Detailed information for compound 1229819

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.363 | Formula: C18H19N3O
  • H donors: 1 H acceptors: 3 LogP: 3.3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1n(CCC2=CCCCC2)cnc2c1nc1c2cccc1
  • InChi: 1S/C18H19N3O/c22-18-17-16(14-8-4-5-9-15(14)20-17)19-12-21(18)11-10-13-6-2-1-3-7-13/h4-6,8-9,12,22H,1-3,7,10-11H2
  • InChiKey: KHLYPNYZYMYTHL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0501 0.0559
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.1077 0.2773
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0638 0.164
Plasmodium vivax SET domain protein, putative 0.0031 0.0184 0.1289
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.1099 0.3496
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0626 0.0841
Leishmania major DNA polymerase kappa, putative 0.0019 0.0065 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0065 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.1346 0.1787
Brugia malayi glutathione reductase 0.0051 0.0396 0.0532
Onchocerca volvulus 0.0195 0.188 0.7866
Loa Loa (eye worm) glutaminase 0.0266 0.2622 0.3507
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0119 0.1099 0.1364
Loa Loa (eye worm) hypothetical protein 0.0074 0.0626 0.0815
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0762 0.7751 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0065 0.0044
Mycobacterium ulcerans L-lysine aminotransferase 0.0044 0.0318 0.0896
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0065 0.017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.1099 0.1244
Schistosoma mansoni hypothetical protein 0.0049 0.0374 0.0385
Onchocerca volvulus 0.0149 0.1409 0.5723
Trypanosoma brucei glucosidase, putative 0.0075 0.0638 0.1747
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0065 0.0044
Echinococcus granulosus microtubule associated protein 2 0.0833 0.849 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.1077 0.1334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1346 0.1537
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0396 0.0966
Mycobacterium leprae conserved hypothetical protein 0.0119 0.1099 0.2855
Mycobacterium ulcerans hypothetical protein 0.0192 0.1853 0.6005
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0044 0.0318 0.0896
Schistosoma mansoni cpg binding protein 0.0035 0.0225 0.0208
Mycobacterium ulcerans glutaminase 0.0266 0.2622 0.8564
Schistosoma mansoni cpg binding protein 0.0035 0.0225 0.0208
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0638 0.4443
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0119 0.0668
Brugia malayi CHE-14 protein 0.0051 0.0393 0.0528
Echinococcus granulosus neutral alpha glucosidase AB 0.0075 0.0638 0.0721
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0065 0.017
Loa Loa (eye worm) glutathione reductase 0.0051 0.0396 0.0505
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0184 0.016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0202 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0638 0.164
Mycobacterium tuberculosis Probable hydrolase 0.0119 0.1099 0.1364
Echinococcus multilocularis beta LACTamase domain containing family member 0.0119 0.1099 0.1075
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0638 0.196
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.019 0.1348
Mycobacterium ulcerans esterase/lipase LipP 0.0119 0.1099 0.3496
Echinococcus granulosus expressed conserved protein 0.0112 0.1021 0.1174
Mycobacterium tuberculosis Probable esterase LipL 0.0119 0.1099 0.1364
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0501 0.1504
Loa Loa (eye worm) hypothetical protein 0.0119 0.1099 0.1454
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0217 0.0292
Echinococcus multilocularis GPCR, family 2 0.0034 0.0217 0.019
Echinococcus granulosus geminin 0.0515 0.5198 0.611
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0044 0.0318 0.0896
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0184 0.1289
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0393 0.0432
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.0638 0.196
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0044 0.0318 0.035
Schistosoma mansoni intermediate filament proteins 0.0033 0.0202 0.0181
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0396 0.0966
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1651 0.4533
Onchocerca volvulus 0.0033 0.0202 0.0224
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0153 0.0205
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1095 0.1262
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0978 0.129
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0044 0.0318 0.035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1346 0.1322
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.849 0.8486
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.019 0.0394
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1255 0.1428
Schistosoma mansoni hypothetical protein 0.0034 0.0217 0.0199
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0598 0.0651
Echinococcus granulosus intermediate filament protein 0.0033 0.0202 0.0206
Trichomonas vaginalis glutaminase, putative 0.0266 0.2622 0.8564
Echinococcus granulosus Aminotransferase class III 0.0044 0.0318 0.0343
Onchocerca volvulus 0.0031 0.0184 0.0144
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0217 0.0292
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0049 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1255 0.1428
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0025
Mycobacterium tuberculosis Probable aminotransferase 0.0308 0.3054 0.3901
Onchocerca volvulus 0.0033 0.0202 0.0224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1346 0.1558
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0119 0.1099 0.3496
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.364 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0119 0.1099 0.1454
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0065 0.0058
Echinococcus granulosus dna polymerase kappa 0.0019 0.0065 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0501 0.0535
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.1355 0.1331
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0065 0.0037
Mycobacterium ulcerans beta-lactamase 0.0119 0.1099 0.3496
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0396 0.0967
Brugia malayi hypothetical protein 0.0144 0.1355 0.1822
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0044 0.0318 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.1021 0.0996
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0065 0.0037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0396 0.0451
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0065 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0638 0.196
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1853 0.2342
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0075 0.0638 0.5608
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.1099 0.2925
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0184 0.016
Mycobacterium tuberculosis Conserved protein 0.0119 0.1099 0.1364
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Echinococcus granulosus lamin 0.0033 0.0202 0.0206
Leishmania major alpha glucosidase II subunit, putative 0.0075 0.0638 0.164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0978 0.1315
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0217 0.019
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0501 0.1259
Echinococcus multilocularis Aminotransferase class III 0.0044 0.0318 0.0291
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0217 0.0224
Brugia malayi Pre-SET motif family protein 0.0211 0.2048 0.2753
Loa Loa (eye worm) TAR-binding protein 0.0134 0.1255 0.1663
Loa Loa (eye worm) hypothetical protein 0.0062 0.0512 0.0661
Plasmodium vivax glutathione reductase, putative 0.0051 0.0396 0.3305
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0049 0.0127
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0501 0.0587
Trichomonas vaginalis esterase, putative 0.0119 0.1099 0.3496
Mycobacterium tuberculosis Probable lipase LipE 0.0119 0.1099 0.1364
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0049 0.0127
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0153 0.0346
Plasmodium vivax ornithine aminotransferase, putative 0.0044 0.0318 0.2564
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0217 0.019
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.1077 0.1334
Loa Loa (eye worm) hypothetical protein 0.0034 0.0217 0.0264
Schistosoma mansoni lamin 0.0033 0.0202 0.0181
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0044 0.0318 0.035
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.1099 0.3496
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0044 0.0318 0.0896
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0044 0.0318 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0184 0.016
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.1077 0.1334
Loa Loa (eye worm) hypothetical protein 0.0119 0.1095 0.1448
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1255 0.1428
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0978 0.1315
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0153 0.0683
Schistosoma mansoni glutaminase 0.0266 0.2622 0.3049
Echinococcus granulosus lamin dm0 0.0033 0.0202 0.0206
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.1355 0.1547
Schistosoma mansoni DNA polymerase eta 0.0045 0.0328 0.0331
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1623 0.1886
Loa Loa (eye worm) hypothetical protein 0.0119 0.1099 0.1454
Loa Loa (eye worm) hypothetical protein 0.0119 0.1099 0.1454
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0501 0.0475
Loa Loa (eye worm) hypothetical protein 0.0051 0.0393 0.0501
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1095 0.1071
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.1255 0.1663
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2048 0.2733
Loa Loa (eye worm) hypothetical protein 0.0045 0.0328 0.0414
Plasmodium falciparum glutathione reductase 0.0051 0.0396 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0153 0.0346
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0044 0.0318 1
Echinococcus granulosus cpg binding protein 0.0035 0.0225 0.0233
Loa Loa (eye worm) glutaminase 2 0.0266 0.2622 0.3507
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0165 0.0163
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.364 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0217 0.0264
Brugia malayi beta-lactamase 0.0119 0.1099 0.1478
Echinococcus multilocularis musashi 0.0033 0.0202 0.0175
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1623 0.16
Schistosoma mansoni survival motor neuron protein 0.0149 0.1409 0.1612
Loa Loa (eye worm) hypothetical protein 0.0031 0.0184 0.022
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0153 0.0346
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.1099 0.2925
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1114 0.1262
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.1099 0.3496
Onchocerca volvulus 0.0119 0.1099 0.4311
Brugia malayi beta-lactamase family protein 0.0119 0.1099 0.1478
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0153 0.0289
Brugia malayi RNA binding protein 0.0134 0.1255 0.1687
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0202 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0393 0.1145
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0075 0.0638 0.0831
Echinococcus granulosus GPCR family 2 0.0034 0.0217 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0184 0.0185
Schistosoma mansoni alpha glucosidase 0.0075 0.0638 0.0698
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.1077 0.1334
Brugia malayi CXXC zinc finger family protein 0.0033 0.0205 0.0276
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.1099 0.3496
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0065 0.0044
Toxoplasma gondii ABC1 family protein 0.0119 0.1099 1
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.1212 0.151
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0065 0.002
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.849 1
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.1255 0.1687
Loa Loa (eye worm) RNA binding protein 0.0134 0.1255 0.1663
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1346 0.1558
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0044 0.0318 0.2564
Loa Loa (eye worm) hypothetical protein 0.0732 0.7437 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0153 0.0289
Brugia malayi beta-lactamase family protein 0.0119 0.1099 0.1478
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0065 0.0044
Echinococcus granulosus dnaJ subfamily B 0.0468 0.4714 0.5538
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0153 0.0346
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0501 0.1504
Mycobacterium ulcerans lipase LipD 0.0119 0.1099 0.3496
Plasmodium vivax hypothetical protein, conserved 0.0119 0.1099 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.1212 0.3267
Echinococcus multilocularis ornithine aminotransferase 0.0044 0.0318 0.0291
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0638 0.196
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.1099 0.1244
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0119 0.2021
Schistosoma mansoni lamin 0.0033 0.0202 0.0181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0132
Trichomonas vaginalis set domain proteins, putative 0.024 0.2348 0.7653
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0184 0.0157
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0153 0.0346
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0044 0.0318 0.0896
Giardia lamblia DINP protein human, muc B family 0.0019 0.0065 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0065 0.0019
Echinococcus granulosus tar DNA binding protein 0.0134 0.1255 0.145
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0638 0.4443
Echinococcus granulosus dna polymerase eta 0.0045 0.0328 0.0355
Echinococcus multilocularis lysosomal alpha glucosidase 0.0337 0.3349 0.333
Schistosoma mansoni alpha-glucosidase 0.029 0.2864 0.3335
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1255 0.1428
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0153 0.0346
Entamoeba histolytica hypothetical protein 0.0144 0.1355 1
Echinococcus multilocularis dnaJ subfamily B 0.0468 0.4714 0.4699
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0065 0.0019
Leishmania major trypanothione reductase 0.0051 0.0396 0.0967
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0044 0.0318 0.0428
Onchocerca volvulus 0.0033 0.0205 0.0239
Mycobacterium tuberculosis Probable reductase 0.0117 0.1077 0.1334
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0393 0.0432
Schistosoma mansoni alpha-glucosidase 0.029 0.2864 0.3335
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Echinococcus multilocularis survival motor neuron protein 1 0.0732 0.7437 0.743
Echinococcus multilocularis lamin 0.0033 0.0202 0.0175
Schistosoma mansoni hypothetical protein 0.0049 0.0374 0.0385
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0521 0.4497
Schistosoma mansoni tar DNA-binding protein 0.0134 0.1255 0.1428
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0638 0.196
Schistosoma mansoni hypothetical protein 0.0034 0.0217 0.0199
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0308 0.3054 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1095 0.1473
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.1409 0.1895
Entamoeba histolytica hypothetical protein 0.0144 0.1355 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0119 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0065 0.017
Echinococcus granulosus lysosomal alpha glucosidase 0.0337 0.3349 0.3925
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0045 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0638 0.196
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1095 0.7989
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0396 0.0436
Schistosoma mansoni hypothetical protein 0.0515 0.5198 0.61
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0308 0.3054 0.3901
Brugia malayi Pre-SET motif family protein 0.0031 0.0184 0.0248
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0328 0.0896
Echinococcus granulosus survival motor neuron protein 1 0.0732 0.7437 0.8756
Toxoplasma gondii hypothetical protein 0.0059 0.0474 0.4044
Loa Loa (eye worm) hypothetical protein 0.0119 0.1099 0.1454
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0396 0.0505
Echinococcus multilocularis cpg binding protein 0.0035 0.0225 0.0198
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0328 0.0441
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0065 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1346 0.1537
Echinococcus multilocularis protein dispatched 1 0.0058 0.0467 0.0441
Schistosoma mansoni hypothetical protein 0.0149 0.1409 0.1612
Onchocerca volvulus 0.0119 0.1099 0.4311
Loa Loa (eye worm) hypothetical protein 0.0108 0.0978 0.129
Echinococcus multilocularis protein patched 0.0051 0.0393 0.0366
Brugia malayi hypothetical protein 0.0025 0.0119 0.016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1651 0.4463
Entamoeba histolytica hypothetical protein 0.0144 0.1355 1
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0308 0.3054 1
Schistosoma mansoni hypothetical protein 0.0034 0.0217 0.0199
Echinococcus multilocularis ornithine aminotransferase 0.0044 0.0318 0.0291
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0119 0.0195
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0119 0.1099 0.1364
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0119 0.2021
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0202 0.0243
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0501 0.4303
Mycobacterium ulcerans hypothetical protein 0.0308 0.3054 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1651 0.4463
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0044 0.0318 0.035
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0127
Treponema pallidum NADH oxidase 0.0018 0.0049 0.5
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.1212 0.151
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0501 0.1504
Schistosoma mansoni hypothetical protein 0.0074 0.0626 0.0683
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.1355 0.1569
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0638 0.196
Echinococcus multilocularis dna polymerase eta 0.0045 0.0328 0.0302
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0119 0.0668
Brugia malayi glutaminase DH11.1 0.0266 0.2622 0.3526
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Echinococcus multilocularis neutral alpha glucosidase AB 0.0075 0.0638 0.0612
Schistosoma mansoni hypothetical protein 0.0049 0.0374 0.0385
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0153 0.0413
Schistosoma mansoni hypothetical protein 0.0049 0.0374 0.0385
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1346 0.1537
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0065 0.0052
Trichomonas vaginalis sucrase-isomaltase, putative 0.0075 0.0638 0.196
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0393 0.0366
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0065 0.0052
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0202 0.0271
Echinococcus multilocularis tar DNA binding protein 0.0134 0.1255 0.1231
Echinococcus multilocularis lysosomal alpha glucosidase 0.0337 0.3349 0.333
Leishmania major DNA polymerase eta, putative 0.0045 0.0328 0.0778
Plasmodium falciparum thioredoxin reductase 0.0051 0.0396 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0065 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0127
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0328 0.0778
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0153 0.0346
Mycobacterium tuberculosis Conserved protein 0.0119 0.1099 0.1364
Leishmania major hypothetical protein, conserved 0.0119 0.1099 0.2925
Leishmania major hypothetical protein, conserved 0.0025 0.0119 0.0195
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0337 0.3349 0.4487
Schistosoma mansoni hypothetical protein 0.0034 0.0217 0.0199
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0638 0.196
Mycobacterium ulcerans hypothetical protein 0.0119 0.1099 0.3496
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0045 0.0032
Onchocerca volvulus 0.024 0.2348 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.1346 0.181
Echinococcus multilocularis lamin dm0 0.0033 0.0202 0.0175
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0119 0.1099 0.1364
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.1212 0.151
Brugia malayi TAR-binding protein 0.0134 0.1255 0.1687
Schistosoma mansoni hypothetical protein 0.0515 0.5198 0.61
Plasmodium falciparum ornithine aminotransferase 0.0044 0.0318 0.7757
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0205 0.0248
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0065 0.0052
Brugia malayi hypothetical protein 0.0732 0.7437 1
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0396 0.3305
Schistosoma mansoni hypothetical protein 0.0144 0.1355 0.1547
Schistosoma mansoni hypothetical protein 0.0468 0.4714 0.5526
Brugia malayi intermediate filament protein 0.0033 0.0202 0.0271
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.1099 0.3496
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.1077 0.1334
Trypanosoma brucei hypothetical protein, conserved 0.0119 0.1099 0.3015
Mycobacterium tuberculosis Probable lipase LipD 0.0119 0.1099 0.1364
Echinococcus granulosus beta LACTamase domain containing family member 0.0119 0.1099 0.1266
Echinococcus multilocularis geminin 0.0515 0.5198 0.5185
Onchocerca volvulus 0.0119 0.1099 0.4311
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0396 0.037
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0396 0.1081
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.0638 0.0858
Trypanosoma brucei unspecified product 0.0019 0.0065 0.017
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0501 0.0535
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0065 0.0052
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0153 0.0289
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0119 0.1099 0.1478
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0184 0.016
Schistosoma mansoni cpg binding protein 0.0033 0.0205 0.0185
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0512 0.1289
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0396 0.0966
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0008
Mycobacterium leprae Probable lipase LipE 0.0119 0.1099 0.2855
Brugia malayi Thioredoxin reductase 0.0051 0.0396 0.0532
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0119 0.032
Trypanosoma brucei trypanothione reductase 0.0051 0.0396 0.1082
Brugia malayi hypothetical protein 0.0016 0.0029 0.0039
Entamoeba histolytica hypothetical protein 0.0144 0.1355 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.017
Toxoplasma gondii thioredoxin reductase 0.0051 0.0396 0.3305
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0153 0.0346
Mycobacterium tuberculosis Conserved protein 0.0119 0.1099 0.1364
Echinococcus granulosus ornithine aminotransferase 0.0044 0.0318 0.0343
Loa Loa (eye worm) hypothetical protein 0.0119 0.1099 0.1454
Mycobacterium ulcerans acetylornithine aminotransferase 0.0044 0.0318 0.0896
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.364 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0184 0.0157
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0217 0.0224
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0308 0.3054 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0196 0.0235
Loa Loa (eye worm) hypothetical protein 0.0028 0.0153 0.0177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1346 0.1322
Loa Loa (eye worm) hypothetical protein 0.0119 0.1099 0.1454
Brugia malayi Glycosyl hydrolases family 31 protein 0.0337 0.3349 0.4503
Loa Loa (eye worm) beta-lactamase 0.0119 0.1099 0.1454
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.364 1
Schistosoma mansoni patched 1 0.0051 0.0393 0.0408
Leishmania major DNA polymerase eta, putative 0.0031 0.019 0.0394
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0393 0.0501

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.72 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 0.4467 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.