Detailed information for compound 1199882

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 442.463 | Formula: C21H19FN4O4S
  • H donors: 0 H acceptors: 3 LogP: 1.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c2nc3c(C)cccn3c(=O)c2cc(c1=N)S(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C21H19FN4O4S/c1-13-4-3-9-26-19(13)24-20-16(21(26)27)12-17(18(23)25(20)10-11-30-2)31(28,29)15-7-5-14(22)6-8-15/h3-9,12,23H,10-11H2,1-2H3
  • InChiKey: FKMUTUQRUSUKSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0016 0.0007
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0016 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Brugia malayi neuropeptide F receptor 0.0009 0.0016 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0016 0.0004
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni intermediate filament proteins 0.003 0.0485 0.0584
Trichomonas vaginalis esterase, putative 0.0043 0.0779 0.3198
Entamoeba histolytica protein kinase, putative 0.0032 0.0524 0.8157
Brugia malayi nuclear hormone receptor 0.001 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Schistosoma mansoni importin beta-1 0.0035 0.0586 0.0708
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0524 0.0512
Onchocerca volvulus 0.003 0.0485 0.6145
Mycobacterium tuberculosis Conserved protein 0.0043 0.0779 0.1093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0236 0.1542
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0016 0.0005
Onchocerca volvulus Putative transporter 0.0015 0.0137 0.1581
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0016 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0103 0.1324
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0016 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0016 0.0004
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2145 0.2136
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0137 0.0154
Echinococcus multilocularis dna polymerase eta 0.0019 0.0236 0.0224
Brugia malayi Dopamine receptor protein 2 0.0009 0.0016 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0779 0.1093
Entamoeba histolytica hypothetical protein 0.0035 0.0589 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0136
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0589 0.0712
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0626 0.7609
Brugia malayi major facilitator superfamily protein 0.0015 0.0137 0.0226
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0136
Schistosoma mansoni DNA polymerase eta 0.0019 0.0236 0.0276
Echinococcus multilocularis somatostatin receptor 0.0009 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Loa Loa (eye worm) hypothetical protein 0.0043 0.0779 0.0947
Echinococcus granulosus orexin receptor type 2 0.0009 0.0016 0.0004
Onchocerca volvulus 0.0015 0.0137 0.1581
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0028 0.0027
Brugia malayi Melatonin receptor type 1A 0.0009 0.0016 0.0007
Entamoeba histolytica hypothetical protein 0.0035 0.0589 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0779 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0524 0.0927
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2145 0.2136
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0779 0.1093
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0236 0.0169
Loa Loa (eye worm) sugar transporter 0.0105 0.2145 0.2634
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0016 0.0004
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0028 0.0015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0589 0.0577
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0524 0.0617
Trypanosoma cruzi hexose transporter 0.0032 0.0533 0.6168
Leishmania major GTP-binding protein, putative 0.0026 0.0381 0.3794
Plasmodium vivax importin-beta 2, putative 0.0035 0.0586 0.0468
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0381 0.6541
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0028 0.0015
Schistosoma mansoni glucose transporter 0.0015 0.0137 0.0154
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0028 0.0027
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0236 0.0276
Leishmania major DNA polymerase kappa, putative 0.0019 0.0236 0.1542
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0509 0.1855
Brugia malayi G-protein coupled receptor 0.0009 0.0016 0.0007
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0016 0.0004
Echinococcus granulosus fmrfamide receptor 0.0009 0.0016 0.0004
Schistosoma mansoni amine GPCR 0.0009 0.0016 0.0005
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.033 0.0201
Onchocerca volvulus 0.003 0.0485 0.6145
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0019
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0016 0.0004
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.033 0.0318
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0236 0.3028
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0016 0.0005
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0135 0.0123
Schistosoma mansoni hypothetical protein 0.0081 0.1619 0.1984
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0533 0.1973
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.033 0.4234
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0028 0.0015
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0016 0.0005
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0137 0.1119
Onchocerca volvulus 0.001 0.0028 0.0148
Echinococcus granulosus g protein coupled receptor 0.0009 0.0016 0.0004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0016 0.0004
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0524 0.0512
Onchocerca volvulus 0.0043 0.0779 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0016 0.0004
Onchocerca volvulus 0.0015 0.0137 0.1581
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0779 0.0947
Schistosoma mansoni sugar transporter 0.0015 0.0137 0.0154
Onchocerca volvulus 0.0015 0.0137 0.1581
Brugia malayi Sugar transporter family protein 0.0015 0.0137 0.0226
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0019
Entamoeba histolytica protein kinase, putative 0.0032 0.0524 0.8157
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0509 0.0614
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0213 0.0363
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0266 0.0641
Loa Loa (eye worm) hypothetical protein 0.0043 0.0779 0.0947
Mycobacterium ulcerans hypothetical protein 0.0043 0.0779 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0016 0.0005
Schistosoma mansoni hypothetical protein 0.0009 0.0016 0.0005
Leishmania major hypothetical protein, conserved 0.0043 0.0779 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0381 0.4884
Mycobacterium tuberculosis Conserved protein 0.0043 0.0779 0.1093
Echinococcus multilocularis serotonin receptor 0.0009 0.0016 0.0004
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0016 0.0004
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.033 0.5182
Onchocerca volvulus 0.0015 0.0137 0.1581
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0524 0.0512
Onchocerca volvulus 0.0015 0.0137 0.1581
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0213 0.0247
Schistosoma mansoni biogenic amine receptor 0.0009 0.0016 0.0005
Onchocerca volvulus 0.0015 0.0137 0.1581
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0779 0.0768
Echinococcus multilocularis serotonin receptor 0.0009 0.0016 0.0004
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0016 0.0004
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0626 0.7609
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0256 0.5531 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0251 0.0195
Schistosoma mansoni hypothetical protein 0.0175 0.372 0.4579
Trichomonas vaginalis ran, putative 0.0026 0.0381 0.1213
Onchocerca volvulus 0.0015 0.0137 0.1581
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0137 0.1757
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.1619 0.1608
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Brugia malayi hypothetical protein 0.0015 0.0137 0.0226
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0016 0.0004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0779 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Toxoplasma gondii protein kinase, putative 0.0296 0.6412 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0586 0.0708
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0485 0.0584
Echinococcus granulosus sex peptide receptor 0.0009 0.0016 0.0004
Onchocerca volvulus 0.0043 0.0779 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Echinococcus granulosus solute carrier family 22 0.0015 0.0137 0.0125
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0524 0.0617
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0236 0.0493
Loa Loa (eye worm) hypothetical protein 0.0081 0.1619 0.1984
Plasmodium falciparum protein kinase 7 0.0296 0.6412 0.6542
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0028 0.0019
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0213 0.0121
Echinococcus granulosus solute carrier family 22 0.0015 0.0137 0.0125
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0524 0.0632
Brugia malayi Calcitonin receptor-like protein seb-1 0.0256 0.5531 1
Schistosoma mansoni hypothetical protein 0.0372 0.811 1
Schistosoma mansoni hypothetical protein 0.0081 0.1619 0.1984
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2145 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0028 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0236 0.1542
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0213 0.118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.2976 0.2967
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0137 0.0125
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0028 0.0019
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0016 0.0004
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.033 0.3788
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.048 0.0468
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0028 0.0019
Leishmania major glucose transporter, lmgt2 0.0032 0.0533 0.6168
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0028 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0016 0.0005
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0381 0.0388
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0213 0.0121
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0016 0.0004
Schistosoma mansoni hypothetical protein 0.0349 0.7604 0.9376
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0137 0.1119
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0381 0.0369
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0016 0.0005
Schistosoma mansoni amine GPCR 0.0009 0.0016 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0081 0.1619 0.2911
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0533 0.6841
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0028 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0485 0.0857
Schistosoma mansoni neuropeptide receptor 0.0009 0.0016 0.0005
Schistosoma mansoni glucose transport protein 0.0105 0.2145 0.2634
Trypanosoma brucei glucose transporter, putative 0.0032 0.0533 0.6841
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0586 0.0574
Brugia malayi Cam kinase protein 1 0.0032 0.0524 0.0927
Brugia malayi hypothetical protein 0.0015 0.0137 0.0226
Echinococcus granulosus somatostatin receptor 0.0009 0.0016 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0533 0.1973
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0236 0.0405
Brugia malayi sulfakinin receptor protein 0.0009 0.0016 0.0007
Schistosoma mansoni lamin 0.003 0.0485 0.0584
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0016 0.0004
Brugia malayi hypothetical protein 0.0035 0.0589 0.1045
Onchocerca volvulus 0.0015 0.0137 0.1581
Brugia malayi ecdysteroid receptor 0.001 0.0028 0.0027
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0533 0.1973
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0016 0.0005
Schistosoma mansoni protein kinase 0.0032 0.0524 0.0632
Schistosoma mansoni hypothetical protein 0.0009 0.0016 0.0005
Entamoeba histolytica hypothetical protein 0.0023 0.033 0.2663
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0016 0.0005
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0509 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Onchocerca volvulus 0.0015 0.0137 0.1581
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0016 0.0004
Trypanosoma brucei unspecified product 0.0013 0.0103 0.1324
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0137 0.0226
Brugia malayi AKH receptor 0.0009 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0779 0.0947
Loa Loa (eye worm) hypothetical protein 0.0031 0.0509 0.0614
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni adenoreceptor 0.0009 0.0016 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0779 0.3198
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0016 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0236 0.0405
Trypanosoma brucei glucose transporter, putative 0.0032 0.0533 0.6841
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Brugia malayi Dopamine receptor protein 1 0.0009 0.0016 0.0007
Mycobacterium leprae Probable lipase LipE 0.0043 0.0779 1
Brugia malayi follicle stimulating hormone receptor 0.0009 0.0016 0.0007
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0213 0.2729
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.033 0.0201
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0524 0.0404
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0236 0.2488
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0016 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.6012 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0028 0.0019
Echinococcus multilocularis lamin 0.003 0.0485 0.0473
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0016 0.0004
Echinococcus granulosus intermediate filament protein 0.003 0.0485 0.0473
Echinococcus granulosus solute carrier family 22 0.0015 0.0137 0.0125
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0509 0.7747
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0524 0.0404
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0236 0.1542
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0056 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0028 0.0019
Schistosoma mansoni hypothetical protein 0.0035 0.0589 0.0712
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0213 0.118
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0019
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0381 0.0667
Schistosoma mansoni amine GPCR 0.0009 0.0016 0.0005
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0439 0.1503
Schistosoma mansoni sugar transporter 0.0015 0.0137 0.0154
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0439 0.1503
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0016 0.0004
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0028 0.0148
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0626 0.7609
Echinococcus granulosus dna polymerase eta 0.0019 0.0236 0.0224
Schistosoma mansoni hypothetical protein 0.0349 0.7604 0.9376
Loa Loa (eye worm) intermediate filament protein 0.003 0.0485 0.0584
Echinococcus multilocularis solute carrier family 22 0.0015 0.0137 0.0125
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0028 0.0015
Echinococcus multilocularis neuropeptide receptor A26 0.0456 1 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0524 0.6724
Echinococcus granulosus g protein coupled receptor 0.0009 0.0016 0.0004
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3585 0.3595
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0524 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0524 0.0632
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0096 0.0103
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0524 0.0404
Brugia malayi hypothetical protein 0.0015 0.0137 0.0226
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.033 0.3005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2976 0.3659
Onchocerca volvulus 0.0015 0.0137 0.1581
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0016 0.0005
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0016 0.0004
Schistosoma mansoni thyroid hormone receptor 0.001 0.0028 0.0019
Onchocerca volvulus 0.0015 0.0137 0.1581
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0779 0.1093
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.2805 0.3448
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Schistosoma mansoni hypothetical protein 0.0081 0.1619 0.1984
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0213 0.02
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Onchocerca volvulus 0.0015 0.0137 0.1581
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0016 0.0004
Schistosoma mansoni histamine h1 receptor 0.0009 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Brugia malayi beta-lactamase 0.0043 0.0779 0.139
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.033 0.0392
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0028 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0028 0.0015
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.033 0.3788
Brugia malayi beta-lactamase family protein 0.0043 0.0779 0.139
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0137 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0028 0.0027
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0524 0.0404
Brugia malayi Importin beta-1 subunit 0.0035 0.0586 0.1039
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0016 0.0004
Schistosoma mansoni ran 0.0026 0.0381 0.0455
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0016 0.0004
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0016 0.0004
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0509 0.0498
Schistosoma mansoni glucose transport protein 0.0105 0.2145 0.2634
Plasmodium vivax CDK-related protein kinase 6, putative 0.0444 0.9728 1
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0016 0.0004
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0016 0.0004
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0213 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0779 0.0947
Brugia malayi G-protein coupled receptor 0.0009 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0586 0.7519
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0028 0.0015
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0028 0.0015
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0016 0.0005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0213 0.02
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0779 0.0947
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0213 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0533 0.1973
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0236 0.1542
Plasmodium falciparum protein kinase 6 0.0444 0.9728 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0779 0.0947
Echinococcus granulosus geminin 0.0349 0.7604 0.7601
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0533 0.6841
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0236 0.0224
Loa Loa (eye worm) hypothetical protein 0.0015 0.0135 0.0151
Loa Loa (eye worm) hypothetical protein 0.0032 0.0524 0.0632
Entamoeba histolytica hypothetical protein 0.0035 0.0589 1
Echinococcus multilocularis sex peptide receptor 0.0009 0.0016 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0236 0.1542
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0137 0.0125
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus multilocularis solute carrier family 22 0.0015 0.0137 0.0125
Schistosoma mansoni sugar transporter 0.0015 0.0137 0.0154
Brugia malayi Sugar transporter family protein 0.0015 0.0137 0.0226
Leishmania major protein kinase, putative 0.0032 0.0524 0.6026
Echinococcus granulosus neuropeptide receptor 0.0009 0.0016 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0236 0.1542
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0137 0.0154
Trypanosoma brucei glucose transporter 1E 0.0032 0.0533 0.6841
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0016 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0256 0.5531 0.6815
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0779 0.0947
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0533 0.6841
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0028 0.0015
Brugia malayi steroid hormone receptor 0.001 0.0028 0.0027
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0779 0.1093
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.033 0.0392
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0509 0.489
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0016 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0028 0.0027
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0016 0.0004
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0524 0.0512
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0381 0.0455
Trypanosoma brucei glucose transporter, putative 0.0032 0.0533 0.6841
Schistosoma mansoni hypothetical protein 0.0081 0.1619 0.1984
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0381 0.3794
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0524 0.0404
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0236 0.0169
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0381 0.0369
Echinococcus granulosus hypothetical protein 0.0009 0.0016 0.0004
Echinococcus granulosus calcium dependent protein kinase 0.003 0.048 0.0468
Brugia malayi Serotonin receptor 0.0009 0.0016 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0236 0.0224
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0016 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Echinococcus granulosus solute carrier family 22 0.0015 0.0137 0.0125
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0016 0.0004
Echinococcus granulosus allatostatin A receptor 0.0009 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0016 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0028 0.0019
Onchocerca volvulus 0.0043 0.0779 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0236 0.2658
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Trypanosoma brucei glucose transporter, putative 0.0032 0.0533 0.6841
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0028 0.0027
Onchocerca volvulus 0.0015 0.0137 0.1581
Schistosoma mansoni hypothetical protein 0.0009 0.0016 0.0005
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2145 0.2136
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3585 0.3595
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0137 0.0154
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0016 0.0005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0381 0.3794
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0524 0.0404
Schistosoma mansoni protein kinase 0.0032 0.0524 0.0632
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0213 0.0079
Echinococcus multilocularis musashi 0.003 0.0485 0.0473
Brugia malayi beta-lactamase family protein 0.0043 0.0779 0.139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2145 0.2136
Entamoeba histolytica Ran family GTPase 0.0026 0.0381 0.4097
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0016 0.0004
Schistosoma mansoni opsin-like receptor 0.0009 0.0016 0.0005
Brugia malayi lysyl-tRNA synthetase 0.0023 0.033 0.0575
Echinococcus granulosus FTZ F1 alpha 0.001 0.0028 0.0015
Trypanosoma brucei glucose transporter, putative 0.0032 0.0533 0.6841
Brugia malayi neuropeptide F receptor 0.0009 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.033 0.0392
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Trypanosoma brucei glucose transporter 2A 0.0032 0.0533 0.6841
Schistosoma mansoni hypothetical protein 0.0105 0.2145 0.2634
Echinococcus granulosus lamin 0.003 0.0485 0.0473
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0028 0.0148
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0016 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.2976 0.2967
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0213 0.0247
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0626 0.051
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0028 0.0148
Trypanosoma brucei unspecified product 0.0019 0.0236 0.3028
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0626 0.7609
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.1619 0.1608
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0779 1
Brugia malayi intermediate filament protein 0.003 0.0485 0.0857
Loa Loa (eye worm) hypothetical protein 0.0026 0.0378 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0533 0.6168
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2145 0.2136
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0779 0.0768
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0016 0.0005
Brugia malayi isocitrate dehydrogenase 0.0018 0.0213 0.0363
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.372 0.6719
Echinococcus multilocularis GPCR, family 2 0.0081 0.1619 0.1608
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0236 0.0493
Echinococcus granulosus importin subunit beta 1 0.0035 0.0586 0.0574
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0028 0.0019
Onchocerca volvulus 0.0015 0.0137 0.1581
Loa Loa (eye worm) hypothetical protein 0.003 0.0485 0.0584
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.2976 0.2967
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0236 0.0276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0028 0.0019
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0016 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0779 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0028 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2976 0.3659
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.1619 0.1608
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0016 0.0005
Mycobacterium ulcerans beta-lactamase 0.0043 0.0779 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0016 0.0004
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0016 0.0005
Schistosoma mansoni myosin xvIII 0.0009 0.0016 0.0005
Mycobacterium ulcerans lipase LipD 0.0043 0.0779 1
Onchocerca volvulus 0.0015 0.0137 0.1581
Echinococcus granulosus g protein coupled receptor 0.0009 0.0016 0.0004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0028 0.0015
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0016 0.0004
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2145 0.2136
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0016 0.0005
Echinococcus granulosus snurportin 1 0.0372 0.811 0.8107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Schistosoma mansoni amine GPCR 0.0009 0.0016 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0028 0.0027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0171 0.0196
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Brugia malayi larval opioid receptor 0.0009 0.0016 0.0007
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0016 0.0005
Entamoeba histolytica hypothetical protein 0.0028 0.0439 0.5746
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0524 0.0512
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.033 0.149
Echinococcus multilocularis solute carrier family 22 0.0015 0.0137 0.0125
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0439 0.47
Loa Loa (eye worm) hypothetical protein 0.0019 0.0236 0.0276
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0779 0.1093
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0524 0.0512
Schistosoma mansoni glucose transport protein 0.0105 0.2145 0.2634
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0236 0.3028
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0016 0.0004
Schistosoma mansoni neuropeptide receptor 0.0009 0.0016 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0236 0.3028
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0524 0.0404
Trypanosoma brucei unspecified product 0.0013 0.0103 0.1324
Echinococcus granulosus GPCR family 2 0.0081 0.1619 0.1608
Echinococcus multilocularis lamin dm0 0.003 0.0485 0.0473
Leishmania major glucose transporter, lmgt1 0.0032 0.0533 0.6168
Plasmodium falciparum importin beta, putative 0.0035 0.0586 0.0468
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0028 0.0019
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0016 0.0004
Brugia malayi GnHR receptor homolog 0.0009 0.0016 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0137 0.1119
Schistosoma mansoni lamin 0.003 0.0485 0.0584
Trypanosoma brucei glucose transporter, putative 0.0032 0.0533 0.6841
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni coup transcription factor 0.001 0.0028 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0779 0.139
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0509 0.0614
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0028 0.0027
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0137 0.0125
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0016 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.1619 0.2911
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2145 0.2136
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.811 1
Echinococcus multilocularis neuropeptide s receptor 0.0456 1 1
Brugia malayi Dopamine receptor 0.0009 0.0016 0.0007
Schistosoma mansoni thyroid hormone receptor 0.001 0.0028 0.0019
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2145 0.3201
Plasmodium falciparum hexose transporter 0.0105 0.2145 0.2094
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0524 0.0632
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0213 0.2729
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0524 0.0404
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.2805 0.3448
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0381 0.0254
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0213 0.02
Brugia malayi G protein-coupled receptor 0.0009 0.0016 0.0007
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0381 0.0254
Entamoeba histolytica hypothetical protein 0.0035 0.0589 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0016 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0028 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.1619 0.1984
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0028 0.0015
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0779 0.1093
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Brugia malayi putative neuropeptide receptor 0.0009 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Echinococcus granulosus dna polymerase kappa 0.0019 0.0236 0.0224
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0779 0.1093
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0779 0.3198
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0103 0.1324
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0626 0.0779
Brugia malayi major facilitator superfamily protein 0.0015 0.0137 0.0226
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0016 0.0005
Onchocerca volvulus 0.0015 0.0137 0.1581
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0524 0.1927
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0016 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Schistosoma mansoni amine GPCR 0.0009 0.0016 0.0005
Plasmodium vivax hexose transporter 0.0105 0.2145 0.2094
Echinococcus multilocularis General substrate transporter 0.009 0.1817 0.1807
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0016 0.0004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0016 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0016 0.0004
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0213 0.0129
Leishmania major glucose transporter, lmgt3 0.0032 0.0533 0.6168
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0779 0.0947
Schistosoma mansoni biogenic amine receptor 0.0009 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0171 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0028 0.0027
Toxoplasma gondii ABC1 family protein 0.0043 0.0779 0.1024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0028 0.0027
Leishmania major importin beta-1 subunit, putative 0.0028 0.0439 0.47
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0251 0.0195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.2976 0.2967
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0016 0.0005
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0533 0.1973
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0779 0.3198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2976 0.3659
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0016 0.0007
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0586 0.0716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0016 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0028 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0016 0.0005
Brugia malayi ORL1-like opioid receptor 0.0009 0.0016 0.0007
Mycobacterium tuberculosis Conserved protein 0.0043 0.0779 0.1093
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0779 0.3198
Schistosoma mansoni opsin-like receptor 0.0009 0.0016 0.0005
Loa Loa (eye worm) sugar transporter 0.0015 0.0137 0.0154
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni protein kinase 0.0032 0.0524 0.0632
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0236 0.0276
Leishmania major DNA polymerase eta, putative 0.0019 0.0236 0.1542
Echinococcus granulosus serotonin receptor 0.0009 0.0016 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0779 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0779 0.067
Echinococcus granulosus General substrate transporter 0.009 0.1817 0.1807
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0439 0.1503
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0236 0.0224
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Trypanosoma brucei sugar transporter, putative 0.0015 0.0137 0.1757
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0213 0.02
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0524 0.0617
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0016 0.0004
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0533 0.6168
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0137 0.0226
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0473 0.0568
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Echinococcus multilocularis snurportin 1 0.0372 0.811 0.8107
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0154
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0016 0.0005
Echinococcus multilocularis geminin 0.0349 0.7604 0.7601
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.033 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0533 0.1973
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0016 0.0005
Echinococcus multilocularis solute carrier family 22 0.0015 0.0137 0.0125
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0016 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0028 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0028 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0779 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0016 0.0007
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0016 0.0004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0028 0.0019
Echinococcus granulosus lamin dm0 0.003 0.0485 0.0473
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0509 0.0498
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0533 0.6168
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.2976 0.3659
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0016 0.0005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0028 0.0015
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0016 0.0005
Brugia malayi RNA, U transporter 1 0.0099 0.202 0.3637
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0137 0.0125
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0509 0.0614
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0016 0.0004
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.033 0.0318
Loa Loa (eye worm) beta-lactamase 0.0043 0.0779 0.0947
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0135 0.0123
Echinococcus granulosus neuropeptide receptor 0.0009 0.0016 0.0004
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Mycobacterium ulcerans sugar transporter 0.0015 0.0137 0.1119
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0626 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0236 0.3028
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0016 0.0005
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0016 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0589 0.0577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0028 0.0019
Brugia malayi MH2 domain containing protein 0.0134 0.2805 0.506
Trypanosoma brucei glucose transporter, putative 0.0032 0.0533 0.6841
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0256 0.5531 0.6815
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.033 0.3005
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0509 0.0901
Schistosoma mansoni opsin-like receptor 0.0009 0.0016 0.0005
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0016 0.0005
Schistosoma mansoni neuropeptide receptor 0.0009 0.0016 0.0005
Schistosoma mansoni nuclear hormone receptor 0.001 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0213 0.02
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0016 0.0004
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0016 0.0004
Brugia malayi Sugar transporter family protein 0.0105 0.2145 0.3865
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0779 0.3198
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0204 0.1052
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0213 0.118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0236 0.2488
Brugia malayi Serotonin receptor 0.0009 0.0016 0.0007
Schistosoma mansoni hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni neuropeptide receptor 0.0009 0.0016 0.0005
Brugia malayi hypothetical protein 0.0009 0.0016 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0028 0.0027
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0016 0.0004
Schistosoma mansoni biogenic amine receptor 0.0009 0.0016 0.0005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0016 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0028 0.0027
Brugia malayi RE15519p 0.0009 0.0016 0.0007
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.033 0.0308
Trypanosoma brucei glucose transporter, putative 0.0032 0.0533 0.6841
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0103 0.1324
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Schistosoma mansoni ran 0.0026 0.0381 0.0455
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0533 0.1973
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0016 0.0004
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2145 0.2136
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0016 0.0004
Brugia malayi nuclear receptor NHR-88 0.001 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Echinococcus granulosus neuropeptide receptor A26 0.0456 1 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.033 0.0961
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.1619 0.1608
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.2976 0.537
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0005
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0533 0.6168
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0016 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0236 0.3028
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0019
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0524 0.0512
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3585 0.5495
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0016 0.0004
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0016 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0016 0.0004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0016 0.0005
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0137 0.5
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0626 0.8029
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0019
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0524 0.0404
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0016 0.0005
Schistosoma mansoni sugar transporter 0.0015 0.0137 0.0154
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0509 0.0901
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0586 0.7519
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0175 0.372 0.4579

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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