TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 336.471 | Formula: C22H28N2O
H donors: 0 H acceptors: 1 LogP: 4.49 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN(C(=O)c1cccc2c1cccc2)[C@H]1CCCC[C@H]1N1CCCC1
InChi: 1S/C22H28N2O/c1-23(20-13-4-5-14-21(20)24-15-6-7-16-24)22(25)19-12-8-10-17-9-2-3-11-18(17)19/h2-3,8-12,20-21H,4-7,13-16H2,1H3/t20-,21+/m0/s1
InChiKey: BRVCKDDOBWKXRT-LEWJYISDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sigma non-opioid intracellular receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Brugia malayi	ERG2 and Sigma1 receptor like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania mexicana	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei gambiense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania donovani	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma cruzi	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania braziliensis	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania major	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Zinc finger domain	0.0015	0.0108	0.5
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0015	0.0108	0.0101
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0108	0.0101
Trypanosoma cruzi	hypothetical protein, conserved	0.0304	0.3509	0.6713
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0041	0.0034
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0015	0.0108	0.0002
Schistosoma mansoni	hypothetical protein	0.0099	0.1099	0.1092
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0041	0.0014
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0041	0.0014
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0091	0.0064
Toxoplasma gondii	hypothetical protein	0.0015	0.0108	0.0002
Echinococcus granulosus	SWI:SNF matrix associated	0.0853	1	1
Schistosoma mansoni	coup transcription factor	0.001	0.0041	0.0034
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Onchocerca volvulus	Netrin receptor homolog	0.0087	0.0958	0.0921
Echinococcus granulosus	lamin	0.0026	0.0233	0.0226
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0106	0.5
Loa Loa (eye worm)	hypothetical protein	0.0445	0.5176	0.5163
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0015	0.0108	0.0101
Onchocerca volvulus		0.0015	0.0108	0.0067
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0106	0.0099
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0015	0.0108	0.5
Leishmania major	DNA repair protein-like protein	0.0015	0.0108	0.0004
Leishmania major	hypothetical protein, conserved	0.0304	0.3509	0.6713
Leishmania major	hypothetical protein, conserved	0.0304	0.3509	0.6713
Schistosoma mansoni	hypothetical protein	0.0853	1	1
Brugia malayi	intermediate filament protein	0.0026	0.0233	0.0208
Echinococcus multilocularis	ring finger protein 113a	0.0015	0.0108	0.0101
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0106	0.008
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0046	0.0469	0.0462
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Entamoeba histolytica	zinc finger domain containing protein	0.0015	0.0108	0.5
Giardia lamblia	Kinase	0.0015	0.0108	0.5
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0304	0.3509	0.3505
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3509	0.3492
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0108	0.0004
Trypanosoma cruzi	hypothetical protein	0.0015	0.0108	0.0004
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0041	0.0034
Schistosoma mansoni	cpg binding protein	0.0029	0.0272	0.0265
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0041	0.0034
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0108	0.0004
Schistosoma mansoni	lamin	0.0026	0.0233	0.0226
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0046	0.0469	0.0443
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0041	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0145	0.1641	0.162
Trichomonas vaginalis	ankyrin, putative	0.0015	0.0108	0.0108
Entamoeba histolytica	zinc finger domain containing protein	0.0015	0.0108	0.5
Giardia lamblia	Hypothetical protein	0.0015	0.0108	0.5
Echinococcus multilocularis	geminin	0.0164	0.1859	0.1853
Echinococcus granulosus	neuropeptide receptor A26	0.0447	0.5201	0.5197
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0445	0.5176	0.5164
Loa Loa (eye worm)	hypothetical protein	0.001	0.0041	0.0014
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0015	0.0108	0.0101
Echinococcus multilocularis	RING finger protein 185	0.0015	0.0108	0.0101
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0041	0.0034
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0041	0.0015
Giardia lamblia	Hypothetical protein	0.0015	0.0108	0.5
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0015	0.0108	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0041	0.0015
Schistosoma mansoni	microtubule-associated protein tau	0.0667	0.7797	0.7796
Trichomonas vaginalis	ion channel nompc, putative	0.0015	0.0108	0.0108
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Schistosoma mansoni	hypothetical protein	0.0015	0.0108	0.0101
Schistosoma mansoni	hypothetical protein	0.0164	0.1859	0.1853
Trypanosoma cruzi	WLM domain containing protein, putative	0.0304	0.3509	0.6713
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0041	0.0034
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0015	0.0108	0.0002
Schistosoma mansoni	TRABID protein (C64 family)	0.0304	0.3509	0.3505
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0041	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Brugia malayi	Zinc finger, C2H2 type family protein	0.0015	0.0108	0.0082
Trypanosoma cruzi	hypothetical protein	0.0015	0.0108	0.0004
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0041	0.0034
Trypanosoma cruzi	hypothetical protein, conserved	0.0304	0.3509	0.6713
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0015	0.0108	0.0101
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0041	0.0015
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Onchocerca volvulus		0.0015	0.0108	0.0067
Giardia lamblia	Hypothetical protein	0.0015	0.0108	0.5
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0853	1	1
Schistosoma mansoni	brg-1 associated factor	0.0853	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0041	0.0034
Brugia malayi	Zinc finger protein 183 homolog	0.0015	0.0108	0.0082
Entamoeba histolytica	zinc finger domain containing protein	0.0015	0.0108	0.5
Brugia malayi	hypothetical protein	0.0015	0.0108	0.0082
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0041	0.0034
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Plasmodium falciparum	trophozoite exported protein 1	0.0015	0.0108	0.0002
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Plasmodium falciparum	zinc finger protein, putative	0.0015	0.0108	0.0002
Echinococcus granulosus	netrin receptor unc 5	0.0087	0.0958	0.0951
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0015	0.0108	0.0004
Trypanosoma brucei	hypothetical protein, conserved	0.0304	0.3509	0.6713
Trichomonas vaginalis	hypothetical protein	0.0015	0.0108	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0041	0.0015
Echinococcus multilocularis	neuropeptide s receptor	0.0447	0.5201	0.5197
Echinococcus multilocularis	netrin receptor unc 5	0.0087	0.0958	0.0951
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0853	1	1
Schistosoma mansoni	hypothetical protein	0.0853	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0041	0.0034
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0304	0.3509	0.3493
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0304	0.3509	0.6713
Echinococcus granulosus	zinc finger protein Ran binding	0.0304	0.3509	0.3505
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Brugia malayi	nuclear hormone receptor	0.001	0.0041	0.0015
Giardia lamblia	Hypothetical protein	0.0015	0.0108	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0046	0.0469	0.0444
Brugia malayi	hypothetical protein	0.0015	0.0108	0.0082
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Echinococcus granulosus	ring and YY1 binding protein	0.0304	0.3509	0.3505
Schistosoma mansoni	hypothetical protein	0.0046	0.0469	0.0462
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0233	0.0207
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0074	0.0067
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Echinococcus multilocularis	SWI:SNF matrix associated	0.0853	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0041	0.0014
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0041	0.0034
Giardia lamblia	Kinase, NEK	0.0015	0.0108	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0108	0.0004
Schistosoma mansoni	ring finger protein 151	0.0015	0.0108	0.0101
Onchocerca volvulus		0.0304	0.3509	0.3483
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0106	0.0079
Brugia malayi	hypothetical protein	0.0015	0.0108	0.0082
Plasmodium vivax	trophozoite exported protein 1, putative	0.0015	0.0108	0.0002
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0853	1	1
Schistosoma mansoni	tumor necrosis factor receptor related	0.0133	0.1501	0.1495
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Brugia malayi	brahma associated protein 60 kDa	0.0853	1	1
Plasmodium vivax	RING zinc finger protein, putative	0.0015	0.0108	0.0002
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0015	0.0108	0.0108
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0106	0.0099
Schistosoma mansoni	ankyrin 23/unc44	0.0087	0.0958	0.0951
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0041	0.0034
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0015	0.0108	0.0101
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0015	0.0108	0.0101
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0015	0.0108	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0469	0.0443
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0015	0.0108	0.0002
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Echinococcus multilocularis	zinc finger protein Ran binding	0.0304	0.3509	0.3505
Giardia lamblia	Hypothetical protein	0.0015	0.0108	0.5
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0046	0.0469	0.0462
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0445	0.5176	1
Echinococcus granulosus	death domain containing protein	0.0087	0.0958	0.0951
Brugia malayi	RING zinc finger protein	0.0015	0.0108	0.0082
Loa Loa (eye worm)	hypothetical protein	0.001	0.0041	0.0014
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0041	0.0015
Onchocerca volvulus		0.0015	0.0108	0.0067
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0304	0.3509	0.3505
Echinococcus multilocularis	GPCR, family 2	0.0046	0.0469	0.0462
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0304	0.3509	0.6713
Leishmania major	hypothetical protein, conserved	0.0304	0.3509	0.6713
Leishmania major	hypothetical protein, unknown function	0.0015	0.0108	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0041	0.0015
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0304	0.3509	0.6713
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0015	0.0108	0.0108
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0041	0.0014
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Schistosoma mansoni	hypothetical protein	0.0046	0.0469	0.0462
Brugia malayi	RING finger protein 20	0.0015	0.0108	0.0082
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Echinococcus granulosus	tumor necrosis factor receptor superfamily	0.0133	0.1501	0.1495
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0041	0.0014
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0304	0.3509	0.3493
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0304	0.3509	0.6713
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0041	0.0034
Trypanosoma brucei	hypothetical protein, conserved	0.0304	0.3509	0.6713
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0041	0.0015
Toxoplasma gondii	RING zinc finger protein	0.0015	0.0108	0.0002
Schistosoma mansoni	zinc finger protein	0.0015	0.0108	0.0101
Onchocerca volvulus		0.0015	0.0108	0.0067
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Echinococcus granulosus	TNFR CD27 30 40 95 cysteine rich region	0.0133	0.1501	0.1495
Toxoplasma gondii	ran binding protein	0.0304	0.3509	0.344
Echinococcus granulosus	neuropeptide s receptor	0.0447	0.5201	0.5197
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0087	0.0958	0.0951
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Schistosoma mansoni	hypothetical protein	0.0046	0.0469	0.0462
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0015	0.0108	0.0108
Trypanosoma brucei	ring finger containing protein	0.0015	0.0108	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Onchocerca volvulus		0.0304	0.3509	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0958	0.0933
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Trypanosoma cruzi	hypothetical protein, conserved	0.0304	0.3509	0.6713
Giardia lamblia	Hypothetical protein	0.0015	0.0108	0.5
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3509	0.3492
Brugia malayi	Protein kinase domain containing protein	0.0087	0.0958	0.0934
Echinococcus granulosus	ring finger protein 113a	0.0015	0.0108	0.0101
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0027	0.002
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0015	0.0108	0.0002
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3509	0.3492
Onchocerca volvulus	Protein neuralized homolog	0.0015	0.0108	0.0067
Entamoeba histolytica	zinc finger domain containing protein	0.0015	0.0108	0.5
Echinococcus granulosus	geminin	0.0164	0.1859	0.1853
Echinococcus granulosus	ring finger protein 170	0.0015	0.0108	0.0101
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0041	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1099	0.1074
Schistosoma mansoni	mind bomb	0.0015	0.0108	0.0101
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0041	0.0034
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0304	0.3509	0.3493
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Schistosoma mansoni	RNA binding protein	0.0304	0.3509	0.3505
Onchocerca volvulus		0.0015	0.0108	0.0067
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0853	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0233	0.0207
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Echinococcus multilocularis	SWI:SNF matrix associated	0.0853	1	1
Toxoplasma gondii	hypothetical protein	0.0015	0.0108	0.0002
Brugia malayi	Latrophilin receptor protein 2	0.0046	0.0469	0.0444
Schistosoma mansoni	hypothetical protein	0.0046	0.0469	0.0462
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0106	0.0099
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0106	0.008
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0041	0.0015
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0041	0.0014
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0106	0.0099
Onchocerca volvulus		0.0028	0.0253	0.0213
Plasmodium falciparum	RING zinc finger protein, putative	0.0015	0.0108	0.0002
Onchocerca volvulus		0.0304	0.3509	0.3483
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0041	0.0014
Giardia lamblia	Kinase, NEK	0.0015	0.0108	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0041	0.0034
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0106	0.0099
Leishmania major	hypothetical protein	0.0015	0.0108	0.0004
Loa Loa (eye worm)	RING finger protein 20	0.0015	0.0108	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0041	0.0015
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Echinococcus multilocularis	musashi	0.0026	0.0233	0.0226
Brugia malayi	Neuralized family protein	0.0015	0.0108	0.0082
Echinococcus granulosus	GPCR family 2	0.0046	0.0469	0.0462
Onchocerca volvulus		0.0853	1	1
Schistosoma mansoni	peter pan-related	0.0015	0.0108	0.0101
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0621	0.0614
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0041	0.0034
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Echinococcus multilocularis	TNFR CD27 30 40 95 cysteine rich region	0.0133	0.1501	0.1495
Trypanosoma cruzi	WLM domain containing protein, putative	0.0304	0.3509	0.6713
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Toxoplasma gondii	hypothetical protein	0.0015	0.0108	0.0002
Brugia malayi	hypothetical protein	0.0015	0.0108	0.0082
Echinococcus multilocularis	Ankyrin	0.0087	0.0958	0.0951
Echinococcus multilocularis	ring finger protein 170	0.0015	0.0108	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0304	0.3509	0.3493
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0015	0.0108	0.0002
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0015	0.0108	0.0108
Trypanosoma brucei	predicted zinc finger protein	0.0015	0.0108	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0227	0.2609	0.2589
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0087	0.0958	0.0933
Schistosoma mansoni	hypothetical protein	0.0853	1	1
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0087	0.0958	0.0951
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Schistosoma mansoni	hypothetical protein	0.0087	0.0958	0.0951
Echinococcus multilocularis	cpg binding protein	0.0029	0.0272	0.0265
Schistosoma mansoni	cpg binding protein	0.0029	0.0272	0.0265
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0087	0.0958	0.0951
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0041	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0015	0.0108	0.0108
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0233	0.0207
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0015	0.0108	0.0101
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0253	0.0228
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0958	0.0933
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0015	0.0108	0.0004
Echinococcus granulosus	dnaJ subfamily B	0.0395	0.4591	0.4588
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0304	0.3509	0.344
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0041	0.0034
Entamoeba histolytica	zinc finger domain containing protein	0.0015	0.0108	0.5
Chlamydia trachomatis	SWIB complex protein	0.0853	1	0.5
Plasmodium vivax	DNA repair protein RAD5, putative	0.0015	0.0108	0.0002
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0015	0.0108	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0069	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0228	0.0201
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0304	0.3509	0.344
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0041	0.0034
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0445	0.5176	1
Schistosoma mansoni	hypothetical protein	0.0304	0.3509	0.3505
Schistosoma mansoni	rnf5	0.0015	0.0108	0.0101
Loa Loa (eye worm)	hypothetical protein	0.001	0.0041	0.0014
Giardia lamblia	Hypothetical protein	0.0015	0.0108	0.5
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0041	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0395	0.4591	0.4588
Schistosoma mansoni	hypothetical protein	0.0164	0.1859	0.1853
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0015	0.0108	0.0101
Echinococcus granulosus	intermediate filament protein	0.0026	0.0233	0.0226
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0304	0.3509	0.6713
Echinococcus granulosus	Zinc finger RanBP2 type	0.0304	0.3509	0.3505
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0041	0.0034
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0015	0.0108	0.0101
Trichomonas vaginalis	ankyrin, putative	0.0015	0.0108	0.0108
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0015	0.0108	0.0082
Loa Loa (eye worm)	RiNg Finger protein family member	0.0015	0.0108	0.0081
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0041	0.0034
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Echinococcus multilocularis	SWI:SNF matrix associated	0.0853	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0074	0.0047
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0853	1	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0853	1	1
Onchocerca volvulus		0.0304	0.3509	0.3483
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0041	0.0015
Schistosoma mansoni	netrin receptor unc5	0.0087	0.0958	0.0951
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0046	0.0469	0.0462
Leishmania major	hypothetical protein, conserved	0.0304	0.3509	0.6713
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0041	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0041	0.0034
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0041	0.0034
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0087	0.0958	0.0934
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0304	0.3509	0.6713
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0015	0.0108	0.0002
Echinococcus granulosus	microtubule associated protein 2	0.0667	0.7797	0.7796
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0108	0.0004
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0041	0.0034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0041	0.0014
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Onchocerca volvulus	Putative RING finger protein 207	0.0015	0.0108	0.0067
Brugia malayi	ecdysteroid receptor	0.001	0.0041	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0091	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0106	0.0099
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0041	0.0015
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0304	0.3509	0.3483
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0027	0.002
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0074	0.0067
Giardia lamblia	Zinc finger domain	0.0015	0.0108	0.5
Onchocerca volvulus	RING finger protein 141 homolog	0.0015	0.0108	0.0067
Echinococcus multilocularis	lamin dm0	0.0026	0.0233	0.0226
Onchocerca volvulus		0.0015	0.0108	0.0067
Echinococcus multilocularis	tumor necrosis factor receptor superfamily	0.0133	0.1501	0.1495
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0015	0.0108	0.0002
Brugia malayi	B-box zinc finger family protein	0.0015	0.0108	0.0082
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0041	0.0015
Schistosoma mansoni	zinc finger protein	0.0304	0.3509	0.3505
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0041	0.0034
Onchocerca volvulus		0.0026	0.0233	0.0193
Toxoplasma gondii	hypothetical protein	0.0015	0.0108	0.0002
Brugia malayi	YY1-associated factor 2	0.0304	0.3509	0.3493
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Entamoeba histolytica	zinc finger domain containing protein	0.0015	0.0108	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0253	0.0227
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Plasmodium vivax	zinc finger protein, putative	0.0015	0.0108	0.0002
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0015	0.0108	0.0002
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0015	0.0108	0.0108
Chlamydia trachomatis	DNA topoisomerase I	0.0853	1	0.5
Echinococcus multilocularis	ring and YY1 binding protein	0.0304	0.3509	0.3505
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0145	0.1641	0.162
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0069	0.0042
Brugia malayi	Uncoordinated protein 44	0.0087	0.0958	0.0934
Echinococcus multilocularis	dnaJ subfamily B	0.0395	0.4591	0.4588
Entamoeba histolytica	hypothetical protein	0.0015	0.0108	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0145	0.1641	0.1619
Trypanosoma brucei	DNA repair protein, putative	0.0015	0.0108	0.0004
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0041	0.0015
Echinococcus granulosus	cpg binding protein	0.0029	0.0272	0.0265
Brugia malayi	nuclear receptor NHR-88	0.001	0.0041	0.0015
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0108	0.0004
Entamoeba histolytica	hypothetical protein	0.0015	0.0108	0.5
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0304	0.3509	0.6713
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Echinococcus multilocularis		0.0015	0.0108	0.0101
Echinococcus granulosus	RING finger protein 185	0.0015	0.0108	0.0101
Brugia malayi	hypothetical protein	0.0015	0.0108	0.0082
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0015	0.0108	0.0101
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0015	0.0108	0.0004
Brugia malayi	latrophilin 2 splice variant baaae	0.0099	0.1099	0.1076
Echinococcus granulosus	Ankyrin	0.0087	0.0958	0.0951
Loa Loa (eye worm)	hypothetical protein	0.001	0.0041	0.0014
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0015	0.0108	0.0101
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Echinococcus multilocularis	neuropeptide receptor A26	0.0447	0.5201	0.5197
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0546	0.0445
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Leishmania major	C-8 sterol isomerase-like protein	0.0445	0.5176	1
Brugia malayi	steroid hormone receptor	0.001	0.0041	0.0015
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Giardia lamblia	Ribonuclease	0.0015	0.0108	0.5
Trichomonas vaginalis	ankyrin, putative	0.0015	0.0108	0.0108
Giardia lamblia	Protein 21.1	0.0015	0.0108	0.5
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1641	0.1619
Schistosoma mansoni	hypothetical protein	0.0015	0.0108	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.0853	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0108	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3509	0.3492
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0304	0.3509	0.3505
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Onchocerca volvulus		0.0026	0.0233	0.0193
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0853	1	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0015	0.0108	0.0004
Loa Loa (eye worm)	brahma associated protein	0.0853	1	1
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0015	0.0108	0.0108
Brugia malayi	SWIB/MDM2 domain containing protein	0.0853	1	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0041	0.0034
Schistosoma mansoni	lamin	0.0026	0.0233	0.0226
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Entamoeba histolytica	SPRY domain protein	0.0015	0.0108	0.5
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0106	0.0099
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Entamoeba histolytica	zinc finger domain containing protein	0.0015	0.0108	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0041	0.0034
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0108	0.0004
Brugia malayi	Death domain containing protein	0.0087	0.0958	0.0934
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0041	0.0034
Schistosoma mansoni	fusion	0.0304	0.3509	0.3505
Loa Loa (eye worm)	hypothetical protein	0.001	0.0041	0.0014
Echinococcus multilocularis	lamin	0.0026	0.0233	0.0226
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0015	0.0108	0.0101
Brugia malayi	hypothetical protein	0.0015	0.0108	0.0082
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0046	0.0469	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Echinococcus granulosus	lamin dm0	0.0026	0.0233	0.0226
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0233	0.0226
Schistosoma mansoni	hypothetical protein	0.0015	0.0108	0.0101
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0853	1	1
Echinococcus multilocularis	microtubule associated protein 2	0.0667	0.7797	0.7796
Giardia lamblia	Ser/Thr protein kinase	0.0015	0.0108	0.5
Leishmania major	hypothetical protein, conserved	0.0304	0.3509	0.6713
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0041	0.0015
Leishmania major	hypothetical protein, conserved	0.0015	0.0108	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0041	0.0015
Toxoplasma gondii	helicase, putative	0.0015	0.0108	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0233	0.0208
Entamoeba histolytica	zinc finger domain containing protein	0.0015	0.0108	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0108	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0108	0.0108
Schistosoma mansoni	peter pan-related	0.0015	0.0108	0.0101
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0041	0.0034
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0015	0.0108	0.0004
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0853	1	1
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0015	0.0108	0.0108
Schistosoma mansoni	cpg binding protein	0.0028	0.0253	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3509	0.3492
Loa Loa (eye worm)	hypothetical protein	0.001	0.0041	0.0014

Activities

Activity type	Activity value	Assay description	Source	Reference
Control (binding)	= 78.66 %	Binding affinity against opioid receptor kappa 1 using [3H]U-69,593 as a radioligand	ChEMBL.	2172538
Control (binding)	= 102.78 %	Binding affinity against opioid receptor kappa 1 using with [3H]-bremazocine as radioligand	ChEMBL.	2172538
IC50 (binding)	= 2593 nM	Binding affinity for sigma opioid receptor using [3H]-(+)-3-PPP as radioligand	ChEMBL.	2172538

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL606891

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1129456