TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 580.197 | Formula: C21H20Cl2INO6
H donors: 3 H acceptors: 5 LogP: 2.5 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(=O)O.Ic1ccc(cc1)C1(CCNCC1)C(=O)OCc1ccc(c(c1)Cl)Cl
InChi: 1S/C19H18Cl2INO2.C2H2O4/c20-16-6-1-13(11-17(16)21)12-25-18(24)19(7-9-23-10-8-19)14-2-4-15(22)5-3-14;3-1(4)2(5)6/h1-6,11,23H,7-10,12H2;(H,3,4)(H,5,6)
InChiKey: CJZABXVCLKCYJQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Dopamine transporter	Starlite/ChEMBL	References
Rattus norvegicus	Serotonin transporter	Starlite/ChEMBL	References
Rattus norvegicus	Transporter	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	582 aa	35.2 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Serotonin transporter	630 aa	617 aa	39.4 %
Echinococcus granulosus	sodium and chloride dependent glycine	Transporter	617 aa	507 aa	38.9 %
Drosophila melanogaster	CG13796 gene product from transcript CG13796-RD	Serotonin transporter	630 aa	638 aa	25.1 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	576 aa	31.8 %
Onchocerca volvulus		Transporter	617 aa	586 aa	37.4 %
Schistosoma mansoni	sodium/chloride dependent transporter	Serotonin transporter	630 aa	605 aa	37.7 %
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Serotonin transporter	630 aa	581 aa	40.1 %
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Dopamine transporter	619 aa	604 aa	37.9 %
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Serotonin transporter	630 aa	520 aa	36.2 %
Onchocerca volvulus	High affinity copper uptake protein 1 homolog	Serotonin transporter	630 aa	629 aa	47.1 %
Drosophila melanogaster	CG1698 gene product from transcript CG1698-RA	Serotonin transporter	630 aa	585 aa	34.2 %
Onchocerca volvulus	Transmembrane protein 120 homolog	Serotonin transporter	630 aa	571 aa	31.2 %
Plasmodium knowlesi	transporter, putative	Serotonin transporter	630 aa	514 aa	20.2 %
Schistosoma mansoni	sodium/chloride dependent transporter	Serotonin transporter	630 aa	552 aa	41.5 %
Onchocerca volvulus		Serotonin transporter	630 aa	611 aa	26.4 %
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	Transporter	617 aa	522 aa	22.0 %
Echinococcus granulosus	sodium and chloride dependent glycine	Serotonin transporter	630 aa	617 aa	39.4 %
Plasmodium falciparum	transporter, putative	Transporter	617 aa	497 aa	21.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	576 aa	30.9 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Transporter	617 aa	507 aa	38.9 %
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	Serotonin transporter	630 aa	509 aa	28.3 %
Plasmodium vivax	hypothetical protein, conserved	Serotonin transporter	630 aa	528 aa	21.2 %
Neospora caninum	sodium-dependent transporter, putative	Dopamine transporter	619 aa	498 aa	32.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0966	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0966	0.0966
Loa Loa (eye worm)	cysteine protease	0.0478	0.3294	0.3294
Plasmodium falciparum	transporter, putative	0.0212	0.0966	0.2931
Trypanosoma cruzi	cysteine peptidase, putative	0.0645	0.4745	1
Loa Loa (eye worm)	hypothetical protein	0.0325	0.1959	0.1959
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0212	0.0966	0.0966
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0254	0.1336	0.1336
Onchocerca volvulus		0.0212	0.0966	0.0966
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0212	0.0966	0.0966
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0254	0.1336	0.1336
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0478	0.3294	1
Echinococcus granulosus	cathepsin b	0.0605	0.4403	0.4403
Brugia malayi	Cathepsin L-like precursor	0.0478	0.3294	0.3294
Trypanosoma cruzi	cysteine peptidase, putative	0.0645	0.4745	1
Entamoeba histolytica	cysteine protease, putative	0.0478	0.3294	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.3294	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0605	0.4403	0.4403
Echinococcus granulosus	cathepsin l1	0.0478	0.3294	0.3294
Echinococcus multilocularis	cathepsin L cysteine protease	0.0478	0.3294	0.3294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Echinococcus multilocularis	cathepsin b	0.0605	0.4403	0.4403
Loa Loa (eye worm)	hypothetical protein	0.0478	0.3294	0.3294
Schistosoma mansoni	cathepsin s	0.0153	0.0454	0.0454
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Plasmodium falciparum	amino acid transporter, putative	0.0212	0.0966	0.2931
Giardia lamblia	Cathepsin B precursor	0.0257	0.1362	1
Brugia malayi	Cathepsin L-like precursor	0.0325	0.1959	0.1959
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0212	0.0966	0.0966
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0212	0.0966	0.0966
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0212	0.0966	0.0966
Plasmodium vivax	hypothetical protein, conserved	0.0212	0.0966	0.2931
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0212	0.0966	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0325	0.1959	0.1959
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.3294	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0153	0.0454	0.0454
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Loa Loa (eye worm)	hypothetical protein	0.0605	0.4403	0.4403
Leishmania major	cathepsin L-like protease	0.0478	0.3294	0.5712
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0454	0.0454
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0212	0.0966	0.0966
Onchocerca volvulus		0.0325	0.1959	0.1959
Entamoeba histolytica	cysteine proteinase, putative	0.0325	0.1959	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0325	0.1959	0.1959
Leishmania major	cathepsin L-like protease	0.0478	0.3294	0.5712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Entamoeba histolytica	cysteine proteinase, putative	0.0478	0.3294	1
Toxoplasma gondii	hypothetical protein	0.0212	0.0966	0.2931
Echinococcus granulosus	sodium and chloride dependent glycine	0.0212	0.0966	0.0966
Leishmania major	cathepsin L-like protease	0.0478	0.3294	0.5712
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.3294	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0478	0.3294	0.3294
Leishmania major	cathepsin L-like protease	0.0478	0.3294	0.5712
Plasmodium vivax	vivapain-1	0.0254	0.1336	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.3294	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0605	0.4403	0.928
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0212	0.0966	0.0966
Brugia malayi	cathepsin B-like cysteine proteinase	0.0605	0.4403	0.4403
Onchocerca volvulus		0.0478	0.3294	0.3294
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0212	0.0966	0.0966
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Onchocerca volvulus	Cathepsin L homolog	0.0478	0.3294	0.3294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0325	0.1959	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.3294	1
Plasmodium vivax	amine transporter, putative	0.0212	0.0966	0.2931
Toxoplasma gondii	hypothetical protein	0.0212	0.0966	0.2931
Onchocerca volvulus		0.0212	0.0966	0.0966
Trypanosoma cruzi	cysteine peptidase, putative	0.0254	0.1336	0.2815
Onchocerca volvulus		0.0478	0.3294	0.3294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0254	0.1336	0.4054
Plasmodium vivax	vivapain-3	0.0254	0.1336	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0325	0.1959	0.5946
Leishmania major	cathepsin L-like protease	0.0645	0.4745	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Brugia malayi	Papain family cysteine protease containing protein	0.0478	0.3294	0.3294
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0478	0.3294	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0212	0.0966	0.0966
Brugia malayi	Cathepsin L-like precursor	0.0478	0.3294	0.3294
Entamoeba histolytica	cysteine proteinase 1, putative	0.0254	0.1336	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0254	0.1336	0.1336
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Echinococcus multilocularis	cathepsin b	0.0605	0.4403	0.4403
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0212	0.0966	0.0966
Leishmania major	cathepsin L-like protease	0.0645	0.4745	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0153	0.0454	0.0957
Entamoeba histolytica	cysteine proteinase, putative	0.0254	0.1336	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0325	0.1959	0.1959
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0212	0.0966	0.0966
Entamoeba histolytica	cysteine proteinase, putative	0.0478	0.3294	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0254	0.1336	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0478	0.3294	0.3294
Onchocerca volvulus		0.0212	0.0966	0.0966
Onchocerca volvulus		0.1247	1	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0212	0.0966	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0966	0.0966
Echinococcus multilocularis	serotonin transporter	0.1247	1	1
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0212	0.0966	0.0966
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Toxoplasma gondii	cathepsin B	0.0257	0.1362	0.4134
Loa Loa (eye worm)	hypothetical protein	0.1247	1	1
Loa Loa (eye worm)	norepinephrine transporter	0.1247	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0257	0.1362	0.4134
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0212	0.0966	0.2931
Echinococcus multilocularis	cysteine protease	0.0478	0.3294	0.3294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Onchocerca volvulus	Cathepsin F homolog	0.0478	0.3294	0.3294
Entamoeba histolytica	cysteine proteinase, putative	0.0254	0.1336	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0325	0.1959	0.1959
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0605	0.4403	0.4403
Entamoeba histolytica	cysteine proteinase 2	0.0254	0.1336	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0254	0.1336	0.1336
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Loa Loa (eye worm)	fibroinase	0.0478	0.3294	0.3294
Echinococcus granulosus	cathepsin l1	0.0325	0.1959	0.1959
Loa Loa (eye worm)	ctsf protein	0.0478	0.3294	0.3294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Loa Loa (eye worm)	serotonin transporter b	0.1247	1	1
Onchocerca volvulus		0.0478	0.3294	0.3294
Trypanosoma cruzi	cysteine protease, putative	0.0254	0.1336	0.2815
Plasmodium vivax	vivapain-2	0.0478	0.3294	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0478	0.3294	0.3294
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0492	0.3409	0.7185
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Brugia malayi	cathepsin L-like precursor	0.0325	0.1959	0.1959
Plasmodium vivax	unspecified product	0.0254	0.1336	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0645	0.4745	1
Leishmania major	cathepsin L-like protease	0.0645	0.4745	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0212	0.0966	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0966	0.0966
Trypanosoma cruzi	cysteine proteinase, putative	0.0254	0.1336	0.2815
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0605	0.4403	0.4403
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0605	0.4403	0.4403
Echinococcus granulosus	cysteine protease	0.0254	0.1336	0.1336
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1247	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0257	0.1362	0.287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Onchocerca volvulus		0.0478	0.3294	0.3294
Brugia malayi	cathepsin F-like cysteine proteinase	0.0153	0.0454	0.0454
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.3294	1
Onchocerca volvulus		0.0478	0.3294	0.3294
Brugia malayi	Cathepsin L-like precursor	0.0478	0.3294	0.3294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0478	0.3294	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0212	0.0966	0.0966
Echinococcus multilocularis	cathepsin L cysteine protease	0.0478	0.3294	0.3294
Echinococcus granulosus	sodium and chloride dependent glycine	0.0212	0.0966	0.0966
Schistosoma mansoni	cathepsin F (C01 family)	0.0478	0.3294	0.3294
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0254	0.1336	0.2815
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0325	0.1959	0.1959
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0212	0.0966	0.0966
Onchocerca volvulus	Cathepsin L homolog	0.0478	0.3294	0.3294
Schistosoma mansoni	sodium/chloride dependent transporter	0.1247	1	1
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0212	0.0966	0.2931
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0212	0.0966	0.0966
Schistosoma mansoni	sodium/chloride dependent transporter	0.0212	0.0966	0.0966
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.3294	0.6943
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0478	0.3294	0.3294
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0966	0.0966
Brugia malayi	Cathepsin L-like precursor	0.0153	0.0454	0.0454
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0478	0.3294	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0153	0.0454	0.0454
Entamoeba histolytica	cysteine proteinase, putative	0.0254	0.1336	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0257	0.1362	0.0077
Trypanosoma cruzi	cruzipain precursor, putative	0.0645	0.4745	1
Giardia lamblia	Cathepsin B precursor	0.0257	0.1362	1
Plasmodium vivax	vivapain-2	0.0478	0.3294	1
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0212	0.0966	0.0966
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0212	0.0966	0.0966
Trypanosoma cruzi	major cysteine proteinase, putative	0.0267	0.145	0.3057
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0478	0.3294	0.3294
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0478	0.3294	1
Toxoplasma gondii	cathepsin CPL	0.0478	0.3294	1
Brugia malayi	Cathepsin L-like precursor	0.0478	0.3294	0.3294
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.3294	1
Brugia malayi	hypothetical protein	0.0212	0.0966	0.0966
Echinococcus multilocularis	cysteine protease	0.0478	0.3294	0.3294
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0454	0.0454
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0254	0.1336	0.2815
Loa Loa (eye worm)	cathepsin B	0.0257	0.1362	0.1362
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0966	0.0966
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0478	0.3294	0.3294
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0212	0.0966	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0966	0.0966
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.3294	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Onchocerca volvulus		0.0478	0.3294	0.3294
Schistosoma mansoni	cathepsin F (C01 family)	0.0478	0.3294	0.3294
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0212	0.0966	0.0966
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0212	0.0966	0.0966
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0254	0.1336	0.4054
Onchocerca volvulus		0.0478	0.3294	0.3294
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0212	0.0966	0.5
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0212	0.0966	0.0966
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0478	0.3294	0.3294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Treponema pallidum	sodium- and chloride- dependent transporter	0.1247	1	0.5
Brugia malayi	Cathepsin L-like precursor	0.0478	0.3294	0.3294
Plasmodium vivax	unspecified product	0.0153	0.0454	0.1378
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0645	0.4745	1
Echinococcus granulosus	cathepsin b	0.0605	0.4403	0.4403
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Echinococcus multilocularis	cathepsin L	0.0254	0.1336	0.1336
Echinococcus granulosus	cathepsin L	0.0254	0.1336	0.1336
Giardia lamblia	Cathepsin B precursor	0.0257	0.1362	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.3294	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0153	0.0454	0.0957
Loa Loa (eye worm)	hypothetical protein	0.1247	1	1
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054
Leishmania major	cysteine peptidase A (CPA)	0.0478	0.3294	0.5712
Echinococcus granulosus	serotonin transporter	0.1247	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0257	0.1362	0.1362
Loa Loa (eye worm)	hypothetical protein	0.1247	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0254	0.1336	0.1336
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.3294	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0454	0.0454
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0254	0.1336	0.1336
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0212	0.0966	0.2931
Entamoeba histolytica	cysteine proteinase, putative	0.0254	0.1336	0.4054
Leishmania major	cathepsin L-like protease	0.0478	0.3294	0.5712
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0212	0.0966	0.0966
Loa Loa (eye worm)	solute carrier family 6 member 4	0.1247	1	1
Entamoeba histolytica	cysteine protease, putative	0.0254	0.1336	0.4054

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 5.9 nM	Displacement of [3H]citalopram from serotonin transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation counting	ChEMBL.	20980153
Ki (binding)	= 4342 nM	Displacement of [3H]WIN 35428 from dopamine transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation counting	ChEMBL.	20980153
Ki (binding)	= 6059 nM	Displacement of [3H]nisoxetine from norepinephrine transporter in Sprague-Dawley rat frontal cortex after 1 hr by liquid scintillation counting	ChEMBL.	20980153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1289972

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1265754