Detailed information for compound 1133388

Basic information

Technical information
  • TDR Targets ID: 1133388
  • Name: (3,5-dimethyl-1,2-oxazol-4-yl)methyl 2-chloro -5-morpholin-4-ylsulfonylbenzoate
  • MW: 414.861 | Formula: C17H19ClN2O6S
  • H donors: 0 H acceptors: 4 LogP: 1.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(ccc1Cl)S(=O)(=O)N1CCOCC1)OCc1c(C)noc1C
  • InChi: 1S/C17H19ClN2O6S/c1-11-15(12(2)26-19-11)10-25-17(21)14-9-13(3-4-16(14)18)27(22,23)20-5-7-24-8-6-20/h3-4,9H,5-8,10H2,1-2H3
  • InChiKey: LWDZZBZTNLTTBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3,5-dimethylisoxazol-4-yl)methyl 2-chloro-5-morpholinosulfonyl-benzoate
  • 2-chloro-5-morpholinosulfonylbenzoic acid (3,5-dimethyl-4-isoxazolyl)methyl ester
  • 2-chloro-5-morpholinosulfonyl-benzoic acid (3,5-dimethylisoxazol-4-yl)methyl ester
  • (3,5-dimethyl-1,2-oxazol-4-yl)methyl 2-chloro-5-morpholin-4-ylsulfonyl-benzoate
  • T5354047
  • ZINC06084272

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.02 0.0384
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.004 0.0061
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0094 0.0146
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0153 0.0237
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0129 0.0759
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0153 0.0237
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.0746 0.4398
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0958 0.4966
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0094 0.0144
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0129 0.0703
Schistosoma mansoni hypothetical protein 0.008 0.0946 0.198
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0153 0.0233
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.079 0.1653
Plasmodium falciparum thioredoxin reductase 0.0023 0.0129 0.1343
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0666 0.3928
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1398 0.2924
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Onchocerca volvulus Peroxidasin homolog 0.0253 0.3416 0.7982
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0042 0.0064
Brugia malayi WGR domain containing protein 0.0143 0.1848 0.2815
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.1398 0.2128
Loa Loa (eye worm) animal heme peroxidase 0.0253 0.3416 0.5202
Schistosoma mansoni hypothetical protein 0.0255 0.345 0.7219
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.1398 0.6951
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0559 0.2324
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0082 0.0858
Onchocerca volvulus 0.0253 0.3416 0.7982
Echinococcus granulosus peroxidasin 0.0253 0.3416 0.5297
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0094 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Echinococcus multilocularis Smad4 0.0017 0.004 0.0061
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.0746 0.1156
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.079 0.1846
Toxoplasma gondii hypothetical protein 0.0028 0.02 0.1036
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0374 0.0579
Brugia malayi ecdysteroid receptor 0.002 0.0094 0.0144
Loa Loa (eye worm) hypothetical protein 0.0173 0.2275 0.3464
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0156 0.1628
Loa Loa (eye worm) hypothetical protein 0.0025 0.0156 0.0237
Brugia malayi Cation transporter family protein 0.0025 0.0153 0.0233
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0143 0.1848 0.3867
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0025 0.0153 0.0233
Loa Loa (eye worm) LGC-31 protein 0.0025 0.0153 0.0233
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0129 0.1343
Echinococcus granulosus poly (ADP ribose) polymerase 0.0044 0.0437 0.0678
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1398 0.8245
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0054 0.0112
Brugia malayi hypothetical protein 0.0109 0.1358 0.2068
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0025 0.0153 0.0233
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.1398 0.1341
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0199
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 0.4654
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0143 0.1848 0.4319
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0025 0.0153 0.0233
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0666 0.3132
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.1398 0.8245
Schistosoma mansoni Smad4 0.0017 0.004 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1135 0.2374
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Onchocerca volvulus Putative nachr subunit 0.0025 0.0153 0.0358
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0015 0.0077
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.004 0.0083
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0958 0.1485
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1358 0.2842
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1398 0.8245
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0094 0.0144
Echinococcus multilocularis thyroid hormone receptor alpha 0.0275 0.3743 0.5804
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0129 0.0759
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.079 0.1225
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0129 0.0759
Echinococcus multilocularis GPCR, family 2 0.008 0.0946 0.1467
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0156 0.092
Onchocerca volvulus 0.0112 0.1398 0.3266
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0094 0.0146
Echinococcus granulosus GPCR family 2 0.008 0.0946 0.1467
Trypanosoma cruzi prolyl endopeptidase 0.0132 0.1695 1
Brugia malayi Latrophilin receptor protein 2 0.008 0.0946 0.1441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0094 0.0144
Brugia malayi Smad1 0.0017 0.004 0.006
Treponema pallidum fructose-bisphosphate aldolase 0.0312 0.4265 1
Plasmodium vivax glutathione reductase, putative 0.0066 0.0746 0.5335
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0025 0.0153 0.0233
Schistosoma mansoni ap endonuclease 0.0018 0.0066 0.0138
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0153 0.032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0153 0.0237
Brugia malayi Thioredoxin reductase 0.0066 0.0746 0.1135
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0025 0.0153 0.0237
Trichomonas vaginalis esterase, putative 0.0112 0.1398 0.3277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1135 0.1759
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0094 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Loa Loa (eye worm) RNA binding protein 0.0076 0.0896 0.1364
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0025 0.0153 0.0237
Onchocerca volvulus 0.0025 0.0153 0.0358
Loa Loa (eye worm) Smad1 0.0017 0.004 0.006
Echinococcus multilocularis geminin 0.0348 0.4779 0.7411
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.1398 0.6951
Onchocerca volvulus 0.0025 0.0153 0.0358
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0153 0.0233
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0269
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0066 0.0154
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Trypanosoma cruzi oligopeptidase b 0.0053 0.0555 0.3271
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.1398 0.1341
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0119 0.0185
Schistosoma mansoni smad1 5 8 and 0.0017 0.004 0.0083
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0025 0.0153 0.0233
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0119 0.0185
Brugia malayi Blistered cuticle protein 3 0.0253 0.3416 0.5202
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0666 0.1033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.1398 0.2167
Leishmania major DNA repair protein, putative 0.0019 0.0069 0.0405
Mycobacterium tuberculosis Conserved protein 0.0112 0.1398 0.1341
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Entamoeba histolytica hypothetical protein 0.0022 0.0119 0.0279
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0129 0.0759
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0666 0.0604
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0608 0.0925
Brugia malayi WGR domain containing protein 0.0079 0.0926 0.141
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0253 0.342 0.5208
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0025 0.0153 0.032
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1398 0.3277
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0094 0.0197
Plasmodium falciparum thioredoxin reductase 0.0066 0.0746 0.7786
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Echinococcus multilocularis smad 0.0017 0.004 0.0061
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.1398 0.1341
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0121 0.0184
Loa Loa (eye worm) animal heme peroxidase 0.0253 0.3416 0.5202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0068 0.0774 0.162
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0559 0.0867
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Brugia malayi nuclear hormone receptor 0.002 0.0094 0.0144
Brugia malayi Cation transporter family protein 0.0025 0.0153 0.0233
Onchocerca volvulus Prolyl endopeptidase homolog 0.0132 0.1695 0.3961
Mycobacterium tuberculosis Conserved protein 0.0112 0.1398 0.1341
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 0.2124
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Loa Loa (eye worm) hypothetical protein 0.0109 0.136 0.207
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.004 0.006
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0094 0.0144
Mycobacterium ulcerans beta-lactamase 0.0112 0.1398 0.6951
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Schistosoma mansoni hypothetical protein 0.008 0.0946 0.198
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 0.4654
Echinococcus granulosus WGR domain containing protein 0.0044 0.0437 0.0678
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0094 0.0197
Onchocerca volvulus Peroxidase homolog 0.0253 0.3416 0.7982
Trypanosoma brucei DNA repair protein, putative 0.0019 0.0069 0.0405
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0053 0.0555 0.255
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1358 0.2106
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0066 0.0389
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0156 0.092
Schistosoma mansoni hypothetical protein 0.0348 0.4779 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0129 0.092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0086
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0066 0.0102
Loa Loa (eye worm) hypothetical protein 0.0145 0.1878 0.2859
Echinococcus granulosus tar DNA binding protein 0.0076 0.0896 0.1389
Onchocerca volvulus 0.0253 0.3416 0.7982
Treponema pallidum NADH oxidase 0.0023 0.0129 0.0149
Onchocerca volvulus 0.0025 0.0153 0.0358
Loa Loa (eye worm) hypothetical protein 0.0332 0.4553 0.6933
Brugia malayi beta-lactamase family protein 0.0112 0.1398 0.2128
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0094 0.022
Echinococcus granulosus FTZ F1 alpha 0.002 0.0094 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Echinococcus granulosus bloom syndrome protein 0.0022 0.0121 0.0188
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0094 0.0144
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0129 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0094 0.0144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0094 0.0146
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0946 0.1441
Echinococcus multilocularis muscleblind protein 0.0145 0.1878 0.2912
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0025 0.0153 0.0237
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0079 0.0926 0.1436
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0149 0.1928 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0327
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0069 0.0405
Brugia malayi Muscleblind-like protein 0.0145 0.1878 0.2859
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0129 0.0667
Brugia malayi MH1 domain containing protein 0.0017 0.004 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0066 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0094 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0094 0.0144
Schistosoma mansoni thyroid hormone receptor 0.0275 0.3743 0.7832
Echinococcus granulosus neuropeptide s receptor 0.0465 0.6449 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0946 0.1467
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0559 0.0497
Onchocerca volvulus Peroxidase homolog 0.0253 0.3416 0.7982
Schistosoma mansoni peroxidasin 0.0253 0.3416 0.7147
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0053 0.0555 0.0492
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0255 0.345 0.535
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0056 0.0608 0.0926
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0153 0.0237
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Echinococcus multilocularis prolyl endopeptidase 0.0132 0.1695 0.2629
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0053 0.0555 0.3271
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0094 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0094 0.0144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0094 0.0144
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.02 0.0319
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1398 0.2924
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0666 0.1014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0066 0.0155
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.1982 1
Brugia malayi hypothetical protein 0.0253 0.3416 0.5202
Schistosoma mansoni smad1 5 8 and 0.0017 0.004 0.0083
Trypanosoma brucei poly(adp-ribose) polymerase 0.0079 0.0926 0.5462
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0153 0.0237
Loa Loa (eye worm) hypothetical protein 0.0081 0.0958 0.1458
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.1398 0.2128
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0025 0.0153 0.0237
Mycobacterium ulcerans hypothetical protein 0.0112 0.1398 0.6951
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0066 0.0688
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1398 0.3277
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0079 0.0926 0.5462
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Schistosoma mansoni hypothetical protein 0.008 0.0946 0.198
Brugia malayi nuclear receptor NHR-88 0.002 0.0094 0.0144
Mycobacterium tuberculosis Conserved protein 0.0112 0.1398 0.1341
Plasmodium falciparum glutathione reductase 0.0066 0.0746 0.7786
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.079 0.1225
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0094 0.0146
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.0746 0.5335
Trypanosoma brucei prolyl endopeptidase 0.0132 0.1695 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0153 0.0237
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0025 0.0153 0.0233
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0066 0.0389
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0094 0.0197
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0129 0.092
Schistosoma mansoni hypothetical protein 0.008 0.0946 0.198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1135 0.1728
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0143 0.1848 0.2866
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0129 0.0759
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0156 0.1116
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0153 0.0237
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.4265 0.9966
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0094 0.0146
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0119 0.0185
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1135 0.1759
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0094 0.0144
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.079 0.1203
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0094 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0094 0.0144
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0023 0.0129 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1135 0.2374
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0066 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0094 0.0144
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0759
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 1
Schistosoma mansoni hypothetical protein 0.0109 0.1358 0.2842
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0094 0.0144
Giardia lamblia Fructose-bisphosphate aldolase 0.0312 0.4265 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0153 0.032
Echinococcus granulosus muscleblind protein 0.0145 0.1878 0.2912
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.079 0.1203
Brugia malayi glutathione reductase 0.0066 0.0746 0.1135
Onchocerca volvulus 0.0025 0.0153 0.0358
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0946 0.1441
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.079 0.466
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0094 0.0144
Onchocerca volvulus Chorion peroxidase homolog 0.0253 0.3416 0.7982
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1398 0.3277
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Brugia malayi TAR-binding protein 0.0076 0.0896 0.1364
Brugia malayi hypothetical protein 0.0025 0.0156 0.0237
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0958 0.2004
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 1
Schistosoma mansoni ap endonuclease 0.0018 0.0066 0.0138
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Entamoeba histolytica hypothetical protein 0.0109 0.1358 0.3174
Brugia malayi MH2 domain containing protein 0.0244 0.3299 0.5023
Echinococcus granulosus prolyl endopeptidase 0.0132 0.1695 0.2629
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0666 0.3132
Leishmania major hypothetical protein, conserved 0.0019 0.0069 0.0405
Plasmodium vivax hypothetical protein, conserved 0.0112 0.1398 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0118 0.1497 0.144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0153 0.0233
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0253 0.342 0.5208
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.3299 0.5023
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.4265 0.9966
Loa Loa (eye worm) hypothetical protein 0.0313 0.4279 0.6516
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0025 0.0153 0.0237
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0053 0.0555 0.3271
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0156 0.1628
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.1398 0.1341
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.0746 0.1156
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1135 0.1728
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0129 0.0063
Schistosoma mansoni hypothetical protein 0.0173 0.2275 0.476
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.1398 0.1341
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.3299 0.5023
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0958 0.4473
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Mycobacterium ulcerans lipase LipD 0.0112 0.1398 0.6951
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1398 0.3277
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.004 0.0061
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0129 0.0703
Entamoeba histolytica hypothetical protein 0.0109 0.1358 0.3174
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0105
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0023 0.0129 0.0063
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0025 0.0153 0.032
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0025 0.0153 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0094 0.0144
Entamoeba histolytica hypothetical protein 0.0109 0.1358 0.3174
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Loa Loa (eye worm) beta-lactamase 0.0112 0.1398 0.2128
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0153 0.0233
Toxoplasma gondii thioredoxin reductase 0.0066 0.0746 0.3866
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0129 0.0759
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.6449 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0094 0.0197
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0094 0.0144
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0759
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0025 0.0153 0.0233
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0094 0.0146
Entamoeba histolytica hypothetical protein, conserved 0.0313 0.4279 1
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1398 0.3277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0094 0.0144
Toxoplasma gondii exonuclease III APE 0.0018 0.0066 0.0342
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1135 0.1759
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Brugia malayi hypothetical protein 0.0016 0.003 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0053 0.0555 0.2298
Brugia malayi prolyl oligopeptidase family protein 0.0132 0.1695 0.2581
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0121 0.0188
Loa Loa (eye worm) hypothetical protein 0.0253 0.342 0.5208
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.02 0.1429
Echinococcus granulosus poly ADP ribose polymerase 1 0.0143 0.1848 0.2866
Loa Loa (eye worm) animal heme peroxidase 0.0253 0.3416 0.5202
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0094 0.0197
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Brugia malayi Cation transporter family protein 0.0025 0.0153 0.0233
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0042 0.0064
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0025 0.0153 0.0233
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0094 0.0197
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0129 0.0667
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0153 0.0237
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Onchocerca volvulus 0.002 0.0094 0.022
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.6449 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0129 0.0301
Echinococcus granulosus Smad4 0.0017 0.004 0.0061
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.6449 1
Mycobacterium leprae Probable lipase LipE 0.0112 0.1398 0.6848
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0199
Onchocerca volvulus 0.0112 0.1398 0.3266
Onchocerca volvulus 0.0025 0.0153 0.0358
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Onchocerca volvulus Dual oxidase homolog 0.0253 0.3416 0.7982
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0129 0.0301
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0255 0.345 0.535
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0129 0.1343
Brugia malayi MH2 domain containing protein 0.0017 0.004 0.006
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0129 0.0063
Brugia malayi steroid hormone receptor 0.002 0.0094 0.0144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.004 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.0746 0.0684
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0946 0.1467
Onchocerca volvulus 0.0112 0.1398 0.3266
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0153 0.0237
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.1982 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0094 0.0146
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0129 0.0759
Leishmania major hypothetical protein, conserved 0.0112 0.1398 0.8245
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0896 0.1364
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0958 0.4966
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0094 0.0146
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0156 0.092
Echinococcus granulosus protein cereblon 0.0313 0.4279 0.6636
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0066 0.0389
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0094 0.0146
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0946 0.1467
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Echinococcus granulosus nAChR subunit 0.0025 0.0153 0.0237
Schistosoma mansoni coup transcription factor 0.002 0.0094 0.0197
Brugia malayi beta-lactamase 0.0112 0.1398 0.2128
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0069 0.0405
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0053 0.0555 0.3271
Mycobacterium tuberculosis Probable peptidase 0.0053 0.0555 0.0492
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Onchocerca volvulus Peroxidasin homolog 0.0253 0.3416 0.7982
Brugia malayi hypothetical protein 0.0313 0.4279 0.6516
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0094 0.0197
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0121 0.0284
Brugia malayi Peroxidasin 0.0253 0.3416 0.5202
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.0746 0.1135
Loa Loa (eye worm) hypothetical protein 0.0132 0.1695 0.2581
Onchocerca volvulus Protein cereblon homolog 0.0313 0.4279 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0094 0.022
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0666 0.1393
Onchocerca volvulus 0.0025 0.0153 0.0358
Echinococcus granulosus transcription factor Dp 1 0.004 0.0374 0.0579
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0153 0.032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.1398 0.2167
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0132 0.1695 1
Brugia malayi MH2 domain containing protein 0.0017 0.004 0.006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0094 0.0144
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0129 0.0301
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Brugia malayi follicle stimulating hormone receptor 0.0473 0.6567 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Loa Loa (eye worm) glutathione reductase 0.0066 0.0746 0.1135
Leishmania major oligopeptidase b 0.0053 0.0555 0.3271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0094 0.0144
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.02 0.2086
Plasmodium falciparum glutathione reductase 0.0023 0.0129 0.1343
Echinococcus multilocularis protein cereblon 0.0313 0.4279 0.6636
Brugia malayi RNA binding protein 0.0076 0.0896 0.1364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1135 0.2374
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0896 0.1364
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0025 0.0153 0.0233
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0129 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0094 0.0144
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0079 0.0926 0.1937
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0094 0.0144
Leishmania major hypothetical protein, conserved 0.0025 0.0156 0.092
Brugia malayi Calcitonin receptor-like protein seb-1 0.0253 0.342 0.5208
Echinococcus granulosus smad 0.0017 0.004 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0275 0.3743 0.7832
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1878 0.2912
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0132 0.1695 0.3547
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.1982 0.1929
Mycobacterium leprae conserved hypothetical protein 0.0112 0.1398 0.6848
Schistosoma mansoni nuclear hormone receptor 0.002 0.0094 0.0197
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) blistered cuticle protein 3 0.0253 0.3416 0.5202
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0025 0.0153 0.0237
Loa Loa (eye worm) hypothetical protein 0.008 0.0946 0.1441
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0017 0.0125
Trypanosoma brucei prolyl oligopeptidase, putative 0.0053 0.0555 0.3271
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0094 0.0197
Onchocerca volvulus DNA ligase 3 homolog 0.0019 0.0069 0.016
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0896 0.1364
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0066 0.0472
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0066 0.0155
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0066 0.01
Trypanosoma cruzi DNA repair protein, putative 0.0019 0.0069 0.0405
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0156 0.0809
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0025 0.0153 0.0237
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0025 0.0153 0.0233
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0559 0.0497
Trypanosoma cruzi oligopeptidase b 0.0053 0.0555 0.3271
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0153 0.0237
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0025 0.0153 0.0233
Brugia malayi MH1 domain containing protein 0.0017 0.004 0.006
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0958 0.1485
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0094 0.0146
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.079 0.466
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0053 0.0555 0.3271
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.004 0.006
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0079 0.0926 0.5462
Toxoplasma gondii ABC1 family protein 0.0112 0.1398 0.7248
Loa Loa (eye worm) RecQ helicase 0.0022 0.0121 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0094 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0066 0.0389
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0666 0.1033
Loa Loa (eye worm) hypothetical protein 0.0079 0.0926 0.141
Echinococcus granulosus geminin 0.0348 0.4779 0.7411
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0066 0.01
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Brugia malayi Probable ClpP-like protease 0.0081 0.0958 0.1458
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0129 0.0327
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0094 0.022
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Schistosoma mansoni smad1 5 8 and 0.0017 0.004 0.0083
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0473 0.6567 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0025 0.0153 0.0233
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0025 0.0153 0.0233
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0896 0.1389
Echinococcus multilocularis nAChR subunit 0.0025 0.0153 0.0237
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0094 0.0144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Toxoplasma gondii prolyl endopeptidase 0.0132 0.1695 0.8791
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0559 0.0867
Leishmania major trypanothione reductase 0.0066 0.0746 0.4398
Entamoeba histolytica hypothetical protein 0.0109 0.1358 0.3174
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.004 0.0061
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Schistosoma mansoni hypothetical protein 0.0348 0.4779 1
Schistosoma mansoni hypothetical protein 0.0313 0.4279 0.8954
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.2275 0.3464
Loa Loa (eye worm) hypothetical protein 0.0145 0.1878 0.2859
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0121 0.0284
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Brugia malayi beta-lactamase family protein 0.0112 0.1398 0.2128
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0025 0.0153 0.0237
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0132 0.1695 0.3547
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0094 0.0146
Trypanosoma brucei oligopeptidase b 0.0053 0.0555 0.3271
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0958 0.6851
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0033 0.0271 0.042
Schistosoma mansoni peroxidasin 0.0253 0.3416 0.7147
Echinococcus granulosus poly adp ribose polymerase 2 0.0079 0.0926 0.1436
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.079 0.466
Schistosoma mansoni smad 0.0017 0.004 0.0083
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.1398 0.1341
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1135 0.1759
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0094 0.0197
Brugia malayi hypothetical protein 0.0127 0.1624 0.2474
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0094 0.0146
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0025 0.0153 0.032
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.079 0.466
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1358 0.2106
Trypanosoma brucei trypanothione reductase 0.0066 0.0746 0.4398
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0946 0.1467
Loa Loa (eye worm) animal heme peroxidase 0.0253 0.3416 0.5202
Brugia malayi excitatory GABA receptor EXP-1A 0.0025 0.0153 0.0233
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.1398 0.1341
Onchocerca volvulus 0.0253 0.3416 0.7982
Echinococcus multilocularis peroxidasin 0.0253 0.3416 0.5297

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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