Detailed information for compound 1265909

Basic information

Technical information
  • TDR Targets ID: 1265909
  • Name: (8R,10R,13S)-10,13-dimethyl-9,11,12,14,15,16- hexahydro-8H-cyclopenta[a]phenanthrene-3,17-d ione
  • MW: 282.377 | Formula: C19H22O2
  • H donors: 0 H acceptors: 2 LogP: 3 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=C[C@]2(C(=C1)C=C[C@@H]1C2CC[C@]2(C1CCC2=O)C)C
  • InChi: 1S/C19H22O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3-4,7,9,11,14-16H,5-6,8,10H2,1-2H3/t14-,15?,16?,18-,19-/m0/s1
  • InChiKey: DKVSUQWCZQBWCP-XBSBRVCNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (8R,10R,13S)-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthrene-3,17-quinone
  • STOCK1N-51472

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus pyruvate kinase 0.0017 0.0102 0.0207
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0121 0.1561 0.3225
Echinococcus granulosus acetylcholinesterase 0.0235 0.3175 0.6564
Echinococcus granulosus caspase 0.0124 0.1607 0.332
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1447 0.4044
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1895 0.3916
Brugia malayi tailless protein 0.0108 0.1379 0.2851
Echinococcus multilocularis caspase 8 0.0047 0.052 0.1073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.052 0.1207
Loa Loa (eye worm) hypothetical protein 0.004 0.042 0.0865
Echinococcus multilocularis neutral alpha glucosidase AB 0.0078 0.0964 0.1991
Brugia malayi hypothetical protein 0.0121 0.1561 0.3228
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Loa Loa (eye worm) hypothetical protein 0.0228 0.308 0.6367
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.023 0.1541
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0313 0.0643
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1215 0.2512
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0271 0.0443
Loa Loa (eye worm) hypothetical protein 0.0017 0.0106 0.0216
Schistosoma mansoni nuclear hormone receptor 0.0228 0.308 0.7432
Echinococcus multilocularis cpg binding protein 0.003 0.0289 0.0594
Echinococcus multilocularis caspase 2 0.009 0.1136 0.2346
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0331 0.0627
Brugia malayi Pre-SET motif family protein 0.0032 0.0313 0.0646
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0409 0.0843
Mycobacterium tuberculosis Conserved protein 0.0112 0.1447 0.1337
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0409 0.0866
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0271 0.0503
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0228 0.308 0.7432
Trichomonas vaginalis sucrase-isomaltase, putative 0.0078 0.0964 0.2566
Schistosoma mansoni cpg binding protein 0.003 0.0289 0.069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0313 0.0748
Brugia malayi nuclear receptor NHR-88 0.0108 0.1379 0.2851
Schistosoma mansoni nuclear receptor 0.0108 0.1379 0.3323
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0228 0.308 0.6367
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0409 0.0866
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0126 0.2947
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0737 0.1773
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0108 0.1379 0.2849
Trypanosoma cruzi metacaspase, putative 0.0047 0.052 0.3561
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0228 0.308 0.7432
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.023 0.3061
Loa Loa (eye worm) hypothetical protein 0.0228 0.308 0.6367
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0047 0.052 0.125
Leishmania major pyruvate kinase 0.0033 0.0331 0.2245
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0348 0.0679
Echinococcus multilocularis caspase 3 0.0077 0.0946 0.1953
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0331 0.0682
Echinococcus multilocularis pyruvate kinase 0.0017 0.0102 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1215 0.2927
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0126 0.0821
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0266 0.0546
Schistosoma mansoni ap endonuclease 0.0019 0.0126 0.0298
Trichomonas vaginalis spcc417.12 protein, putative 0.004 0.042 0.0899
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.1447 0.2992
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0313 0.0748
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0337 0.2283
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Brugia malayi beta-lactamase 0.0112 0.1447 0.2992
Leishmania major pyruvate kinase 0.0033 0.0331 0.2245
Echinococcus granulosus tumor protein p63 0.0348 0.4767 0.9857
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0126 0.1072
Schistosoma mansoni alpha-glucosidase 0.0303 0.4143 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0228 0.308 0.6367
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.004 0.042 0.0899
Mycobacterium ulcerans hypothetical protein 0.0112 0.1447 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0313 0.0748
Schistosoma mansoni coup transcription factor 0.0228 0.308 0.7432
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0121 0.1561 0.3763
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0337 0.2283
Trypanosoma cruzi metacaspase, putative 0.0047 0.052 0.3561
Mycobacterium ulcerans beta-lactamase 0.0112 0.1447 1
Brugia malayi ecdysteroid receptor 0.0228 0.308 0.6369
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0351 0.0228
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0313 0.2115
Onchocerca volvulus 0.0112 0.1447 0.4082
Echinococcus multilocularis lysosomal alpha glucosidase 0.0353 0.4836 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.308 0.6367
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0126 0.0258
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.004 0.042 0.0865
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0331 0.2245
Mycobacterium tuberculosis Conserved protein 0.0112 0.1447 0.1337
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.004 0.042 0.0297
Echinococcus granulosus lysosomal alpha glucosidase 0.0353 0.4836 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0228 0.308 0.7432
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.052 0.1207
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0331 0.0627
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0271 0.056
Onchocerca volvulus 0.0108 0.1379 0.3874
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0337 0.2283
Schistosoma mansoni gliotactin 0.004 0.042 0.1007
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0331 0.0685
Loa Loa (eye worm) carboxylesterase 0.004 0.042 0.0865
Brugia malayi hypothetical protein 0.004 0.042 0.0868
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0126 0.0258
Onchocerca volvulus 0.004 0.042 0.0956
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.052 0.1207
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0126 0.5
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0331 0.1551
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0409 0.0843
Schistosoma mansoni inositol monophosphatase 0.0039 0.0409 0.0981
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0331 0.2245
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0228 0.308 0.6369
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0475 0.0979
Echinococcus multilocularis muscleblind protein 0.018 0.2406 0.4973
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0228 0.308 0.6369
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0026 0.005
Schistosoma mansoni alpha-glucosidase 0.0303 0.4143 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Brugia malayi Plexin repeat family protein 0.0017 0.0106 0.0219
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.052 0.3561
Echinococcus multilocularis muscleblind protein 1 0.018 0.2406 0.4973
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0409 0.0866
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.052 0.3561
Loa Loa (eye worm) hypothetical protein 0.018 0.2406 0.4973
Mycobacterium tuberculosis Conserved protein 0.0112 0.1447 0.1337
Loa Loa (eye worm) hypothetical protein 0.0235 0.3175 0.6564
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.1027 1
Trypanosoma brucei metacaspase 5, putative 0.0047 0.052 0.3561
Schistosoma mansoni pyruvate kinase 0.0033 0.0331 0.0793
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Loa Loa (eye worm) nuclear hormone receptor 0.0108 0.1379 0.2849
Echinococcus multilocularis pyruvate kinase 0.0033 0.0331 0.0682
Loa Loa (eye worm) hypothetical protein 0.004 0.042 0.0865
Schistosoma mansoni hypothetical protein 0.0012 0.0026 0.0055
Brugia malayi Carboxylesterase family protein 0.0235 0.3175 0.6566
Loa Loa (eye worm) DR-78 0.0108 0.1379 0.2849
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0228 0.308 0.7432
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0108 0.1379 0.2851
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.052 0.3561
Brugia malayi nuclear hormone receptor 0.0108 0.1379 0.2851
Brugia malayi ecdysone receptor 0.0108 0.1379 0.2851
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.023 0.1541
Loa Loa (eye worm) inositol-1 0.0039 0.0409 0.0843
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Trichomonas vaginalis maltase-glucoamylase, putative 0.0078 0.0964 0.2566
Onchocerca volvulus 0.0044 0.0475 0.1124
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.023 0.1541
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0228 0.308 0.6367
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0102 0.065
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0964 0.2566
Echinococcus granulosus pyruvate kinase 0.0033 0.0331 0.0682
Mycobacterium tuberculosis Carboxylesterase LipT 0.004 0.042 0.0297
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0121 0.1561 0.3225
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0964 0.6644
Echinococcus multilocularis ecdysone induced protein 78C 0.0228 0.308 0.6367
Brugia malayi Pre-SET motif family protein 0.022 0.2964 0.6128
Brugia malayi MH2 domain containing protein 0.0144 0.1895 0.3918
Onchocerca volvulus 0.0029 0.0266 0.0486
Brugia malayi orphan nuclear receptor NR2E1 0.0108 0.1379 0.2851
Schistosoma mansoni nuclear hormone receptor 0.0108 0.1379 0.3323
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.1447 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2964 0.6127
Brugia malayi hypothetical protein 0.0044 0.0475 0.0982
Brugia malayi Nuclear hormone receptor-like 1 0.0121 0.1561 0.3228
Schistosoma mansoni nuclear hormone receptor 0.0108 0.1379 0.3323
Mycobacterium leprae Probable lipase LipE 0.0112 0.1447 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0126 0.0258
Schistosoma mansoni steroid hormone receptor ad4bp 0.0228 0.308 0.7432
Schistosoma mansoni thyroid hormone receptor 0.0228 0.308 0.7432
Brugia malayi Cell death protein 3 precursor 0.009 0.1136 0.2349
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0108 0.1379 0.3323
Brugia malayi hypothetical protein 0.0017 0.0099 0.0204
Trypanosoma brucei metacaspase MCA2 0.0047 0.052 0.3561
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0228 0.308 0.6367
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0964 0.2566
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0331 0.1706
Loa Loa (eye worm) hypothetical protein 0.0044 0.0475 0.0979
Brugia malayi Glycosyl hydrolases family 31 protein 0.0353 0.4836 1
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0331 0.2245
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0271 0.1827
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0288 0.0593
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0108 0.1379 0.2849
Brugia malayi nuclear receptor NHR-67 0.0108 0.1379 0.2851
Loa Loa (eye worm) hypothetical protein 0.0121 0.1561 0.3225
Brugia malayi Steroid receptor seven-up type 2 0.0228 0.308 0.6369
Echinococcus granulosus family S9 non peptidase ue S09 family 0.004 0.042 0.0865
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.004 0.042 0.0297
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0409 0.2786
Trichomonas vaginalis set domain proteins, putative 0.025 0.3391 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0108 0.1379 0.2849
Loa Loa (eye worm) hypothetical protein 0.0026 0.023 0.0472
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1447 0.4044
Echinococcus granulosus cpg binding protein 0.003 0.0289 0.0594
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0228 0.308 0.6367
Brugia malayi nuclear hormone receptor 0.0228 0.308 0.6369
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0228 0.308 0.6367
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0228 0.308 0.6367
Brugia malayi Carboxylesterase family protein 0.004 0.042 0.0868
Schistosoma mansoni plexin 0.0017 0.0106 0.0248
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0409 0.3139
Loa Loa (eye worm) hypothetical protein 0.004 0.042 0.0865
Onchocerca volvulus 0.004 0.042 0.0956
Brugia malayi conserved hypotetical protein 0.0108 0.1379 0.2851
Brugia malayi CXXC zinc finger family protein 0.0029 0.0266 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.052 0.1207
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0124 0.1607 0.332
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.1447 0.1337
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0409 0.2786
Schistosoma mansoni ap endonuclease 0.0019 0.0126 0.0298
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) carboxylesterase 0.004 0.042 0.0865
Loa Loa (eye worm) hypothetical protein 0.0112 0.1447 0.2989
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0124 0.1607 0.332
Echinococcus granulosus BC026374 protein S09 family 0.004 0.042 0.0865
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0331 0.0208
Loa Loa (eye worm) hypothetical protein 0.0228 0.308 0.6367
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1447 0.4044
Loa Loa (eye worm) hypothetical protein 0.004 0.042 0.0865
Leishmania major hypothetical protein, conserved 0.0112 0.1447 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0228 0.308 0.9053
Loa Loa (eye worm) hypothetical protein 0.0228 0.308 0.6367
Loa Loa (eye worm) hypothetical protein 0.0112 0.1447 0.2989
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.052 0.1207
Giardia lamblia Pyruvate kinase 0.0033 0.0331 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.1027 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0228 0.308 0.6367
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0271 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0228 0.308 0.6367
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.004 0.042 0.1007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.1447 0.1337
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.052 0.1207
Schistosoma mansoni pyruvate kinase 0.0033 0.0331 0.0793
Brugia malayi nuclear receptor RXR 0.0108 0.1379 0.2851
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.004 0.042 0.1007
Schistosoma mansoni rotamase 0.0035 0.0348 0.0834
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0337 0.2283
Echinococcus multilocularis caspase 0.0124 0.1607 0.332
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0348 0.072
Schistosoma mansoni hypothetical protein 0.0191 0.2558 0.617
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0228 0.308 0.6369
Echinococcus granulosus pyruvate kinase 0.0017 0.0102 0.0207
Plasmodium vivax hypothetical protein, conserved 0.0112 0.1447 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0228 0.308 0.6367
Loa Loa (eye worm) carboxylesterase 0.0235 0.3175 0.6564
Loa Loa (eye worm) hypothetical protein 0.018 0.2406 0.4973
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0271 0.1827
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0409 0.2786
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0228 0.308 0.6367
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0331 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0228 0.308 0.6369
Schistosoma mansoni hypothetical protein 0.0044 0.0475 0.114
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0002 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1447 0.4044
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0108 0.1379 0.2849
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0964 0.9301
Leishmania major alpha glucosidase II subunit, putative 0.0078 0.0964 0.6644
Onchocerca volvulus 0.0112 0.1447 0.4082
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1215 0.2509
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0337 0.2335
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0228 0.308 0.6369
Brugia malayi Carboxylesterase family protein 0.004 0.042 0.0868
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0126 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0228 0.308 0.6369
Brugia malayi Carboxylesterase family protein 0.004 0.042 0.0868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0228 0.308 0.6367
Mycobacterium ulcerans lipase LipD 0.0112 0.1447 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.023 0.3061
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0287 0.0591
Schistosoma mansoni inositol monophosphatase 0.0039 0.0409 0.0981
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.1447 0.1337
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0121 0.1561 0.3225
Onchocerca volvulus 0.0204 0.2738 0.8012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0557
Echinococcus granulosus pyruvate kinase 0.0033 0.0331 0.0682
Brugia malayi nuclear hormone receptor family member nhr-6 0.0108 0.1379 0.2851
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.1447 0.1337
Schistosoma mansoni retinoic acid receptor RXR 0.0228 0.308 0.7432
Onchocerca volvulus Cell death protein 3 homolog 0.009 0.1136 0.3135
Loa Loa (eye worm) hypothetical protein 0.0047 0.052 0.1073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.052 0.1207
Schistosoma mansoni caspase-7 (C14 family) 0.009 0.1136 0.2736
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0331 0.0686
Loa Loa (eye worm) hypothetical protein 0.0023 0.0189 0.0387
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.1447 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0271 0.0443
Toxoplasma gondii ABC1 family protein 0.0112 0.1447 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.1561 0.3225
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0228 0.308 0.6369
Schistosoma mansoni caspase-3 (C14 family) 0.0124 0.1607 0.3874
Echinococcus granulosus Nuclear hormone receptor HR96 0.0108 0.1379 0.2849
Brugia malayi Cytochrome P450 family protein 0.003 0.0288 0.0596
Onchocerca volvulus 0.0032 0.0313 0.0629
Brugia malayi hypothetical protein 0.0108 0.1379 0.2851
Onchocerca volvulus Protein ultraspiracle homolog 0.0228 0.308 0.9053
Mycobacterium leprae conserved hypothetical protein 0.0112 0.1447 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0271 0.1606
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0331 0.0682
Echinococcus granulosus neutral alpha glucosidase AB 0.0078 0.0964 0.1991
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.052 0.1207
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0409 0.2786
Echinococcus multilocularis pyruvate kinase 0.0017 0.0102 0.0207
Toxoplasma gondii exonuclease III APE 0.0019 0.0126 0.0821
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.1447 1
Plasmodium falciparum pyruvate kinase 0.0033 0.0331 0.548
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0353 0.4836 1
Loa Loa (eye worm) beta-lactamase 0.0112 0.1447 0.2989
Onchocerca volvulus 0.0108 0.1379 0.3874
Brugia malayi hypothetical protein 0.0026 0.023 0.0475
Echinococcus multilocularis pyruvate kinase 0.0026 0.0232 0.0476
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0964 0.2566
Brugia malayi Glycosyl hydrolases family 31 protein 0.0078 0.0964 0.1993
Echinococcus multilocularis FTZ F1 alpha 0.0228 0.308 0.6367
Schistosoma mansoni BC026374 protein (S09 family) 0.004 0.042 0.1007
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0078 0.0964 0.6644
Brugia malayi steroid hormone receptor 0.0228 0.308 0.6369
Onchocerca volvulus Bile acid receptor homolog 0.0228 0.308 0.9053
Loa Loa (eye worm) hypothetical protein 0.0235 0.3175 0.6564
Echinococcus granulosus ecdysone induced protein 78C 0.0228 0.308 0.6367
Echinococcus granulosus nuclear receptor nhr 48 0.0108 0.1379 0.2849
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.1447 0.2989
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0228 0.308 0.6367
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0271 0.0443
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0228 0.308 0.6367
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0126 0.0183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0108 0.1379 0.2849
Echinococcus granulosus pyruvate kinase 0.0017 0.0102 0.0207
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0228 0.308 0.6369
Brugia malayi Nuclear hormone receptor E75 0.0108 0.1379 0.2851
Echinococcus multilocularis nuclear receptor nhr 48 0.0108 0.1379 0.2849
Schistosoma mansoni neuroligin 3 (S09 family) 0.004 0.042 0.1007
Trypanosoma brucei metacaspase 0.0047 0.052 0.3561
Echinococcus multilocularis tumor protein p63 0.0348 0.4767 0.9857
Loa Loa (eye worm) hypothetical protein 0.004 0.042 0.0865
Trichomonas vaginalis rotamase, putative 0.0035 0.0348 0.0679
Onchocerca volvulus 0.004 0.042 0.0956
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.052 0.1207
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.052 0.1207
Brugia malayi plexin A 0.0021 0.0151 0.0312
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.052 0.1207
Echinococcus granulosus FTZ F1 alpha 0.0228 0.308 0.6367
Schistosoma mansoni nuclear receptor 0.0108 0.1379 0.3323
Schistosoma mansoni alpha glucosidase 0.0078 0.0964 0.2321
Trypanosoma brucei Metacaspase-4 0.0047 0.052 0.3561
Leishmania major hypothetical protein, conserved 0.0026 0.023 0.1541
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0026 0.005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0409 0.2141
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0313 0.0748
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0964 0.9301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0228 0.308 0.6367
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Loa Loa (eye worm) hypothetical protein 0.0121 0.1561 0.3225
Echinococcus multilocularis carboxylesterase 5A 0.0235 0.3175 0.6564
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0126 0.0821
Brugia malayi hypothetical protein 0.0121 0.1561 0.3228
Loa Loa (eye worm) plexin A 0.0021 0.0151 0.0309
Echinococcus granulosus thyroid hormone receptor alpha 0.0108 0.1379 0.2849
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0409 0.2786
Brugia malayi beta-lactamase family protein 0.0112 0.1447 0.2992
Trypanosoma cruzi metacaspase, putative 0.0047 0.052 0.3561
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1447 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0271 0.0443
Echinococcus multilocularis para nitrobenzyl esterase 0.004 0.042 0.0865
Brugia malayi nuclear hormone receptor family member odr-7 0.0108 0.1379 0.2851
Loa Loa (eye worm) hypothetical protein 0.0051 0.0578 0.1192
Brugia malayi Nuclear hormone receptor-like 1 0.0228 0.308 0.6369
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0121 0.1561 0.3763
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1215 0.2509
Trypanosoma brucei metacaspase MCA3 0.0047 0.052 0.3561
Echinococcus granulosus neuroligin 0.004 0.042 0.0865
Loa Loa (eye worm) hypothetical protein 0.0112 0.1447 0.2989
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0108 0.1379 0.2849
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0271 0.0443
Brugia malayi Nuclear hormone receptor E75 0.0108 0.1379 0.2851
Trichomonas vaginalis esterase, putative 0.0112 0.1447 0.4044
Echinococcus multilocularis acetylcholinesterase 0.0235 0.3175 0.6564
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1215 0.2509
Echinococcus granulosus expressed protein 0.0035 0.0348 0.0717
Schistosoma mansoni acetylcholinesterase 0.004 0.042 0.1007
Echinococcus granulosus caspase 3 0.0077 0.0946 0.1953
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0964 0.2566
Schistosoma mansoni pyruvate kinase 0.0017 0.0102 0.0238
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0271 0.1827
Brugia malayi Muscleblind-like protein 0.018 0.2406 0.4975
Loa Loa (eye worm) hypothetical protein 0.0112 0.1447 0.2989
Echinococcus granulosus para nitrobenzyl esterase 0.004 0.042 0.0865
Onchocerca volvulus 0.0112 0.1447 0.4082
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0578 0.1389
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0228 0.308 0.6367
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.1447 0.1337
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0108 0.1379 0.3874
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0108 0.1379 0.2849
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0228 0.308 0.6369
Loa Loa (eye worm) nuclear receptor NHR-67 0.0108 0.1379 0.2849
Echinococcus granulosus geminin 0.0191 0.2558 0.5287
Mycobacterium ulcerans carboxylesterase, LipT 0.004 0.042 0.2224
Brugia malayi Carboxylesterase family protein 0.004 0.042 0.0868
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0964 0.2566
Brugia malayi photoreceptor-specific nuclear receptor 0.0228 0.308 0.6369
Echinococcus granulosus carboxylesterase 5A 0.0235 0.3175 0.6564
Chlamydia trachomatis pyruvate kinase 0.0033 0.0331 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0271 0.0443
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.052 0.1207
Schistosoma mansoni caspase-7 (C14 family) 0.0124 0.1607 0.3874
Echinococcus granulosus muscleblind protein 0.018 0.2406 0.4973
Echinococcus multilocularis pyruvate kinase 0.0033 0.0331 0.0682
Echinococcus multilocularis neuroligin 0.004 0.042 0.0865
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0108 0.1379 0.3323
Echinococcus granulosus acetylcholinesterase 0.0235 0.3175 0.6564
Loa Loa (eye worm) hypothetical protein 0.0083 0.1027 0.2121
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.004 0.042 0.1007
Echinococcus multilocularis BC026374 protein (S09 family) 0.004 0.042 0.0865
Brugia malayi hypothetical protein 0.0108 0.1379 0.2851
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0313 0.0643
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0126 0.0261
Loa Loa (eye worm) hypothetical protein 0.0228 0.308 0.6367
Schistosoma mansoni thyroid hormone receptor 0.0228 0.308 0.7432
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1895 0.3916
Schistosoma mansoni zinc finger protein 0.0108 0.1379 0.3323
Echinococcus granulosus caspase 8 0.0047 0.052 0.1073
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0108 0.1379 0.2849
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0331 0.0686
Echinococcus multilocularis lysosomal alpha glucosidase 0.0353 0.4836 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0964 0.2566
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0331 0.0686
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1447 0.3487
Schistosoma mansoni cpg binding protein 0.003 0.0289 0.069
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0964 0.2566
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0108 0.1379 0.3874
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0351 0.0182
Loa Loa (eye worm) acetylcholinesterase 1 0.0235 0.3175 0.6564
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.052 0.1207
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1447 0.4044
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.052 0.3561
Echinococcus granulosus plexin a4 0.0021 0.0151 0.0309
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0228 0.308 0.7432
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0228 0.308 0.6369
Brugia malayi nuclear receptor RXR 0.0121 0.1561 0.3228
Brugia malayi Nuclear hormone receptor-like 1 0.0121 0.1561 0.3228
Plasmodium vivax SET domain protein, putative 0.0032 0.0313 0.1567
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0331 0.0682
Schistosoma mansoni hypothetical protein 0.0191 0.2558 0.617
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0348 0.0717
Trichomonas vaginalis rotamase, putative 0.0034 0.0337 0.0644
Plasmodium falciparum metacaspase-like protein 0.0047 0.052 1
Brugia malayi nuclear receptor NHR-88 0.0228 0.308 0.6369
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0078 0.0964 0.1991
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0126 0.0821
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0331 0.2245
Loa Loa (eye worm) hypothetical protein 0.0108 0.1379 0.2849
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0047 0.052 0.1076
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0228 0.308 0.6367
Plasmodium falciparum metacaspase 1 0.0047 0.052 1
Onchocerca volvulus 0.0228 0.308 0.9053
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1447 1
Loa Loa (eye worm) hypothetical protein 0.004 0.042 0.0865
Schistosoma mansoni RAR-like nuclear receptor 0.0228 0.308 0.7432
Loa Loa (eye worm) hypothetical protein 0.0121 0.1561 0.3225
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0228 0.308 0.6367
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0313 0.0643
Plasmodium vivax metacaspase 1, putative 0.0047 0.052 0.3113
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0643
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1215 0.2509
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0189 0.0691
Loa Loa (eye worm) steroid hormone receptor 0.0228 0.308 0.6367
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0964 0.6644
Echinococcus multilocularis expressed protein 0.0035 0.0348 0.0717
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0228 0.308 0.6367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1215 0.2927
Loa Loa (eye worm) hypothetical protein 0.0228 0.308 0.6367
Loa Loa (eye worm) hypothetical protein 0.0228 0.308 0.6367
Brugia malayi beta-lactamase family protein 0.0112 0.1447 0.2992
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.052 0.1207
Schistosoma mansoni nuclear receptor nhr-48 0.0108 0.1379 0.3323
Schistosoma mansoni cpg binding protein 0.0029 0.0266 0.0634
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0228 0.308 0.6367
Echinococcus multilocularis acetylcholinesterase 0.0235 0.3175 0.6564
Echinococcus granulosus Nuclear hormone receptor HR96 0.0108 0.1379 0.2849
Echinococcus granulosus caspase 2 0.009 0.1136 0.2346
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0337 0.2283
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0228 0.308 0.6369
Trypanosoma cruzi metacaspase, putative 0.0047 0.052 0.3561
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.023 0.1541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1215 0.2927
Loa Loa (eye worm) hypothetical protein 0.0121 0.1561 0.3225
Loa Loa (eye worm) hypothetical protein 0.009 0.1136 0.2346
Plasmodium vivax hypothetical protein, conserved 0.0047 0.052 0.3113
Echinococcus multilocularis thyroid hormone receptor alpha 0.0228 0.308 0.6367
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0228 0.308 0.6369
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0271 0.1827
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.023 0.0953
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0235 0.3175 0.7662
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.1447 0.1337
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.1447 0.2989
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0645 0.4427
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.052 0.3561
Echinococcus multilocularis pyruvate kinase 0.0017 0.0102 0.0207
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0331 0.2245
Loa Loa (eye worm) hypothetical protein 0.004 0.042 0.0865
Trypanosoma brucei glucosidase, putative 0.0078 0.0964 0.6644
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.052 0.1207
Loa Loa (eye worm) hypothetical protein 0.0112 0.1447 0.2989
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0228 0.308 0.6369
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0331 0.0685
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0126 0.0821
Onchocerca volvulus 0.025 0.3391 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0228 0.308 0.7432
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0189 0.0387
Leishmania major metacaspase, putative 0.0047 0.052 0.3561
Echinococcus multilocularis plexin a4 0.0021 0.0151 0.0309
Loa Loa (eye worm) hypothetical protein 0.0112 0.1447 0.2989
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1447 0.3487
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1215 0.2509
Brugia malayi Carboxylesterase family protein 0.0235 0.3175 0.6566
Onchocerca volvulus 0.004 0.042 0.0956
Echinococcus multilocularis geminin 0.0191 0.2558 0.5287
Onchocerca volvulus 0.004 0.042 0.0956
Onchocerca volvulus 0.0051 0.0578 0.1437
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.1447 0.2989
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0475 0.0979
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0271 0.0443
Brugia malayi Inositol-1 0.0039 0.0409 0.0846
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.1447 0.1337

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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