Detailed information for compound 1279638

Basic information

Technical information
  • TDR Targets ID: 1279638
  • Name: T5311877
  • MW: 396.864 | Formula: C18H18ClFN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccccc1F)Nc1cc(ccc1Cl)S(=O)(=O)N1CCCC1
  • InChi: 1S/C18H18ClFN2O3S/c19-15-8-7-14(26(24,25)22-9-3-4-10-22)12-17(15)21-18(23)11-13-5-1-2-6-16(13)20/h1-2,5-8,12H,3-4,9-11H2,(H,21,23)
  • InChiKey: RQNCFNHQSZPFKU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.0038 0.0028 0.4899
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0056 0.1001
Loa Loa (eye worm) glutamate receptor 0.0016 0.0002 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0093 0.2374
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0056 0.1001
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0047 0.0465
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.004 0.094
Brugia malayi TAR-binding protein 0.0062 0.0056 0.1001
Echinococcus granulosus intermediate filament protein 0.0053 0.0046 0.1113
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.0023 0.0503
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0093 0.096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0005 0.0084
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0005 0.0084
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.0114 0.1191
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.0205 0.5392
Loa Loa (eye worm) hypothetical protein 0.0351 0.0397 0.7094
Brugia malayi Latrophilin receptor protein 2 0.0111 0.0114 0.2041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0154
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0155 0.1631
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0011 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Schistosoma mansoni Smad4 0.0026 0.0013 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0199 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0028 1
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.8498 1 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0011 0.5
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0011 0.1296
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0009 0.1635
Loa Loa (eye worm) hypothetical protein 0.0097 0.0098 0.1745
Loa Loa (eye worm) RNA binding protein 0.0062 0.0056 0.1001
Mycobacterium leprae Probable lipase LipE 0.0038 0.0028 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0017 0.0304
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0056 0.0558
Giardia lamblia DINP protein human, muc B family 0.0019 0.0006 1
Brugia malayi MH2 domain containing protein 0.0026 0.0013 0.024
Echinococcus multilocularis lamin 0.0053 0.0046 0.045
Schistosoma mansoni lamin 0.0053 0.0046 0.1113
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0053 0.0525
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0098 0.2497
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0606
Loa Loa (eye worm) glutamate receptor 0.0041 0.0031 0.0557
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0039
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0053 1
Schistosoma mansoni hypothetical protein 0.0334 0.0377 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0047 0.0849
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0507
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0098 0.101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.0114 0.2943
Entamoeba histolytica hypothetical protein 0.0025 0.0013 0.0859
Echinococcus granulosus metabotropic glutamate receptor 5 0.005 0.0042 0.1008
Schistosoma mansoni hypothetical protein 0.0334 0.0377 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0053 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.0114 0.2943
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0013 0.0087
Echinococcus multilocularis dna polymerase eta 0.0019 0.0006 0.0016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0489 0.0559 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0014 0.0097
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0056 0.1001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0351 0.0397 0.7094
Brugia malayi MH1 domain containing protein 0.0026 0.0013 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0028 0.1217
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0028 0.0022
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0017 0.0304
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0006 0.0297
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0013 0.3554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0093 0.2374
Entamoeba histolytica hypothetical protein 0.0023 0.0011 0.0674
Brugia malayi beta-lactamase family protein 0.0038 0.0028 0.0507
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0507
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0082 0.2065
Mycobacterium ulcerans AcrR family transcriptional regulator 0.8498 1 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0114 0.2041
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0606
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0028 0.0257
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0005 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0028 1
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0147 0.3815
Echinococcus granulosus Smad4 0.0026 0.0013 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0028 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0507
Brugia malayi intermediate filament protein 0.0053 0.0046 0.0825
Loa Loa (eye worm) hypothetical protein 0.0052 0.0045 0.0804
Onchocerca volvulus Huntingtin homolog 0.0262 0.0292 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0053 0.1298
Loa Loa (eye worm) hypothetical protein 0.0145 0.0155 0.2765
Loa Loa (eye worm) MH2 domain-containing protein 0.0374 0.0425 0.759
Echinococcus multilocularis geminin 0.0334 0.0377 0.4045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0068 0.0684
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0056 0.1379
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0028 0.0507
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0056 0.1379
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0028 0.0507
Schistosoma mansoni hypothetical protein 0.004 0.0031 0.0696
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0082 0.2065
Echinococcus granulosus smad 0.0026 0.0013 0.0234
Echinococcus multilocularis expressed conserved protein 0.0091 0.0091 0.0935
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.004 0.094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0093 0.096
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0147 0.1543
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0028 0.0022
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0013 0.0214
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0028 0.0022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0093 0.1663
Onchocerca volvulus Huntingtin homolog 0.0262 0.0292 1
Mycobacterium ulcerans lipase LipD 0.0038 0.0028 0.0022
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0006 0.0039
Brugia malayi RNA binding protein 0.0062 0.0056 0.1001
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.004 0.094
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0013 0.0234
Schistosoma mansoni smad 0.0026 0.0013 0.0234
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0028 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0507
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0013 0.0234
Brugia malayi Metabotropic glutamate receptor precursor. 0.0041 0.0031 0.0557
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0014 0.024
Mycobacterium ulcerans hypothetical protein 0.0038 0.0028 0.0022
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0047 0.115
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0013 0.0227
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0013 1
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0023 0.0503
Brugia malayi hypothetical protein 0.0071 0.0068 0.1208
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.0114 0.2041
Loa Loa (eye worm) transcription factor SMAD2 0.0374 0.0425 0.759
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.024 0.0266 0.4755
Loa Loa (eye worm) hypothetical protein 0.0051 0.0043 0.0776
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0037 0.0027 0.0477
Schistosoma mansoni intermediate filament proteins 0.0053 0.0046 0.1113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0028 0.0636
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0006 0.0074
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0053 0.0047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0028 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0006 0.0606
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0011 0.0005
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0046 0.0825
Brugia malayi hypothetical protein 0.0262 0.0292 0.5223
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0013 0.0214
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0053 0.0047
Loa Loa (eye worm) MBCTL1 0.0054 0.0047 0.0849
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0011 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0013 0.3371
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0028 0.0017
Trypanosoma brucei unspecified product 0.0019 0.0006 0.0606
Loa Loa (eye worm) hypothetical protein 0.005 0.0042 0.0755
Brugia malayi Smad1 0.0026 0.0013 0.024
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0013 0.3554
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0013 0.0234
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.004 0.038
Mycobacterium ulcerans beta-lactamase 0.0038 0.0028 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0028 0.1217
Echinococcus multilocularis lamin dm0 0.0053 0.0046 0.045
Schistosoma mansoni lamin 0.0053 0.0046 0.1113
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0082 0.0835
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.0023 0.0203
Schistosoma mansoni patched 1 0.0042 0.0032 0.0744
Mycobacterium ulcerans transcriptional regulator 0.8498 1 1
Schistosoma mansoni hypothetical protein 0.0111 0.0114 0.2943
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0028 0.0022
Echinococcus granulosus GPCR family 2 0.0111 0.0114 0.2943
Brugia malayi CHE-14 protein 0.0042 0.0032 0.0579
Echinococcus granulosus lamin dm0 0.0053 0.0046 0.1113
Leishmania major DNA polymerase kappa, putative 0.0019 0.0006 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0056 0.1379
Brugia malayi beta-lactamase family protein 0.0038 0.0028 0.0507
Loa Loa (eye worm) hypothetical protein 0.0188 0.0205 0.3666
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0046 0.0038 0.0887
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Schistosoma mansoni hypothetical protein 0.004 0.0031 0.0696
Schistosoma mansoni hypothetical protein 0.004 0.0031 0.0696
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0006 0.0074
Schistosoma mansoni hypothetical protein 0.004 0.0031 0.0696
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0056 0.1379
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0093 0.1663
Brugia malayi mbt repeat family protein 0.0048 0.004 0.0709
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0099 0.2544
Schistosoma mansoni smad1 5 8 and 0.0026 0.0013 0.0234
Leishmania major hypothetical protein, conserved 0.0038 0.0028 0.4899
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0005 0.0084
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0006 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0351 0.0397 0.7094
Loa Loa (eye worm) hypothetical protein 0.0048 0.004 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0032 0.1424
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0032 0.0301
Brugia malayi MH2 domain containing protein 0.0026 0.0013 0.024
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.0205 0.2181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0224
Loa Loa (eye worm) hypothetical protein 0.0054 0.0047 0.0849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.041
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0507
Entamoeba histolytica hypothetical protein 0.0071 0.0068 0.6769
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.0924 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0028 0.0022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0046 0.0825
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.011
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0047 0.0465
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0013 0.1741
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0224
Schistosoma mansoni hypothetical protein 0.0071 0.0068 0.169
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0028 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0028 0.1217
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0053 0.0047
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0028 0.0636
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0013 0.1652
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0032 0.0579
Loa Loa (eye worm) Smad1 0.0026 0.0013 0.024
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0005 0.0084
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0006 0.0606
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0507
Loa Loa (eye worm) beta-lactamase 0.0038 0.0028 0.0507
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0032 0.0744
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Echinococcus multilocularis smad 0.0026 0.0013 0.0095
Brugia malayi MH1 domain containing protein 0.0026 0.0013 0.024
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0006 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0013 0.0095
Leishmania major DNA polymerase eta, putative 0.0019 0.0006 0.0297
Entamoeba histolytica hypothetical protein 0.0071 0.0068 0.6769
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0068 0.169
Schistosoma mansoni hypothetical protein 0.0111 0.0114 0.2943
Brugia malayi beta-lactamase 0.0038 0.0028 0.0507
Schistosoma mansoni DNA polymerase eta 0.0019 0.0006 0.0039
Onchocerca volvulus 0.0053 0.0046 0.0673
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0006 0.011
Schistosoma mansoni hypothetical protein 0.0111 0.0114 0.2943
Onchocerca volvulus 0.0053 0.0046 0.0673
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0013 0.3554
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0028 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0013 0.024
Entamoeba histolytica hypothetical protein 0.0071 0.0068 0.6769
Brugia malayi mbt repeat family protein 0.0048 0.004 0.0709
Brugia malayi Muscleblind-like protein 0.0145 0.0155 0.2765
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0351 0.0397 0.7094
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.0114 0.2041
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0011 0.1296
Echinococcus granulosus lamin 0.0053 0.0046 0.1113
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0011 0.1296
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0082 0.1457
Onchocerca volvulus 0.0083 0.0082 0.2015
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0016
Schistosoma mansoni smad1 5 8 and 0.0026 0.0013 0.0234
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0047 0.115
Loa Loa (eye worm) hypothetical protein 0.0145 0.0155 0.2765
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0053 0.1298
Loa Loa (eye worm) hypothetical protein 0.0083 0.0082 0.1457
Entamoeba histolytica hypothetical protein 0.0071 0.0068 0.6769
Loa Loa (eye worm) hypothetical protein 0.0262 0.0292 0.5223
Echinococcus multilocularis musashi 0.0053 0.0046 0.045
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0013 0.0095
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.004 0.094
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0013 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0011 0.2644
Mycobacterium tuberculosis Conserved protein 0.0038 0.0028 0.0022
Trichomonas vaginalis esterase, putative 0.0038 0.0028 0.1217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0093 0.2374
Brugia malayi hypothetical protein 0.0016 0.0003 0.0046
Mycobacterium tuberculosis Conserved protein 0.0038 0.0028 0.0022
Loa Loa (eye worm) hypothetical protein 0.0042 0.0032 0.0579
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0056 0.1379
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.004 0.0709
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.0114 0.1191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0235
Onchocerca volvulus 0.0048 0.004 0.0429
Echinococcus multilocularis GPCR, family 2 0.0111 0.0114 0.1191
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0188 0.0205 0.3666
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.004 0.0429
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0013 0.1236
Schistosoma mansoni hypothetical protein 0.0111 0.0114 0.2943
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0007 0.0052
Schistosoma mansoni hypothetical protein 0.024 0.0266 0.7025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0013 0.024
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0011 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.024 0.0266 0.4755
Echinococcus granulosus expressed conserved protein 0.0091 0.0091 0.2311
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.004 0.038
Echinococcus multilocularis metabotropic glutamate receptor 5 0.005 0.0042 0.0408
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0093 0.2374
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0068 0.169
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0032 0.0744
Echinococcus granulosus geminin 0.0334 0.0377 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0013 0.3371
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0028 0.0022
Echinococcus granulosus dna polymerase kappa 0.0019 0.0006 0.0039
Leishmania major hypothetical protein, conserved 0.0025 0.0013 0.1741
Echinococcus multilocularis protein patched 0.0042 0.0032 0.0301
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0028 0.1217
Echinococcus granulosus dna polymerase eta 0.0019 0.0006 0.0039
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.011
Echinococcus granulosus muscleblind protein 0.0145 0.0155 0.4032
Echinococcus granulosus tar DNA binding protein 0.0062 0.0056 0.1379
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0606
Schistosoma mansoni hypothetical protein 0.029 0.0326 0.863
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0098 1
Brugia malayi hypothetical protein 0.0025 0.0013 0.0235
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0028 0.1217
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.004 0.094
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.0271 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0028 1
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0007 0.0119
Loa Loa (eye worm) hypothetical protein 0.0262 0.0292 0.5223
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0053 0.1298
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0053 0.0047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0028 0.0636
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0093 0.2374
Echinococcus multilocularis muscleblind protein 0.0145 0.0155 0.1631
Echinococcus multilocularis protein dispatched 1 0.0047 0.0039 0.0376
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0011 0.0005
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0005 0.0017
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0047 0.115
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0098 0.1745
Brugia malayi MH2 domain containing protein 0.0374 0.0425 0.759
Loa Loa (eye worm) hypothetical protein 0.0053 0.0046 0.0825
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0046 0.0825
Mycobacterium ulcerans TetR family transcriptional regulator 0.8498 1 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0013 0.0234
Brugia malayi follicle stimulating hormone receptor 0.0489 0.0559 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0606
Echinococcus multilocularis Smad4 0.0026 0.0013 0.0095

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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