Detailed information for compound 1224453

Basic information

Technical information
  • TDR Targets ID: 1224453
  • Name: N-(2,5-diethoxy-4-morpholin-4-ylphenyl)-4-imi dazol-1-yl-3-nitrobenzamide
  • MW: 481.501 | Formula: C24H27N5O6
  • H donors: 1 H acceptors: 4 LogP: 2.76 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(N2CCOCC2)c(cc1NC(=O)c1ccc(c(c1)[N+](=O)[O-])n1ccnc1)OCC
  • InChi: 1S/C24H27N5O6/c1-3-34-22-15-21(27-9-11-33-12-10-27)23(35-4-2)14-18(22)26-24(30)17-5-6-19(20(13-17)29(31)32)28-8-7-25-16-28/h5-8,13-16H,3-4,9-12H2,1-2H3,(H,26,30)
  • InChiKey: YAAXKIGWCZLTQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-diethoxy-4-morpholino-phenyl)-4-imidazol-1-yl-3-nitro-benzamide
  • N-(2,5-diethoxy-4-morpholinophenyl)-4-(1-imidazolyl)-3-nitrobenzamide
  • N-(2,5-diethoxy-4-morpholin-4-yl-phenyl)-4-imidazol-1-yl-3-nitro-benzamide
  • T5218096

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0119 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0525 0.1362
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Echinococcus multilocularis zinc finger protein 0.0024 0.0214 0.0333
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.051 0.0604
Onchocerca volvulus 0.0012 0.0028 0.006
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.2061 0.3212
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0426 0.0499
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0426 0.0499
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0132 0.0239
Trypanosoma brucei glucose transporter, putative 0.0037 0.0434 0.033
Schistosoma mansoni hypothetical protein 0.0129 0.1895 0.2953
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.1702 0.3137
Loa Loa (eye worm) hypothetical protein 0.005 0.0628 0.1629
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0414 0.0645
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0119 0.0115
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0441 0.1405
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0441 0.0658
Trypanosoma cruzi hexose transporter 0.0037 0.0434 0.033
Schistosoma mansoni chromobox protein 0.0073 0.1007 0.1568
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0107 0.0277
Schistosoma mansoni glucose transport protein 0.0121 0.1763 0.2746
Schistosoma mansoni hypothetical protein 0.0197 0.2984 0.465
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0119 1
Onchocerca volvulus 0.0032 0.0351 0.0793
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0088 0.0136
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0426 0.0499
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0441 0.0688
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.1763 0.2748
Plasmodium vivax hexose transporter 0.0121 0.1763 0.2173
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0434 0.033
Brugia malayi hypothetical protein 0.0012 0.0028 0.0069
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0001 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0441 0.0945
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0107 0.0181
Echinococcus multilocularis cpg binding protein 0.0033 0.0359 0.0559
Loa Loa (eye worm) helicase 0.0012 0.0028 0.0072
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0119 0.0013
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0664
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0434 0.033
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0201 0.0186
Echinococcus multilocularis solute carrier family 22 0.0017 0.0107 0.0167
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0266 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0084 0.0128
Onchocerca volvulus 0.0017 0.0107 0.024
Brugia malayi glutathione reductase 0.0051 0.0654 0.1694
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0266 0.0161
Echinococcus granulosus Chromo domain 0.0012 0.0028 0.0043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0441 0.1145
Trypanosoma brucei glucose transporter, putative 0.0037 0.0434 0.033
Echinococcus granulosus solute carrier family 22 0.0017 0.0107 0.0167
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0088 0.0138
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0266 0.0413
Onchocerca volvulus 0.0017 0.0107 0.024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0441 0.0658
Trichomonas vaginalis set domain proteins, putative 0.0287 0.4407 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Brugia malayi Bromodomain containing protein 0.0086 0.1209 0.3134
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0664
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0441 0.1142
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.1702 0.3137
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0414 0.0644
Loa Loa (eye worm) hypothetical protein 0.0038 0.0441 0.1145
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0142 0.022
Plasmodium falciparum thioredoxin reductase 0.0051 0.0654 0.0784
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0072
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0434 0.0927
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0044 0.0111
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0434 0.033
Trypanosoma brucei glucose transporter, putative 0.0037 0.0434 0.033
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0414 0.97
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.191 0.3547
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0119 0.0013
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0414 0.0644
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0121 0.1763 0.2748
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.6416 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0637 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1843 0.4783
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Brugia malayi Sugar transporter family protein 0.0121 0.1763 0.4573
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0426 0.0664
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0119 0.0209
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.1763 0.2748
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0107 0.0181
Plasmodium falciparum glutathione reductase 0.0051 0.0654 0.0784
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0481 0.075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0001 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0132 0.0239
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.1702 0.3137
Trypanosoma brucei glucose transporter 2A 0.0037 0.0434 0.033
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0426 0.0499
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.051 0.0407
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0001 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Onchocerca volvulus 0.0017 0.0107 0.024
Brugia malayi Protein cec-1. 0.0012 0.0028 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0441 0.0686
Brugia malayi Sugar transporter family protein 0.0017 0.0107 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0001 0.0003
Brugia malayi Sugar transporter family protein 0.0017 0.0107 0.0274
Echinococcus multilocularis General substrate transporter 0.0104 0.1492 0.2325
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0426 0.0499
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0441 0.0518
Echinococcus granulosus Chromobox protein 3 0.0012 0.0028 0.0043
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.1265 0.1171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0072
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0426 0.0499
Leishmania major glucose transporter, lmgt1 0.0037 0.0434 0.033
Schistosoma mansoni chromobox protein 0.0012 0.0028 0.0041
Brugia malayi MH2 domain containing protein 0.0126 0.1843 0.4782
Schistosoma mansoni hypothetical protein 0.0413 0.6416 1
Plasmodium falciparum thioredoxin reductase 0.0018 0.0119 0.0115
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0119 0.0175
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0084 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0132 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.0613 0.0953
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.1763 0.2748
Loa Loa (eye worm) hypothetical protein 0.0038 0.0441 0.1145
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0142 0.0221
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0266 0.0161
Schistosoma mansoni zinc finger protein 0.0024 0.0214 0.0331
Onchocerca volvulus 0.0038 0.0441 0.0999
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0389 0.0607
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0421 0.0748
Toxoplasma gondii sugar transporter ST3 0.0017 0.0107 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Toxoplasma gondii ABC1 family protein 0.0038 0.0441 0.0787
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0119 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0421 0.0656
Loa Loa (eye worm) hypothetical protein 0.018 0.2712 0.7038
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.1007 0.2614
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0119 0.0115
Schistosoma mansoni hypothetical protein 0.0197 0.2984 0.465
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.1702 0.8781
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0132 0.0239
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0001 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0056 0.0727 0.1133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0727 0.1131
Schistosoma mansoni hypothetical protein 0.0017 0.0111 0.017
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0206 0.0535
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0654 0.1019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Echinococcus multilocularis muscleblind protein 0.018 0.2712 0.4227
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.1763 0.2748
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0001 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Schistosoma mansoni sugar transporter 0.0017 0.0107 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Leishmania major trypanothione reductase 0.0051 0.0654 0.0553
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Echinococcus granulosus solute carrier family 22 0.0017 0.0107 0.0167
Mycobacterium tuberculosis Conserved hypothetical protein 0.0336 0.519 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.039 0.0607
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0434 0.033
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Plasmodium falciparum hexose transporter 0.0121 0.1763 0.2173
Trypanosoma cruzi ISWI complex protein 0.0017 0.0111 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0426 0.0499
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0434 0.0927
Trypanosoma brucei glucose transporter, putative 0.0037 0.0434 0.033
Echinococcus multilocularis muscleblind protein 1 0.018 0.2712 0.4227
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0142 0.0221
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0028 0.0041
Mycobacterium leprae Probable lipase LipE 0.0038 0.0441 0.1405
Echinococcus granulosus zinc finger protein 0.0024 0.0214 0.0333
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0267 0.0416
Loa Loa (eye worm) hypothetical protein 0.008 0.1105 0.2869
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0934 0.1456
Toxoplasma gondii facilitative glucose transporter GT1 0.0121 0.1763 0.3304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0001 0.0002
Schistosoma mansoni protein kinase 0.0037 0.0426 0.0662
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Onchocerca volvulus 0.0017 0.0107 0.024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0119 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Echinococcus granulosus dnaJ subfamily B 0.0413 0.6416 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0426 0.1103
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0072
Onchocerca volvulus 0.0017 0.0107 0.024
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0119 0.0184
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0119 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0441 0.0338
Trypanosoma brucei glucose transporter 1E 0.0037 0.0434 0.033
Echinococcus granulosus muscleblind protein 0.018 0.2712 0.4227
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0493 0.1062
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1007 0.2237
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0426 0.0499
Loa Loa (eye worm) hypothetical protein 0.0029 0.0306 0.0793
Plasmodium falciparum mitogen-activated protein kinase 2 0.0195 0.295 0.3659
Echinococcus multilocularis chromobox protein 1 0.0073 0.1007 0.157
Trypanosoma brucei glucose transporter, putative 0.0037 0.0434 0.033
Trypanosoma brucei trypanothione reductase 0.0051 0.0654 0.0553
Echinococcus multilocularis chromobox protein 1 0.0073 0.1007 0.157
Brugia malayi hypothetical protein 0.0017 0.0107 0.0274
Brugia malayi CHD4 protein 0.0016 0.0088 0.0226
Onchocerca volvulus 0.0017 0.0107 0.024
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.051 0.0918
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0107 0.0099
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0028 0.0069
Onchocerca volvulus 0.0017 0.0107 0.024
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0434 0.0927
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0001 0.0002
Schistosoma mansoni glucose transporter 0.0017 0.0107 0.0165
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0267 0.0414
Plasmodium vivax glutathione reductase, putative 0.0051 0.0654 0.0784
Schistosoma mansoni chromobox protein 0.0073 0.1007 0.1568
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0119 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0434 0.0927
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0654 0.0784
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0119 0.0013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0119 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0266 0.0439
Schistosoma mansoni glucose transport protein 0.0121 0.1763 0.2746
Schistosoma mansoni hypothetical protein 0.0121 0.1763 0.2746
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0027 0.0266 0.5985
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0441 0.0658
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0028 0.0069
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0441 0.0779
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0132 0.0239
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0195 0.295 0.5563
Echinococcus granulosus cpg binding protein 0.0033 0.0359 0.0559
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0109 0.1578 0.1487
Brugia malayi Muscleblind-like protein 0.018 0.2712 0.7038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Loa Loa (eye worm) hypothetical protein 0.0037 0.0426 0.1105
Mycobacterium ulcerans beta-lactamase 0.0038 0.0441 0.0779
Echinococcus multilocularis geminin 0.0197 0.2984 0.4651
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0107 0.0151
Brugia malayi Bromodomain containing protein 0.0043 0.0523 0.1356
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0441 0.0658
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Schistosoma mansoni cpg binding protein 0.0033 0.0359 0.0557
Brugia malayi beta-lactamase family protein 0.0038 0.0441 0.1142
Treponema pallidum NADH oxidase 0.0018 0.0119 1
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0153 0.0397
Echinococcus multilocularis Chromo domain 0.0012 0.0028 0.0043
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0088 0.0229
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0637 1 1
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0434 0.033
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0107 0.0167
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0664
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.191 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0001 0.0003
Onchocerca volvulus 0.0012 0.0028 0.006
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0426 0.091
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0107 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0119 0.0013
Mycobacterium tuberculosis Conserved protein 0.0038 0.0441 0.0658
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3853 1
Schistosoma mansoni cpg binding protein 0.0029 0.0298 0.0463
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.191 0.3547
Schistosoma mansoni bromodomain containing protein 0.0073 0.0998 0.1554
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0119 0.0186
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0001 0.0002
Echinococcus granulosus chromobox protein 2 0.0012 0.0028 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0301 0.0624
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0934 0.1456
Mycobacterium ulcerans sugar transporter 0.0017 0.0107 0.013
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0028 0.0041
Entamoeba histolytica protein kinase, putative 0.0037 0.0426 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0072
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0266 0.0379
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.051 0.0407
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Schistosoma mansoni thyroid hormone receptor 0.014 0.2061 0.321
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0119 0.0025
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0119 0.0186
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.051 0.0407
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0389 0.0607
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0266 0.0415
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0107 0.0167
Loa Loa (eye worm) hypothetical protein 0.0036 0.0414 0.1074
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0426 0.1105
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0001 0.0003
Brugia malayi CXXC zinc finger family protein 0.0029 0.0298 0.077
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0107 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0001 0.0003
Trypanosoma brucei glucose transporter, putative 0.0037 0.0434 0.033
Loa Loa (eye worm) hypothetical protein 0.0046 0.0567 0.1472
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.1763 0.3962
Trypanosoma brucei glucose transporter, putative 0.0037 0.0434 0.033
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0441 0.0688
Brugia malayi chromobox protein homolog 3 0.0041 0.0493 0.1275
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0426 0.1105
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0441 0.0945
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.1763 0.2748
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0266 0.0413
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0654 0.1019
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.1895 0.2954
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Onchocerca volvulus 0.0017 0.0107 0.024
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0266 0.0687
Leishmania major protein kinase, putative 0.0037 0.0426 0.0323
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0266 0.0454
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0032 0.0081
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0414 0.1246
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.051 0.0407
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0664
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0107 0.0274
Loa Loa (eye worm) hypothetical protein 0.0041 0.0493 0.1278
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0542 0.1228
Trypanosoma cruzi ISWI complex protein 0.0017 0.0111 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0132 0.0239
Brugia malayi hypothetical protein 0.0017 0.0107 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0001 0.0003
Toxoplasma gondii thioredoxin reductase 0.0051 0.0654 0.1192
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0493 0.1115
Brugia malayi SET domain containing protein 0.0014 0.0059 0.015
Loa Loa (eye worm) glutathione reductase 0.0051 0.0654 0.1697
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0441 0.1145
Schistosoma mansoni sugar transporter 0.0017 0.0107 0.0165
Echinococcus granulosus histone lysine methyltransferase setb 0.0056 0.0727 0.1133
Brugia malayi major facilitator superfamily protein 0.0017 0.0107 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0107 0.0181
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0107 0.0167
Loa Loa (eye worm) hypothetical protein 0.0038 0.0441 0.1145
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0441 0.0338
Loa Loa (eye worm) hypothetical protein 0.0038 0.0441 0.1145
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0434 0.033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0266 0.069
Brugia malayi Thioredoxin reductase 0.0051 0.0654 0.1694
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0001 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0001 0.0002
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0001 0.0002
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0028 0.0041
Brugia malayi Cam kinase protein 1 0.0037 0.0426 0.1103
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1007 0.2237
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1843 0.4783
Onchocerca volvulus 0.0017 0.0107 0.024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0132 0.0239
Echinococcus multilocularis solute carrier family 22 0.0017 0.0107 0.0167
Leishmania major hypothetical protein, conserved 0.0017 0.0111 0.0004
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0028 0.0069
Brugia malayi hypothetical protein 0.0017 0.0107 0.0274
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0073 0.019
Plasmodium falciparum protein kinase 7 0.0341 0.528 0.6577
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.3703 0.7076
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.1895 0.2954
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0213 0.0423
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.1702 0.3137
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0201 0.0186
Trypanosoma brucei ISWI complex protein 0.0017 0.0111 0.0004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0119 0.3506
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0119 0.0154
Echinococcus multilocularis solute carrier family 22 0.0017 0.0107 0.0167
Leishmania major glucose transporter, lmgt2 0.0037 0.0434 0.033
Plasmodium falciparum glutathione reductase 0.0018 0.0119 0.0115
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0302 0.4646 0.4588
Onchocerca volvulus Putative transporter 0.0017 0.0107 0.024
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0426 0.0759
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0119 0.0013
Schistosoma mansoni thyroid hormone receptor 0.014 0.2061 0.321
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Brugia malayi PHD-finger family protein 0.003 0.0309 0.08
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0426 0.0499
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Onchocerca volvulus 0.0038 0.0441 0.0999
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0414 0.0645
Echinococcus granulosus solute carrier family 22 0.0017 0.0107 0.0167
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0302 0.4646 0.4588
Mycobacterium tuberculosis Conserved protein 0.0038 0.0441 0.0658
Loa Loa (eye worm) sugar transporter 0.0017 0.0107 0.0277
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0664
Onchocerca volvulus 0.0017 0.0107 0.024
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0107 0.013
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.1763 0.2748
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0001 0.0002
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0028 0.0043
Loa Loa (eye worm) hypothetical protein 0.0056 0.0727 0.1886
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0001 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0132 0.0239
Mycobacterium tuberculosis Probable reductase 0.0117 0.1702 0.3137
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0302 0.4646 0.4588
Schistosoma mansoni protein kinase 0.0037 0.0426 0.0662
Onchocerca volvulus 0.0049 0.0613 0.1387
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0266 0.0298
Onchocerca volvulus 0.0017 0.0107 0.024
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0441 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0301 0.0624
Onchocerca volvulus 0.0017 0.0107 0.024
Onchocerca volvulus 0.0038 0.0441 0.0999
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0414 0.1072
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0654 0.0553
Echinococcus granulosus FTZ F1 alpha 0.001 0.0001 0.0002
Brugia malayi Pre-SET motif family protein 0.0252 0.3853 1
Echinococcus granulosus geminin 0.0197 0.2984 0.4651
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0266 0.0544
Schistosoma mansoni sugar transporter 0.0017 0.0107 0.0165
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0119 0.0154
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0107 0.0165
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0001 0.0002
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0654 0.1697
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0542 0.1175
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0441 0.0945
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0119 0.0013
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0434 0.033
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0266 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0107 0.013
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0028 0.0043
Onchocerca volvulus 0.0017 0.0107 0.024
Echinococcus granulosus chromobox protein 1 0.0073 0.1007 0.157
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0119 1
Brugia malayi major facilitator superfamily protein 0.0017 0.0107 0.0274
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0654 0.1076
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0072
Trypanosoma brucei DNA polymerase beta thumb, putative 0.009 0.1265 0.1171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0727 0.1131
Echinococcus multilocularis chromobox protein 2 0.0012 0.0028 0.0043
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Plasmodium falciparum proline--tRNA ligase 0.0042 0.051 0.0604
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0119 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0414 0.0882
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0426 0.0759
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0119 0.0209
Schistosoma mansoni protein kinase 0.0037 0.0426 0.0662
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0195 0.295 0.3659
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0434 0.0927
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0266 0.5182
Mycobacterium ulcerans hypothetical protein 0.0336 0.519 1
Brugia malayi Pre-SET motif family protein 0.0037 0.0421 0.1089
Toxoplasma gondii sugar transporter ST1 0.0017 0.0107 0.0151
Onchocerca volvulus 0.0017 0.0107 0.024
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0637 1 1
Trichomonas vaginalis esterase, putative 0.0038 0.0441 0.0945
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0441 0.0658
Trypanosoma cruzi hexose transporter, putative 0.002 0.0163 0.0056
Onchocerca volvulus 0.0287 0.4407 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0044 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0426 0.0662
Schistosoma mansoni hypothetical protein 0.0012 0.0028 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.009 0.1265 0.1171
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0119 0.0406
Onchocerca volvulus 0.0029 0.0298 0.0673
Echinococcus granulosus solute carrier family 22 0.0017 0.0107 0.0167
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0441 0.0686
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0426 0.0759
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0119 0.0175
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0434 0.0927
Mycobacterium ulcerans lipase LipD 0.0038 0.0441 0.0779
Schistosoma mansoni hypothetical protein 0.0023 0.0206 0.032
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Toxoplasma gondii sugar transporter ST2 0.0017 0.0107 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0107 0.0181
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0107 0.0274
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0441 0.0945
Brugia malayi beta-lactamase 0.0038 0.0441 0.1142
Schistosoma mansoni cpg binding protein 0.0033 0.0359 0.0557
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0426 0.0323
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0119 0.0013
Echinococcus granulosus chromobox protein 1 0.0073 0.1007 0.157
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0266 0.0415
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0441 0.0658
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0001 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0837 0.1303
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0434 0.0927
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.1702 0.3137
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0441 0.0658
Plasmodium vivax SET domain protein, putative 0.0037 0.0421 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0142 0.022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0421 0.0654
Onchocerca volvulus 0.0017 0.0107 0.024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0481 0.075
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0107 0.0277
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.1763 0.2748
Loa Loa (eye worm) beta-lactamase 0.0038 0.0441 0.1145
Leishmania major hypothetical protein, conserved 0.0038 0.0441 0.0338
Trypanosoma brucei glucose transporter, putative 0.0037 0.0434 0.033
Schistosoma mansoni zinc finger protein 0.0017 0.0111 0.017
Leishmania major glucose transporter, lmgt3 0.0037 0.0434 0.033
Toxoplasma gondii protein kinase, putative 0.0341 0.528 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0441 0.0945
Loa Loa (eye worm) hypothetical protein 0.0038 0.0441 0.1145
Plasmodium falciparum protein kinase 6 0.0513 0.8015 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0267 0.0416
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0775 0.1423
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0072
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0266 0.0298
Onchocerca volvulus 0.0017 0.0107 0.024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0107 0.0277
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0072
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0119 0.0013
Entamoeba histolytica protein kinase, putative 0.0037 0.0426 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0107 0.0167
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0266 0.0439
Echinococcus multilocularis solute carrier family 22 0.0017 0.0107 0.0167
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0664
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.051 0.0407
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0119 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Toxoplasma gondii hypothetical protein 0.0103 0.1475 0.2756
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0107 0.013
Schistosoma mansoni chromobox protein 0.0012 0.0028 0.0041
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0107 0.0181
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0119 0.0013
Brugia malayi Heterochromatin protein 1 0.0073 0.1007 0.2612
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0119 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Mycobacterium ulcerans hypothetical protein 0.0038 0.0441 0.0779
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0028 0.0069
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.1265 0.1171
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Loa Loa (eye worm) hypothetical protein 0.0032 0.0351 0.091
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0298 0.0773
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0107 0.0181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0119 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0119 0.0013
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0028 0.0043
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0426 0.0664
Schistosoma mansoni glucose transport protein 0.0121 0.1763 0.2746
Plasmodium vivax CDK-related protein kinase 6, putative 0.0513 0.8015 1
Plasmodium vivax sugar transporter, putative 0.0017 0.0107 0.0099
Echinococcus granulosus General substrate transporter 0.0104 0.1492 0.2325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0076 0.0111
Mycobacterium tuberculosis Conserved protein 0.0038 0.0441 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0493 0.1062
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0414 0.1074
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0414 0.1072
Loa Loa (eye worm) hypothetical protein 0.018 0.2712 0.7038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0119 0.0013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0001 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0441 0.0779
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0107 0.0274
Brugia malayi beta-lactamase family protein 0.0038 0.0441 0.1142
Schistosoma mansoni sugar transporter 0.0017 0.0107 0.0165
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.191 0.3547
Loa Loa (eye worm) sugar transporter 0.0121 0.1763 0.4575
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0088 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0107 0.0181
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0542 0.1175

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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