi nuclear receptor NHR-88 0.004 0.0173 0.0614
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0148 0.0148
Brugia malayi nuclear receptor NHR-88 0.0019 0.0041 0.0144
Loa Loa (eye worm) hypothetical protein 0.015 0.0857 0.3039
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.03 0.1892
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0105
Onchocerca volvulus 0.0095 0.0513 0.7657
Brugia malayi Sphingomyelin synthase-related 1 0.0024 0.0073 0.0259
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0178 0.0633
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0041 0.0144
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.0363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0173 0.0614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.1733 0.7703
Echinococcus granulosus survival motor neuron protein 1 0.0466 0.2818 1
Entamoeba histolytica hypothetical protein 0.0112 0.0619 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0614
Trichomonas vaginalis hypothetical protein 0.0024 0.0073 0.2432
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0529 0.2349
Onchocerca volvulus 0.004 0.0173 0.2584
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0181 0.6006
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.033 0.1171
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0173 0.0614
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0028 0.01
Loa Loa (eye worm) beta-lactamase 0.0042 0.0181 0.0642
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.0363
Plasmodium vivax sphingomyelin synthase 2, putative 0.0024 0.0073 0.2375
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0148 0.0827
Entamoeba histolytica hypothetical protein 0.0112 0.0619 1
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0322
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0173 0.0173
Plasmodium vivax JmjC domain containing protein 0.0017 0.0028 0.0872
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0066 0.0718
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0234
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0041 0.0041
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0073 0.2432
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0465 0.281 0.9969
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0173 0.0614
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0181 0.1136
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0614
Entamoeba histolytica hypothetical membrane-spanning protein 0.0024 0.0073 0.1179
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0041 0.0606
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0173 0.0173
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.033 0.1171
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1179
Schistosoma mansoni nuclear receptor 0.0019 0.0041 0.018
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0148 0.0827
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0194
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0173 0.0769
Schistosoma mansoni hypothetical protein 0.0077 0.0401 0.1782
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0642
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.03 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0073 0.0402
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0173 0.0769
Schistosoma mansoni cpg binding protein 0.0031 0.0115 0.0513
Loa Loa (eye worm) hypothetical protein 0.0465 0.281 0.9969
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0148 0.4924
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0173 0.0614
Echinococcus granulosus muscleblind protein 0.015 0.0857 0.3039
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0173 0.0769
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0614
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0002 0.0002
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0028 0.0028
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0293 0.1301
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0259
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.003 1
Echinococcus granulosus geminin 0.0374 0.225 0.7984
Echinococcus multilocularis protein dispatched 1 0.0047 0.0215 0.0215
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0508 0.3213
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0173 0.0614
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0181 0.1136
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0066 0.0363
Schistosoma mansoni hypothetical protein 0.0374 0.225 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0005 0.0018
Brugia malayi ecdysteroid receptor 0.004 0.0173 0.0614
Brugia malayi Inositol-1 0.0036 0.0148 0.0524
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0181 0.1136
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.003 0.0922
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0105
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.003 0.0922
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0181 0.1136
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0073 0.0259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0173 0.0614
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0237 0.1337
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0094 0.0333
Schistosoma mansoni hypothetical protein 0.0036 0.0144 0.0639
Schistosoma mansoni hypothetical protein 0.004 0.0169 0.0752
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0181 0.0804
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.03 0.1064
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0028 0.01
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.03 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0173 0.0614
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0066 0.0406
Onchocerca volvulus Huntingtin homolog 0.012 0.067 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0173 0.0769
Schistosoma mansoni gabp alpha 0.0076 0.0397 0.1765
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0066 0.1067
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0156 0.0156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.03 0.1693
Schistosoma mansoni zinc finger protein 0.0019 0.0041 0.018
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0024 0.0073 0.0402
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0614
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0041 0.0144
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0144 0.051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.0622 0.2209
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0401 0.1422
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0619 0.2195
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0028 0.01
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0173 0.0614
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0513 0.182
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0055 0.0243
Toxoplasma gondii hypothetical protein 0.0048 0.0219 0.7274
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0633
Echinococcus granulosus intermediate filament protein 0.0028 0.0094 0.0333
Brugia malayi hypothetical protein 0.0112 0.0619 0.2195
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0397 0.0397
Brugia malayi glutathione reductase 0.0037 0.0153 0.0543
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0028 0.01
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0508 0.3213
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0066 0.0234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0291 0.1733 0.615
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0173 0.0614
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0024 0.0073 0.0259
Trypanosoma brucei trypanothione reductase 0.0037 0.0153 0.0858
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.1575 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0144
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0293 0.1653
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0293 0.1847
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0002 0.0074

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1430 nM Displacement of [33P]ADP from human recombinant P2Y12 receptor expressed in CHO cells ChEMBL. 20141147

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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