Detailed information for compound 1121400
Basic information
Technical information
- TDR Targets ID: 1121400
- Name: 1-pyridin-4-yl-N-(thiophen-2-ylmethyl)methana mine hydrochloride
- MW: 240.752 | Formula: C11H13ClN2S
-
H donors: 1
H acceptors: 1
LogP: 2.23
Rotable bonds: 4
Rule of 5 violations (Lipinski): 1 - SMILES: n1ccc(cc1)CNCc1cccs1.Cl
- InChi: 1S/C11H12N2S.ClH/c1-2-11(14-7-1)9-13-8-10-3-5-12-6-4-10;/h1-7,13H,8-9H2;1H
- InChiKey: YHLFWXMFQWSZKU-UHFFFAOYSA-N
Network
Hover on a compound node to display the structore
Synonyms
- 1-(4-pyridyl)-N-(2-thienylmethyl)methanamine hydrochloride
- 4-pyridylmethyl-(2-thenyl)amine hydrochloride
- MLS000719283
- SMR000291551
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Brugia malayi | hypothetical protein | 0.0031 | 0.0109 | 0.0058 |
| Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0165 | 0.1542 | 0.5 |
| Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | hypothetical protein | 0.0031 | 0.0109 | 0.0058 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.006 | 0.0037 |
| Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0518 | 0.0496 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | protein tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0031 | 0.0109 | 0.0085 |
| Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.1292 | 1 |
| Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | hypothetical protein | 0.0031 | 0.0109 | 0.0058 |
| Schistosoma mansoni | protein-tyrosine phosphatase non-receptor type nt5 | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Schistosoma mansoni | receptor protein tyrosine phosphatase r (pcptp1) | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | neuropeptide receptor A26 | 0.0534 | 0.5482 | 0.5471 |
| Brugia malayi | Protein-tyrosine phosphatase 1 | 0.0031 | 0.0109 | 0.0058 |
| Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Schistosoma mansoni | protein tyrosine phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0284 | 0.0284 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0308 | 0.0308 |
| Schistosoma mansoni | pcd6 interacting protein-related | 0.0031 | 0.0109 | 0.0085 |
| Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | Bromodomain containing protein | 0.0087 | 0.0707 | 0.0659 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase 1 | 0.0031 | 0.0109 | 0.0109 |
| Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Schistosoma mansoni | protein tyrosine phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0518 | 0.0496 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Schistosoma mansoni | receptor protein tyrosine phosphatase n (ia2) | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0956 | 1 | 1 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | Bromodomain containing protein | 0.0044 | 0.0254 | 0.0204 |
| Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus multilocularis | protein tyrosine phosphatase n9 | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Treponema pallidum | fructose-bisphosphate aldolase | 0.0337 | 0.3385 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0165 | 0.1542 | 1 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0384 | 0.3886 | 0.3871 |
| Echinococcus multilocularis | 0.0031 | 0.0109 | 0.0085 | |
| Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.006 | 0.0037 |
| Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0037 | 0.0037 |
| Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0225 | 0.0202 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Brugia malayi | Dual specificity protein phosphatase CDC14B | 0.0031 | 0.0109 | 0.0058 |
| Schistosoma mansoni | hypothetical protein | 0.0186 | 0.177 | 0.175 |
| Brugia malayi | hypothetical protein | 0.0031 | 0.0109 | 0.0058 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | protein-tyrosine-phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0037 | 0.0013 |
| Schistosoma mansoni | non-receptor protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | neuropeptide s receptor | 0.0534 | 0.5482 | 0.5471 |
| Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0956 | 1 | 1 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0956 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Echinococcus granulosus | protein tyrosine phosphatase n9 | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0384 | 0.3886 | 0.3871 |
| Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1025 | 0.0979 |
| Echinococcus multilocularis | neuropeptide receptor A26 | 0.0534 | 0.5482 | 0.5471 |
| Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.0396 | 0.0347 |
| Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0031 | 0.0109 | 1 |
| Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0956 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.0186 | 0.177 | 0.175 |
| Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1292 | 0.1292 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.0396 | 0.0396 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | hypothetical protein | 0.0141 | 0.1292 | 0.1248 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus multilocularis | hypothetical protein | 0.0031 | 0.0109 | 0.0085 |
| Schistosoma mansoni | protein-tyrosine phosphatase n9 | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Loa Loa (eye worm) | dual specificity protein phosphatase CDC14B | 0.0031 | 0.0109 | 0.0109 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Echinococcus granulosus | geminin | 0.0186 | 0.177 | 0.175 |
| Leishmania major | tyrosine specific protein phosphatase, putative | 0.0031 | 0.0109 | 1 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1292 | 0.1292 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase H | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | CYP4Cod1 | 0.0025 | 0.0051 | 0.0051 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0031 | 0.0109 | 0.0085 |
| Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.0562 | 0.054 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Brugia malayi | protein-tyrosine phosphatase Lar-like precursor, putative | 0.0031 | 0.0109 | 0.0058 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Brugia malayi | Protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0058 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0384 | 0.3886 | 0.3871 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | Protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0058 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.0051 | 0.0051 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0031 | 0.0109 | 1 |
| Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Echinococcus multilocularis | geminin | 0.0186 | 0.177 | 0.175 |
| Brugia malayi | hypothetical protein | 0.0031 | 0.0109 | 0.0058 |
| Schistosoma mansoni | protein tyrosine phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1025 | 0.1025 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | PHD-finger family protein | 0.0029 | 0.0089 | 0.0038 |
| Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0654 | 0.0654 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0031 | 0.0109 | 1 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Schistosoma mansoni | receptor protein tyrosine phosphatase n (ia2) | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0031 | 0.0109 | 0.0085 |
| Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0337 | 0.3385 | 1 |
| Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0031 | 0.0109 | 1 |
| Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0031 | 0.0109 | 1 |
| Echinococcus multilocularis | neuropeptide s receptor | 0.0534 | 0.5482 | 0.5471 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.0051 | 0.0051 |
| Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0255 | 0.0255 |
| Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.1292 | 1 |
| Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0031 | 0.0109 | 0.0085 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.006 | 0.0037 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0165 | 0.1542 | 0.5 |
| Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0225 | 0.0202 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Giardia lamblia | Fructose-bisphosphate aldolase | 0.0337 | 0.3385 | 1 |
| Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0031 | 0.0109 | 0.0058 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1025 | 0.1025 |
| Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Schistosoma mansoni | rgs-gaip interacting protein gipc | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0031 | 0.0109 | 0.0109 |
| Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0031 | 0.0109 | 0.0085 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0109 | 0.0109 |
| Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0031 | 0.0109 | 0.0085 |
| Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0031 | 0.0109 | 0.0085 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1870612
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.