Detailed information for compound 1183323

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.412 | Formula: C17H17N5O6S
  • H donors: 3 H acceptors: 8 LogP: 0.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)n1ncc2c1ncnc2SCc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C17H17N5O6S/c23-6-12-13(24)14(25)17(28-12)21-15-11(5-20-21)16(19-8-18-15)29-7-9-1-3-10(4-2-9)22(26)27/h1-5,8,12-14,17,23-25H,6-7H2/t12-,13-,14-,17?/m1/s1
  • InChiKey: NSHWXIMQXLHUQU-OMNQEHGGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0119
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0038
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0108 0.0119
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0034 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.023 0.0254
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0108 0.0119
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0122 0.0134
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0038
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0002 0.0042
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0041 0.0045
Brugia malayi Inositol-1 0.0042 0.0235 0.0259
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0108 0.0119
Onchocerca volvulus 0.0074 0.0434 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0002 0.0002
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0108 0.0119
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.003 0.0161 0.0177
Brugia malayi Ets-domain containing protein 0.0076 0.0444 0.049
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0108 0.0119
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0002 0.0002
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0034 0.0037
Trichomonas vaginalis helicase, putative 0.0007 0.0013 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0318 0.0314
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0052 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0038
Brugia malayi hypothetical protein 0.0005 0.0005 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0299 0.0329
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0582 0.3585 0.3952
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0299 0.0329
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0444 0.0444
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.1113 0.1227
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0434 0.0479
Schistosoma mansoni glutathione synthetase 0.0411 0.2525 0.2784
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0108 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0997 0.11
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0038
Mycobacterium ulcerans hypothetical protein 0.0184 0.1113 0.1227
Echinococcus multilocularis protein C ets 2 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus protein C ets 2 0.0011 0.0041 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Brugia malayi Polyprenyl synthetase family protein 0.0411 0.2525 0.2784
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1465 0.907 1
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0411 0.2525 1
Schistosoma mansoni DNA helicase recq1 0.001 0.0034 0.0037
Schistosoma mansoni inositol monophosphatase 0.0042 0.0235 0.0259
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0444 0.049
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Brugia malayi CXXC zinc finger family protein 0.0029 0.0151 0.0166
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.009 0.0099
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0035 0.0038
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0004 0.0004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0318 0.035
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0411 0.2525 0.2784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0038
Toxoplasma gondii hypothetical protein 0.0056 0.0322 0.0355
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Brugia malayi nuclear hormone receptor 0.001 0.0035 0.0038
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Schistosoma mansoni gabp alpha 0.0076 0.0444 0.049
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0411 0.2525 0.2784
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0005 0.0006
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0035 0.0035
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0444 0.049
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0035 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0038
Loa Loa (eye worm) polyprenyl synthetase 0.0411 0.2525 0.2784
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0235 0.0259
Brugia malayi nuclear receptor RXR 0.0005 0.0002 0.0002
Echinococcus granulosus muscleblind protein 0.032 0.1962 0.2164
Loa Loa (eye worm) hypothetical protein 0.0074 0.0434 0.0479
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0235 0.0259
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0017 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0017 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0035 0.0038
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0235 0.0259
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0208 0.0229
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0002 0.0002
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0041 0.0041
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0235 0.0931
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Brugia malayi nuclear receptor NHR-88 0.001 0.0035 0.0038
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0411 0.2525 0.2784
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0434 0.0479
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0035 0.0035
Brugia malayi ecdysone receptor 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0299 0.0329
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0002 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.023 0.0254
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0035 0.0038
Schistosoma mansoni nuclear receptor 0.0005 0.0002 0.0002
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0108 0.0119
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1465 0.907 1
Brugia malayi Ets-domain containing protein 0.0076 0.0444 0.049
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0034 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0151 0.0166
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0318 0.1257
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0041 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0052 0.0057
Brugia malayi ecdysteroid receptor 0.001 0.0035 0.0038
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0002 0.0002
Brugia malayi nuclear hormone receptor 0.0005 0.0002 0.0002
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0411 0.2525 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0002 0.0002
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0108 0.0119
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0235 0.0259
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0235 0.0259
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0277 0.0305
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1465 0.907 0.907
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0037
Schistosoma mansoni DNA helicase recq5 0.001 0.0034 0.0037
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0108 0.0119
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0002 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Brugia malayi Fli-1 protein 0.0231 0.1405 0.1549
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Onchocerca volvulus 0.0022 0.0108 0.2488
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0041 0.0045
Leishmania major polyprenyl synthase, putative 0.0582 0.3585 0.3952
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0434 0.172
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0434 0.0479
Onchocerca volvulus 0.0022 0.0108 0.2488
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0005 0.0006
Treponema pallidum octaprenyl-diphosphate synthase 0.0582 0.3585 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0277 0.0305
Echinococcus granulosus cpg binding protein 0.003 0.0161 0.0177
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0108 0.0119
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0028 0.0028
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.2138 0.2358
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0434 0.172
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1465 0.907 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0035 0.0799
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0002 0.0002
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0411 0.2525 0.2525
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0034 0.0037
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0034 0.0034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0035
Echinococcus granulosus bloom syndrome protein 0.0024 0.0122 0.0134
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.0913
Brugia malayi steroid hormone receptor 0.001 0.0035 0.0038
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0052 0.0057
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0035 0.0038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Schistosoma mansoni nuclear hormone receptor 0.001 0.0035 0.0038
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0108 0.0119
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0035 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0038
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1465 0.907 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi conserved hypotetical protein 0.0005 0.0002 0.0002
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0428
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1465 0.907 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0002 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0299 0.0329
Entamoeba histolytica recQ family helicase, putative 0.0005 0.0003 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0298 0.0328
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0035 0.0038
Giardia lamblia Farnesyl diphosphate synthase 0.1465 0.907 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0349 0.2138 0.2358
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0035 0.0038
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0002 0.0002
Schistosoma mansoni elf1 0.0011 0.0041 0.0045
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.0913
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0411 0.2525 0.2784
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Schistosoma mansoni nuclear receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0052 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0411 0.2525 1
Schistosoma mansoni trans-prenyltransferase 0.0411 0.2525 0.2784
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.0913
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0411 0.2525 1
Schistosoma mansoni hypothetical protein 0.0042 0.023 0.0254
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0041 0.0041
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0411 0.2525 0.2784
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0035 0.0038
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0004 0.0004
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0002 0.0002
Schistosoma mansoni inositol monophosphatase 0.0042 0.0235 0.0259
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0434 0.0479
Brugia malayi hypothetical protein 0.0042 0.023 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0035 0.0038
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0108 0.0119
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0034 0.0037
Loa Loa (eye worm) fli-1 protein 0.0231 0.1405 0.1549
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0038
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0108 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Brugia malayi transcription factor E74 isoform 0.0011 0.0041 0.0045
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0235 0.0259
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0041 0.0045
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0119
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0108 0.0119
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0108 0.0119
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.0913
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1465 0.907 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0723 0.0797
Loa Loa (eye worm) hypothetical protein 0.032 0.1962 0.2164
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0277 0.0305
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0235 0.0259
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Echinococcus granulosus geminin 0.0196 0.1188 0.1309
Trypanosoma cruzi polyprenyl synthase, putative 0.0582 0.3585 0.3952
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0041 0.0041
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0108 0.0119
Trypanosoma cruzi polyprenyl synthase, putative 0.0582 0.3585 0.3952
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0041 0.0045
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0041 0.0041
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0073 0.0078
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0411 0.2525 0.2784
Loa Loa (eye worm) hypothetical protein 0.0074 0.0434 0.0479
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0002 0.0002
Loa Loa (eye worm) polyprenyl synthetase 0.1465 0.907 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0298 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.2138 0.2358
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0411 0.2525 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1465 0.907 1
Mycobacterium ulcerans hypothetical protein 0.0074 0.0434 0.0479
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0038
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0041 0.0045
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0235 0.0259
Echinococcus granulosus FTZ F1 alpha 0.001 0.0035 0.0038
Brugia malayi Muscleblind-like protein 0.032 0.1962 0.2164
Brugia malayi nuclear receptor RXR 0.0005 0.0005 0.0006
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0434 0.0479
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0298 0.0298
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0318 0.0347
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0411 0.2525 0.2784
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0035 0.0038
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1465 0.907 1
Echinococcus multilocularis geminin 0.0196 0.1188 0.1188
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0108 0.0119
Onchocerca volvulus 0.0022 0.0108 0.2488
Brugia malayi nuclear receptor NHR-88 0.0005 0.0002 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0002 0.0002
Schistosoma mansoni ets 0.0011 0.0041 0.0045
Schistosoma mansoni hypothetical protein 0.0196 0.1188 0.1309
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0072 0.0079
Schistosoma mansoni hypothetical protein 0.0011 0.0041 0.0045
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0022 0.0108 0.0428
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0035 0.0038
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0122 0.0134
Echinococcus multilocularis cpg binding protein 0.003 0.0161 0.0161
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0041 0.0045
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0108 0.0119
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1465 0.907 1
Onchocerca volvulus 0.0005 0.0002 0.0042
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0035 0.0799
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0434 0.0479
Loa Loa (eye worm) oxidoreductase 0.0022 0.0108 0.0119
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0005 0.0006
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0004 0.0004
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1465 0.907 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0035 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0038
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0002 0.0002
Leishmania major farnesyl pyrophosphate synthase 0.1465 0.907 1
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0411 0.2525 0.2784
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0035 0.0038
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0411 0.2525 0.2784
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.001 0.0035 0.0038
Echinococcus multilocularis muscleblind protein 1 0.032 0.1962 0.1962
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0108 0.0119
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.031 0.0342
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0235 0.0259
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0434 0.0479
Loa Loa (eye worm) hypothetical protein 0.0065 0.0376 0.0414
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0434 0.0479
Echinococcus multilocularis muscleblind protein 0.032 0.1962 0.1962
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0005 0.0006
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0038
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0434 0.172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0005 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0108 0.0428
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0002 0.0002
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0434 0.0479
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0108 0.0119
Loa Loa (eye worm) DR-78 0.0005 0.0002 0.0002
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0002 0.0002
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0002 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0434 0.0479
Leishmania major mitochondrial DNA polymerase beta 0.0349 0.2138 0.2358
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0041 0.0045
Schistosoma mansoni ets-related 0.0011 0.0041 0.0045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.0014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0035 0.0038
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0041 0.0045
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1465 0.907 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0411 0.2525 0.2784
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0034 0.0037
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0108 0.0116
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0041 0.0041
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0041 0.0041
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0411 0.2525 0.2525
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0027 0.003
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0411 0.2525 1
Echinococcus multilocularis ets variant gene 4 0.0011 0.0041 0.0041
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0035 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0108 0.0119
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0041 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0434 0.0479
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0108 0.0119
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0005 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0298 0.0328
Brugia malayi tailless protein 0.0005 0.0002 0.0002
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0108 0.0119
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0034 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0298 0.0328
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0582 0.3585 0.3585
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0035 0.0799
Onchocerca volvulus 0.001 0.0035 0.0799
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0411 0.2525 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1465 0.907 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0434 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0041 0.0045
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0411 0.2525 0.2784
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0035 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0108 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0411 0.2525 0.2784
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1465 0.907 1
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0235 0.0235
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0108 0.0119
Schistosoma mansoni zinc finger protein 0.0005 0.0002 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0997 0.11
Brugia malayi hypothetical protein 0.0005 0.0005 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0298 0.0328
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0108 0.0119
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0017 0.0018
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0108 0.0119
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0235 0.0259
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0108 0.0119
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0028 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0089 0.0098
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0034 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0298 0.0298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0103 0.0077
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0351 0.0387
Schistosoma mansoni hypothetical protein 0.0011 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0074 0.0434 0.0479
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0052 0.0206
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0582 0.3585 0.3952
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0298 0.0328
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0997 0.11
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.0014
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0208 0.0822
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0434 0.0479
Schistosoma mansoni cpg binding protein 0.0029 0.0151 0.0166
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0108 0.0119
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0434 0.0479
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0434 0.172
Brugia malayi Polyprenyl synthetase family protein 0.1465 0.907 1
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1465 0.907 1
Leishmania major solanesyl-diphosphate synthase, putative 0.0411 0.2525 0.2784
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0002 0.0002
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0582 0.3585 0.3952
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0434 0.172
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0028 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0298 0.0328
Brugia malayi nuclear receptor NHR-67 0.0005 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0038
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0318 0.035
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0122 0.0134
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Onchocerca volvulus 0.0022 0.0108 0.2488
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0411 0.2525 0.2757
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0034 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0038
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0122 0.0122
Brugia malayi Ets-domain containing protein 0.0011 0.0041 0.0045
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0344 0.0379
Loa Loa (eye worm) RecQ helicase 0.0024 0.0122 0.0134
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0002 0.0002
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0119
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.023 0.023
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0108 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0038
Onchocerca volvulus 0.0029 0.0151 0.3472
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0038
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Loa Loa (eye worm) inositol-1 0.0042 0.0235 0.0259
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0035 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0434 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.032 0.1962 0.2164
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0582 0.3585 0.3952
Schistosoma mansoni cpg binding protein 0.003 0.0161 0.0177
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0119
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0004 0.0015
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0108 0.0119
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0277 0.0305
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0411 0.2525 0.2782
Schistosoma mansoni ets-related 0.0231 0.1405 0.1549
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0196 0.1188 0.1309
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) ~ 0.001 M In vitro inhibition of growth of L1210 mouse leukemic cells ChEMBL. 7328577
ILS (functional) = 1 % Increase in life span of tumor L1210 leukemic mice 1-5 days after 200 mg/kg of the compound administered ChEMBL. 7328577

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.