Detailed information for compound 1195494

Basic information

Technical information
  • TDR Targets ID: 1195494
  • Name: N-(4-bromo-2-methylphenyl)-2-[methyl-[2-[(4-m ethylphenyl)methylsulfanyl]acetyl]amino]aceta mide
  • MW: 435.378 | Formula: C20H23BrN2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.22 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1C)Br)CN(C(=O)CSCc1ccc(cc1)C)C
  • InChi: 1S/C20H23BrN2O2S/c1-14-4-6-16(7-5-14)12-26-13-20(25)23(3)11-19(24)22-18-9-8-17(21)10-15(18)2/h4-10H,11-13H2,1-3H3,(H,22,24)
  • InChiKey: LRXHFQBYCIJETJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromo-2-methyl-phenyl)-2-[methyl-[2-[(4-methylphenyl)methylsulfanyl]acetyl]amino]acetamide
  • N-(4-bromo-2-methylphenyl)-2-[methyl-[2-[(4-methylphenyl)methylthio]-1-oxoethyl]amino]acetamide
  • N-(4-bromo-2-methyl-phenyl)-2-[methyl-[2-[(4-methylbenzyl)thio]acetyl]amino]acetamide
  • N-(4-bromo-2-methyl-phenyl)-2-[methyl-[2-[(4-methylphenyl)methylsulfanyl]ethanoyl]amino]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0383 0.4686 0.4933
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0268 0.0487
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0017 0.0058 0.0061
Plasmodium vivax CDK-related protein kinase 6, putative 0.0456 0.5602 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0386 0.0736
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0042 0.0373 0.0709
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0058 0.0056
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0322 0.0569
Mycobacterium tuberculosis Conserved protein 0.0043 0.0386 0.107
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0058 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0524 0.1029
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.015 0.0158
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0912 0.1852
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0386 0.0406
Onchocerca volvulus 0.0015 0.0038 0.0076
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0667 0.1351
Giardia lamblia PHD finger protein 15 0.0031 0.0244 0.0437
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0386 0.0736
Brugia malayi PHD-finger family protein 0.0031 0.0244 0.0493
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0268 0.0487
Trichomonas vaginalis esterase, putative 0.0043 0.0386 0.0736
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0322 0.2144
Loa Loa (eye worm) latrophilin receptor protein 2 0.0087 0.0941 0.1907
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0389 0.4756 1
Trypanosoma brucei SIR2-like protein 4, putative 0.0017 0.0058 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2278 0.4747
Entamoeba histolytica protein kinase, putative 0.0033 0.0263 0.0436
Onchocerca volvulus 0.0015 0.0038 0.0076
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0015
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0224 0.0395
Echinococcus granulosus microtubule associated protein 2 0.0764 0.9497 1
Onchocerca volvulus 0.0015 0.0038 0.0076
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.1203 0.3201
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0017 0.0058 0.015
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0193 0.0204
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0545 0.0574
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3362 0.7045
Schistosoma mansoni hypothetical protein 0.0087 0.0941 0.0989
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0244 0.0257
Schistosoma mansoni tar DNA-binding protein 0.0068 0.071 0.0745
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0268 0.0487
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0912 0.0958
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0038 0.0062
Brugia malayi hypothetical protein 0.0036 0.0308 0.0623
Onchocerca volvulus 0.0043 0.0386 0.0807
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0052 0.0507 0.3549
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3362 0.7045
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0058 0.0153
Entamoeba histolytica hypothetical protein 0.0036 0.0308 0.0533
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1203 0.1267
Brugia malayi MH1 domain containing protein 0.0015 0.0039 0.0076
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0618 0.123
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.015 0.0308
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1072 0.1129
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.1203 0.1203
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0389 0.4756 0.9656
Brugia malayi MH2 domain containing protein 0.0402 0.4926 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0061 0.0618 0.0649
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0263 0.0263
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.1361 0.2803
Schistosoma mansoni chromatin regulatory protein sir2 0.0052 0.0507 0.0532
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0386 0.3573
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0274 0.3303 0.6704
Schistosoma mansoni glucose transport protein 0.0107 0.1203 0.1265
Schistosoma mansoni hypothetical protein 0.0087 0.0941 0.0989
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0618 0.123
Brugia malayi transcriptional regulator, Sir2 family protein 0.0017 0.0058 0.0114
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0618 0.4388
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0386 0.107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0263 0.0277
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0104 0.0139
Leishmania major protein kinase, putative 0.0033 0.0263 0.1698
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0254 0.0513
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0308 0.0322
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Leishmania major glucose transporter, lmgt3 0.0033 0.0268 0.1738
Echinococcus granulosus solute carrier family 22 0.0015 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.0087 0.0941 0.1907
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0912 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0386 0.078
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0269 0.3243 0.987
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.0058 0.0059
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.015 0.0697
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0389 0.4756 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0386 0.078
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0017 0.0058 0.0058
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0389 0.4756 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0087 0.0941 0.0941
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0386 0.0736
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Trypanosoma brucei glucose transporter, putative 0.0033 0.0268 0.1738
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0386 0.0736
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0389 0.4756 0.9656
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0378
Schistosoma mansoni cpg binding protein 0.0034 0.0277 0.0289
Loa Loa (eye worm) transcriptional regulator 0.0017 0.0058 0.0114
Brugia malayi MH2 domain containing protein 0.0027 0.0193 0.039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0254 0.0513
Loa Loa (eye worm) hypothetical protein 0.0187 0.2209 0.4483
Echinococcus multilocularis microtubule associated protein 2 0.0764 0.9497 0.9497
Plasmodium vivax hexose transporter 0.0107 0.1203 0.2143
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0016 0.0016
Loa Loa (eye worm) Smad1 0.0027 0.0193 0.039
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0017 0.0058 0.0058
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0322 0.2144
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0386 0.078
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.012 0.1361 1
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0244 0.0493
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0017 0.0058 0.0042
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0038 0.0074
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0254 0.0254
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0237 0.0237
Echinococcus granulosus mothers against decapentaplegic 2 0.0012 0.0002 0.0002
Brugia malayi MH1 domain containing protein 0.0027 0.0193 0.039
Plasmodium falciparum protein kinase 7 0.0303 0.3678 0.6564
Brugia malayi Calcitonin receptor-like protein seb-1 0.0274 0.3303 0.6704
Onchocerca volvulus 0.0015 0.0038 0.0076
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0268 0.1738
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0058 0.0153
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0386 0.0736
Leishmania major silent information regulator 2, putative 0.0017 0.0058 0.015
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0912 1
Brugia malayi jmjC domain containing protein 0.0103 0.1147 0.2326
Schistosoma mansoni hypothetical protein 0.0087 0.0941 0.0989
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1072 0.1072
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0322 0.2144
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0322 0.0569
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0244 0.0255
Trypanosoma brucei glucose transporter, putative 0.0033 0.0268 0.1738
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0263 0.0617
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Plasmodium falciparum phd finger protein, putative 0.0031 0.0244 0.043
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0244 0.0244
Onchocerca volvulus 0.0043 0.0386 0.0807
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.0114
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.0058 0.0042
Echinococcus multilocularis cpg binding protein 0.0036 0.0301 0.0301
Brugia malayi major facilitator superfamily protein 0.0015 0.0038 0.0074
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0052 0.0507 0.09
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0017 0.0058 0.0061
Schistosoma mansoni sugar transporter 0.0015 0.0038 0.0038
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0038 0.0038
Loa Loa (eye worm) transcriptional regulator 0.0017 0.0058 0.0114
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0038 0.004
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0193 0.0193
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0058 0.0059
Schistosoma mansoni protein kinase 0.0033 0.0263 0.0274
Brugia malayi hypothetical protein 0.0015 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Trypanosoma brucei glucose transporter, putative 0.0033 0.0268 0.1738
Trypanosoma brucei glucose transporter, putative 0.0033 0.0268 0.1738
Leishmania major hypothetical protein, conserved 0.012 0.1361 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.015 0.0847
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0308 0.0308
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0087 0.0941 0.0941
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0389 0.4756 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Echinococcus multilocularis geminin 0.0383 0.4686 0.4686
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0618 0.4388
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0244 0.0566
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0263 0.0277
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0058 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2154 0.4483
Schistosoma mansoni cpg binding protein 0.0036 0.0301 0.0315
Echinococcus granulosus General substrate transporter 0.0092 0.1013 0.1066
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2154 0.4483
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0263 0.0464
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0912 0.1623
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0268 0.1738
Plasmodium vivax sugar transporter, putative 0.0015 0.0038 0.0062
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0188 0.0188
Loa Loa (eye worm) MH2 domain-containing protein 0.0012 0.0002 0.0001
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0278 0.3362 0.6824
Schistosoma mansoni Smad4 0.0027 0.0193 0.0202
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0017 0.0058 0.0058
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0193 0.0204
Echinococcus granulosus dnaJ subfamily B 0.0484 0.5961 0.6277
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0038 0.004
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.015 0.0847
Schistosoma mansoni hypothetical protein 0.0484 0.5961 0.6276
Leishmania major hypothetical protein, conserved 0.0043 0.0386 0.2627
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0017 0.0058 0.015
Loa Loa (eye worm) hypothetical protein 0.0084 0.0912 0.1848
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0104 0.0204
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0193 0.039
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.1147 0.1208
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0254 0.0268
Plasmodium vivax NAD-dependent deacetylase, putative 0.0052 0.0507 0.09
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0268 0.1738
Toxoplasma gondii hypothetical protein 0.0054 0.0524 0.1334
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0058 0.0062
Mycobacterium ulcerans hypothetical protein 0.0043 0.0386 0.0736
Schistosoma mansoni sugar transporter 0.0015 0.0038 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0068 0.071 0.0745
Toxoplasma gondii hypothetical protein 0.0019 0.0093 0.0151
Schistosoma mansoni smad1 5 8 and 0.0027 0.0193 0.0202
Onchocerca volvulus 0.0015 0.0038 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0386 0.0736
Echinococcus multilocularis tumor protein p63 0.0374 0.4572 0.4572
Onchocerca volvulus 0.0015 0.0038 0.0076
Schistosoma mansoni hypothetical protein 0.0187 0.2209 0.2325
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0254 0.0458
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0058 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0618 0.123
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0016 0.0017
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0224 0.1407
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0017 0.0058 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.1203 0.2469
Schistosoma mansoni hypothetical protein 0.0383 0.4686 0.4933
Echinococcus granulosus cpg binding protein 0.0036 0.0301 0.0317
Brugia malayi MH2 domain containing protein 0.0012 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0036 0.0308 0.0322
Brugia malayi isocitrate dehydrogenase 0.0017 0.0058 0.0115
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0052 0.0507 0.3549
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0058 0.0058
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.0058 0.0042
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0389 0.4756 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0386 0.078
Echinococcus granulosus GPCR family 2 0.0087 0.0941 0.0991
Brugia malayi Sugar transporter family protein 0.0015 0.0038 0.0074
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0618 0.4388
Plasmodium falciparum hexose transporter 0.0107 0.1203 0.2143
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0263 0.0464
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0087 0.0941 0.0991
Echinococcus granulosus mothers against decapentaplegic 6 0.0012 0.0002 0.0002
Schistosoma mansoni protein kinase 0.0033 0.0263 0.0274
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0912 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0058 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0386 0.078
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0386 0.2627
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Echinococcus granulosus solute carrier family 22 0.0015 0.0038 0.004
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0061 0.0618 0.4388
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0618 0.123
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0277 0.0559
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0618 0.123
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1203 0.1267
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0061 0.0618 0.123
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0188 0.0317
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0386 0.0404
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0912 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0263 0.0274
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0912 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0263 0.0464
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0254 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0524 0.1029
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1203 0.1267
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0274 0.3303 0.6704
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0389 0.4756 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.1203 0.1203
Schistosoma mansoni hypothetical protein 0.0107 0.1203 0.1265
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0263 0.0263
Trypanosoma brucei glucose transporter 1E 0.0033 0.0268 0.1738
Loa Loa (eye worm) sugar transporter 0.0107 0.1203 0.244
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0352 0.0371
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0389 0.4756 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0263 0.053
Brugia malayi NAD-dependent deacetylase SIRT1 0.0017 0.0058 0.0114
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0618 0.123
Onchocerca volvulus Alhambra homolog 0.0031 0.0244 0.0509
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0058 0.0061
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0254 0.0266
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0188 0.0378
Schistosoma mansoni protein kinase 0.0033 0.0263 0.0274
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.0058 0.0042
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0618 0.0651
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2154 0.4483
Brugia malayi TAR-binding protein 0.0068 0.071 0.1438
Plasmodium falciparum mitogen-activated protein kinase 2 0.0173 0.2038 0.3635
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.0058 0.0059
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.015 0.0237
Echinococcus granulosus solute carrier family 22 0.0015 0.0038 0.004
Loa Loa (eye worm) RNA binding protein 0.0068 0.071 0.1438
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0389 0.4756 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.0058 0.0042
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0058 0.0056
Giardia lamblia Sirtuin type 2 0.0017 0.0058 0.0042
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.0058 0.0059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0084 0.0086
Echinococcus multilocularis dnaJ subfamily B 0.0484 0.5961 0.5961
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0188 0.0317
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.1203 0.1203
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0386 0.0683
Brugia malayi Sugar transporter family protein 0.0015 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0032 0.0254 0.0513
Loa Loa (eye worm) hypothetical protein 0.0026 0.0178 0.0358
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0386 0.078
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0224 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0068 0.071 0.0745
Onchocerca volvulus 0.0034 0.0277 0.0578
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0058 0.0153
Loa Loa (eye worm) hypothetical protein 0.0274 0.3303 0.6704
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.1147 0.1147
Loa Loa (eye worm) transcriptional regulator 0.0017 0.0058 0.0114
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0263 0.0263
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.015 0.0156
Brugia malayi jmjC domain containing protein 0.004 0.0352 0.0712
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0268 0.0487
Loa Loa (eye worm) hypothetical protein 0.0054 0.0528 0.1068
Brugia malayi Latrophilin receptor protein 2 0.0087 0.0941 0.1907
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0036 0.0297 0.2491
Brugia malayi hypothetical protein 0.0015 0.0038 0.0074
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.0058 0.0059
Mycobacterium ulcerans Sir2-like regulatory protein 0.0017 0.0058 0.0042
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0263 0.0464
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0386 0.107
Toxoplasma gondii ABC1 family protein 0.0043 0.0386 0.0955
Echinococcus granulosus tar DNA binding protein 0.0068 0.071 0.0747
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0017 0.0058 0.0098
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Mycobacterium ulcerans NAD-dependent deacetylase 0.0052 0.0507 0.0995
Echinococcus multilocularis GPCR, family 2 0.0087 0.0941 0.0941
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0758 0.0796
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0386 0.0736
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.0058 0.0059
Echinococcus multilocularis mothers against decapentaplegic 6 0.0012 0.0002 0.0002
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0224 0.1407
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Onchocerca volvulus 0.0015 0.0038 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2278 0.4747
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0386 0.0404
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0058 0.0098
Schistosoma mansoni jumonji domain containing protein 0.0082 0.088 0.0924
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0545 0.1561
Brugia malayi Probable ClpP-like protease 0.0084 0.0912 0.1848
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0224 0.0395
Brugia malayi lysyl-tRNA synthetase 0.0024 0.015 0.0302
Brugia malayi transcriptional regulator, Sir2 family protein 0.0017 0.0058 0.0114
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0389 0.4756 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0254 0.1968
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0254 0.0458
Brugia malayi MH2 domain containing protein 0.0027 0.0193 0.039
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0618 0.123
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0545 0.5521
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0263 0.053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0244 0.0493
Brugia malayi hypothetical protein 0.003 0.0224 0.0452
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1072 0.1072
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0058 0.0058
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0052 0.0507 0.0957
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.015 0.0237
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0017 0.0058 0.0061
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0263 0.0263
Mycobacterium tuberculosis Conserved protein 0.0043 0.0386 0.107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Onchocerca volvulus 0.0043 0.0386 0.0807
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0052 0.0507 0.0995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1072 0.1127
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0061 0.0618 0.0618
Trypanosoma brucei glucose transporter 2A 0.0033 0.0268 0.1738
Onchocerca volvulus 0.0389 0.4756 1
Toxoplasma gondii hypothetical protein 0.0019 0.0093 0.0151
Schistosoma mansoni smad1 5 8 and 0.0027 0.0193 0.0202
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0539 0.0565
Loa Loa (eye worm) hypothetical protein 0.0019 0.0093 0.0186
Schistosoma mansoni glucose transport protein 0.0107 0.1203 0.1265
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.071 0.1438
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0386 0.107
Brugia malayi Smad1 0.0027 0.0193 0.039
Echinococcus multilocularis solute carrier family 22 0.0015 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0093 0.0117
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0058 0.0153
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0093 0.016
Mycobacterium tuberculosis Conserved protein 0.0043 0.0386 0.107
Giardia lamblia Hypothetical protein 0.0017 0.0058 0.0042
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.0058 0.0042
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0061 0.0618 0.123
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0058 0.0058
Onchocerca volvulus 0.0015 0.0038 0.0076
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0061 0.0618 0.4388
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0173 0.2038 0.3635
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0188 0.0317
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0058 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0068 0.071 0.0745
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0087 0.0941 0.1907
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0263 0.0464
Leishmania major sir2-family protein-like protein 0.0017 0.0058 0.015
Loa Loa (eye worm) TAR-binding protein 0.0068 0.071 0.1438
Loa Loa (eye worm) MH1 domain-containing protein 0.0012 0.0002 0.0001
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0254 0.0418
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2154 0.4483
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2154 0.4483
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0545 0.1561
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0912 0.24
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0076
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0618 0.123
Entamoeba histolytica hypothetical protein 0.0036 0.0308 0.0533
Loa Loa (eye worm) sugar transporter 0.0015 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.0058 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1072 0.1127
Schistosoma mansoni glucose transporter 0.0015 0.0038 0.0038
Mycobacterium ulcerans lipase LipD 0.0043 0.0386 0.0736
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.0058 0.0042
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0188 0.0378
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0268 0.1738
Plasmodium falciparum protein kinase 6 0.0456 0.5602 1
Schistosoma mansoni sugar transporter 0.0015 0.0038 0.0038
Leishmania major glucose transporter, lmgt1 0.0033 0.0268 0.1738
Brugia malayi major facilitator superfamily protein 0.0015 0.0038 0.0074
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0545 0.0545
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0052 0.0507 0.3549
Schistosoma mansoni glucose transport protein 0.0107 0.1203 0.1265
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0058 0.0153
Entamoeba histolytica hypothetical protein 0.0036 0.0308 0.0533
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0093 0.0169
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.015 0.0237
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0093 0.0117
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0214 0.0377
Brugia malayi Cam kinase protein 1 0.0033 0.0263 0.053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1072 0.1127
Toxoplasma gondii histone deacetylase SIR2 0.0052 0.0507 0.1289
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0093 0.0117
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0244 0.043
Loa Loa (eye worm) transcription factor SMAD2 0.0402 0.4926 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0263 0.053
Brugia malayi MH1 domain containing protein 0.0027 0.0193 0.039
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.1361 0.2803
Echinococcus granulosus solute carrier family 22 0.0015 0.0038 0.004
Echinococcus granulosus chromatin regulatory protein sir2 0.0017 0.0058 0.0061
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0017 0.0058 0.0058
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0173 0.2038 0.5495
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0014 0.0026
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0328 0.0328
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0052 0.0507 0.1445
Schistosoma mansoni microtubule-associated protein tau 0.0764 0.9497 1
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3362 0.7045
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0386 0.2627
Trypanosoma brucei glucose transporter, putative 0.0033 0.0268 0.1738
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0352 0.0712
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0322 0.2144
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3362 0.7045
Brugia malayi latrophilin 2 splice variant baaae 0.0187 0.2209 0.4483
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0038 0.0074
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0214 0.0377
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.1072 0.2174
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0386 0.0386
Entamoeba histolytica protein kinase, putative 0.0033 0.0263 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0268 0.0487
Brugia malayi hypothetical protein 0.0019 0.0091 0.0181
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0093 0.0117
Echinococcus multilocularis solute carrier family 22 0.0015 0.0038 0.0038
Echinococcus multilocularis chromatin regulatory protein sir2 0.0017 0.0058 0.0058
Onchocerca volvulus 0.0015 0.0038 0.0076
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0193 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1072 0.1129
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.0058 0.0042
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0278 0.3362 0.6824
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0263 0.0464
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0268 0.1738
Echinococcus multilocularis solute carrier family 22 0.0015 0.0038 0.0038
Brugia malayi hypothetical protein 0.0015 0.0038 0.0074
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Trypanosoma cruzi hexose transporter 0.0033 0.0268 0.1738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0386 0.078
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0268 0.1738
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0237 0.0249
Onchocerca volvulus 0.0015 0.0038 0.0076
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.0058 0.0042
Echinococcus multilocularis solute carrier family 22 0.0015 0.0038 0.0038
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0052 0.0507 0.0995
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0087 0.0941 0.0991
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0052 0.0507 0.0995
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0113 0.0158
Schistosoma mansoni sugar transporter 0.0015 0.0038 0.0038
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.071 0.1438
Brugia malayi beta-lactamase family protein 0.0043 0.0386 0.078
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0389 0.4756 1
Loa Loa (eye worm) nuclear factor I 0.0015 0.0039 0.0076
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.015 0.0156
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0322 0.0779
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Onchocerca volvulus 0.0015 0.0038 0.0076
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0038 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0386 0.2627
Trypanosoma brucei glucose transporter, putative 0.0033 0.0268 0.1738
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0244 0.0566
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0263 0.1698
Brugia malayi transcriptional regulator, Sir2 family protein 0.0017 0.0058 0.0114
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0188 0.0198
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0214 0.1479
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0017 0.0058 0.0061
Schistosoma mansoni smad1 5 8 and 0.0027 0.0193 0.0202
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0263 0.0277
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0263 0.0617
Schistosoma mansoni tar DNA-binding protein 0.0068 0.071 0.0745
Loa Loa (eye worm) MH2 domain-containing protein 0.0402 0.4926 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0038 0.0038
Brugia malayi MH1 domain containing protein 0.0015 0.0039 0.0076
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0661 0.171
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.015 0.0262
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0263 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.1361 1
Echinococcus granulosus jumonji domain containing protein 0.0044 0.04 0.0421
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0352 0.0369
Loa Loa (eye worm) hypothetical protein 0.0043 0.0386 0.078
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.015 0.0847
Loa Loa (eye worm) hypothetical protein 0.003 0.0224 0.0452
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.015 0.0237
Trypanosoma brucei glucose transporter, putative 0.0033 0.0268 0.1738
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0272 0.3285 1
Echinococcus multilocularis tar DNA binding protein 0.0068 0.071 0.071
Toxoplasma gondii histone deacetylase SIR2-like 0.0017 0.0058 0.0054
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.0373 0.0709
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2154 0.4483
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.1361 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.015 0.0262
Brugia malayi RNA binding protein 0.0068 0.071 0.1438
Onchocerca volvulus 0.0015 0.0038 0.0076
Entamoeba histolytica hypothetical protein 0.0024 0.015 0.0196
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0352 0.0369
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0386 0.107
Echinococcus granulosus geminin 0.0383 0.4686 0.4934
Mycobacterium leprae Probable lipase LipE 0.0043 0.0386 0.3573
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0058 0.0058
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.1203 0.1203
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0052 0.0507 0.3549
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0386 0.107
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0618 0.123
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0188 0.0196
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0263 0.053
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0108 0.0217
Loa Loa (eye worm) hypothetical protein 0.0055 0.0539 0.1091
Schistosoma mansoni smad 0.0027 0.0193 0.0202
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.015 0.015
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0263 0.0464
Brugia malayi beta-lactamase family protein 0.0043 0.0386 0.078
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0093 0.016
Leishmania major hypothetical protein, conserved 0.003 0.0224 0.1407
Loa Loa (eye worm) hypothetical protein 0.0043 0.0386 0.078
Echinococcus granulosus Smad4 0.0027 0.0193 0.0204
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0254 0.0266
Onchocerca volvulus 0.0015 0.0038 0.0076
Brugia malayi CXXC zinc finger family protein 0.0034 0.0277 0.0559
Loa Loa (eye worm) sirtuin 4 0.0017 0.0058 0.0114
Brugia malayi beta-lactamase 0.0043 0.0386 0.078
Onchocerca volvulus 0.0015 0.0038 0.0076
Leishmania major glucose transporter, lmgt2 0.0033 0.0268 0.1738
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0104 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2154 0.4483
Echinococcus granulosus peregrin 0.0031 0.0244 0.0257
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0224 0.0511
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0077 0.0296
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1203 0.1267
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0268 0.0487
Schistosoma mansoni cpg binding protein 0.0036 0.0301 0.0315
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0386 0.107
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0308 0.0325
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0912 0.1852
Schistosoma mansoni hypothetical protein 0.0087 0.0941 0.0989
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3362 0.7045
Onchocerca volvulus Putative transporter 0.0015 0.0038 0.0076
Mycobacterium ulcerans beta-lactamase 0.0043 0.0386 0.0736
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0912 0.24
Brugia malayi Sugar transporter family protein 0.0107 0.1203 0.244
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0322 0.2144
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0093 0.0151
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0912 0.1623
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0224 0.1407
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.2154 0.4525
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3362 0.7045
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Loa Loa (eye worm) hypothetical protein 0.0024 0.015 0.0302
Entamoeba histolytica hypothetical protein 0.0036 0.0308 0.0533
Onchocerca volvulus 0.0015 0.0038 0.0076
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0061 0.0618 0.123
Echinococcus granulosus tumor protein p63 0.0374 0.4572 0.4815
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0524 0.1029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.1072 0.2174
Echinococcus multilocularis smad 0.0027 0.0193 0.0193
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0912 0.096
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0193 0.0193
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0263 0.0464
Brugia malayi mothers against decapentaplegic homolog 3 0.0012 0.0002 0.0001
Echinococcus multilocularis Smad4 0.0027 0.0193 0.0193
Echinococcus multilocularis General substrate transporter 0.0092 0.1013 0.1013
Brugia malayi Bromodomain containing protein 0.0031 0.0244 0.0493
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0263 0.0476
Schistosoma mansoni hypothetical protein 0.0031 0.0244 0.0255
Echinococcus multilocularis peregrin 0.0031 0.0244 0.0244
Trypanosoma brucei glucose transporter, putative 0.0033 0.0268 0.1738
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0074
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0268 0.0487
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0268 0.1738
Giardia lamblia Transcriptional regulator, Sir2 family 0.0052 0.0507 0.0995
Echinococcus granulosus smad 0.0027 0.0193 0.0204
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0386 0.107
Onchocerca volvulus 0.0055 0.0539 0.1129
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0038 0.0074
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0263 0.0464
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0038 0.0038
Onchocerca volvulus 0.0015 0.0038 0.0076
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0263 0.0617
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0912 0.0912
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0042 0.0373 0.2531
Toxoplasma gondii hypothetical protein 0.0029 0.0214 0.0484
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0193 0.039
Toxoplasma gondii protein kinase, putative 0.0303 0.3678 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0093 0.0169
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0618 0.123

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5805 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) 0.6513 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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