Detailed information for compound 1133388

Basic information

Technical information
  • TDR Targets ID: 1133388
  • Name: (3,5-dimethyl-1,2-oxazol-4-yl)methyl 2-chloro -5-morpholin-4-ylsulfonylbenzoate
  • MW: 414.861 | Formula: C17H19ClN2O6S
  • H donors: 0 H acceptors: 4 LogP: 1.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(ccc1Cl)S(=O)(=O)N1CCOCC1)OCc1c(C)noc1C
  • InChi: 1S/C17H19ClN2O6S/c1-11-15(12(2)26-19-11)10-25-17(21)14-9-13(3-4-16(14)18)27(22,23)20-5-7-24-8-6-20/h3-4,9H,5-8,10H2,1-2H3
  • InChiKey: LWDZZBZTNLTTBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3,5-dimethylisoxazol-4-yl)methyl 2-chloro-5-morpholinosulfonyl-benzoate
  • 2-chloro-5-morpholinosulfonylbenzoic acid (3,5-dimethyl-4-isoxazolyl)methyl ester
  • 2-chloro-5-morpholinosulfonyl-benzoic acid (3,5-dimethylisoxazol-4-yl)methyl ester
  • (3,5-dimethyl-1,2-oxazol-4-yl)methyl 2-chloro-5-morpholin-4-ylsulfonyl-benzoate
  • T5354047
  • ZINC06084272

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0129 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0143 0.1848 0.4319
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0958 0.1485
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.6449 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0958 0.4966
Echinococcus multilocularis protein cereblon 0.0313 0.4279 0.6636
Loa Loa (eye worm) hypothetical protein 0.0332 0.4553 0.6933
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0121 0.0188
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Onchocerca volvulus 0.0112 0.1398 0.3266
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0094 0.022
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.4265 0.9966
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0094 0.022
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1358 0.2106
Echinococcus granulosus neuropeptide s receptor 0.0465 0.6449 1
Onchocerca volvulus 0.0025 0.0153 0.0358
Brugia malayi nuclear receptor NHR-88 0.002 0.0094 0.0144
Entamoeba histolytica hypothetical protein 0.0109 0.1358 0.3174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0094 0.0144
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0094 0.0146
Echinococcus granulosus muscleblind protein 0.0145 0.1878 0.2912
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0025 0.0153 0.0237
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0069 0.0405
Trypanosoma brucei oligopeptidase b 0.0053 0.0555 0.3271
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1135 0.1759
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.3299 0.5023
Brugia malayi MH2 domain containing protein 0.0244 0.3299 0.5023
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0053 0.0555 0.3271
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.1398 0.2128
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0129 0.0759
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0079 0.0926 0.1436
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0066 0.0389
Onchocerca volvulus 0.0253 0.3416 0.7982
Brugia malayi Cation transporter family protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.1398 0.6951
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0129 0.0759
Brugia malayi prolyl oligopeptidase family protein 0.0132 0.1695 0.2581
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1135 0.1728
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0094 0.0146
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0255 0.345 0.535
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0118 0.1497 0.144
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0066 0.0389
Toxoplasma gondii thioredoxin reductase 0.0066 0.0746 0.3866
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0025 0.0153 0.0233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0094 0.022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0094 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1135 0.2374
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0666 0.1033
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0068 0.0774 0.162
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.004 0.0061
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0025 0.0153 0.0233
Onchocerca volvulus 0.0112 0.1398 0.3266
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0473 0.6567 1
Schistosoma mansoni hypothetical protein 0.008 0.0946 0.198
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.079 0.1225
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0156 0.092
Schistosoma mansoni ap endonuclease 0.0018 0.0066 0.0138
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.0746 0.1156
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0033 0.0271 0.042
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.1398 0.1341
Echinococcus granulosus poly (ADP ribose) polymerase 0.0044 0.0437 0.0678
Brugia malayi Probable ClpP-like protease 0.0081 0.0958 0.1458
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0025 0.0153 0.0233
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0156 0.0809
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.079 0.466
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.02 0.1429
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0129 0.0063
Brugia malayi steroid hormone receptor 0.002 0.0094 0.0144
Echinococcus multilocularis thyroid hormone receptor alpha 0.0275 0.3743 0.5804
Trypanosoma cruzi prolyl endopeptidase 0.0132 0.1695 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.1398 0.1341
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0559 0.0497
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0129 0.1343
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1878 0.2912
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0023 0.0129 0.0063
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0946 0.1467
Mycobacterium tuberculosis Conserved protein 0.0112 0.1398 0.1341
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0143 0.1848 0.3867
Brugia malayi hypothetical protein 0.0313 0.4279 0.6516
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0094 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0094 0.0144
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0025 0.0153 0.0233
Trypanosoma brucei prolyl oligopeptidase, putative 0.0053 0.0555 0.3271
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1398 0.8245
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.1398 0.1341
Schistosoma mansoni peroxidasin 0.0253 0.3416 0.7147
Echinococcus granulosus GPCR family 2 0.008 0.0946 0.1467
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0129 0.0063
Schistosoma mansoni hypothetical protein 0.0348 0.4779 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0056 0.0608 0.0926
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0253 0.342 0.5208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0094 0.0144
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0958 0.6851
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0066 0.0389
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0946 0.1467
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0025 0.0153 0.0233
Trichomonas vaginalis esterase, putative 0.0112 0.1398 0.3277
Echinococcus granulosus smad 0.0017 0.004 0.0061
Onchocerca volvulus Putative nachr subunit 0.0025 0.0153 0.0358
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.3299 0.5023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0094 0.0146
Echinococcus multilocularis GPCR, family 2 0.008 0.0946 0.1467
Brugia malayi Peroxidasin 0.0253 0.3416 0.5202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1398 0.2924
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0666 0.3928
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0042 0.0064
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0079 0.0926 0.5462
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0042 0.0064
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.0746 0.0684
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0094 0.0144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.1398 0.6951
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0025 0.0153 0.032
Leishmania major hypothetical protein, conserved 0.0025 0.0156 0.092
Brugia malayi Cation transporter family protein 0.0025 0.0153 0.0233
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.1982 0.1929
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.079 0.1846
Brugia malayi WGR domain containing protein 0.0079 0.0926 0.141
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0129 0.0196
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0129 0.0759
Onchocerca volvulus 0.0253 0.3416 0.7982
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0153 0.0237
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0666 0.1393
Echinococcus multilocularis muscleblind protein 0.0145 0.1878 0.2912
Loa Loa (eye worm) hypothetical protein 0.0173 0.2275 0.3464
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.0746 0.5335
Schistosoma mansoni hypothetical protein 0.008 0.0946 0.198
Schistosoma mansoni hypothetical protein 0.0173 0.2275 0.476
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.1398 0.2167
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0199
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0896 0.1364
Schistosoma mansoni coup transcription factor 0.002 0.0094 0.0197
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.02 0.2086
Brugia malayi Muscleblind-like protein 0.0145 0.1878 0.2859
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0094 0.0146
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0094 0.0197
Loa Loa (eye worm) animal heme peroxidase 0.0253 0.3416 0.5202
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0156 0.092
Trypanosoma cruzi oligopeptidase b 0.0053 0.0555 0.3271
Onchocerca volvulus 0.0253 0.3416 0.7982
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0066 0.0155
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0025 0.0153 0.0237
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0094 0.0197
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Schistosoma mansoni smad1 5 8 and 0.0017 0.004 0.0083
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0066 0.01
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0666 0.3132
Loa Loa (eye worm) glutathione reductase 0.0066 0.0746 0.1135
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.2275 0.3464
Plasmodium vivax glutathione reductase, putative 0.0066 0.0746 0.5335
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0153 0.0237
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0153 0.0233
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.079 0.466
Onchocerca volvulus Chorion peroxidase homolog 0.0253 0.3416 0.7982
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.079 0.466
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1398 0.3277
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0129 0.0301
Trypanosoma brucei prolyl endopeptidase 0.0132 0.1695 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Entamoeba histolytica hypothetical protein 0.0109 0.1358 0.3174
Echinococcus granulosus protein cereblon 0.0313 0.4279 0.6636
Echinococcus multilocularis peroxidasin 0.0253 0.3416 0.5297
Echinococcus multilocularis smad 0.0017 0.004 0.0061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0156 0.0237
Leishmania major hypothetical protein, conserved 0.0112 0.1398 0.8245
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0129 0.0759
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0946 0.1467
Loa Loa (eye worm) hypothetical protein 0.0313 0.4279 0.6516
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0066 0.0154
Onchocerca volvulus Protein cereblon homolog 0.0313 0.4279 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0066 0.0155
Echinococcus granulosus Smad4 0.0017 0.004 0.0061
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0946 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0094 0.0144
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.079 0.1653
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0153 0.0237
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Mycobacterium tuberculosis Conserved protein 0.0112 0.1398 0.1341
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0958 0.4473
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0025 0.0153 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0094 0.0144
Brugia malayi hypothetical protein 0.0025 0.0156 0.0237
Echinococcus granulosus FTZ F1 alpha 0.002 0.0094 0.0146
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.1982 1
Onchocerca volvulus Peroxidasin homolog 0.0253 0.3416 0.7982
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0094 0.0144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Onchocerca volvulus Peroxidasin homolog 0.0253 0.3416 0.7982
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0094 0.0197
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.1398 0.8245
Schistosoma mansoni ap endonuclease 0.0018 0.0066 0.0138
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0094 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Loa Loa (eye worm) LGC-31 protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1135 0.1759
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0017 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Schistosoma mansoni hypothetical protein 0.0313 0.4279 0.8954
Brugia malayi Smad1 0.0017 0.004 0.006
Loa Loa (eye worm) animal heme peroxidase 0.0253 0.3416 0.5202
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0025 0.0153 0.0237
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Brugia malayi ecdysteroid receptor 0.002 0.0094 0.0144
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0149 0.1928 1
Brugia malayi Latrophilin receptor protein 2 0.008 0.0946 0.1441
Brugia malayi follicle stimulating hormone receptor 0.0473 0.6567 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Treponema pallidum NADH oxidase 0.0023 0.0129 0.0149
Trypanosoma cruzi DNA repair protein, putative 0.0019 0.0069 0.0405
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0025 0.0153 0.0233
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0094 0.0197
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0153 0.032
Echinococcus granulosus bloom syndrome protein 0.0022 0.0121 0.0188
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.02 0.0319
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0129 0.0759
Onchocerca volvulus Peroxidase homolog 0.0253 0.3416 0.7982
Schistosoma mansoni hypothetical protein 0.008 0.0946 0.198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0094 0.0144
Mycobacterium ulcerans lipase LipD 0.0112 0.1398 0.6951
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0025 0.0153 0.0233
Echinococcus granulosus nAChR subunit 0.0025 0.0153 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0896 0.1389
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0094 0.0144
Schistosoma mansoni smad1 5 8 and 0.0017 0.004 0.0083
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Echinococcus granulosus glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0066 0.0102
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 0.4654
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0053 0.0555 0.3271
Echinococcus granulosus transcription factor Dp 1 0.004 0.0374 0.0579
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0759
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0119 0.0185
Loa Loa (eye worm) hypothetical protein 0.008 0.0946 0.1441
Toxoplasma gondii exonuclease III APE 0.0018 0.0066 0.0342
Echinococcus multilocularis geminin 0.0348 0.4779 0.7411
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0023 0.0129 0.0063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Loa Loa (eye worm) hypothetical protein 0.0253 0.342 0.5208
Echinococcus multilocularis Smad4 0.0017 0.004 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1135 0.1759
Loa Loa (eye worm) animal heme peroxidase 0.0253 0.3416 0.5202
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0759
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0053 0.0555 0.255
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0094 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.1398 0.1341
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.1982 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0129 0.0667
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0559 0.0867
Brugia malayi hypothetical protein 0.0127 0.1624 0.2474
Loa Loa (eye worm) hypothetical protein 0.0079 0.0926 0.141
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0015 0.0077
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0132 0.1695 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.004 0.006
Echinococcus granulosus poly adp ribose polymerase 2 0.0079 0.0926 0.1436
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.1398 0.1341
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0666 0.0604
Brugia malayi beta-lactamase family protein 0.0112 0.1398 0.2128
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0129 0.1343
Mycobacterium tuberculosis Probable peptidase 0.0053 0.0555 0.0492
Loa Loa (eye worm) RecQ helicase 0.0022 0.0121 0.0184
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.0145 0.1878 0.2859
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0132 0.1695 0.3547
Schistosoma mansoni hypothetical protein 0.008 0.0946 0.198
Onchocerca volvulus 0.0112 0.1398 0.3266
Loa Loa (eye worm) RNA binding protein 0.0076 0.0896 0.1364
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0153 0.0237
Loa Loa (eye worm) ACC-1 protein 0.0025 0.0153 0.0233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0129 0.0759
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Toxoplasma gondii ABC1 family protein 0.0112 0.1398 0.7248
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1135 0.1728
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0253 0.342 0.5208
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0129 0.0759
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0119 0.0185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1135 0.2374
Loa Loa (eye worm) hypothetical protein 0.0109 0.136 0.207
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.004 0.0061
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.1398 0.2167
Mycobacterium leprae Probable lipase LipE 0.0112 0.1398 0.6848
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0156 0.1628
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0025 0.0153 0.0237
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0559 0.0497
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0153 0.032
Leishmania major oligopeptidase b 0.0053 0.0555 0.3271
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0025 0.0153 0.0233
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.079 0.1203
Loa Loa (eye worm) hypothetical protein 0.0132 0.1695 0.2581
Schistosoma mansoni thyroid hormone receptor 0.0275 0.3743 0.7832
Mycobacterium leprae conserved hypothetical protein 0.0112 0.1398 0.6848
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0255 0.345 0.535
Loa Loa (eye worm) blistered cuticle protein 3 0.0253 0.3416 0.5202
Toxoplasma gondii hypothetical protein 0.0028 0.02 0.1036
Onchocerca volvulus DNA ligase 3 homolog 0.0019 0.0069 0.016
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0094 0.0146
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0156 0.1628
Entamoeba histolytica hypothetical protein 0.0109 0.1358 0.3174
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0094 0.0197
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0129 0.092
Plasmodium falciparum glutathione reductase 0.0066 0.0746 0.7786
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 1
Entamoeba histolytica hypothetical protein 0.0022 0.0119 0.0279
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0094 0.0144
Treponema pallidum fructose-bisphosphate aldolase 0.0312 0.4265 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0025 0.0153 0.0237
Leishmania major trypanothione reductase 0.0066 0.0746 0.4398
Brugia malayi MH1 domain containing protein 0.0017 0.004 0.006
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0121 0.0284
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0094 0.0146
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0119 0.0185
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0132 0.1695 0.3547
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0053 0.0555 0.2298
Trypanosoma brucei poly(adp-ribose) polymerase 0.0079 0.0926 0.5462
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.4265 0.9966
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0958 0.1485
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0153 0.0233
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0129 0.0703
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0129 0.0327
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0094 0.0197
Schistosoma mansoni smad1 5 8 and 0.0017 0.004 0.0083
Mycobacterium ulcerans hypothetical protein 0.0112 0.1398 0.6951
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0094 0.0146
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0069 0.0405
Entamoeba histolytica hypothetical protein 0.0109 0.1358 0.3174
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.004 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1135 0.1759
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.079 0.466
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0153 0.0237
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Onchocerca volvulus 0.0025 0.0153 0.0358
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0025 0.0153 0.0233
Leishmania major DNA repair protein, putative 0.0019 0.0069 0.0405
Onchocerca volvulus 0.002 0.0094 0.022
Giardia lamblia Fructose-bisphosphate aldolase 0.0312 0.4265 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0094 0.0144
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Brugia malayi MH2 domain containing protein 0.0017 0.004 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0094 0.0144
Brugia malayi Blistered cuticle protein 3 0.0253 0.3416 0.5202
Schistosoma mansoni hypothetical protein 0.0348 0.4779 1
Plasmodium falciparum thioredoxin reductase 0.0023 0.0129 0.1343
Onchocerca volvulus Peroxidase homolog 0.0253 0.3416 0.7982
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0094 0.0144
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0025 0.0153 0.0237
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.0746 0.4398
Brugia malayi MH1 domain containing protein 0.0017 0.004 0.006
Echinococcus granulosus glycine receptor subunit beta 0.0025 0.0153 0.0237
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Echinococcus granulosus peroxidasin 0.0253 0.3416 0.5297
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0025 0.0153 0.0237
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0559 0.2324
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1358 0.2106
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0094 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0094 0.0144
Schistosoma mansoni nuclear hormone receptor 0.002 0.0094 0.0197
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0094 0.0146
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0053 0.0555 0.3271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.002 0.0094 0.0144
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.6449 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0094 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0094 0.0144
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.0746 0.1156
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0129 0.0703
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0094 0.0197
Onchocerca volvulus Prolyl endopeptidase homolog 0.0132 0.1695 0.3961
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0156 0.092
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0129 0.0301
Schistosoma mansoni hypothetical protein 0.0255 0.345 0.7219
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0156 0.1116
Schistosoma mansoni peroxidasin 0.0253 0.3416 0.7147
Trypanosoma brucei trypanothione reductase 0.0066 0.0746 0.4398
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1398 0.3277
Schistosoma mansoni hypothetical protein 0.0109 0.1358 0.2842
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0094 0.0144
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0121 0.0284
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.0746 0.1135
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1358 0.2842
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0094 0.0144
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0025 0.0153 0.0237
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0094 0.0146
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1398 0.3277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1135 0.2374
Schistosoma mansoni thyroid hormone receptor 0.0275 0.3743 0.7832
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 0.2124
Loa Loa (eye worm) hypothetical protein 0.0081 0.0958 0.1458
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0666 0.1033
Brugia malayi hypothetical protein 0.0109 0.1358 0.2068
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0094 0.0146
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0025 0.0153 0.0237
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0066 0.0472
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0079 0.0926 0.5462
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0066 0.0389
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0025 0.0153 0.0237
Brugia malayi beta-lactamase 0.0112 0.1398 0.2128
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0066 0.0155
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0025 0.0153 0.0237
Echinococcus granulosus prolyl endopeptidase 0.0132 0.1695 0.2629
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 0.4654
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.02 0.0384
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0025 0.0153 0.032
Trypanosoma cruzi oligopeptidase b 0.0053 0.0555 0.3271
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0054 0.0112
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0053 0.0555 0.0492
Leishmania major hypothetical protein, conserved 0.0019 0.0069 0.0405
Loa Loa (eye worm) Smad1 0.0017 0.004 0.006
Brugia malayi MH2 domain containing protein 0.0017 0.004 0.006
Plasmodium vivax hypothetical protein, conserved 0.0112 0.1398 1
Brugia malayi nuclear hormone receptor 0.002 0.0094 0.0144
Loa Loa (eye worm) animal heme peroxidase 0.0253 0.3416 0.5202
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0666 0.3132
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0079 0.0926 0.1937
Echinococcus multilocularis glycine receptor subunit beta 0.0025 0.0153 0.0237
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0066 0.0102
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0025 0.0153 0.0233
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0094 0.0146
Brugia malayi hypothetical protein 0.0253 0.3416 0.5202
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1398 0.3277
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0958 0.4966
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.6449 1
Mycobacterium ulcerans beta-lactamase 0.0112 0.1398 0.6951
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0129 0.0667
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1398 0.2924
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Brugia malayi Cation transporter family protein 0.0025 0.0153 0.0233
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.004 0.0083
Onchocerca volvulus 0.0025 0.0153 0.0358
Echinococcus granulosus WGR domain containing protein 0.0044 0.0437 0.0678
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.079 0.1203
Echinococcus granulosus poly ADP ribose polymerase 1 0.0143 0.1848 0.2866
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0025 0.0153 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0896 0.1875
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.1398 0.2128
Toxoplasma gondii prolyl endopeptidase 0.0132 0.1695 0.8791
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0129 0.092
Brugia malayi RNA binding protein 0.0076 0.0896 0.1364
Brugia malayi Animal haem peroxidase family protein 0.0253 0.3416 0.5202
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0066 0.0688
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0608 0.0925
Brugia malayi hypothetical protein 0.0016 0.003 0.0046
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.004 0.0061
Loa Loa (eye worm) beta-lactamase 0.0112 0.1398 0.2128
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0025 0.0153 0.0237
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.079 0.1225
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0946 0.1441
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0094 0.0144
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1398 0.3277
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0958 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0066 0.01
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0129 0.0327
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.004 0.006
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0896 0.1364
Onchocerca volvulus Dual oxidase homolog 0.0253 0.3416 0.7982
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0094 0.0144
Onchocerca volvulus 0.0025 0.0153 0.0358
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0094 0.0144
Plasmodium falciparum glutathione reductase 0.0023 0.0129 0.1343
Brugia malayi beta-lactamase family protein 0.0112 0.1398 0.2128
Entamoeba histolytica hypothetical protein, conserved 0.0313 0.4279 1
Echinococcus multilocularis prolyl endopeptidase 0.0132 0.1695 0.2629
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0374 0.0579
Schistosoma mansoni smad 0.0017 0.004 0.0083
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0121 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0094 0.0144
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0946 0.1441
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Brugia malayi Thioredoxin reductase 0.0066 0.0746 0.1135
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.1398 0.1341
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0559 0.0867
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0094 0.0197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.4265 1
Brugia malayi TAR-binding protein 0.0076 0.0896 0.1364
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0025 0.0153 0.0233
Schistosoma mansoni nAChR subunit 0.0025 0.0153 0.032
Mycobacterium tuberculosis Conserved protein 0.0112 0.1398 0.1341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0025 0.0153 0.0233
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0958 0.2004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0094 0.0144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0153 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0094 0.0144
Onchocerca volvulus 0.0025 0.0153 0.0358
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.1398 0.1341
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1398 0.8245
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0025 0.0153 0.0237
Trypanosoma brucei DNA repair protein, putative 0.0019 0.0069 0.0405
Echinococcus granulosus geminin 0.0348 0.4779 0.7411
Loa Loa (eye worm) hypothetical protein 0.0145 0.1878 0.2859
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0053 0.0555 0.3271
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0666 0.1014
Echinococcus granulosus tar DNA binding protein 0.0076 0.0896 0.1389
Brugia malayi glutathione reductase 0.0066 0.0746 0.1135
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0025 0.0153 0.032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0896 0.1364
Brugia malayi Calcitonin receptor-like protein seb-1 0.0253 0.342 0.5208
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0143 0.1848 0.2866
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Loa Loa (eye worm) hypothetical protein 0.0253 0.3416 0.5202
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0082 0.0858
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0094 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0759
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0025 0.0153 0.032
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0129 0.0199
Plasmodium falciparum thioredoxin reductase 0.0066 0.0746 0.7786
Brugia malayi WGR domain containing protein 0.0143 0.1848 0.2815
Onchocerca volvulus 0.0025 0.0153 0.0358
Loa Loa (eye worm) hypothetical protein 0.0112 0.1398 0.2128
Echinococcus multilocularis nAChR subunit 0.0025 0.0153 0.0237
Schistosoma mansoni Smad4 0.0017 0.004 0.0083

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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