Detailed information for compound 1183897

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 491.575 | Formula: C29H33NO6
  • H donors: 2 H acceptors: 4 LogP: 4.12 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.COc1ccc(cc1OC)CCN(CCC=C(c1ccccc1)c1ccccc1)C
  • InChi: 1S/C27H31NO2.C2H2O4/c1-28(20-18-22-16-17-26(29-2)27(21-22)30-3)19-10-15-25(23-11-6-4-7-12-23)24-13-8-5-9-14-24;3-1(4)2(5)6/h4-9,11-17,21H,10,18-20H2,1-3H3;(H,3,4)(H,5,6)
  • InChiKey: ABHDNPLQZPDZMM-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0665 0.2766 0.2764
Loa Loa (eye worm) hypothetical protein 0.0042 0.0112 0.0411
Loa Loa (eye worm) hypothetical protein 0.0061 0.0195 0.0715
Toxoplasma gondii hypothetical protein 0.0131 0.0492 0.1969
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.067 0.2822
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0307 0.124 0.5562
Trichomonas vaginalis CMGC family protein kinase 0.0523 0.2163 1
Trypanosoma cruzi cyclin 6, putative 0.0307 0.124 0.5562
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0081 0.0081
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0042 0.0112 0.0141
Echinococcus multilocularis cyclins 0.0173 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0303
Schistosoma mansoni cyclin k 0.0042 0.0112 0.0108
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0173 0.0671 0.2461
Trichomonas vaginalis cyclin A, putative 0.0042 0.0112 0.0141
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0055 0.0167 0.0167
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0042 0.0112 0.0141
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0195 0.0195
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0083 0.0079
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0081 0.0285
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0004 0.0004
Trichomonas vaginalis cyclins, putative 0.0042 0.0112 0.0141
Schistosoma mansoni hypothetical protein 0.0055 0.0167 0.0164
Loa Loa (eye worm) cyclin domain-containing protein 0.0655 0.2724 1
Trypanosoma cruzi cyclin, putative 0.0307 0.124 0.5562
Trichomonas vaginalis cyclin B3, putative 0.0042 0.0112 0.0141
Onchocerca volvulus 0.0034 0.0081 0.0359
Echinococcus granulosus cyclin G2 0.0042 0.0112 0.0112
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0083 0.0303
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0113 0.0415 0.1513
Echinococcus multilocularis cyclin A3 4 0.0042 0.0112 0.0112
Giardia lamblia Kinase, CMGC CDK 0.024 0.0957 0.436
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0081 0.0298
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0655 0.2724 0.2724
Trichomonas vaginalis cyclin D, putative 0.0173 0.067 0.2822
Brugia malayi hypothetical protein 0.004 0.0107 0.0379
Trichomonas vaginalis cyclins, putative 0.0307 0.124 0.5562
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0021 0.0024 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0081 0.0081
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0068 0.0223 0.022
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.027 0.1084 0.1081
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0112 0.0398
Trypanosoma cruzi cdc2-related kinase 1 0.024 0.0957 0.4201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0081 0.0298
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.007 0.0245
Echinococcus granulosus GPCR family 2 0.0055 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0042 0.0112 0.0411
Giardia lamblia Cyclin B-like protein 0.0042 0.0112 0.041
Giardia lamblia Kinase, CMGC GSK 0.0523 0.2163 1
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0042 0.0112 0.0112
Trypanosoma cruzi CYC2-like cyclin, putative 0.0307 0.124 0.5562
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0112 0.0141
Entamoeba histolytica cyclin, putative 0.0173 0.067 0.3018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0081 0.0285
Entamoeba histolytica cyclin, domain containing protein 0.0042 0.0112 0.041
Brugia malayi beta-lactamase 0.0035 0.0083 0.029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Echinococcus granulosus protocadherin 11 0.0021 0.0024 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.024 0.0957 0.4201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0081 0.0285
Trypanosoma cruzi cdc2-related kinase 1 0.024 0.0957 0.4201
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0021 0.0024 0.0024
Echinococcus granulosus cyclin t1 0.0042 0.0112 0.0112
Echinococcus multilocularis X box binding protein 1 0.0665 0.2766 0.2766
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0081 0.0081
Giardia lamblia G2/mitotic-specific cyclin B 0.0307 0.124 0.5683
Mycobacterium leprae Probable lipase LipE 0.0035 0.0083 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0081 0.0081
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.0021 0.0024 0.002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0083 0.029
Brugia malayi cell division control protein 2 homolog 0.024 0.0957 0.3503
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0042 0.0112 0.0112
Echinococcus multilocularis lamin 0.0032 0.007 0.007
Entamoeba histolytica protein kinase, putative 0.0523 0.2163 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0505 0.1852
Echinococcus granulosus cyclins 0.0042 0.0112 0.0112
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0021 0.0024 0.0024
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.024 0.0957 0.4201
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0112 0.0411
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0523 0.2163 0.794
Trypanosoma cruzi cdc2-related kinase 3 0.024 0.0957 0.4201
Schistosoma mansoni cyclin B3 0.0655 0.2724 0.2722
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0068 0.0223 0.1765
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0042 0.0112 0.0141
Trichomonas vaginalis cyclin B, putative 0.0307 0.124 0.5562
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0195 0.0191
Echinococcus multilocularis cyclin 0.0042 0.0112 0.0112
Trypanosoma brucei cdc2-related kinase 3 0.024 0.0957 0.4201
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0021 0.0024 0.0024
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0112 0.0411
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Trichomonas vaginalis cyclin D, putative 0.0173 0.067 0.2822
Trypanosoma brucei mitotic cyclin 0.0042 0.0112 0.0141
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.0881 1
Toxoplasma gondii cyclin dependent kinase binding protein 0.0042 0.0112 0.0141
Echinococcus granulosus cyclin G2 0.0042 0.0112 0.0112
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0081 0.0081
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0212 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0303
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0195 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0112 0.0141
Trypanosoma brucei mitotic cyclin 6 0.0307 0.124 0.5562
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0112 0.0141
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0042 0.0112 0.0411
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Echinococcus multilocularis cyclins 0.0173 0.067 0.067
Brugia malayi Cyclin, N-terminal domain containing protein 0.0307 0.124 0.4543
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0081 0.0285
Brugia malayi latrophilin 2 splice variant baaae 0.0118 0.0438 0.1595
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0004 0.0004
Echinococcus multilocularis survival motor neuron protein 1 0.0554 0.2293 0.2293
Schistosoma mansoni hypothetical protein 0.0042 0.0112 0.0108
Schistosoma mansoni survival motor neuron protein 0.0113 0.0415 0.0412
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0042 0.0112 0.0112
Trichomonas vaginalis cyclins, putative 0.0176 0.0682 0.2881
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0012 0.0044
Entamoeba histolytica cell division protein kinase 2, putative 0.024 0.0957 0.436
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0112 0.0411
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0004 0.0004
Trichomonas vaginalis cyclins, putative 0.0307 0.124 0.5562
Onchocerca volvulus 0.0021 0.0024 0.0095
Leishmania major mitotic cyclin, putative 0.0042 0.0112 0.0141
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0298
Trichomonas vaginalis cyclin B3, putative 0.0042 0.0112 0.0141
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0195 0.0702
Onchocerca volvulus 0.0307 0.124 0.5724
Echinococcus granulosus cyclin dependent kinase 5 0.024 0.0957 0.0957
Giardia lamblia Kinase, CMGC CDK 0.024 0.0957 0.436
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0112 0.0398
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0081 0.0078
Brugia malayi Cyclin, N-terminal domain containing protein 0.0655 0.2724 1
Echinococcus multilocularis protocadherin 11 0.0021 0.0024 0.0024
Echinococcus granulosus protein kinase shaggy 0.0523 0.2163 0.2163
Echinococcus granulosus cyclin k 0.0042 0.0112 0.0112
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0523 0.2163 1
Echinococcus multilocularis cyclin G2 0.0042 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0303
Echinococcus granulosus neuropeptide receptor A26 0.1578 0.6654 0.6654
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0081 0.0285
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0004 0.0014
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.024 0.0957 0.4201
Echinococcus granulosus neuropeptide s receptor 0.1578 0.6654 0.6654
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.024 0.0957 0.4201
Trichomonas vaginalis cyclins, putative 0.0042 0.0112 0.0141
Loa Loa (eye worm) hypothetical protein 0.0055 0.0167 0.0614
Brugia malayi intermediate filament protein 0.0032 0.007 0.0245
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0044
Toxoplasma gondii hypothetical protein 0.0042 0.0112 0.0141
Echinococcus multilocularis cyclins 0.0173 0.067 0.067
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0068 0.0223 0.0807
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0298
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0112 0.0398
Echinococcus multilocularis cyclin y 0.0042 0.0112 0.0112
Schistosoma mansoni lamin 0.0032 0.007 0.0067
Echinococcus multilocularis cyclin k 0.0042 0.0112 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0081 0.0285
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Entamoeba histolytica cyclin family protein 0.0173 0.067 0.3018
Plasmodium falciparum cyclin 0.0173 0.067 0.2719
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0112 0.0398
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0004 0.0004
Echinococcus multilocularis cyclins 0.0173 0.067 0.067
Loa Loa (eye worm) cell death specification protein 2 0.0021 0.0024 0.0089
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0081 0.0081
Entamoeba histolytica protein kinase domain containing protein 0.0523 0.2163 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0163 0.0163
Entamoeba histolytica cyclin family protein 0.0173 0.067 0.3018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0173 0.0671 0.2451
Brugia malayi hypothetical protein 0.0018 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.007 0.0258
Echinococcus granulosus cyclins 0.0173 0.067 0.067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0081 0.0298
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Loa Loa (eye worm) cyclin C 0.0042 0.0112 0.0411
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0107 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0523 0.2163 1
Giardia lamblia Hypothetical protein 0.0042 0.0112 0.041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0081 0.0285
Trichomonas vaginalis cyclins, putative 0.0307 0.124 0.5562
Brugia malayi Cell death specification protein 2 0.0021 0.0024 0.0075
Echinococcus multilocularis cyclin dependent kinase 0.024 0.0957 0.0957
Trichomonas vaginalis cyclin D, putative 0.0042 0.0112 0.0141
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0298
Echinococcus granulosus cyclins 0.0173 0.067 0.067
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0081 0.0078
Echinococcus granulosus G1:S specific cyclin D1 0.0042 0.0112 0.0112
Echinococcus granulosus cyclins 0.0173 0.067 0.067
Echinococcus granulosus lamin dm0 0.0032 0.007 0.007
Plasmodium vivax protein kinase Crk2 0.024 0.0957 0.4201
Entamoeba histolytica cyclin, domain containing protein 0.0042 0.0112 0.041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0957 0.0953
Toxoplasma gondii cyclin 4, putative 0.0042 0.0112 0.0141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Plasmodium vivax cyclin homologue, putative 0.0042 0.0112 0.0141
Schistosoma mansoni cyclin B 0.0307 0.124 0.1237
Echinococcus multilocularis G1:S specific cyclin D1 0.0042 0.0112 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0081 0.0298
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0112 0.0398
Schistosoma mansoni cyclin l 0.0042 0.0112 0.0108
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0523 0.2163 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0055 0.0167 0.0167
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0042 0.0112 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0112 0.0141
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0021 0.0024 0.002
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.024 0.0957 0.3511
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0163 0.0163
Trichomonas vaginalis cyclin B, putative 0.0307 0.124 0.5562
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0055 0.0167 0.0167
Echinococcus multilocularis geminin 0.038 0.1553 0.1553
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0112 0.0141
Schistosoma mansoni hypothetical protein 0.038 0.1553 0.1549
Trichomonas vaginalis cyclins, putative 0.0307 0.124 0.5562
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.027 0.1084 0.1084
Plasmodium falciparum protein kinase 5 0.024 0.0957 0.4118
Echinococcus granulosus cyclin dependent kinase 1 0.024 0.0957 0.0957
Trypanosoma cruzi cdc2-related kinase 3 0.024 0.0957 0.4201
Trypanosoma brucei cyclin 3 0.0042 0.0112 0.0141
Trypanosoma cruzi cyclin, putative 0.0307 0.124 0.5562
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0112 0.0411
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0204 0.0749
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.024 0.0957 0.3511
Brugia malayi beta-lactamase family protein 0.0035 0.0083 0.029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0081 0.0298
Trypanosoma cruzi mitotic cyclin, putative 0.0042 0.0112 0.0141
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0021 0.0024 0.0024
Giardia lamblia Cyclin fold protein 1, putative 0.0042 0.0112 0.041
Trichomonas vaginalis cyclin B, putative 0.0042 0.0112 0.0141
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0042 0.0112 0.0112
Trichomonas vaginalis cyclin B3, putative 0.0173 0.067 0.2822
Echinococcus granulosus cyclin B3 1 0.0173 0.067 0.067
Trichomonas vaginalis cyclin B, putative 0.0042 0.0112 0.0141
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Echinococcus multilocularis GPCR, family 2 0.0055 0.0167 0.0167
Echinococcus granulosus intermediate filament protein 0.0032 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0203 0.08 0.2935
Schistosoma mansoni hypothetical protein 0.038 0.1553 0.1549
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0081 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0081 0.0298
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0163 0.0163
Leishmania major cyclin 9, putative 0.0042 0.0112 0.0141
Echinococcus granulosus ccaat enhancer binding protein delta 0.0021 0.0024 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0004 0.0004
Echinococcus granulosus cyclin B 0.0307 0.124 0.124
Brugia malayi hypothetical protein 0.0021 0.0024 0.0075
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.024 0.0957 0.0957
Plasmodium vivax glycogen synthase kinase 3, putative 0.0523 0.2163 1
Loa Loa (eye worm) hypothetical protein 0.0554 0.2293 0.8415
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0044
Echinococcus multilocularis cyclin B 0.0307 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0081 0.0081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0021 0.0024 0.0024
Trypanosoma brucei protein kinase, putative 0.0523 0.2163 1
Schistosoma mansoni Cyclin fold protein 0.0042 0.0112 0.0108
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0004 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0083 0.0083
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.024 0.0957 0.3511
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0298
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0118 0.0438 0.0434
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0298
Brugia malayi Hepatic leukemia factor 0.0021 0.0024 0.0075
Onchocerca volvulus 0.0035 0.0083 0.0365
Onchocerca volvulus 0.0032 0.007 0.0308
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0081 0.0359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0081 0.0285
Echinococcus multilocularis neuropeptide receptor A26 0.1578 0.6654 0.6654
Brugia malayi mbt repeat family protein 0.0054 0.0163 0.0586
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0044
Brugia malayi hypothetical protein 0.0042 0.0112 0.0398
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0012 0.0031
Brugia malayi nuclear receptor NHR-88 0.0034 0.0081 0.0285
Echinococcus granulosus cyclin y 0.0042 0.0112 0.0112
Echinococcus multilocularis cyclin G2 0.0042 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0307 0.124 0.4551
Onchocerca volvulus Protein CNPPD1 homolog 0.0042 0.0112 0.0501
Echinococcus multilocularis cyclin y 0.0042 0.0112 0.0112
Brugia malayi Calcitonin receptor-like protein seb-1 0.0173 0.0671 0.2451
Schistosoma mansoni hypothetical protein 0.0326 0.1324 0.1321
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0303
Loa Loa (eye worm) hypothetical protein 0.0233 0.0925 0.3394
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0081 0.0078
Echinococcus multilocularis Cyclin L1 0.0042 0.0112 0.0112
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0163 0.0159
Loa Loa (eye worm) hypothetical protein 0.027 0.1084 0.3979
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0203 0.08 0.3685
Schistosoma mansoni lamin 0.0032 0.007 0.0067
Onchocerca volvulus 0.0032 0.007 0.0308
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0298
Schistosoma mansoni hypothetical protein 0.0042 0.0112 0.0108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0004 0.0004
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0163 0.0159
Echinococcus multilocularis musashi 0.0032 0.007 0.007
Entamoeba histolytica hypothetical protein 0.004 0.0107 0.0387
Trypanosoma brucei cyclin 9 0.0042 0.0112 0.0141
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0163 0.0738
Onchocerca volvulus 0.0042 0.0112 0.0501
Leishmania major mitotic cyclin, putative 0.0042 0.0112 0.0141
Schistosoma mansoni hypothetical protein 0.0055 0.0167 0.0164
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0007 0.0026
Brugia malayi mbt repeat family protein 0.0054 0.0163 0.0586
Brugia malayi bZIP transcription factor family protein 0.0021 0.0024 0.0075
Schistosoma mansoni hypothetical protein 0.0055 0.0167 0.0164
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0081 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0081 0.0285
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Echinococcus granulosus cyclin b3 0.0173 0.067 0.067
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0068 0.0223 0.0677
Loa Loa (eye worm) beta-lactamase 0.0035 0.0083 0.0303
Loa Loa (eye worm) hypothetical protein 0.0129 0.0485 0.1779
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0195 0.0195
Echinococcus granulosus Cyclin L1 0.0042 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0021 0.0024 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0112 0.0141
Giardia lamblia Cyclin A 0.0173 0.067 0.3018
Trichomonas vaginalis cyclin B, putative 0.0173 0.067 0.2822
Echinococcus multilocularis cyclin dependent kinase 5 0.024 0.0957 0.0957
Echinococcus granulosus survival motor neuron protein 1 0.0554 0.2293 0.2293
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0081 0.0359
Trichomonas vaginalis cyclins, putative 0.0173 0.067 0.2822
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.004 0.0107 0.0387
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0055 0.0167 0.0601
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Brugia malayi Cell death specification protein 2 0.0021 0.0024 0.0075
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0004 0.0014
Schistosoma mansoni intermediate filament proteins 0.0032 0.007 0.0067
Brugia malayi hypothetical protein 0.0021 0.0024 0.0075
Entamoeba histolytica cyclin C, putative 0.0042 0.0112 0.041
Trypanosoma cruzi cyclin 9, putative 0.0042 0.0112 0.0141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0081 0.0081
Brugia malayi hypothetical protein 0.0129 0.0485 0.1768
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0081 0.0078
Echinococcus granulosus cyclin 0.0042 0.0112 0.0112
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0081 0.0078
Onchocerca volvulus 0.0035 0.0083 0.0365
Onchocerca volvulus 0.0523 0.2163 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0081 0.0285
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0081 0.0081
Brugia malayi N-terminal motif family protein 0.0203 0.08 0.2925
Entamoeba histolytica cyclin, putative 0.0307 0.124 0.5683
Echinococcus granulosus geminin 0.038 0.1553 0.1553
Giardia lamblia Hypothetical protein 0.0173 0.067 0.3018
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0112 0.0398
Entamoeba histolytica protein kinase domain containing protein 0.0523 0.2163 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0112 0.0398
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0655 0.2724 0.2724
Entamoeba histolytica cell division protein kinase 2, putative 0.024 0.0957 0.436
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0081 0.0081
Schistosoma mansoni coup transcription factor 0.0034 0.0081 0.0078
Brugia malayi Cell death specification protein 2 0.0021 0.0024 0.0075
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0112 0.0411
Loa Loa (eye worm) hypothetical protein 0.0307 0.124 0.4551
Echinococcus granulosus lamin 0.0032 0.007 0.007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0081 0.0081
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0081 0.0285
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0081 0.0078
Echinococcus multilocularis lamin dm0 0.0032 0.007 0.007
Trypanosoma brucei cdc2-related kinase 1 0.024 0.0957 0.4201
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0081 0.0285
Loa Loa (eye worm) hypothetical protein 0.0129 0.0485 0.1779
Echinococcus multilocularis cyclin b3 0.0173 0.067 0.067
Brugia malayi steroid hormone receptor 0.0034 0.0081 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0081 0.0285
Echinococcus multilocularis protocadherin 11 0.0021 0.0024 0.0024
Loa Loa (eye worm) CYL-1 protein 0.0042 0.0112 0.0411
Giardia lamblia Kinase, CMGC GSK 0.0523 0.2163 1
Echinococcus granulosus cyclin A3 4 0.0042 0.0112 0.0112
Onchocerca volvulus 0.0054 0.0163 0.0738
Echinococcus multilocularis cyclins 0.0173 0.067 0.067
Loa Loa (eye worm) cyclin domain-containing protein 0.0042 0.0112 0.0411
Echinococcus granulosus cyclins 0.0173 0.067 0.067
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0081 0.0081
Onchocerca volvulus Cyclin L homolog 0.0042 0.0112 0.0501
Echinococcus granulosus protocadherin 11 0.0021 0.0024 0.0024
Brugia malayi hypothetical protein 0.0554 0.2293 0.8413
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0303
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0021 0.0024 0.0024
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0523 0.2163 0.2163
Brugia malayi ecdysteroid receptor 0.0034 0.0081 0.0285
Brugia malayi Protein kinase domain containing protein 0.024 0.0957 0.3503
Echinococcus multilocularis cyclins 0.0173 0.067 0.067
Loa Loa (eye worm) latrophilin receptor protein 2 0.0055 0.0167 0.0614
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0042 0.0112 0.0108
Onchocerca volvulus Cyclin L homolog 0.0042 0.0112 0.0501
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0523 0.2163 0.216
Trichomonas vaginalis cyclin B, putative 0.0307 0.124 0.5562
Echinococcus granulosus cyclin dependent kinase 0.024 0.0957 0.0957
Brugia malayi intracellular kinase 0.0523 0.2163 0.7937
Echinococcus granulosus X box binding protein 1 0.0665 0.2766 0.2766
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.007 0.0258
Onchocerca volvulus 0.0035 0.0083 0.0365
Schistosoma mansoni cyclins 0.0173 0.067 0.0666
Schistosoma mansoni cyclin G2 0.0042 0.0112 0.0108
Echinococcus multilocularis neuropeptide s receptor 0.1578 0.6654 0.6654
Loa Loa (eye worm) intermediate filament protein 0.0032 0.007 0.0258
Schistosoma mansoni thyrotroph embryonic factor related 0.0021 0.0024 0.002
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0103
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0303
Echinococcus multilocularis cyclins 0.0173 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0118 0.0438 0.1606
Echinococcus multilocularis cyclin dependent kinase 1 0.024 0.0957 0.0957
Brugia malayi hypothetical protein 0.0018 0.0012 0.0031
Leishmania major cyclin 0.0307 0.124 0.5562
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Schistosoma mansoni hypothetical protein 0.0055 0.0167 0.0164
Brugia malayi Latrophilin receptor protein 2 0.0055 0.0167 0.0601
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0004 0.0004
Trichomonas vaginalis cyclin B, putative 0.0307 0.124 0.5562
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0004 0.0014
Brugia malayi beta-lactamase family protein 0.0035 0.0083 0.029
Brugia malayi Cyclin C 0.0042 0.0112 0.0398
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0957 0.0953
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.0223 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0107 0.0107
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0081 0.0359
Plasmodium falciparum glycogen synthase kinase 3 0.0523 0.2163 1
Brugia malayi cyclin fold protein 1 variant b 0.0042 0.0112 0.0398
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.0223 1
Onchocerca volvulus 0.0021 0.0024 0.0095
Onchocerca volvulus 0.0113 0.0415 0.1907
Schistosoma mansoni g1/s-specific cyclin C 0.0042 0.0112 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.024 0.0957 0.4201
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0004 0.0004
Echinococcus granulosus cyclin y 0.0042 0.0112 0.0112
Brugia malayi hypothetical protein 0.0021 0.0024 0.0075
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0212 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0081 0.0285
Schistosoma mansoni cyclin G 0.0042 0.0112 0.0108
Echinococcus multilocularis cyclin t1 0.0042 0.0112 0.0112
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0081 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0298
Brugia malayi hypothetical protein 0.0042 0.0112 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0081 0.0298
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0523 0.2163 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0083 0.0079
Echinococcus multilocularis cyclin B3 1 0.0173 0.067 0.067
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0523 0.2163 0.2163
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0012 0.0008
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.004 0.0107 0.0387
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0163 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0081 0.0298
Brugia malayi nuclear receptor RXR 0.0018 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0298
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0081 0.0078
Entamoeba histolytica hypothetical protein 0.004 0.0107 0.0387
Onchocerca volvulus 0.0021 0.0024 0.0095
Loa Loa (eye worm) hypothetical protein 0.0031 0.0068 0.0249
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0012 0.0008
Loa Loa (eye worm) DR-78 0.0016 0.0004 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.024 0.0957 0.4201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0081 0.0285
Schistosoma mansoni hypothetical protein 0.0113 0.0415 0.0412
Echinococcus granulosus cyclins 0.0173 0.067 0.067
Onchocerca volvulus 0.0021 0.0024 0.0095
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0163 0.0598
Loa Loa (eye worm) hypothetical protein 0.0054 0.0163 0.0598
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0021 0.0024 0.0024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0012 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0055 0.0167 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0081 0.0081
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0014
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0081 0.0078
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0081 0.0081
Plasmodium vivax cyclin 4, putative 0.0042 0.0112 0.0141
Trichomonas vaginalis cyclin A, putative 0.0307 0.124 0.5562
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0163 0.0163
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0523 0.2163 0.794
Loa Loa (eye worm) hypothetical protein 0.0173 0.0671 0.2461
Giardia lamblia Hypothetical protein 0.0042 0.0112 0.041
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0107 0.0103
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0081 0.0081
Brugia malayi nuclear hormone receptor 0.0034 0.0081 0.0285
Loa Loa (eye worm) bZIP transcription factor family protein 0.0021 0.0024 0.0089
Brugia malayi Cyclin, N-terminal domain containing protein 0.0307 0.124 0.4543
Entamoeba histolytica hypothetical protein 0.0042 0.0112 0.041
Loa Loa (eye worm) MBCTL1 0.0061 0.0195 0.0715
Schistosoma mansoni cyclin d 0.0042 0.0112 0.0108
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.027 0.1084 0.1084
Echinococcus multilocularis protein kinase shaggy 0.0523 0.2163 0.2163
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0012 0.0031
Schistosoma mansoni par domain protein 0.0021 0.0024 0.002
Echinococcus multilocularis cyclin dependent kinase 1 0.024 0.0957 0.0957
Trypanosoma cruzi mitotic cyclin, putative 0.0042 0.0112 0.0141
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0083 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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