Detailed information for compound 1223195

Basic information

Technical information
  • TDR Targets ID: 1223195
  • Name: 4-methoxy-N-(piperidine-1-carbothioyl)benzami de
  • MW: 278.37 | Formula: C14H18N2O2S
  • H donors: 1 H acceptors: 1 LogP: 2.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)NC(=S)N1CCCCC1
  • InChi: 1S/C14H18N2O2S/c1-18-12-7-5-11(6-8-12)13(17)15-14(19)16-9-3-2-4-10-16/h5-8H,2-4,9-10H2,1H3,(H,15,17,19)
  • InChiKey: FFXVNEGIEKMEFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methoxy-N-(1-piperidyl-thioxomethyl)benzamide
  • 4-methoxy-N-piperidin-1-ylcarbothioyl-benzamide
  • ZINC00437325
  • 4-methoxy-N-(1-piperidinylcarbonothioyl)benzamide
  • Oprea1_464810
  • SMR000140220
  • MLS000532782

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyruvate kinase 0.0017 0.002 0.0029
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0073 0.0426 0.4774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.004 0.004
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0429 0.1705
Loa Loa (eye worm) hypothetical protein 0.0073 0.0426 0.0426
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.004 0.0057
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0832 1
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0119 0.0474
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0429 1
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0073 0.0426 0.1768
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0136 0.1311
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0026 0.0141
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0073 0.0426 1
Entamoeba histolytica hypothetical protein 0.0073 0.0426 1
Schistosoma mansoni hypothetical protein 0.0084 0.0503 0.1934
Trypanosoma brucei inositol phosphorylceramide synthase 0.0073 0.0426 0.4774
Giardia lamblia Pyruvate kinase 0.0033 0.0136 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.004 0.004
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0026 0.0141
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0221 1
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0136 0.0486
Loa Loa (eye worm) hypothetical protein 0.0052 0.0277 0.0277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1301 0.513
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0037 0.0264
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0026 0.0141
Loa Loa (eye worm) hypothetical protein 0.0033 0.0136 0.0136
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0221 0.4844
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0166 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.004 0.0015
Schistosoma mansoni thyroid hormone receptor 0.002 0.004 0.0078
Schistosoma mansoni nuclear hormone receptor 0.002 0.004 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.004 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0037 0.0053
Brugia malayi Inositol-1 0.0045 0.0221 0.0197
Schistosoma mansoni coup transcription factor 0.002 0.004 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0073 0.0426 0.1768
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.004 0.0015
Brugia malayi glutaminase DH11.1 0.033 0.2287 0.2268
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0188 0.0742
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0073 0.0426 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.004 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0084 0.0503 0.0479
Loa Loa (eye worm) glutathione reductase 0.0051 0.0267 0.0267
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0221 0.4884
Schistosoma mansoni hypothetical protein 0.0362 0.2517 1
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0037 0.0398
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0026 0.0023
Plasmodium falciparum glutathione reductase 0.0051 0.0267 0.6071
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0026 0.0494
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.004 0.0078
Brugia malayi Thioredoxin reductase 0.0051 0.0267 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.004 0.0015
Brugia malayi hypothetical protein 0.0027 0.0095 0.007
Brugia malayi Pre-SET motif family protein 0.0251 0.1717 0.1696
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1301 0.1863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.004 0.004
Plasmodium vivax sphingomyelin synthase 1, putative 0.0073 0.0426 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.002 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.004 0.004
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0073 0.0426 0.4774
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0026 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1301 0.513
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0206 0.0295
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0267 0.0267
Plasmodium falciparum glutathione reductase 0.0018 0.0026 0.0141
Loa Loa (eye worm) hypothetical protein 0.0073 0.0426 0.0426
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0621 0.2469
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Trichomonas vaginalis hypothetical protein 0.0073 0.0426 0.1768
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.004 0.0015
Echinococcus granulosus pyruvate kinase 0.0017 0.002 0.0081
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0026 0.0104
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0136 0.0136
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0037 0.0053
Loa Loa (eye worm) hypothetical protein 0.0073 0.0426 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.004 0.0015
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0073 0.0426 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0221 0.0805
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0473 0.1812
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.004 0.0015
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0037 0.0401
Entamoeba histolytica hypothetical protein 0.0073 0.0426 1
Brugia malayi jmjC domain containing protein 0.01 0.0621 0.0598
Leishmania major trypanothione reductase 0.0051 0.0267 0.5965
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.0738 0.8837
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0037 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0037 0.0053
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0354 0.0354
Schistosoma mansoni inositol monophosphatase 0.0045 0.0221 0.0805
Schistosoma mansoni hypothetical protein 0.0181 0.1205 0.4744
Schistosoma mansoni hypothetical protein 0.003 0.0119 0.0396
Loa Loa (eye worm) hypothetical protein 0.0264 0.1809 0.1809
Schistosoma mansoni hypothetical protein 0.0362 0.2517 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.004 0.0159
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0037 0.0126
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0095 0.1819
Schistosoma mansoni hypothetical protein 0.0084 0.0503 0.1934
Echinococcus multilocularis pyruvate kinase 0.0026 0.0086 0.0123
Mycobacterium tuberculosis Probable reductase 0.0116 0.0738 0.8837
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0037 0.0262
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.004 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0095 0.1717
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.1301 0.1301
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.015 0.0595
Brugia malayi Latrophilin receptor protein 2 0.0084 0.0503 0.0479
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0429 0.1637
Echinococcus granulosus pyruvate kinase 0.0017 0.002 0.0081
Loa Loa (eye worm) inositol-1 0.0045 0.0221 0.0221
Giardia lamblia PHD finger protein 15 0.003 0.0119 0.856
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.004 0.0057
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0084 0.0503 0.0721
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0084 0.0503 0.1934
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0084 0.0503 0.1999
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.0738 0.8837
Loa Loa (eye worm) hypothetical protein 0.0023 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0558 0.3936 0.3936
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1968 0.859
Leishmania major hypothetical protein, conserved 0.0027 0.0095 0.1703
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0136 0.0111
Echinococcus granulosus GPCR family 2 0.0084 0.0503 0.1999
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0073 0.0426 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1301 0.513
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.004 0.0057
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0026 0.0141
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.004 0.0159
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0267 0.0382
Brugia malayi nuclear receptor NHR-88 0.002 0.004 0.0015
Brugia malayi Calcitonin receptor-like protein seb-1 0.0264 0.1809 0.1789
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0267 0.6071
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0221 0.0863
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Schistosoma mansoni spingomyelin synthetase-related 0.0073 0.0426 0.1624
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0073 0.0426 0.1768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.004 0.004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.004 0.0078
Echinococcus granulosus peregrin 0.003 0.0119 0.0474
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.004 0.0015
Brugia malayi latrophilin 2 splice variant baaae 0.0181 0.1205 0.1183
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0413 0.0592
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0221 0.2332
Echinococcus multilocularis pyruvate kinase 0.0033 0.0136 0.0195
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0136 0.1363
Brugia malayi nuclear hormone receptor 0.002 0.004 0.0015
Brugia malayi isocitrate dehydrogenase 0.0019 0.0037 0.0011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.004 0.0159
Treponema pallidum NADH oxidase 0.0018 0.0026 0.5
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0119 0.2419
Echinococcus granulosus geminin 0.0362 0.2517 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.004 0.0015
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0136 0.2826
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0073 0.0426 0.061
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0136 0.0498
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0136 0.0498
Entamoeba histolytica hypothetical protein 0.0073 0.0426 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.004 0.0078
Loa Loa (eye worm) hypothetical protein 0.0162 0.1074 0.1074
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0095 0.1834
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0429 0.1783
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1301 0.5169
Plasmodium vivax sphingomyelin synthase 2, putative 0.0073 0.0426 1
Plasmodium falciparum phd finger protein, putative 0.003 0.0119 0.2439
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0267 0.6015
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0206 0.0817
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0159 0.0228
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0221 0.4916
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0095 0.1834
Echinococcus multilocularis GPCR, family 2 0.0084 0.0503 0.0721
Entamoeba histolytica hypothetical protein 0.0073 0.0426 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0119 0.2439
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0136 0.0136
Brugia malayi steroid hormone receptor 0.002 0.004 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.004 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.004 0.004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0159 0.0557
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1717 0.1717
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0136 0.0486
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0264 0.1809 0.1809
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0136 0.2849
Echinococcus multilocularis peregrin 0.003 0.0119 0.0171
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0084 0.0503 0.0503
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0037 0.0131
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0136 0.1311
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0073 0.0426 0.1768
Brugia malayi small heat shock protein 0.0558 0.3936 0.3921
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.004 0.0159
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0136 0.0136
Leishmania major pyruvate kinase 0.0033 0.0136 0.2724
Plasmodium falciparum pyruvate kinase 0.0033 0.0136 0.2849
Trichomonas vaginalis glutaminase, putative 0.033 0.2287 1
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0037 0.0398
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0429 0.1783
Echinococcus multilocularis geminin 0.0362 0.2517 0.3604
Echinococcus granulosus sphingomyelin synthase protein 1 0.0073 0.0426 0.1692
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0221 0.0863
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0136 0.0486
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0037 0.0401
Echinococcus granulosus pyruvate kinase 0.0033 0.0136 0.054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Brugia malayi jmjC domain containing protein 0.0037 0.0166 0.0141
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0136 0.2747
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1301 0.5169
Loa Loa (eye worm) glutaminase 0.033 0.2287 0.2287
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0037 0.0126
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0429 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0188 0.2004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0832 1
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0073 0.0426 0.9917
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.004 0.0159
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0221 0.0863
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0166 0.0658
Schistosoma mansoni pyruvate kinase 0.0033 0.0136 0.0463
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.004 0.0057
Brugia malayi glutathione reductase 0.0051 0.0267 0.0242
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0119 0.0119
Echinococcus multilocularis FTZ F1 alpha 0.002 0.004 0.0057
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0073 0.0426 1
Entamoeba histolytica hypothetical membrane-spanning protein 0.0073 0.0426 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0084 0.0503 0.1999
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0073 0.0426 0.4774
Schistosoma mansoni hypothetical protein 0.0133 0.0863 0.3376
Brugia malayi ecdysteroid receptor 0.002 0.004 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0159 0.0557
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0221 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.004 0.0015
Onchocerca volvulus 0.0286 0.1969 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0159 0.0557
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0832 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0159 0.0228
Schistosoma mansoni hypothetical protein 0.0084 0.0503 0.1934
Loa Loa (eye worm) hypothetical protein 0.0036 0.0159 0.0159
Trypanosoma brucei trypanothione reductase 0.0051 0.0267 0.2872
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1301 0.1863
Onchocerca volvulus 0.0036 0.0159 0.062
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0026 0.0037
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0136 0.2747
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.004 0.0078
Onchocerca volvulus 0.0162 0.1074 0.5362
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.0119
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0073 0.0426 0.0402
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0429 0.5004
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0136 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.004 0.0015
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0119 0.2419
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.0738 0.8837
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0119 0.0171
Schistosoma mansoni thyroid hormone receptor 0.002 0.004 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.004 0.0159
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0221 0.4884
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0136 0.0498
Loa Loa (eye worm) latrophilin receptor protein 2 0.0084 0.0503 0.0503
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.004 0.0159
Echinococcus granulosus FTZ F1 alpha 0.002 0.004 0.0159
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0084 0.0503 0.0721
Schistosoma mansoni glutaminase 0.033 0.2287 0.9079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.004 0.0078
Schistosoma mansoni pyruvate kinase 0.0033 0.0136 0.0463
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6984 1
Plasmodium falciparum thioredoxin reductase 0.0051 0.0267 0.6071
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0267 0.2985
Leishmania major pyruvate kinase 0.0033 0.0136 0.2724
Loa Loa (eye worm) glutaminase 2 0.033 0.2287 0.2287
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.004 0.0015
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0095 0.082
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0832 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0159 0.0634
Brugia malayi hypothetical protein 0.0162 0.1074 0.1052
Loa Loa (eye worm) hypothetical protein 0.0073 0.0426 0.0426
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0159 0.3401
Brugia malayi Pre-SET motif family protein 0.0036 0.0159 0.0135
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0037 0.0011
Onchocerca volvulus Alhambra homolog 0.003 0.0119 0.0411
Brugia malayi PHD-finger family protein 0.003 0.0119 0.0094
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0026 0.0139
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0621 0.089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.004 0.0057
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0166 0.0237
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0429 0.0615
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0037 0.0264
Echinococcus granulosus pyruvate kinase 0.0017 0.002 0.0081
Entamoeba histolytica hypothetical protein 0.0073 0.0426 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.004 0.0078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.004 0.0015
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.004 0.0078
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0037 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.004 0.004
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0119 0.0396
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.1301 0.1279
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0037 0.0146
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0413 0.1642
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.0738 0.8837
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.004 0.0078
Chlamydia trachomatis pyruvate kinase 0.0033 0.0136 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0073 0.0426 0.0402
Loa Loa (eye worm) hypothetical protein 0.1396 1 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0136 0.054
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0429 0.1637
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0073 0.0426 0.0402
Brugia malayi Steroid receptor seven-up type 2 0.002 0.004 0.0015
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0064 0.0064
Plasmodium vivax glutathione reductase, putative 0.0051 0.0267 0.6071
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0221 0.088
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0221 0.0317
Toxoplasma gondii thioredoxin reductase 0.0051 0.0267 0.6021
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.004 0.0159
Echinococcus multilocularis pyruvate kinase 0.0017 0.002 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0429 0.1783
Echinococcus multilocularis pyruvate kinase 0.0033 0.0136 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.004 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0426 0.1768
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0073 0.0426 0.0402
Plasmodium vivax SET domain protein, putative 0.0036 0.0159 0.343
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.0738 0.8654
Plasmodium falciparum thioredoxin reductase 0.0018 0.0026 0.0141
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0267 0.1059
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0264 0.1809 0.1789
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.004 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.0738 0.8837
Loa Loa (eye worm) hypothetical protein 0.0181 0.1205 0.1205
Loa Loa (eye worm) hypothetical protein 0.0073 0.0426 0.0426
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0159 0.0557
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0026 0.0139
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0037 0.0065
Brugia malayi Bromodomain containing protein 0.003 0.0119 0.0094
Mycobacterium ulcerans glutaminase 0.033 0.2287 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0095 0.1834
Toxoplasma gondii hypothetical protein 0.0073 0.0426 0.9918
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0166 0.0582
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0095 0.1717
Trypanosoma brucei RNA helicase, putative 0.0133 0.0863 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.004 0.0057
Brugia malayi Sphingomyelin synthase-related 1 0.0073 0.0426 0.0402
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0221 0.4347

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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