Detailed information for compound 1095459

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 520.395 | Formula: C19H22F2N4O11
  • H donors: 3 H acceptors: 7 LogP: -0.91 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)OC[C@H]1O[C@@H](NC(=O)CNC(=O)n2cc(F)c(=O)[nH]c2=O)[C@@H]([C@H]([C@@H]1OC(=O)C)OC(=O)C)F
  • InChi: 1S/C19H22F2N4O11/c1-7(26)33-6-11-14(34-8(2)27)15(35-9(3)28)13(21)17(36-11)23-12(29)4-22-18(31)25-5-10(20)16(30)24-19(25)32/h5,11,13-15,17H,4,6H2,1-3H3,(H,22,31)(H,23,29)(H,24,30,32)/t11-,13-,14-,15-,17-/m1/s1
  • InChiKey: ZUAPDEDJSAAABX-WDGOXLLCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chromobox protein 0.0067 0.0405 0.0653
Trichomonas vaginalis myo-inositol transporter, putative 0.0045 0.0243 0.1041
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0459 0.3297 1
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0646 0.2808
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0054 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.016
Schistosoma mansoni hypothetical protein 0.0322 0.2286 0.3794
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0405 0.1753
Brugia malayi TAR-binding protein 0.0063 0.0372 0.1126
Toxoplasma gondii exonuclease III APE 0.0019 0.0049 0.0034
Trypanosoma cruzi hexose transporter, putative 0.0055 0.0312 0.3994
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.023 0.0984
Loa Loa (eye worm) hypothetical protein 0.0231 0.1615 0.4897
Brugia malayi hypothetical protein 0.002 0.0054 0.016
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0646 0.868
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0754 0.1102
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1615 0.269
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0198 0.033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0265 0.0801
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Echinococcus multilocularis calcium dependent protein kinase 0.0093 0.0592 0.0985
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0045 0.0243 0.2402
Trypanosoma cruzi hexose transporter, putative 0.0045 0.0243 0.303
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0042 0.0218
Loa Loa (eye worm) sugar transporter 0.0045 0.0243 0.0734
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0097 0.0622 0.1015
Chlamydia trachomatis lysine--tRNA ligase 0.0072 0.0439 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.004 0.0201 0.0608
Leishmania major hypothetical protein, conserved 0.0045 0.0243 0.303
Toxoplasma gondii transporter, major facilitator family protein 0.0045 0.0243 0.0327
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0087 0.0357
Echinococcus granulosus solute carrier family 22 0.0045 0.0243 0.0405
Leishmania major threonyl-tRNA synthetase, putative 0.0018 0.0042 0.0218
Schistosoma mansoni hypothetical protein 0.0826 0.6003 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0372 0.0597
Schistosoma mansoni glucose transport protein 0.0322 0.2286 0.3794
Onchocerca volvulus 0.0045 0.0243 0.1218
Leishmania major glucose transporter, lmgt2 0.01 0.0646 0.868
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0072 0.0439 0.5783
Plasmodium vivax proline--tRNA ligase, putative 0.0113 0.074 0.0738
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0116 0.0136
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0282 0.0446
Plasmodium falciparum hexose transporter 0.0322 0.2286 0.2284
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0099 0.0637 0.106
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0049 0.0035
Brugia malayi chromobox protein homolog 3 0.0038 0.0187 0.0565
Trichomonas vaginalis sugar transporter, putative 0.01 0.0646 0.2808
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0113 0.074 0.1081
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.868
Trypanosoma cruzi hexose transporter, putative 0.01 0.0646 0.868
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.023 0.0308
Echinococcus multilocularis solute carrier family 22 0.0045 0.0243 0.0405
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0185 0.0284
Leishmania major lysyl-tRNA synthetase, putative 0.0072 0.0439 0.5783
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0027 0.0093
Plasmodium vivax SET domain protein, putative 0.003 0.0131 0.0128
Plasmodium falciparum calcium-dependent protein kinase 3 0.0099 0.0637 0.0635
Brugia malayi Pre-SET motif family protein 0.003 0.0131 0.0394
Plasmodium vivax threonine--tRNA ligase, putative 0.0018 0.0042 0.004
Onchocerca volvulus 0.023 0.1607 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0027 0.0093
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0246 0.1725 0.5231
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0091 0.0128
Brugia malayi major facilitator superfamily protein 0.0045 0.0243 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0243 0.1041
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0072 0.0439 0.4584
Leishmania major glucose transporter, lmgt1 0.01 0.0646 0.868
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0927 1
Plasmodium vivax hexose transporter 0.0322 0.2286 0.2284
Onchocerca volvulus 0.0045 0.0243 0.1218
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0097 0.0622 0.1036
Onchocerca volvulus 0.0045 0.0243 0.1218
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0042 0.007
Schistosoma mansoni glucose transport protein 0.0322 0.2286 0.3794
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0483 0.1463
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0014 0.0041
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0054 0.0089
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0097 0.0622 0.1036
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0637 0.1039
Echinococcus multilocularis peregrin 0.0032 0.0143 0.0239
Plasmodium falciparum calcium-dependent protein kinase 4 0.0099 0.0637 0.0635
Brugia malayi Sugar transporter family protein 0.0322 0.2286 0.6934
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0372 0.1126
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0045 0.0243 0.2402
Plasmodium falciparum threonine--tRNA ligase 0.0018 0.0042 0.004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0049 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Echinococcus multilocularis GPCR, family 2 0.0078 0.0483 0.0805
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0243 0.1041
Brugia malayi SET domain containing protein 0.0013 0.0007 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0049 0.0314
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0116 0.0136
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0042 0.0218
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.1993 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0131 0.0195
Schistosoma mansoni hypothetical protein 0.0047 0.0257 0.0405
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0072 0.0439 0.1902
Plasmodium falciparum protein kinase 7 0.091 0.6626 0.6625
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Echinococcus granulosus geminin 0.0337 0.2398 0.3995
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0637 0.2767
Trypanosoma cruzi glucose transporter, putative 0.0045 0.0243 0.303
Echinococcus granulosus tar DNA binding protein 0.0063 0.0372 0.062
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0054 0.0089
Schistosoma mansoni loxhd1 0.002 0.0054 0.0066
Onchocerca volvulus Putative transporter 0.0045 0.0243 0.1218
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.074 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1993 0.8713
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0405 0.1753
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0018 0.0042 0.0173
Leishmania major glucose transporter, lmgt3 0.01 0.0646 0.868
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.023 0.0308
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0042 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0243 0.1041
Echinococcus granulosus solute carrier family 22 0.0045 0.0243 0.0405
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0099 0.0637 0.0635
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0049 0.0047
Schistosoma mansoni glucose transport protein 0.0322 0.2286 0.3794
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0042 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Plasmodium falciparum calcium-dependent protein kinase 1 0.0099 0.0637 0.0635
Toxoplasma gondii facilitative glucose transporter GT1 0.0322 0.2286 0.3424
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0045 0.0243 0.0405
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0087 0.0357
Plasmodium falciparum calcium-dependent protein kinase 5 0.0099 0.0637 0.0635
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0042 0.0126
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0099 0.0637 0.855
Trypanosoma cruzi hexose transporter 0.01 0.0646 0.868
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0927 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Onchocerca volvulus 0.0047 0.0257 0.1307
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1993 0.8713
Echinococcus multilocularis lysyl tRNA synthetase 0.0072 0.0439 0.0732
Brugia malayi CXXC zinc finger family protein 0.0058 0.0336 0.1018
Schistosoma mansoni sugar transporter 0.0045 0.0243 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.2286 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0246 0.1725 0.5231
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0087 0.0357
Onchocerca volvulus 0.0045 0.0243 0.1218
Echinococcus granulosus calcium dependent protein kinase 0.0093 0.0592 0.0985
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0589 0.0982
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Plasmodium falciparum proline--tRNA ligase 0.0113 0.074 0.0738
Echinococcus multilocularis cpg binding protein 0.0061 0.0361 0.0601
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0042 0.0126
Loa Loa (eye worm) hypothetical protein 0.0078 0.0483 0.1463
Brugia malayi Sugar transporter family protein 0.0045 0.0243 0.0734
Brugia malayi Doublecortin family protein 0.002 0.0054 0.016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0246 0.1725 0.5231
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.025 0.0757
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0116 0.0194
Brugia malayi hypothetical protein 0.0231 0.1615 0.4897
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0336 0.1018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0483 0.0805
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0049 0.0145
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0045 0.0243 0.2402
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0131 0.0158
Mycobacterium ulcerans integral membrane transport protein 0.0045 0.0243 0.2402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.025 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0372 0.0597
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0243 0.0734
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0018 0.0042 0.0024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0483 0.0805
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0018 0.0042 0.0161
Onchocerca volvulus 0.0045 0.0243 0.1218
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0646 0.2808
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.0565
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0049 0.0146
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0097 0.0622 0.1884
Brugia malayi hypothetical protein 0.002 0.0054 0.016
Schistosoma mansoni hypothetical protein 0.0337 0.2398 0.3981
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0776 0.1293
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0208 0.0889
Echinococcus multilocularis solute carrier family 22 0.0045 0.0243 0.0405
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0049 0.0081
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0054 0.0051
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0439 0.071
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0049 0.0191
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0372 0.062
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0042 0.0126
Entamoeba histolytica hypothetical protein 0.0072 0.0439 0.2035
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.868
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.025 0.0417
Brugia malayi latrophilin 2 splice variant baaae 0.0168 0.115 0.3487
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1884
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.025 0.0417
Schistosoma mansoni lipoxygenase 0.0082 0.0515 0.0836
Schistosoma mansoni chromobox protein 0.0067 0.0405 0.0653
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0521 0.3751 0.3749
Toxoplasma gondii protein kinase, putative 0.091 0.6626 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1993 0.8713
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1615 0.269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0087 0.0357
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.1993 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Schistosoma mansoni sugar transporter 0.0045 0.0243 0.0382
Plasmodium falciparum lysine--tRNA ligase 0.0072 0.0439 0.0437
Onchocerca volvulus 0.0045 0.0243 0.1218
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1993 0.8713
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0023 0.0038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0049 0.0047
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0243 0.0734
Entamoeba histolytica protein kinase, putative 0.0099 0.0637 0.3047
Schistosoma mansoni hypothetical protein 0.0168 0.115 0.1897
Trichomonas vaginalis glucose transporter, putative 0.01 0.0646 0.2808
Schistosoma mansoni rab6-interacting 0.002 0.0054 0.0066
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0131 0.0218
Giardia lamblia Prolyl-tRNA synthetase 0.0097 0.0622 0.2972
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0131 0.0218
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0042 0.0126
Loa Loa (eye worm) doublecortin family protein 0.002 0.0054 0.016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0049 0.0314
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0099 0.0637 0.0635
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1002 0.1649
Plasmodium vivax lysine--tRNA ligase, putative 0.0072 0.0439 0.0437
Echinococcus granulosus cpg binding protein 0.0061 0.0361 0.0601
Brugia malayi MH2 domain containing protein 0.0119 0.0787 0.2385
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0042 0.0126
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0372 0.1126
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0042 0.0218
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0097 0.0622 0.2972
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0338 0.1022
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0927 1
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0115 0.0346
Brugia malayi jmjC domain containing protein 0.0037 0.0185 0.0557
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.576 0.9595
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1993 0.8713
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0049 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Schistosoma mansoni glucose transporter 0.0045 0.0243 0.0382
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0049 0.0081
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0257 0.0776
Brugia malayi major facilitator superfamily protein 0.0045 0.0243 0.0734
Schistosoma mansoni hypothetical protein 0.0078 0.0483 0.0783
Loa Loa (eye worm) hypothetical protein 0.0051 0.0282 0.0852
Brugia malayi Bromodomain containing protein 0.0032 0.0143 0.0432
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0045 0.0243 0.303
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Onchocerca volvulus 0.0045 0.0243 0.1218
Echinococcus granulosus General substrate transporter 0.0277 0.1952 0.3252
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.1884
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0099 0.0637 0.106
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0971 0.1618
Onchocerca volvulus 0.0045 0.0243 0.1218
Loa Loa (eye worm) sugar transporter 0.0322 0.2286 0.6934
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0113 0.074 1
Giardia lamblia Sugar-proton symporter 0.0045 0.0243 0.1028
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0322 0.2286 0.3809
Brugia malayi hypothetical protein 0.0045 0.0243 0.0734
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0099 0.0637 0.0925
Brugia malayi PHD-finger family protein 0.0028 0.0116 0.0351
Onchocerca volvulus 0.0058 0.0336 0.1821
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0106 0.0439
Trichomonas vaginalis sugar transporter, putative 0.01 0.0646 0.2808
Loa Loa (eye worm) hypothetical protein 0.0168 0.115 0.3487
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0322 0.2286 0.3809
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0116 0.0194
Leishmania major myo-inositol/proton symporter (MIT) 0.0045 0.0243 0.303
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Trypanosoma brucei glucose transporter 2A 0.01 0.0646 0.868
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.868
Plasmodium vivax sugar transporter, putative 0.0045 0.0243 0.024
Onchocerca volvulus 0.0051 0.0282 0.1467
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0087 0.0357
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0243 0.0734
Schistosoma mansoni survival motor neuron protein 0.0047 0.0257 0.0405
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Schistosoma mansoni protein kinase 0.0099 0.0637 0.1039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0087 0.0357
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0208 0.0889
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0483 0.0805
Plasmodium vivax CDK-related protein kinase 6, putative 0.1367 1 1
Schistosoma mansoni ap endonuclease 0.0019 0.0049 0.0058
Onchocerca volvulus 0.0045 0.0243 0.1218
Schistosoma mansoni cpg binding protein 0.0061 0.0361 0.0579
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0034 0.016 0.1486
Brugia malayi follicle stimulating hormone receptor 0.0459 0.3297 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0072 0.0439 0.5783
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0322 0.2286 0.3809
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0776 0.1293
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0042 0.007
Schistosoma mansoni cpg binding protein 0.0058 0.0336 0.0538
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0049 0.0146
Schistosoma mansoni hypothetical protein 0.0078 0.0483 0.0783
Schistosoma mansoni hypothetical protein 0.0337 0.2398 0.3981
Onchocerca volvulus 0.0045 0.0243 0.1218
Mycobacterium ulcerans sugar transporter 0.0045 0.0243 0.2402
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0097 0.0622 0.1015
Plasmodium falciparum phd finger protein, putative 0.0028 0.0116 0.0114
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0061 0.0359 0.3695
Echinococcus granulosus synaptic vesicle 2 protein 0.0045 0.0243 0.0405
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0372 0.1126
Schistosoma mansoni rab6-interacting 0.002 0.0054 0.0066
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0116 0.0351
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0099 0.0637 0.106
Brugia malayi RNA binding protein 0.0063 0.0372 0.1126
Schistosoma mansoni sugar transporter 0.0045 0.0243 0.0382
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0449 0.0727
Brugia malayi jmjC domain containing protein 0.0092 0.0589 0.1786
Brugia malayi hypothetical protein 0.0045 0.0243 0.0734
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0394
Chlamydia trachomatis proline--tRNA ligase 0.0034 0.016 0.2978
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0114 0.0189
Loa Loa (eye worm) RNA binding protein 0.0063 0.0372 0.1126
Trypanosoma brucei glucose transporter 1E 0.01 0.0646 0.868
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0483 0.0805
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0113 0.074 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0372 0.0597
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0054 0.0089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0483 0.1463
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1002 0.1669
Brugia malayi Sugar transporter family protein 0.0045 0.0243 0.0734
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0099 0.0637 0.106
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0439 0.4584
Echinococcus granulosus lysyl tRNA synthetase 0.0072 0.0439 0.0732
Loa Loa (eye worm) hypothetical protein 0.0079 0.0488 0.1478
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1993 0.8713
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0203 0.0825
Entamoeba histolytica protein kinase, putative 0.0099 0.0637 0.3047
Schistosoma mansoni hypothetical protein 0.0028 0.0116 0.0171
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.0359 0.3695
Echinococcus multilocularis dnaJ subfamily B 0.0826 0.6003 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0045 0.0243 0.024
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.868
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0439 0.071
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0097 0.0622 0.1884
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0521 0.3751 0.5643
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0099 0.0637 0.0635
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Echinococcus granulosus chromobox protein 1 0.0067 0.0405 0.0675
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0208 0.0995
Toxoplasma gondii sugar transporter ST2 0.0045 0.0243 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0042 0.016
Trichomonas vaginalis glucose transporter, putative 0.0045 0.0243 0.1041
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Echinococcus multilocularis chromobox protein 1 0.0067 0.0405 0.0675
Onchocerca volvulus 0.0045 0.0243 0.1218
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0035 0.0128
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0198 0.033
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0018 0.0042 0.0173
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0787 0.2385
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0054 0.0089
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0045 0.0243 1
Giardia lamblia PHD finger protein 15 0.0028 0.0116 0.038
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0099 0.0637 0.1929
Echinococcus multilocularis RUN 0.002 0.0054 0.0089
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0042 0.004
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.074 1
Echinococcus granulosus solute carrier family 22 0.0045 0.0243 0.0405
Schistosoma mansoni polycystin 1-related 0.002 0.0054 0.0066
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0243 0.0734
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Trichomonas vaginalis sugar transport protein, putative 0.0045 0.0243 0.1041
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0054 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0116 0.0171
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0787 0.2385
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0099 0.0637 0.0925
Brugia malayi CHD4 protein 0.0014 0.0014 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.025 0.0395
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0824 0.1352
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0243 0.0734
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0049 0.0314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0483 0.1463
Echinococcus granulosus dnaJ subfamily B 0.0826 0.6003 1
Echinococcus multilocularis General substrate transporter 0.0277 0.1952 0.3252
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0027 0.0093
Brugia malayi Heterochromatin protein 1 0.0067 0.0405 0.1227
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0589 0.0982
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0131 0.0195
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0097 0.0622 0.6613
Toxoplasma gondii sugar transporter ST3 0.0045 0.0243 0.0327
Trypanosoma brucei sugar transporter, putative 0.0045 0.0243 0.303
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0322 0.2286 0.3809
Echinococcus granulosus peregrin 0.0032 0.0143 0.0239
Schistosoma mansoni protein kinase 0.0099 0.0637 0.1039
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0049 0.0249
Trichomonas vaginalis set domain proteins, putative 0.023 0.1607 0.7022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1993 0.8713
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0049 0.0249
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0063 0.0374 0.1615
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Onchocerca volvulus 0.0045 0.0243 0.1218
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Brugia malayi Pre-SET motif family protein 0.0202 0.1402 0.4251
Brugia malayi lysyl-tRNA synthetase 0.0072 0.0439 0.133
Plasmodium vivax calcium-dependent protein kinase, putative 0.0099 0.0637 0.0635
Loa Loa (eye worm) hypothetical protein 0.0072 0.0439 0.133
Schistosoma mansoni ap endonuclease 0.0019 0.0049 0.0058
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0116 0.0114
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.023 0.0383
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.1993 1
Toxoplasma gondii lysine-tRNA ligase 0.0072 0.0439 0.0625
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0045 0.0243 0.2402
Trypanosoma cruzi hexose transporter, putative 0.01 0.0646 0.868
Loa Loa (eye worm) hypothetical protein 0.0246 0.1725 0.5231
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0405 0.1227
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.016
Leishmania major protein kinase, putative 0.0099 0.0637 0.855
Plasmodium falciparum calcium-dependent protein kinase 2 0.0099 0.0637 0.0635
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.025 0.0757
Schistosoma mansoni protein kinase 0.0099 0.0637 0.1039
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0054 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.025 0.0417
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0126
Echinococcus granulosus RUN 0.002 0.0054 0.0089
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0185 0.0557
Onchocerca volvulus 0.0045 0.0243 0.1218
Echinococcus multilocularis chromobox protein 1 0.0067 0.0405 0.0675
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Brugia malayi Cam kinase protein 1 0.0099 0.0637 0.1929
Leishmania major glucose transporter/membrane transporter D2, putative 0.01 0.0646 0.868
Onchocerca volvulus 0.0041 0.0212 0.102
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0131 0.0195
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0099 0.0637 0.1929
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0099 0.0637 0.0925
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0382
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0646 0.868
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0187 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0243 0.1041
Trypanosoma cruzi hexose transporter, putative 0.01 0.0646 0.868
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0099 0.0637 0.106
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0049 0.0191
Schistosoma mansoni cpg binding protein 0.0061 0.0361 0.0579
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0042 0.016
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.074 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0023 0.0038
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0646 0.868
Echinococcus multilocularis solute carrier family 22 0.0045 0.0243 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0106 0.0439
Treponema pallidum prolyl-tRNA synthetase 0.0034 0.016 0.0606
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0439 0.4584
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0099 0.0637 0.106
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0372 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0099 0.0637 0.106
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0049 0.0082
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.016 0.0267
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0049 0.0314
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0042 0.007
Onchocerca volvulus 0.003 0.0127 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0187 0.0796
Onchocerca volvulus 0.0045 0.0243 0.1218
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.1993 1
Giardia lamblia Lysyl-tRNA synthetase 0.0072 0.0439 0.2035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0087 0.0357
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0131 0.0218
Trypanosoma cruzi sugar transporter, putative 0.0045 0.0243 0.303
Giardia lamblia Hexose transporter 0.0045 0.0243 0.1028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.1993 0.8713
Echinococcus multilocularis solute carrier family 22 0.0045 0.0243 0.0405
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1002 0.3037
Plasmodium falciparum mitogen-activated protein kinase 2 0.0521 0.3751 0.3749
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0322 0.2286 0.3809
Echinococcus multilocularis synaptic vesicle 2 protein 0.0045 0.0243 0.0405
Schistosoma mansoni hypothetical protein 0.002 0.0054 0.0066
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0049 0.034
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Onchocerca volvulus Alhambra homolog 0.0028 0.0116 0.0404
Echinococcus granulosus GPCR family 2 0.0078 0.0483 0.0805
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0087 0.0357
Echinococcus granulosus Sugar transporter ERD6 protein 0.0045 0.0243 0.0405
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0322 0.2286 0.3809
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0372 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0212 0.033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.025 0.0395
Toxoplasma gondii sugar transporter ST1 0.0045 0.0243 0.0327
Echinococcus multilocularis tumor protein p63 0.0345 0.2457 0.4093
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1402 0.4251
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0023 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.868
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0042 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.025 0.0417
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.023 0.0227
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0203 0.0201
Echinococcus multilocularis geminin 0.0337 0.2398 0.3995
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0099 0.0637 0.1929
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.023 0.0984
Brugia malayi hypothetical protein 0.0045 0.0243 0.0734
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0097 0.0622 0.2703
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0187 0.0796
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.0359 0.3695
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0099 0.0637 0.106
Loa Loa (eye worm) acetyltransferase 0.0148 0.1002 0.3037
Echinococcus granulosus tumor protein p63 0.0345 0.2457 0.4093
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0023 0.0038
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.868
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0734
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0185 0.0307
Schistosoma mansoni hypothetical protein 0.0078 0.0483 0.0783
Onchocerca volvulus 0.0045 0.0243 0.1218
Trichomonas vaginalis glucose transporter, putative 0.01 0.0646 0.2808
Loa Loa (eye worm) hypothetical protein 0.0099 0.0637 0.1929
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0243 0.1041
Onchocerca volvulus 0.0045 0.0243 0.1218
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0322 0.2286 0.3809
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0322 0.2286 0.3809
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Echinococcus granulosus solute carrier family 22 0.0045 0.0243 0.0405
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0203 0.0825
Schistosoma mansoni sugar transporter 0.0045 0.0243 0.0382
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0042 0.0024
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.868
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0185 0.0284
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0243 0.1041
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0045 0.0243 0.0382
Echinococcus granulosus chromobox protein 1 0.0067 0.0405 0.0675
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0049 0.0082
Schistosoma mansoni hypothetical protein 0.0078 0.0483 0.0783
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.868
Schistosoma mansoni lipoxygenase 0.0118 0.0776 0.1272
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0042 0.0173
Trichomonas vaginalis sugar transporter, putative 0.01 0.0646 0.2808
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0018 0.0042 0.0173

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3 uM Antiproliferative activity against human PA1 cells after 48 hrs by resazurin reduction test ChEMBL. 21530016
IC50 (functional) = 11 uM Antiproliferative activity against human MCF7 cells after 48 hrs by resazurin reduction test ChEMBL. 21530016

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21530016

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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