Detailed information for compound 1140602

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 453.281 | Formula: C13H21N5O9P2
  • H donors: 4 H acceptors: 7 LogP: -2.02 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: [N-]=[N+]=NC1CC(OC1COP(=O)(CCCP(=O)(O)O)O)n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C13H21N5O9P2/c1-8-6-18(13(20)15-12(8)19)11-5-9(16-17-14)10(27-11)7-26-29(24,25)4-2-3-28(21,22)23/h6,9-11H,2-5,7H2,1H3,(H,24,25)(H,15,19,20)(H2,21,22,23)
  • InChiKey: DPYCUHBHVJJTTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0122 0.0435
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0406 0.0399
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0598 0.0597
Brugia malayi kap beta 3 protein 0.0016 0.007 0.0249
Trypanosoma brucei glucose transporter, putative 0.0065 0.0607 0.7227
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0122 0.0116
Onchocerca volvulus 0.003 0.0215 0.0672
Echinococcus multilocularis lamin 0.014 0.1425 0.142
Plasmodium falciparum protein kinase 6 0.0894 0.9692 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0122
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0583 0.0578
Echinococcus granulosus General substrate transporter 0.0181 0.1875 0.187
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0013 0.0001
Echinococcus multilocularis translational activator gcn1 0.0016 0.007 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0122 0.0122
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0215 0.0209
Onchocerca volvulus 0.003 0.0215 0.0672
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0328 0.5587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1361
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0135 0.3243
Loa Loa (eye worm) hypothetical protein 0.0137 0.1397 0.1397
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0068 0.0631 0.0625
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0122 0.011
Onchocerca volvulus 0.0148 0.1514 1
Plasmodium vivax hexose transporter 0.0211 0.22 0.2253
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0077 0.0861
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0215 0.0769
Onchocerca volvulus 0.003 0.0215 0.0672
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0607 0.274
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0598 0.0598
Echinococcus granulosus smad 0.0018 0.0089 0.0082
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0215 0.303
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.002 0.0218
Brugia malayi Sugar transporter family protein 0.0211 0.22 0.7862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0365 0.164
Trypanosoma brucei glucose transporter 1E 0.0065 0.0607 0.7227
Leishmania major hypothetical protein, conserved 0.003 0.0215 0.303
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0583 0.2085
Brugia malayi beta-NAC-like protein 0.0034 0.0266 0.0951
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0583 0.2085
Onchocerca volvulus 0.003 0.0215 0.0672
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0077 0.1035
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0122 0.0116
Onchocerca volvulus 0.003 0.0215 0.0672
Onchocerca volvulus 0.003 0.0215 0.0672
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0122
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0266 0.0254
Trypanosoma brucei importin beta-1 subunit, putative 0.0086 0.0837 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0894 0.9692 1
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0266 0.3852
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0607 0.274
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0607 0.868
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0077 0.1035
Echinococcus granulosus neuropeptide s receptor 0.0453 0.4859 0.4856
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Schistosoma mansoni smad1 5 8 and 0.0018 0.0089 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0122 0.0116
Leishmania major hypothetical protein, conserved 0.0025 0.0162 0.2255
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0598 0.0597
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Echinococcus multilocularis short transient receptor potential channel 6 0.0129 0.1309 0.1304
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0215 0.0956
Brugia malayi nuclear receptor RXR 0.0011 0.0013 0.0045
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0162 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0077 0.0327
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0122 0.0435
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Schistosoma mansoni importin-beta 2 0.0016 0.007 0.0058
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Onchocerca volvulus 0.014 0.1425 0.9363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0191 0.0845
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0583 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0837 0.0837
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0277 0.0265
Brugia malayi MH2 domain containing protein 0.0018 0.0089 0.0316
Trypanosoma brucei glucose transporter, putative 0.0065 0.0607 0.7227
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.1058 0.1047
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0077 0.1035
Onchocerca volvulus 0.003 0.0215 0.0672
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0012 0.0006
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0583 0.2634
Brugia malayi hypothetical protein 0.0011 0.0013 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0333 0.1492
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0607 0.274
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0598 0.0592
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.002 0.0008
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0215 0.0209
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0077 0.0071
Plasmodium vivax sugar transporter, putative 0.003 0.0215 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0215 0.0956
Echinococcus granulosus GTP binding nuclear protein Ran 0.0064 0.0587 0.0582
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0598 0.0586
Schistosoma mansoni ran 0.0064 0.0587 0.0576
Loa Loa (eye worm) kap beta 3 protein 0.0016 0.007 0.007
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0215 0.5239
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.002 0.0073
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0592
Echinococcus granulosus transient receptor potential ion channel A 0.0189 0.1964 0.1959
Trichomonas vaginalis glucose transporter, putative 0.003 0.0215 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Schistosoma mansoni protein kinase 0.0065 0.0598 0.0586
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0447 0.1596
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0215 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0191 0.0845
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0447 0.668
Echinococcus granulosus lamin dm0 0.014 0.1425 0.142
Plasmodium falciparum transportin 0.0016 0.007 0.0051
Schistosoma mansoni hypothetical protein 0.0922 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0122 0.011
Trypanosoma brucei glucose transporter, putative 0.0065 0.0607 0.7227
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0216 0.0216
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.4859 0.4856
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0447 0.5303
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0215 0.0203
Schistosoma mansoni hypothetical protein 0.0035 0.0277 0.0265
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0077 0.1035
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.22 0.2195
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0064 0.0587 0.0908
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0406 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0392 0.0392
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.002 0.0182
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0215 0.0209
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0406 0.6932
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0223 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0215 0.0956
Trypanosoma brucei glucose transporter, putative 0.0065 0.0607 0.7227
Plasmodium vivax transportin, putative 0.0016 0.007 0.0051
Schistosoma mansoni sugar transporter 0.003 0.0215 0.0203
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0607 0.274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0263 0.1177
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0554 0.0548
Echinococcus multilocularis solute carrier family 22 0.003 0.0215 0.0209
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0447 0.0441
Toxoplasma gondii sugar transporter ST1 0.003 0.0215 0.0327
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0607 0.7227
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0175 0.0175
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0215 0.6499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1361
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.1342 0.1337
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0122 0.0435
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0447 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0122 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0251 0.1122
Schistosoma mansoni hypothetical protein 0.0423 0.4531 0.4524
Echinococcus granulosus transportin 1 0.0016 0.007 0.0063
Leishmania major protein kinase, putative 0.0065 0.0598 0.855
Loa Loa (eye worm) hypothetical protein 0.0068 0.0631 0.0631
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0698 1
Brugia malayi MH2 domain containing protein 0.0018 0.0089 0.0316
Onchocerca volvulus Putative transporter 0.003 0.0215 0.0672
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0223 0.0991
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.002 0.0262
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Brugia malayi MH2 domain containing protein 0.0265 0.2798 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1361
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.034 0.3622 0.3724
Brugia malayi cytoplasmic intermediate filament protein 0.0075 0.0713 0.2547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0122 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0392 0.0386
Trypanosoma brucei glucose transporter, putative 0.0065 0.0607 0.7227
Giardia lamblia Hexose transporter 0.003 0.0215 0.3435
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.002 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1361
Brugia malayi ecdysteroid receptor 0.0021 0.0122 0.0435
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0075 0.0713 0.0713
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.1342 0.1337
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0122 0.0435
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0698 0.0701
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0013 0.0013
Brugia malayi glycyl-tRNA synthetase 0.0012 0.002 0.0073
Trypanosoma cruzi sugar transporter, putative 0.003 0.0215 0.303
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.002 0.0218
Onchocerca volvulus 0.003 0.0215 0.0672
Plasmodium vivax importin-beta 2, putative 0.0086 0.0837 0.0845
Giardia lamblia Sugar-proton symporter 0.003 0.0215 0.3435
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0215 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0122 0.0122
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0583 0.0572
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0304 0.0466
Leishmania major glucose transporter, lmgt2 0.0065 0.0607 0.868
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0122 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0607 0.274
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0392 0.0386
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0122 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0333 0.1492
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0447 0.6369
Onchocerca volvulus 0.003 0.0215 0.0672
Schistosoma mansoni hypothetical protein 0.0211 0.22 0.2191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0191 0.0845
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0089 0.0089
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0406 0.4815
Loa Loa (eye worm) sugar transporter 0.003 0.0215 0.0215
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.4859 0.4856
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0215 0.6499
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0089 0.0089
Leishmania major GTP-binding protein, putative 0.0064 0.0587 0.8402
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0215 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0215 0.0956
Brugia malayi hypothetical protein 0.003 0.0215 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.019 0.0843
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0266 0.0407
Toxoplasma gondii protein kinase, putative 0.0595 0.6415 1
Loa Loa (eye worm) transcription factor SMAD2 0.0265 0.2798 0.2798
Schistosoma mansoni lamin 0.014 0.1425 0.1415
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.22 0.2195
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0266 0.3765
Echinococcus granulosus solute carrier family 22 0.003 0.0215 0.0209
Entamoeba histolytica protein kinase, putative 0.0065 0.0598 0.9048
Schistosoma mansoni Smad4 0.0018 0.0089 0.0077
Entamoeba histolytica hypothetical protein 0.0035 0.0277 0.4022
Entamoeba histolytica hypothetical protein 0.007 0.0658 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0447 0.6369
Echinococcus multilocularis importin 5 0.0016 0.007 0.0063
Echinococcus granulosus dnaJ subfamily B 0.0423 0.4531 0.4527
Brugia malayi intermediate filament protein 0.014 0.1425 0.5094
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0122 0.0435
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0121 0.1396
Echinococcus multilocularis importin subunit beta 1 0.0086 0.0837 0.0832
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0122
Echinococcus granulosus lamin 0.014 0.1425 0.142
Trypanosoma cruzi hexose transporter, putative 0.003 0.0215 0.303
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0406 0.0399
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0598 0.7118
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.4531 0.4527
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0215 0.5239
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Echinococcus granulosus translational activator gcn1 0.0016 0.007 0.0063
Trypanosoma brucei importin beta-1 subunit, putative 0.0086 0.0837 1
Brugia malayi MH1 domain containing protein 0.0018 0.0089 0.0316
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0073 0.0688 0.0682
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0598 0.0597
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0122 0.011
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0598 0.0597
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0698 1
Echinococcus granulosus solute carrier family 22 0.003 0.0215 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0219 0.0976
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0089 0.0077
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Brugia malayi hypothetical protein 0.003 0.0215 0.0769
Schistosoma mansoni protein kinase 0.0065 0.0598 0.0586
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0068 0.0631 0.0625
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0122 0.0116
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.007 0.01
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.007 0.01
Echinococcus granulosus solute carrier family 22 0.003 0.0215 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0122 0.0122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0122 0.0435
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Brugia malayi Sugar transporter family protein 0.003 0.0215 0.0769
Schistosoma mansoni transient receptor potential channel 4 0.0196 0.2035 0.2026
Echinococcus granulosus short transient receptor potential channel 6 0.0129 0.1309 0.1304
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0122 0.0435
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0447 0.6369
Schistosoma mansoni smad1 5 8 and 0.0018 0.0089 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0122 0.0435
Echinococcus granulosus Smad4 0.0018 0.0089 0.0082
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0698 1
Entamoeba histolytica hypothetical protein 0.0034 0.0266 0.3852
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0598 0.0597
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0447 0.0441
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0607 0.274
Schistosoma mansoni cpg binding protein 0.003 0.0216 0.0204
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0592
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0064 0.0587 0.2099
Echinococcus granulosus intermediate filament protein 0.014 0.1425 0.142
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0064 0.0587 0.0586
Trichomonas vaginalis importin beta-1, putative 0.007 0.0658 0.2976
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.002 0.0114 0.1303
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Schistosoma mansoni sugar transporter 0.003 0.0215 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0077 0.0327
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0333 0.3941
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0122
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0089 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0122
Giardia lamblia GTOR 0.0051 0.0447 0.7516
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0392 0.038
Onchocerca volvulus 0.003 0.0215 0.0672
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0277 0.0271
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0013 0.0045
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.0333 0.4734
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0135 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0607 0.7227
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0406 0.0625
Entamoeba histolytica hypothetical protein 0.0047 0.0406 0.6044
Trichomonas vaginalis hypothetical protein 0.0016 0.007 0.0293
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0013 0.0001
Echinococcus multilocularis transportin 1 0.0016 0.007 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0122 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1361
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0266 0.1188
Loa Loa (eye worm) hypothetical protein 0.0063 0.0583 0.0583
Schistosoma mansoni glucose transporter 0.003 0.0215 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.019 0.0843
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0089 0.0082
Schistosoma mansoni transient receptor potential channel 0.0196 0.2035 0.2026
Echinococcus multilocularis geminin 0.0166 0.1711 0.1706
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0266 0.1188
Loa Loa (eye worm) hypothetical protein 0.0073 0.0688 0.0688
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0607 0.868
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0583 0.0578
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0598 0.0597
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0598 0.2699
Brugia malayi hypothetical protein 0.0025 0.0162 0.0577
Schistosoma mansoni smad 0.0018 0.0089 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.004 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0219 0.0976
Schistosoma mansoni transient receptor potential channel 0.0129 0.1309 0.1299
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0211 0.22 0.2195
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.034 0.3622 0.5643
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0333 0.1492
Loa Loa (eye worm) hypothetical protein 0.0065 0.0603 0.0603
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0162 0.1878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0191 0.0845
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.002 0.0218
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0447 0.5303
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.002 0.0073
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.002 0.002
Schistosoma mansoni protein kinase 0.0065 0.0598 0.0586
Onchocerca volvulus 0.003 0.0215 0.0672
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0122 0.0116
Plasmodium falciparum hexose transporter 0.0211 0.22 0.2253
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0598 0.0597
Entamoeba histolytica hypothetical protein 0.0035 0.0277 0.4022
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0122 0.011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0582 0.057
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0122 0.0122
Trypanosoma brucei sugar transporter, putative 0.003 0.0215 0.2522
Echinococcus granulosus importin 5 0.0016 0.007 0.0063
Schistosoma mansoni importin beta-1 0.0086 0.0837 0.0826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0122 0.0435
Entamoeba histolytica protein kinase, putative 0.0065 0.0598 0.9048
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0013 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.019 0.0843
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Loa Loa (eye worm) hypothetical protein 0.0066 0.0617 0.0617
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0077 0.0275
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.002 0.0468
Loa Loa (eye worm) MH2 domain-containing protein 0.0265 0.2798 0.2798
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0598 0.0925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0447 0.2011
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Onchocerca volvulus 0.014 0.1425 0.9363
Loa Loa (eye worm) sugar transporter 0.0211 0.22 0.22
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0333 0.1492
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.22 0.2195
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0077 0.0071
Echinococcus granulosus cpg binding protein 0.0031 0.0235 0.0229
Loa Loa (eye worm) hypothetical protein 0.0065 0.0603 0.0603
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0122 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0122 0.0122
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0598 0.0597
Schistosoma mansoni glucose transport protein 0.0211 0.22 0.2191
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0122 0.0116
Brugia malayi MH1 domain containing protein 0.0018 0.0089 0.0316
Brugia malayi CXXC zinc finger family protein 0.003 0.0216 0.0773
Entamoeba histolytica Ran family GTPase 0.0064 0.0587 0.8888
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0406 1
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0215 0.0769
Echinococcus multilocularis snurportin 1 0.0922 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0122 0.0122
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0122 0.0435
Echinococcus multilocularis transcription factor btf3 0.0034 0.0266 0.026
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0215 0.0201
Trypanosoma brucei glucose transporter 2A 0.0065 0.0607 0.7227
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.0333 0.4734
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0122 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0122
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.002 0.0182
Entamoeba histolytica HEAT repeat domain containing protein 0.0016 0.007 0.0771
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0122 0.011
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0077 0.0065
Onchocerca volvulus 0.0107 0.1058 0.6726
Brugia malayi Transient-receptor-potential like protein 0.0073 0.0688 0.2459
Plasmodium falciparum importin beta, putative 0.0086 0.0837 0.0845
Schistosoma mansoni ran 0.0064 0.0587 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0304 0.1361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0077 0.0327
Toxoplasma gondii facilitative glucose transporter GT1 0.0211 0.22 0.3424
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0406 0.04
Brugia malayi major facilitator superfamily protein 0.003 0.0215 0.0769
Echinococcus multilocularis short transient receptor potential channel 6 0.0129 0.1309 0.1304
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0598 0.2136
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.22 0.2195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0122 0.0116
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0282 0.3994
Loa Loa (eye worm) hypothetical protein 0.0148 0.1514 0.1514
Echinococcus granulosus geminin 0.0166 0.1711 0.1706
Entamoeba histolytica hypothetical protein 0.0035 0.0277 0.4022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0013
Onchocerca volvulus 0.003 0.0215 0.0672
Echinococcus multilocularis solute carrier family 22 0.003 0.0215 0.0209
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.002 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0064 0.0587 0.6996
Trypanosoma cruzi importin beta-1 subunit, putative 0.007 0.0658 0.9426
Echinococcus granulosus TRP transient receptor potential channel 0.0073 0.0688 0.0682
Loa Loa (eye worm) hypothetical protein 0.0107 0.1058 0.1058
Entamoeba histolytica hypothetical protein 0.0035 0.0277 0.4022
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0215 0.0215
Trichomonas vaginalis ran, putative 0.0064 0.0587 0.2653
Brugia malayi nuclear receptor NHR-88 0.0021 0.0122 0.0435
Toxoplasma gondii sugar transporter ST2 0.003 0.0215 0.0327
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0122 0.0116
Trypanosoma brucei glucose transporter, putative 0.0065 0.0607 0.7227
Echinococcus granulosus solute carrier family 22 0.003 0.0215 0.0209
Schistosoma mansoni sugar transporter 0.003 0.0215 0.0203
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0508 0.0784
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.22 0.2195
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0583 0.0572
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0406 0.5783
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0122 0.0116
Schistosoma mansoni thyroid hormone receptor 0.0154 0.1573 0.1563
Brugia malayi major facilitator superfamily protein 0.003 0.0215 0.0769
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0162 0.0244
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0013
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0342 0.1536
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0583 0.8824
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.4859 0.4856
Onchocerca volvulus 0.003 0.0215 0.0672
Loa Loa (eye worm) Smad1 0.0018 0.0089 0.0089
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0153 0.1781
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0698 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0162 0.0146
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0012 0.0006
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0215 0.0215
Echinococcus multilocularis Smad4 0.0018 0.0089 0.0082
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0064 0.0587 0.8402
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0607 0.274
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.002 0.0377
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Onchocerca volvulus 0.003 0.0215 0.0672
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Echinococcus multilocularis tumor protein p63 0.0728 0.7868 0.7867
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0122
Mycobacterium ulcerans sugar transporter 0.003 0.0215 0.5239
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0406 0.5783
Brugia malayi hypothetical protein 0.0148 0.1514 0.5411
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0215 0.5239
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Schistosoma mansoni smad1 5 8 and 0.0018 0.0089 0.0077
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.002 0.0069
Schistosoma mansoni transient receptor potential channel 0.0129 0.1309 0.1299
Brugia malayi Importin beta-1 subunit 0.0086 0.0837 0.2993
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0266 0.3765
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0266 0.0254
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0598 0.0598
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0122 0.0116
Echinococcus multilocularis cpg binding protein 0.0031 0.0235 0.0229
Brugia malayi hypothetical protein 0.003 0.0215 0.0769
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0406 0.68
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0607 0.7227
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0333 0.1492
Brugia malayi hypothetical protein 0.0035 0.0277 0.099
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.002 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0077 0.0327
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0266 0.0266
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Trichomonas vaginalis Importin beta-1 subunit, putative 0.007 0.0658 0.2976
Echinococcus multilocularis General substrate transporter 0.0181 0.1875 0.187
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0607 0.868
Schistosoma mansoni cpg binding protein 0.0031 0.0235 0.0223
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0215 0.2522
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0122 0.0435
Onchocerca volvulus 0.003 0.0215 0.0672
Echinococcus granulosus transient receptor potential gamma protein 0.0196 0.2035 0.203
Brugia malayi hypothetical protein 0.0011 0.0013 0.0045
Echinococcus granulosus tumor protein p63 0.0728 0.7868 0.7867
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0122 0.011
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0406 0.1451
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.002 0.0014
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.22 0.2195
Schistosoma mansoni intermediate filament proteins 0.014 0.1425 0.1415
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0077 0.0077
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Leishmania major importin beta-1 subunit, putative 0.007 0.0658 0.9426
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0266 0.3134
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Toxoplasma gondii HEAT repeat-containing protein 0.0086 0.0837 0.1298
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0013
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0008 0.0004
Brugia malayi Smad1 0.0018 0.0089 0.0316
Echinococcus granulosus importin subunit beta 1 0.0086 0.0837 0.0832
Brugia malayi RNA, U transporter 1 0.0246 0.2583 0.9233
Loa Loa (eye worm) intermediate filament protein 0.014 0.1425 0.1425
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0215 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Loa Loa (eye worm) hypothetical protein 0.0123 0.1238 0.1238
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0077 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.22 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0447 0.2011
Echinococcus multilocularis solute carrier family 22 0.003 0.0215 0.0209
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0592
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0122 0.0435
Brugia malayi steroid hormone receptor 0.0021 0.0122 0.0435
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0598 0.0925
Leishmania major hypothetical protein, conserved 0.0016 0.007 0.0928
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0698 0.0701
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0162 0.2255
Schistosoma mansoni lamin 0.014 0.1425 0.1415
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0583 0.9928
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Loa Loa (eye worm) hypothetical protein 0.0196 0.2035 0.2035
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Schistosoma mansoni thyroid hormone receptor 0.0154 0.1573 0.1563
Echinococcus multilocularis transient receptor potential ion channel A 0.0189 0.1964 0.1959
Plasmodium falciparum protein kinase 7 0.0595 0.6415 0.6612
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0922 1 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0215 0.0209
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0392 0.14
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0064 0.0587 1
Schistosoma mansoni glucose transport protein 0.0211 0.22 0.2191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0392 0.038
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0122 0.0116
Loa Loa (eye worm) hypothetical protein 0.0063 0.0583 0.0583
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0122 0.011
Echinococcus multilocularis lamin dm0 0.014 0.1425 0.142
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0406 0.0394
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0592
Echinococcus multilocularis musashi 0.014 0.1425 0.142
Echinococcus multilocularis smad 0.0018 0.0089 0.0082
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0215 0.0327
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Brugia malayi Sugar transporter family protein 0.003 0.0215 0.0769
Leishmania major glucose transporter, lmgt1 0.0065 0.0607 0.868
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0162 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0122 0.0435
Trypanosoma cruzi glucose transporter, putative 0.003 0.0215 0.303
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0089 0.0082
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0447 0.6369
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0064 0.0587 0.0582
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.014 0.1425 0.1425
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0122 0.011
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0592
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0122 0.011
Trypanosoma brucei glucose transporter, putative 0.0065 0.0607 0.7227
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0698 0.1081
Schistosoma mansoni sugar transporter 0.003 0.0215 0.0203
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0277 0.0271
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.002 0.0014
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0122 0.0116
Toxoplasma gondii sugar transporter ST3 0.003 0.0215 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0266 0.1188
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.002 0.0024
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0215 0.0769
Echinococcus granulosus transcription factor btf3 0.0034 0.0266 0.026
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.002 0.0014
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0447 0.668
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0016 0.007 0.0773
Onchocerca volvulus 0.003 0.0216 0.068
Brugia malayi nuclear hormone receptor 0.0021 0.0122 0.0435
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0064 0.0587 0.8402
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0122 0.0435
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0554 0.0548
Loa Loa (eye worm) importin-beta domain-containing protein 0.0016 0.007 0.007
Schistosoma mansoni coup transcription factor 0.0021 0.0122 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0392 0.0386
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0698 0.8326
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0598 0.0597
Schistosoma mansoni cpg binding protein 0.0031 0.0235 0.0223
Brugia malayi Intermediate filament tail domain containing protein 0.014 0.1425 0.5094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0392 0.038
Leishmania major glucose transporter, lmgt3 0.0065 0.0607 0.868
Loa Loa (eye worm) hypothetical protein 0.0047 0.0406 0.0406
Schistosoma mansoni hypothetical protein 0.0132 0.1342 0.1332
Plasmodium falciparum mitogen-activated protein kinase 2 0.034 0.3622 0.3724
Loa Loa (eye worm) hypothetical protein 0.0025 0.0162 0.0162
Trypanosoma cruzi hexose transporter 0.0065 0.0607 0.868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0077 0.0327
Schistosoma mansoni transcription factor btf3 0.0034 0.0266 0.0254
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0215
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0122 0.0116
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0064 0.0587 0.0586
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0135 0.2978
Trichomonas vaginalis Importin beta-1 subunit, putative 0.007 0.0658 0.2976
Loa Loa (eye worm) hypothetical protein 0.014 0.1425 0.1425
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0064 0.0587 0.0587
Echinococcus multilocularis transient receptor potential gamma protein 0.0196 0.2035 0.203
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0406 0.04
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0406 0.0394
Schistosoma mansoni glucose transport protein 0.0211 0.22 0.2191
Brugia malayi hypothetical protein 0.0016 0.0065 0.0234
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0598 0.0925
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0122 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0223 0.0991
Leishmania major basic transcription factor 3a, putative 0.0034 0.0266 0.3765
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0598 0.0592
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.0011
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0328 1
Trypanosoma brucei glucose transporter, putative 0.0065 0.0607 0.7227
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0162 0.2255
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0122 0.0116
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0089 0.0082
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0406 0.1826
Schistosoma mansoni hypothetical protein 0.0166 0.1711 0.1701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0447 0.2011
Brugia malayi Cam kinase protein 1 0.0065 0.0598 0.2136
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.1573 0.1568
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Loa Loa (eye worm) hypothetical protein 0.0021 0.0122 0.0122
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0328 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.22 0.2195
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0013 0.0045
Onchocerca volvulus 0.003 0.0215 0.0672
Schistosoma mansoni hypothetical protein 0.0166 0.1711 0.1701
Trichomonas vaginalis sugar transporter, putative 0.003 0.0215 0.0956
Echinococcus granulosus short transient receptor potential channel 6 0.0129 0.1309 0.1304
Loa Loa (eye worm) hypothetical protein 0.0051 0.0453 0.0453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0392 0.0386
Loa Loa (eye worm) hypothetical protein 0.0065 0.0598 0.0598
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0607 0.868
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0215 0.0956

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 39 uM Inhibitory activity of the compound was tested against HIV-1 reverse transcriptase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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