TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 277.334 | Formula: C16H20FNO2
H donors: 0 H acceptors: 1 LogP: 2.72 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C1C2CC[C@@H](N2C)C[C@@H]1c1cccc(c1)F
InChi: 1S/C16H20FNO2/c1-18-12-6-7-14(18)15(16(19)20-2)13(9-12)10-4-3-5-11(17)8-10/h3-5,8,12-15H,6-7,9H2,1-2H3/t12-,13-,14?,15?/m1/s1
InChiKey: KBWLRHKLMPNABK-LMRVLLHPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Dopamine transporter	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Dopamine transporter	619 aa	604 aa	37.9 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	578 aa	32.9 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	636 aa	31.8 %
Schistosoma mansoni	sodium/chloride dependent transporter	Dopamine transporter	619 aa	558 aa	41.8 %
Drosophila melanogaster	CG1698 gene product from transcript CG1698-RA	Dopamine transporter	619 aa	522 aa	36.0 %
Echinococcus granulosus	sodium and chloride dependent glycine	Dopamine transporter	619 aa	594 aa	41.4 %
Neospora caninum	sodium-dependent transporter, putative	Dopamine transporter	619 aa	498 aa	32.3 %
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Dopamine transporter	619 aa	509 aa	40.1 %
Schistosoma mansoni	sodium/chloride dependent transporter	Dopamine transporter	619 aa	588 aa	40.3 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Dopamine transporter	619 aa	599 aa	41.9 %
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Dopamine transporter	619 aa	551 aa	39.9 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	578 aa	33.4 %
Onchocerca volvulus	High affinity copper uptake protein 1 homolog	Dopamine transporter	619 aa	599 aa	44.2 %
Drosophila melanogaster	CG13796 gene product from transcript CG13796-RD	Dopamine transporter	619 aa	557 aa	23.9 %
Plasmodium vivax	hypothetical protein, conserved	Dopamine transporter	619 aa	657 aa	20.1 %
Onchocerca volvulus		Dopamine transporter	619 aa	612 aa	23.5 %
Onchocerca volvulus	Transmembrane protein 120 homolog	Dopamine transporter	619 aa	578 aa	32.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0007	0.0068
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0072	0.0147
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.03
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0048	0.0176
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0087	0.14
Trichomonas vaginalis	helicase, putative	0.0007	0.0002	0.03
Schistosoma mansoni	hypothetical protein	0.0173	0.033	0.5332
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.0564	0.9127
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.0087	0.0842
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0048	0.0059
Brugia malayi	CXXC zinc finger family protein	0.003	0.0048	0.0065
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0007	0.0113
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0032	0.0119
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.1388	0.2723	1
Plasmodium vivax	telomerase reverse transcriptase, putative	0.1388	0.2723	1
Plasmodium falciparum	importin beta, putative	0.003	0.0048	0.0176
Plasmodium falciparum	telomerase reverse transcriptase	0.1388	0.2723	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0087	0.0119
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0032	0.0119
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0037	0.0135
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.03
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0087	0.14
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0032	0.0118
Echinococcus granulosus	neuropeptide s receptor	0.0527	0.1027	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0008	0.0077
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0087	0.0119
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0025	0.0247
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.03
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0032	0.0315
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.03
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0072	0.07
Brugia malayi	Importin beta-1 subunit	0.003	0.0048	0.0066
Plasmodium falciparum	amino acid transporter, putative	0.005	0.0087	0.0318
Schistosoma mansoni	hypothetical protein	0.0019	0.0025	0.041
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0087	0.14
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0072	0.07
Echinococcus granulosus	snurportin 1	0.0319	0.0618	0.6018
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0008	0.0077
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0007	0.0009
Leishmania major	GTP-binding protein, putative	0.0022	0.0032	0.0118
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0106	0.0197	0.1922
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0048	0.0465
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.0087	0.0842
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0003	0.0056
Brugia malayi	RNA, U transporter 1	0.0085	0.0157	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.03
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.14
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0025	0.0247
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0032	0.0524
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0059	0.0104	0.0143
Loa Loa (eye worm)	hypothetical protein	0.003	0.0048	0.0773
Echinococcus multilocularis	serotonin transporter	0.0292	0.0564	0.5493
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0025	0.0247
Schistosoma mansoni	smad	0.001	0.0008	0.0128
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.14
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0087	0.14
Schistosoma mansoni	hypothetical protein	0.0019	0.0025	0.041
Toxoplasma gondii	RNA-directed DNA polymerase	0.1388	0.2723	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.03
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.0087	0.0119
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.0072	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0037	0.5098
Schistosoma mansoni	ran	0.0022	0.0032	0.0521
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0032	0.0315
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0059	0.0104	0.1686
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0032	0.0118
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0072	0.0147
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0032	0.0044
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0087	0.0318
Echinococcus granulosus	neuropeptide receptor A26	0.0527	0.1027	1
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0032	0.4502
Echinococcus granulosus	serotonin transporter	0.0292	0.0564	0.5493
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0087	0.0842
Brugia malayi	MH1 domain containing protein	0.001	0.0008	0.0011
Schistosoma mansoni	hypothetical protein	0.0019	0.0025	0.041
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0032	0.0118
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.0087	0.14
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0003	0.0033
Schistosoma mansoni	smad1 5 8 and	0.001	0.0008	0.0128
Schistosoma mansoni	ran	0.0022	0.0032	0.0521
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0042	0.0072	1
Schistosoma mansoni	ap endonuclease	0.0022	0.0032	0.0524
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.03
Echinococcus multilocularis	ubiquitin specific protease 41	0.0042	0.0072	0.07
Leishmania major	hypothetical protein, conserved	0.003	0.0048	0.0176
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0048	0.0769
Echinococcus multilocularis	neuropeptide receptor A26	0.0527	0.1027	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0072	0.0264
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0087	0.0318
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0087	0.14
Echinococcus granulosus	Smad4	0.001	0.0008	0.0077
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0048	0.0176
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0008	0.0128
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0087	0.14
Echinococcus multilocularis	neuropeptide s receptor	0.0527	0.1027	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0072	0.07
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.03
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.0564	0.9127
Echinococcus granulosus	cpg binding protein	0.0031	0.0051	0.0496
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0106	0.0197	0.1922
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0072	0.07
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0059	0.0104	0.0143
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0002	0.03
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0037	0.5098
Schistosoma mansoni	hypothetical protein	0.0319	0.0618	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0037	0.0016
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.0564	0.9127
Schistosoma mansoni	cpg binding protein	0.0031	0.0051	0.0824
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0087	0.0842
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0048	0.0176
Brugia malayi	MH2 domain containing protein	0.001	0.0008	0.0011
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0008	0.0077
Brugia malayi	MH2 domain containing protein	0.0142	0.0269	0.037
Loa Loa (eye worm)	transcription factor SMAD2	0.0142	0.0269	0.4351
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0048	0.0176
Giardia lamblia	Telomerase catalytic subunit	0.1388	0.2723	1
Brugia malayi	hypothetical protein	0.003	0.0048	0.0066
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0087	0.0842
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.0087	0.0842
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0003	0.0033
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0032	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.14
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0087	0.14
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0113	0.1834
Echinococcus granulosus	smad	0.001	0.0008	0.0077
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0042	0.0072	0.0147
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0087	0.0842
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0015	0.015
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.03
Echinococcus multilocularis	snurportin 1	0.0319	0.0618	0.6018
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0032	0.0314
Echinococcus multilocularis	Smad4	0.001	0.0008	0.0077
Loa Loa (eye worm)	hypothetical protein	0.004	0.0068	0.1095
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0032	0.0314
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0008	0.0128
Schistosoma mansoni	smad1 5 8 and	0.001	0.0008	0.0128
Schistosoma mansoni	importin beta-1	0.003	0.0048	0.0773
Brugia malayi	Telomerase reverse transcriptase	0.3692	0.7266	1
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0025	0.0247
Onchocerca volvulus		0.005	0.0087	0.0039
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.14
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0564	0.9127
Leishmania major	telomerase reverse transcriptase, putative	0.1388	0.2723	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0008	0.0128
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.03
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.1388	0.2723	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0048	0.0176
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0048	0.0059
Trypanosoma brucei	telomerase reverse transcriptase	0.1388	0.2723	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0048	0.0776
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0106	0.0197	0.3193
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.0564	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0106	0.0197	0.1922
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0087	0.0318
Echinococcus granulosus	importin subunit beta 1	0.003	0.0048	0.0465
Schistosoma mansoni	ap endonuclease	0.0022	0.0032	0.0524
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0042	0.0072	0.1163
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0002	0.03
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0072	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.0564	0.0777
Plasmodium vivax	importin-beta 2, putative	0.003	0.0048	0.0176
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0032	0.0521
Toxoplasma gondii	hypothetical protein	0.005	0.0087	0.0318
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0106	0.0197	0.3193
Entamoeba histolytica	Ran family GTPase	0.0022	0.0032	0.4484
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0032	0.4502
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.0087	0.0842
Echinococcus multilocularis	cpg binding protein	0.0031	0.0051	0.0496
Schistosoma mansoni	cpg binding protein	0.003	0.0048	0.0769
Onchocerca volvulus		0.005	0.0087	0.0039
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0048	0.0176
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0037	0.5098
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0025	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0564	0.9127
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0042	0.0072	0.1163
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.0087	0.0842
Echinococcus granulosus	ubiquitin specific protease 41	0.0042	0.0072	0.07
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0087	0.14
Plasmodium falciparum	transporter, putative	0.005	0.0087	0.0318
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0003	0.0033
Schistosoma mansoni	smad1 5 8 and	0.001	0.0008	0.0128
Onchocerca volvulus		0.0292	0.0564	0.0519
Entamoeba histolytica	hypothetical protein	0.0024	0.0037	0.5098
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0032	0.0118
Schistosoma mansoni	hypothetical protein	0.0013	0.0015	0.0249
Loa Loa (eye worm)	MH2 domain-containing protein	0.0142	0.0269	0.4351
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0032	0.4502
Brugia malayi	MH2 domain containing protein	0.001	0.0008	0.0011
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.0564	0.9127
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0032	0.0119
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0015	0.015
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.0564	0.9127
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.03
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0087	0.14
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0068	0.0093
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0087	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.03
Schistosoma mansoni	hypothetical protein	0.0173	0.033	0.5332
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0087	0.0842
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.03
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0003	0.0033
Schistosoma mansoni	hypothetical protein	0.004	0.0068	0.1095
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0042	0.0072	0.0264
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0008	0.0077
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.03
Brugia malayi	MH1 domain containing protein	0.001	0.0008	0.0011
Brugia malayi	hypothetical protein	0.0019	0.0027	0.0037
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0087	0.0842
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.14
Brugia malayi	hypothetical protein	0.005	0.0087	0.0119
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0048	0.0176
Toxoplasma gondii	exonuclease III APE	0.0022	0.0032	0.0119
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.0087	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.14
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0106	0.0197	0.1922
Onchocerca volvulus		0.005	0.0087	0.0039
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0106	0.0197	0.0272
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0106	0.0197	0.3193
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0025	0.041
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.01	0.0368
Echinococcus granulosus	GPCR family 2	0.0019	0.0025	0.0247
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0087	0.0318
Brugia malayi	Smad1	0.001	0.0008	0.0011
Loa Loa (eye worm)	Smad1	0.001	0.0008	0.0128
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0042	0.0072	0.0099
Schistosoma mansoni	Smad4	0.001	0.0008	0.0128
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0025	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0564	0.9127
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0104	0.1686
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.03
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0032	0.5
Toxoplasma gondii	hypothetical protein	0.005	0.0087	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0025	0.041
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0032	0.0045
Trichomonas vaginalis	ran, putative	0.0022	0.0032	0.4484
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0025	0.0247
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0087	0.14
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.14
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0319	0.0618	1
Echinococcus multilocularis	geminin	0.0173	0.033	0.3209
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.0072	1
Echinococcus granulosus	geminin	0.0173	0.033	0.3209
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0087	0.14
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0087	0.14
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0032	0.5
Schistosoma mansoni	hypothetical protein	0.0019	0.0025	0.041
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0007	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0072	0.1163
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0106	0.0197	0.3193
Plasmodium vivax	amine transporter, putative	0.005	0.0087	0.0318
Echinococcus multilocularis	smad	0.001	0.0008	0.0077
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0032	0.0119
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0048	0.0176
Schistosoma mansoni	cpg binding protein	0.0031	0.0051	0.0824

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 16.4 nM	Concentration required to inhibit 50% of radioligand binding ([3H]-WIN 35428) to the dopamine (DA) transporter in rat	ChEMBL.	8071935

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL606933

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1136013