Detailed information for compound 1147589

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 745.78 | Formula: C48H42Cl2N4++
  • H donors: 0 H acceptors: 0 LogP: 12.74 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)N(c1cc[n+](c2c1cccc2)Cc1ccc(cc1)CCc1ccc(cc1)C[n+]1ccc(c2c1cccc2)N(c1ccc(cc1)Cl)C)C
  • InChi: 1S/C48H42Cl2N4/c1-51(41-25-21-39(49)22-26-41)45-29-31-53(47-9-5-3-7-43(45)47)33-37-17-13-35(14-18-37)11-12-36-15-19-38(20-16-36)34-54-32-30-46(44-8-4-6-10-48(44)54)52(2)42-27-23-40(50)24-28-42/h3-10,13-32H,11-12,33-34H2,1-2H3/q+2
  • InChiKey: ACVCCPNAZMTMNO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0488 1
Brugia malayi Bromodomain containing protein 0.0077 0.1513 0.4551
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0602 0.0748
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0213 0.0265
Schistosoma mansoni bromodomain containing protein 0.0065 0.124 0.1539
Schistosoma mansoni glucose transport protein 0.0106 0.2176 0.2702
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0133 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.3126 0.3882
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0512 0.8107
Trypanosoma brucei glucose transporter, putative 0.0033 0.0512 0.8212
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0336 0.101
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0608 1
Plasmodium falciparum importin beta, putative 0.0034 0.0541 0.0442
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0601 0.0746
Entamoeba histolytica hypothetical protein 0.0028 0.0394 0.4662
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0503 0.0404
Schistosoma mansoni ran 0.0025 0.0336 0.0417
Loa Loa (eye worm) hypothetical protein 0.0072 0.1413 0.1755
Leishmania major GTP-binding protein, putative 0.0025 0.0336 0.4608
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0336 0.0417
Loa Loa (eye worm) hypothetical protein 0.0037 0.0602 0.0747
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0303 0.2134
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0512 0.1973
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0303 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Loa Loa (eye worm) hypothetical protein 0.002 0.0213 0.0265
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0503 0.0617
Leishmania major DNA polymerase kappa, putative 0.002 0.0213 0.2175
Trypanosoma brucei glucose transporter, putative 0.0033 0.0512 0.8212
Brugia malayi PHD-finger family protein 0.0026 0.0345 0.1038
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.002 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.1156 0.1436
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0303 0.0961
Plasmodium vivax hexose transporter 0.0106 0.2176 0.2094
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0503 0.0404
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0303 0.486
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0608 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0213 0.2609
Brugia malayi isocitrate dehydrogenase 0.0016 0.0133 0.0399
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0222 0.0236
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0601 0.0746
Echinococcus multilocularis GPCR, family 2 0.0049 0.0891 0.1106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0503 0.0624
Loa Loa (eye worm) hypothetical protein 0.0044 0.0759 0.0942
Mycobacterium tuberculosis Conserved protein 0.0037 0.0602 0.0994
Loa Loa (eye worm) hypothetical protein 0.0024 0.0303 0.0376
Leishmania major hypothetical protein, conserved 0.0026 0.0352 0.4928
Onchocerca volvulus 0.0015 0.0103 0.172
Echinococcus multilocularis solute carrier family 22 0.0015 0.0103 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0336 0.6045
Schistosoma mansoni glucose transport protein 0.0106 0.2176 0.2702
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0602 0.0994
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0503 0.0624
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0503 0.0624
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0213 0.2175
Onchocerca volvulus 0.0015 0.0103 0.172
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0352 0.4928
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0512 0.8212
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0602 0.0748
Schistosoma mansoni hypothetical protein 0.0037 0.0601 0.0746
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.3126 0.3882
Loa Loa (eye worm) sugar transporter 0.0015 0.0103 0.0128
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0488 0.1855
Echinococcus granulosus importin subunit beta 1 0.0034 0.0541 0.0672
Loa Loa (eye worm) hypothetical protein 0.0034 0.0541 0.0672
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0457 0.0568
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0488 0.0606
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0213 0.2175
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0602 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0602 1
Mycobacterium ulcerans sugar transporter 0.0015 0.0103 0.1436
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0103 0.1436
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0303 0.4285
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0488 0.0606
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0503 0.0624
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0103 0.0128
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0336 0.0417
Plasmodium falciparum hexose transporter 0.0106 0.2176 0.2094
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0512 0.8107
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0336 0.0235
Loa Loa (eye worm) hypothetical protein 0.0049 0.0891 0.1106
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0222 0.0236
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0213 0.0265
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0512 0.8107
Entamoeba histolytica Ran family GTPase 0.0025 0.0336 0.3163
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0602 0.0747
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0503 0.1513
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0608 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0213 0.2609
Brugia malayi major facilitator superfamily protein 0.0015 0.0103 0.0311
Trypanosoma brucei unspecified product 0.002 0.0213 0.2609
Schistosoma mansoni hypothetical protein 0.0016 0.0121 0.015
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0602 0.0994
Loa Loa (eye worm) hypothetical protein 0.0037 0.0602 0.0747
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0103 0.0311
Schistosoma mansoni sugar transporter 0.0015 0.0103 0.0128
Echinococcus multilocularis solute carrier family 22 0.0015 0.0103 0.0128
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0213 0.2609
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0213 0.2175
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0602 0.0994
Echinococcus granulosus solute carrier family 22 0.0015 0.0103 0.0128
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0601 0.0746
Trypanosoma brucei glucose transporter, putative 0.0033 0.0512 0.8212
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0103 0.0128
Onchocerca volvulus 0.0037 0.0602 1
Onchocerca volvulus 0.0037 0.0602 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0336 0.0359
Onchocerca volvulus 0.0015 0.0103 0.172
Onchocerca volvulus 0.0015 0.0103 0.172
Leishmania major glucose transporter, lmgt2 0.0033 0.0512 0.8107
Echinococcus granulosus solute carrier family 22 0.0015 0.0103 0.0128
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0891 0.1106
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0602 0.2404
Brugia malayi hypothetical protein 0.0015 0.0103 0.0311
Onchocerca volvulus 0.0015 0.0103 0.172
Loa Loa (eye worm) hypothetical protein 0.0037 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.0032 0.0503 0.0624
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0394 0.1402
Schistosoma mansoni hypothetical protein 0.0049 0.0891 0.1106
Loa Loa (eye worm) hypothetical protein 0.0156 0.3324 0.4128
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0103 0.1436
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0541 0.8747
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0512 0.1973
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0352 0.0251
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0394 0.1402
Mycobacterium tuberculosis Conserved protein 0.0037 0.0602 0.0994
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Brugia malayi beta-lactamase 0.0037 0.0602 0.181
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0503 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0512 0.1973
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0061 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0891 0.1106
Brugia malayi Bromodomain containing protein 0.0039 0.0657 0.1977
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.3324 1
Schistosoma mansoni hypothetical protein 0.0364 0.8054 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.5114 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2176 0.2702
Brugia malayi hypothetical protein 0.0015 0.0103 0.0311
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.1156 0.1436
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0213 0.0529
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2176 0.2702
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0503 0.0624
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0213 0.0529
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0503 0.0617
Schistosoma mansoni hypothetical protein 0.0106 0.2176 0.2702
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0213 0.0219
Schistosoma mansoni hypothetical protein 0.0049 0.0891 0.1106
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.3661 0.5495
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.3126 0.3882
Giardia lamblia DINP protein human, muc B family 0.002 0.0213 0.2854
Entamoeba histolytica protein kinase, putative 0.0032 0.0503 0.7468
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0336 0.0235
Loa Loa (eye worm) sugar transporter 0.0106 0.2176 0.2702
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0303 0.0376
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0162 0.0201
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0133 0.0058
Loa Loa (eye worm) beta-lactamase 0.0037 0.0602 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2176 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0133 0.0579
Leishmania major importin beta-1 subunit, putative 0.0028 0.0394 0.5761
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0303 0.0201
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0213 0.0265
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0303 1
Brugia malayi Sugar transporter family protein 0.0015 0.0103 0.0311
Loa Loa (eye worm) hypothetical protein 0.0032 0.0488 0.0606
Schistosoma mansoni hypothetical protein 0.0049 0.0891 0.1106
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0133 0.0165
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.3324 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0608 1
Onchocerca volvulus 0.0015 0.0103 0.172
Schistosoma mansoni ran 0.0025 0.0336 0.0417
Schistosoma mansoni sugar transporter 0.0015 0.0103 0.0128
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0608 0.0779
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.0017 0.0162 0.0201
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0213 0.0641
Echinococcus granulosus GPCR family 2 0.0049 0.0891 0.1106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.3126 0.3882
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0133 0.0165
Onchocerca volvulus Putative transporter 0.0015 0.0103 0.172
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0133 0.0165
Plasmodium vivax importin-beta 2, putative 0.0034 0.0541 0.0442
Trypanosoma brucei sugar transporter, putative 0.0015 0.0103 0.0554
Loa Loa (eye worm) hypothetical protein 0.0026 0.0352 0.0437
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0488 0.0606
Schistosoma mansoni hypothetical protein 0.0021 0.0245 0.0305
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0162 0.0201
Brugia malayi Sugar transporter family protein 0.0106 0.2176 0.6546
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0503 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0213 0.2609
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0602 0.0994
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0602 0.0747
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0602 0.0994
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0891 0.1106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2176 0.2702
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0608 0.051
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0602 0.9886
Echinococcus multilocularis solute carrier family 22 0.0015 0.0103 0.0128
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0602 0.2404
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0336 0.0417
Plasmodium falciparum protein kinase 7 0.0299 0.6578 0.6542
Schistosoma mansoni glucose transport protein 0.0106 0.2176 0.2702
Leishmania major hypothetical protein, conserved 0.0016 0.0121 0.0348
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0133 0.0165
Leishmania major hypothetical protein, conserved 0.0037 0.0602 0.9879
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.029 0.036
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0103 0.5
Leishmania major glucose transporter, lmgt3 0.0033 0.0512 0.8107
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0336 0.4608
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0303 0.0376
Echinococcus granulosus solute carrier family 22 0.0015 0.0103 0.0128
Schistosoma mansoni protein kinase 0.0032 0.0503 0.0624
Echinococcus granulosus solute carrier family 22 0.0015 0.0103 0.0128
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0173 0.1383
Brugia malayi hypothetical protein 0.0026 0.0352 0.1059
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0103 0.1436
Mycobacterium ulcerans hypothetical protein 0.0037 0.0602 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0602 0.0747
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0213 0.0265
Trypanosoma brucei glucose transporter, putative 0.0033 0.0512 0.8212
Brugia malayi RNA, U transporter 1 0.0097 0.1972 0.5934
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0602 0.0994
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.3126 0.3882
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0245 0.0305
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.3126 0.9404
Leishmania major DNA polymerase eta, putative 0.002 0.0213 0.2175
Trypanosoma brucei glucose transporter, putative 0.0033 0.0512 0.8212
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0602 0.2404
Echinococcus multilocularis zinc finger protein 0.002 0.0221 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0602 1
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0303 0.0376
Trichomonas vaginalis esterase, putative 0.0037 0.0602 0.2404
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0133 0.003
Schistosoma mansoni sugar transporter 0.0015 0.0103 0.0128
Onchocerca volvulus 0.0015 0.0103 0.172
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0891 0.268
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0352 0.0251
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0503 0.0624
Echinococcus granulosus zinc finger protein 0.002 0.0221 0.0274
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.3126 0.3882
Schistosoma mansoni zinc finger protein 0.002 0.0221 0.0274
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0352 0.4928
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0394 0.5761
Onchocerca volvulus 0.0015 0.0103 0.172
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0133 0.0579
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0488 0.1468
Trypanosoma cruzi ISWI complex protein 0.0016 0.0121 0.0348
Brugia malayi hypothetical protein 0.0017 0.0144 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Trypanosoma brucei glucose transporter 2A 0.0033 0.0512 0.8212
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0512 0.8107
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0488 0.7083
Brugia malayi hypothetical protein 0.0015 0.0103 0.0311
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0133 0.1101
Toxoplasma gondii protein kinase, putative 0.0299 0.6578 1
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0457 0.0568
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0541 0.8747
Schistosoma mansoni hypothetical protein 0.0012 0.0028 0.0035
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0162 0.0201
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0133 0.0165
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.3661 0.3595
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0352 0.0251
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0133 0.1101
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0303 0.0911
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0336 0.4907
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0303 0.395
Brugia malayi Cam kinase protein 1 0.0032 0.0503 0.1513
Schistosoma mansoni glucose transporter 0.0015 0.0103 0.0128
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0608 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0602 0.0747
Echinococcus multilocularis dna polymerase eta 0.002 0.0213 0.0265
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Loa Loa (eye worm) hypothetical protein 0.0026 0.0352 0.0437
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0352 0.0384
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.3324 0.4128
Loa Loa (eye worm) hypothetical protein 0.0107 0.2198 0.2729
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0503 0.0617
Onchocerca volvulus 0.0015 0.0103 0.172
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0503 0.0404
Trypanosoma brucei glucose transporter 1E 0.0033 0.0512 0.8212
Plasmodium vivax CDK-related protein kinase 6, putative 0.045 1 1
Onchocerca volvulus 0.0015 0.0103 0.172
Loa Loa (eye worm) hypothetical protein 0.0032 0.0488 0.0606
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.273 0.339
Schistosoma mansoni hypothetical protein 0.0049 0.0891 0.1106
Onchocerca volvulus 0.0015 0.0103 0.172
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0213 0.2175
Entamoeba histolytica hypothetical protein 0.0037 0.0601 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0602 1
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0608 0.051
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0103 0.0311
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0891 0.1106
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0103 0.0128
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0488 0.1468
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0512 0.1973
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0503 0.0624
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2176 0.2702
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0512 0.8212
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0213 0.3322
Echinococcus multilocularis General substrate transporter 0.0091 0.1837 0.2281
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0103 0.0128
Schistosoma mansoni importin beta-1 0.0034 0.0541 0.0672
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0503 0.1927
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0891 0.1106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0503 0.0624
Echinococcus multilocularis dna polymerase kappa 0.002 0.0213 0.0265
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0213 0.0219
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0488 0.0606
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0602 0.0994
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0394 0.1402
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0162 0.0201
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0602 1
Onchocerca volvulus 0.0015 0.0103 0.172
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Trypanosoma brucei ISWI complex protein 0.0016 0.0121 0.0883
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0133 0.0579
Trypanosoma brucei glucose transporter, putative 0.0033 0.0512 0.8212
Entamoeba histolytica protein kinase, putative 0.0032 0.0503 0.7468
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0602 0.2404
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0028 0.0035
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0352 0.5209
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0303 0.5182
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0503 0.0404
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.273 0.339
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0236 0.0641
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0133 0.0045
Entamoeba histolytica hypothetical protein 0.0037 0.0601 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0503 0.0624
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0103 0.0128
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.2198 0.6612
Loa Loa (eye worm) hypothetical protein 0.0037 0.0602 0.0747
Brugia malayi beta-lactamase family protein 0.0037 0.0602 0.181
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0503 0.0404
Onchocerca volvulus 0.0037 0.0602 1
Entamoeba histolytica hypothetical protein 0.0037 0.0601 1
Entamoeba histolytica hypothetical protein 0.0037 0.0601 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0512 0.1973
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0213 0.3322
Onchocerca volvulus 0.0015 0.0103 0.172
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0133 0.0165
Echinococcus granulosus dna polymerase kappa 0.002 0.0213 0.0265
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0602 0.2404
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0162 0.0201
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0103 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0512 0.1973
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0303 0.0376
Brugia malayi Importin beta-1 subunit 0.0034 0.0541 0.1627
Brugia malayi Sugar transporter family protein 0.0015 0.0103 0.0311
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0336 0.4608
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0503 0.0624
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0103 0.0128
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0028 0.0035
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2176 0.2702
Echinococcus granulosus snurportin 1 0.0364 0.8054 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0162 0.0201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0162 0.0201
Toxoplasma gondii ABC1 family protein 0.0037 0.0602 0.0769
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0303 0.486
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0503 0.0404
Echinococcus multilocularis snurportin 1 0.0364 0.8054 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0714 0.0887
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0213 0.2609
Schistosoma mansoni hypothetical protein 0.0107 0.2198 0.2729
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0602 0.181
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.3661 0.3595
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0503 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0512 0.1973
Schistosoma mansoni DNA polymerase eta 0.002 0.0213 0.0265
Leishmania major glucose transporter, lmgt1 0.0033 0.0512 0.8107
Brugia malayi MH2 domain containing protein 0.013 0.273 0.8213
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0213 0.0265
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0602 0.0747
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0488 0.7007
Onchocerca volvulus 0.0015 0.0103 0.172
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0602 0.9879
Trypanosoma brucei glucose transporter, putative 0.0033 0.0512 0.8212
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0213 0.2175
Schistosoma mansoni sugar transporter 0.0015 0.0103 0.0128
Leishmania major protein kinase, putative 0.0032 0.0503 0.7919
Onchocerca volvulus 0.0015 0.0103 0.172
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0541 0.0672
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0133 0.0045
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0133 0.0399
Schistosoma mansoni protein kinase 0.0032 0.0503 0.0624
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.3126 0.3882
Trypanosoma cruzi ISWI complex protein 0.0016 0.0121 0.0348
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0512 0.8212
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0503 0.8034
Trypanosoma brucei glucose transporter, putative 0.0033 0.0512 0.8212
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0103 0.0128
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0103 0.0554
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0303 0.395
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2176 0.2702
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.029 0.036
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0133 0.0165
Mycobacterium leprae Probable lipase LipE 0.0037 0.0602 1
Onchocerca volvulus 0.0015 0.0103 0.172
Echinococcus granulosus dna polymerase eta 0.002 0.0213 0.0265
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0133 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0602 0.9879
Mycobacterium tuberculosis Conserved protein 0.0037 0.0602 0.0994
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0213 0.2175
Loa Loa (eye worm) hypothetical protein 0.0037 0.0602 0.0747
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2176 0.3201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2176 0.2702
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0891 0.268
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0162 0.0201
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0541 0.0676
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0303 0.0308
Schistosoma mansoni zinc finger protein 0.0016 0.0121 0.015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.3126 0.3882
Schistosoma mansoni protein kinase 0.0032 0.0503 0.0624
Brugia malayi beta-lactamase family protein 0.0037 0.0602 0.181
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.029 0.036
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0213 0.0641
Entamoeba histolytica hypothetical protein 0.0024 0.0303 0.2307
Brugia malayi major facilitator superfamily protein 0.0015 0.0103 0.0311
Echinococcus multilocularis solute carrier family 22 0.0015 0.0103 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0659 0.0818
Trypanosoma cruzi hexose transporter 0.0033 0.0512 0.8107
Brugia malayi hypothetical protein 0.0037 0.0601 0.1808
Trichomonas vaginalis ran, putative 0.0025 0.0336 0.1121
Echinococcus granulosus General substrate transporter 0.0091 0.1837 0.2281
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2176 0.2702
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0602 0.0503
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0503 0.0624
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0176 0.0219
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0364 0.8054 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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