Detailed information for compound 1268253

Basic information

Technical information
  • TDR Targets ID: 1268253
  • Name: 3-(1H-benzimidazol-2-yl)-N-(pyridin-3-ylmethy l)aniline
  • MW: 300.357 | Formula: C19H16N4
  • H donors: 2 H acceptors: 2 LogP: 3.56 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cn1)CNc1cccc(c1)c1nc2c([nH]1)cccc2
  • InChi: 1S/C19H16N4/c1-2-9-18-17(8-1)22-19(23-18)15-6-3-7-16(11-15)21-13-14-5-4-10-20-12-14/h1-12,21H,13H2,(H,22,23)
  • InChiKey: BVBAHXUGPUGMKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1H-benzimidazol-2-yl)-N-(3-pyridylmethyl)aniline
  • [3-(1H-benzimidazol-2-yl)phenyl]-(3-pyridylmethyl)amine
  • MLS000332401
  • SMR000221715
  • [3-(1H-Benzoimidazol-2-yl)-phenyl]-pyridin-3-ylmethyl-amine
  • 3-(1H-benzimidazol-2-yl)-N-(3-pyridinylmethyl)aniline
  • AN-465/43369382
  • STK283887

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Brugia malayi Nuclear hormone receptor-like 1 0.0138 0.1217 0.4294
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0076 0.0066
Mycobacterium ulcerans hypothetical protein 0.0029 0.0076 1
Brugia malayi Nuclear hormone receptor E75 0.0123 0.1063 0.3723
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0076 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0261 0.2504 0.9058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0261 0.2504 0.9078
Brugia malayi hypothetical protein 0.0123 0.1063 0.3723
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0261 0.2504 0.9058
Echinococcus granulosus thyroid hormone receptor alpha 0.0123 0.1063 0.3294
Loa Loa (eye worm) nuclear receptor NHR-67 0.0123 0.1063 0.3854
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0076 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0518 0.1139
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0261 0.2504 0.2327
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0261 0.2504 0.2327
Plasmodium falciparum acyl-CoA synthetase 0.0021 0 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0309 0.1122
Loa Loa (eye worm) hypothetical protein 0.0148 0.1321 0.4791
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0261 0.2504 0.9058
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0123 0.1063 0.0852
Entamoeba histolytica hypothetical protein 0.0043 0.023 0.1641
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0076 1
Brugia malayi nuclear receptor NHR-88 0.0261 0.2504 0.9058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0076 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0385 0.068
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2758 0.2587
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0261 0.2504 0.9058
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1018 0.3556
Schistosoma mansoni nuclear receptor 0.0123 0.1063 0.3663
Brugia malayi nuclear hormone receptor 0.0123 0.1063 0.3723
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0261 0.2504 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0123 0.1063 0.3723
Schistosoma mansoni hypothetical protein 0.0049 0.029 0.0263
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Brugia malayi steroid hormone receptor 0.0261 0.2504 0.9058
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0309 0.5
Schistosoma mansoni hypothetical protein 0.0205 0.1913 0.7402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0261 0.2504 0.9078
Brugia malayi hypothetical protein 0.0138 0.1217 0.4294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0274
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0518 0.1879
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0518 0.1266
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0261 0.2504 0.9058
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0261 0.2504 0.2327
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0123 0.1063 0.3663
Brugia malayi hypothetical protein 0.0043 0.023 0.0639
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0138 0.1217 0.4342
Schistosoma mansoni nuclear receptor nhr-48 0.0123 0.1063 0.3663
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0123 0.1063 0.4067
Schistosoma mansoni hypothetical protein 0.0049 0.029 0.0263
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0261 0.2504 0.2327
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2758 1
Brugia malayi ecdysteroid receptor 0.0261 0.2504 0.9058
Brugia malayi nuclear receptor NHR-88 0.0123 0.1063 0.3723
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0309 0.0313
Echinococcus granulosus expressed conserved protein 0.0112 0.0943 0.2818
Brugia malayi nuclear receptor RXR 0.0123 0.1063 0.3723
Schistosoma mansoni nuclear hormone receptor 0.0123 0.1063 0.3663
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0261 0.2504 0.8994
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0261 0.2504 0.9058
Brugia malayi photoreceptor-specific nuclear receptor 0.0261 0.2504 0.9058
Brugia malayi hypothetical protein 0.0138 0.1217 0.4294
Schistosoma mansoni RAR-like nuclear receptor 0.0261 0.2504 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1551 0.5223
Loa Loa (eye worm) hypothetical protein 0.0261 0.2504 0.9078
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0261 0.2504 0.9058
Echinococcus granulosus ecdysone induced protein 78C 0.0261 0.2504 0.8994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0261 0.2504 0.9078
Brugia malayi hypothetical protein 0.0286 0.2758 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0261 0.2504 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0309 0.1122
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0076 1
Entamoeba histolytica hypothetical protein 0.0043 0.023 0.1641
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0076 1
Onchocerca volvulus 0.0261 0.2504 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0261 0.2504 0.8994
Brugia malayi CHE-14 protein 0.0051 0.0309 0.0931
Brugia malayi jmjC domain containing protein 0.0071 0.0518 0.1705
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0076 0.5
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0261 0.2504 0.9058
Loa Loa (eye worm) hypothetical protein 0.0138 0.1217 0.4414
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0261 0.2504 1
Echinococcus multilocularis geminin 0.0205 0.1913 0.1722
Onchocerca volvulus 0.0123 0.1063 0.4067
Schistosoma mansoni thyroid hormone receptor 0.0261 0.2504 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0123 0.1063 0.3854
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0261 0.2504 0.9058
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0261 0.2504 0.9058
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0076 0.0066
Loa Loa (eye worm) hypothetical protein 0.0261 0.2504 0.9078
Entamoeba histolytica hypothetical protein 0.0043 0.023 0.1641
Echinococcus granulosus Nuclear hormone receptor HR96 0.0123 0.1063 0.3294
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0138 0.1217 0.4342
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0261 0.2504 0.8994
Echinococcus multilocularis FTZ F1 alpha 0.0261 0.2504 0.2327
Entamoeba histolytica hypothetical protein 0.0043 0.023 0.1641
Brugia malayi jmjC domain containing protein 0.0071 0.0518 0.1705
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0261 0.2504 0.8994
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0076 0.5
Loa Loa (eye worm) hypothetical protein 0.0138 0.1217 0.4414
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1551 0.1351
Loa Loa (eye worm) hypothetical protein 0.0138 0.1217 0.4414
Loa Loa (eye worm) hypothetical protein 0.0261 0.2504 0.9078
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0076 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0123 0.1063 0.0852
Loa Loa (eye worm) hypothetical protein 0.0138 0.1217 0.4414
Loa Loa (eye worm) hypothetical protein 0.0261 0.2504 0.9078
Loa Loa (eye worm) hypothetical protein 0.0261 0.2504 0.9078
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0309 0.0081
Schistosoma mansoni zinc finger protein 0.0123 0.1063 0.3663
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0123 0.1063 0.4067
Echinococcus granulosus FTZ F1 alpha 0.0261 0.2504 0.8994
Loa Loa (eye worm) hypothetical protein 0.0261 0.2504 0.9078
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0 0.5
Echinococcus granulosus geminin 0.0205 0.1913 0.6657
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1018 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0261 0.2504 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0261 0.2504 0.9078
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0261 0.2504 1
Brugia malayi orphan nuclear receptor NR2E1 0.0123 0.1063 0.3723
Onchocerca volvulus 0.0123 0.1063 0.4067
Schistosoma mansoni hypothetical protein 0.0049 0.029 0.0263
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0123 0.1063 0.3663
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Onchocerca volvulus Bile acid receptor homolog 0.0261 0.2504 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0261 0.2504 0.2327
Brugia malayi ecdysone receptor 0.0123 0.1063 0.3723
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0138 0.1217 0.4414
Loa Loa (eye worm) hypothetical protein 0.0148 0.1321 0.4791
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0274
Loa Loa (eye worm) nuclear hormone receptor 0.0123 0.1063 0.3854
Brugia malayi nuclear hormone receptor family member nhr-6 0.0123 0.1063 0.3723
Brugia malayi Steroid receptor seven-up type 2 0.0261 0.2504 0.9058
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1018 0.0806
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0518 0.1266
Loa Loa (eye worm) hypothetical protein 0.0286 0.2758 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0261 0.2504 0.9058
Brugia malayi nuclear hormone receptor family member odr-7 0.0123 0.1063 0.3723
Onchocerca volvulus Huntingtin homolog 0.0148 0.1321 0.513
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0138 0.1217 0.3905
Schistosoma mansoni hypothetical protein 0.0205 0.1913 0.7402
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Schistosoma mansoni steroid hormone receptor ad4bp 0.0261 0.2504 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0518 0.0295
Onchocerca volvulus Protein ultraspiracle homolog 0.0261 0.2504 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0261 0.2504 0.2327
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0123 0.1063 0.0852
Loa Loa (eye worm) hypothetical protein 0.0138 0.1217 0.4414
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0518 0.0295
Schistosoma mansoni hypothetical protein 0.0049 0.029 0.0263
Schistosoma mansoni hypothetical protein 0.0058 0.0385 0.068
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0518 0.1266
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0058 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0261 0.2504 0.9078
Brugia malayi tailless protein 0.0123 0.1063 0.3723
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Brugia malayi nuclear hormone receptor 0.0261 0.2504 0.9058
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0309 0.0313
Brugia malayi nuclear receptor RXR 0.0138 0.1217 0.4294
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0261 0.2504 0.9058
Echinococcus multilocularis thyroid hormone receptor alpha 0.0261 0.2504 0.2327
Brugia malayi Nuclear hormone receptor E75 0.0123 0.1063 0.3723
Brugia malayi hypothetical protein 0.0123 0.1063 0.3723
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0076 0.5
Schistosoma mansoni patched 1 0.0051 0.0309 0.0348
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0385 0.1211
Brugia malayi hypothetical protein 0.0148 0.1321 0.4679
Loa Loa (eye worm) DR-78 0.0123 0.1063 0.3854
Schistosoma mansoni retinoic acid receptor RXR 0.0261 0.2504 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1037 0.3549
Brugia malayi Nuclear hormone receptor-like 1 0.0261 0.2504 0.9058
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0076 0.5
Loa Loa (eye worm) hypothetical protein 0.0261 0.2504 0.9078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0261 0.2504 0.9078
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0138 0.1217 0.101
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0123 0.1063 0.3294
Echinococcus multilocularis ecdysone induced protein 78C 0.0261 0.2504 0.2327
Loa Loa (eye worm) hypothetical protein 0.0261 0.2504 0.9078
Onchocerca volvulus 0.0058 0.0385 0.1273
Brugia malayi nuclear receptor NHR-67 0.0123 0.1063 0.3723
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0076 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0123 0.1063 0.3294
Brugia malayi conserved hypotetical protein 0.0123 0.1063 0.3723
Schistosoma mansoni nuclear receptor 0.0123 0.1063 0.3663
Loa Loa (eye worm) hypothetical protein 0.0062 0.0429 0.1556
Echinococcus multilocularis protein dispatched 1 0.0058 0.0385 0.0158
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0076 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1321 0.513
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0123 0.1063 0.3294
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0261 0.2504 0.8994
Schistosoma mansoni coup transcription factor 0.0261 0.2504 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0274
Echinococcus multilocularis expressed conserved protein 0.0112 0.0943 0.0729
Echinococcus multilocularis protein patched 0.0051 0.0309 0.0081
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0076 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0261 0.2504 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0261 0.2504 0.8994
Echinococcus multilocularis nuclear receptor nhr 48 0.0123 0.1063 0.0852
Brugia malayi Nuclear hormone receptor-like 1 0.0138 0.1217 0.4294
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0261 0.2504 1
Schistosoma mansoni nuclear hormone receptor 0.0261 0.2504 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0123 0.1063 0.0852
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0076 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0261 0.2504 0.8994
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0261 0.2504 0.9058
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854
Schistosoma mansoni nuclear hormone receptor 0.0123 0.1063 0.3663
Echinococcus granulosus nuclear receptor nhr 48 0.0123 0.1063 0.3294
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0123 0.1063 0.0852
Schistosoma mansoni thyroid hormone receptor 0.0261 0.2504 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1018 0.3691
Loa Loa (eye worm) steroid hormone receptor 0.0261 0.2504 0.9078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0261 0.2504 0.9078
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0518 0.1139
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1018 0.3116
Loa Loa (eye worm) hypothetical protein 0.0123 0.1063 0.3854

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0046 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.13 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.5686 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.