Detailed information for compound 1284019

Basic information

Technical information
  • TDR Targets ID: 1284019
  • Name: 2-phenyl-N-pyridin-2-ylpropanamide
  • MW: 226.274 | Formula: C14H14N2O
  • H donors: 1 H acceptors: 2 LogP: 2.53 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(c1ccccc1)C)Nc1ccccn1
  • InChi: 1S/C14H14N2O/c1-11(12-7-3-2-4-8-12)14(17)16-13-9-5-6-10-15-13/h2-11H,1H3,(H,15,16,17)
  • InChiKey: LHPOUVZZNFLHER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-phenyl-N-(2-pyridyl)propanamide
  • 2-phenyl-N-(2-pyridyl)propionamide
  • 2-phenyl-N-pyridin-2-yl-propanamide
  • AN-329/03770049
  • Enamine_004075
  • Oprea1_384252
  • Oprea1_791779
  • 2-Phenyl-N-pyridin-2-yl-propionamide
  • ST039879
  • ARONIS001383
  • BAS 00444670

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0292 0.0404
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0027
Loa Loa (eye worm) hypothetical protein 0.0111 0.0951 0.1763
Schistosoma mansoni Protein aveugle 0.0028 0.0057 0.0057
Trichomonas vaginalis set domain proteins, putative 0.0264 0.2594 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0032 0.0098 0.0076
Echinococcus multilocularis polycomb protein SCMH1 0.0294 0.2918 0.3044
Schistosoma mansoni hypothetical protein 0.0362 0.365 0.365
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0032 0.0098 0.0188
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0292 0.0255
Echinococcus multilocularis Sterile alpha motif type 0.0028 0.0057 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.0518 0.0518
Echinococcus granulosus glycine receptor subunit alpha 1 0.0032 0.0098 0.0076
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0114 0.0066
Schistosoma mansoni chromobox protein 0.0218 0.2102 0.2102
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0028 0.0057 0.0008
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0038 0.0161 0.0115
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0161 0.0161
Onchocerca volvulus 0.0032 0.0098 0.0188
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.0909 0.0909
Loa Loa (eye worm) CHromoDomain protein family member 0.0034 0.0124 0.0157
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0032 0.0098 0.0048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Loa Loa (eye worm) glutamate receptor 0.0043 0.0223 0.035
Echinococcus granulosus zinc finger protein 0.006 0.0405 0.0594
Plasmodium falciparum thioredoxin reductase 0.0037 0.0154 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0032 0.0098 0.0048
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0028 0.0057 0.0027
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0028 0.0057 0.011
Onchocerca volvulus Tankyrase homolog 0.0028 0.0057 0.011
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0052 0.01
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0188
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0032 0.0098 0.0048
Plasmodium vivax JmjC domain containing protein 0.0032 0.0103 0.4749
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0394 0.0575
Brugia malayi Cation transporter family protein 0.0104 0.0871 0.1676
Loa Loa (eye worm) glutamate receptor 0.0067 0.0472 0.0833
Trypanosoma brucei ISWI complex protein 0.0034 0.0119 0.6432
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0188
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0027
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.0608 0.059
Schistosoma mansoni metabotropic glutamate receptor 0.0082 0.0643 0.0643
Loa Loa (eye worm) glutathione reductase 0.0037 0.0154 0.0215
Schistosoma mansoni myelin transcription factor 1 myt1 0.0106 0.0897 0.0897
Mycobacterium tuberculosis Probable reductase 0.0084 0.0662 0.8342
Schistosoma mansoni zinc finger protein 0.006 0.0405 0.0405
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0098 0.0098
Echinococcus multilocularis zinc finger protein 0.006 0.0405 0.0375
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Brugia malayi cask-interacting protein 2 0.0028 0.0057 0.011
Echinococcus multilocularis lysine specific demethylase 5A 0.0086 0.0679 0.0666
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0149 0.1355 0.1384
Echinococcus multilocularis pdz domain containing protein 0.0028 0.0057 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0354 0.0604
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0032 0.0098 0.0076
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0161 0.0161
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0394 0.5
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0032 0.0098 0.0188
Loa Loa (eye worm) hypothetical protein 0.0084 0.0665 0.1208
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0763 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0032 0.0098 0.0188
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0394 0.0394
Echinococcus granulosus glycine receptor subunit beta 0.0032 0.0098 0.0076
Trypanosoma cruzi ISWI complex protein 0.0034 0.0119 0.6432
Brugia malayi AIDA-1b 0.0028 0.0057 0.011
Brugia malayi Sphingomyelin synthase-related 1 0.0028 0.0057 0.011
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0043 0.0223 0.035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0394 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0292 0.0484
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0032 0.0098 0.0048
Loa Loa (eye worm) hypothetical protein 0.0104 0.0871 0.1607
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0027
Brugia malayi MH2 domain containing protein 0.0116 0.1001 0.1926
Onchocerca volvulus 0.0104 0.0871 0.1676
Brugia malayi Pre-SET motif family protein 0.0232 0.2249 0.4329
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0098 0.0188
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0032 0.0098 0.0188
Echinococcus granulosus polyhomeotic protein 2 0.0028 0.0057 0.0008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.2249 0.4282
Loa Loa (eye worm) ACC-1 protein 0.0032 0.0098 0.0106
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0903 0.9468 1
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0175 0.0257
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0032 0.0098 0.0188
Toxoplasma gondii PLU-1 family protein 0.0049 0.028 0.6566
Brugia malayi Pre-SET motif family protein 0.0033 0.0114 0.022
Loa Loa (eye worm) hypothetical protein 0.009 0.0722 0.1317
Schistosoma mansoni hypothetical protein 0.0027 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0038 0.0165 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0251 0.0251
Schistosoma mansoni spingomyelin synthetase-related 0.0028 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0067 0.0475 0.0475
Schistosoma mansoni polyhomeotic 0.0028 0.0057 0.0057
Echinococcus granulosus glycine receptor subunit beta 0.0032 0.0098 0.0076
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0067 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1001 0.1859
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0032 0.0098 0.0048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0662 0.8342
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0032 0.0098 0.0106
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0043 0.0223 0.035
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0028 0.0059 0.0008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0763 1
Trypanosoma brucei trypanothione reductase 0.0037 0.0154 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0098 0.0188
Loa Loa (eye worm) MBCTL1 0.0106 0.0897 0.1658
Echinococcus granulosus Sterile alpha motif type 0.0028 0.0057 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0154 1
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.1871 0.7153
Echinococcus granulosus tar DNA binding protein 0.0062 0.0422 0.0622
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.0909 0.0909
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0422 0.0422
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0028 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Toxoplasma gondii thioredoxin reductase 0.0037 0.0154 0.2779
Echinococcus granulosus methyl CpG binding domain protein 2 0.0038 0.0161 0.0183
Echinococcus granulosus Sterile alpha motif SAM 0.0028 0.0057 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0422 0.0422
Brugia malayi Bromodomain containing protein 0.0084 0.0664 0.1278
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0032 0.0098 0.0188
Echinococcus multilocularis glycine receptor subunit beta 0.0032 0.0098 0.0048
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0292 0.0562
Onchocerca volvulus 0.0028 0.0057 0.011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0114 0.0114
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0422 0.0812
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0028 0.0057 0.0005
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0106 0.0897 0.0897
Echinococcus multilocularis liprin alpha 2 0.0028 0.0057 0.0005
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0036 0.0142 0.2425
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0098
Loa Loa (eye worm) AIDA-1b 0.0028 0.0057 0.0027
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0067 0.0475 0.045
Echinococcus granulosus chromobox protein 2 0.0218 0.2102 0.3447
Loa Loa (eye worm) mbt repeat family protein 0.0306 0.3047 0.5829
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.0518 0.0518
Onchocerca volvulus 0.0028 0.0057 0.011
Brugia malayi TAR-binding protein 0.0062 0.0422 0.0812
Schistosoma mansoni hypothetical protein 0.0189 0.1786 0.1786
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0032 0.0098 0.0076
Giardia lamblia Kinesin-13 0.0028 0.0057 0.5
Echinococcus granulosus sphingomyelin synthase protein 1 0.0028 0.0057 0.0008
Loa Loa (eye worm) hypothetical protein 0.0106 0.0897 0.1658
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0362 0.365 0.6051
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0032 0.0098 0.0048
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0154 1
Schistosoma mansoni bromodomain containing protein 0.0027 0.0043 0.0043
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0032 0.0098 0.0076
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0028 0.0057 0.0005
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0422 0.0392
Onchocerca volvulus 0.0156 0.1436 0.2764
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0159 0.018
Brugia malayi Liprin-alpha 2 0.0028 0.0057 0.011
Leishmania major trypanothione reductase 0.0037 0.0154 0.1257
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0354 0.0681
Onchocerca volvulus 0.0334 0.3347 0.6441
Trypanosoma cruzi ISWI complex protein 0.0034 0.0119 0.6432
Brugia malayi Receptor family ligand binding region containing protein 0.0043 0.0223 0.0429
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0098
Loa Loa (eye worm) LGC-31 protein 0.0032 0.0098 0.0106
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0362 0.365 0.3821
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0354 0.0681
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0034 0.0124 0.0076
Brugia malayi RNA binding protein 0.0062 0.0422 0.0812
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0045 0.0237 0.5283
Brugia malayi Shank2E 0.0028 0.0057 0.011
Plasmodium falciparum glutathione reductase 0.0037 0.0154 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0422 0.0422
Brugia malayi hypothetical protein 0.0156 0.1436 0.2764
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0394 0.3941
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0662 0.8342
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0032 0.0098 0.0076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0165 0.0237
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.0608 0.0934
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0027
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0098 0.0098
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0159 0.0114
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0202 0.1931 0.3716
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0188
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0098
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0032 0.0098 0.0048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0098
Echinococcus granulosus liprin alpha 2 0.0028 0.0057 0.0008
Onchocerca volvulus 0.0032 0.0098 0.0188
Echinococcus granulosus liprin alpha 2 0.0028 0.0057 0.0008
Brugia malayi hypothetical protein 0.0028 0.0057 0.011
Brugia malayi bicaudal-C 0.0028 0.0057 0.011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0394 1
Brugia malayi Thioredoxin reductase 0.0037 0.0154 0.0296
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0394 0.5
Brugia malayi hypothetical protein 0.0028 0.0057 0.011
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0032 0.0098 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0027
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0032 0.0098 0.0106
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0104 0.0871 0.0871
Brugia malayi mbt repeat family protein 0.0506 0.5196 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0032 0.0098 0.0188
Echinococcus granulosus endonuclease exonuclease phosphatase 0.058 0.5998 1
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0098
Echinococcus multilocularis SAM and MBT domain containing protein 0.0426 0.4336 0.4549
Brugia malayi glutathione reductase 0.0037 0.0154 0.0296
Echinococcus granulosus polycomb protein SCMH1 0.0294 0.2918 0.482
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0032 0.0098 0.0098
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0422 0.0735
Echinococcus granulosus SAM and MBT domain containing protein 0.0426 0.4336 0.7204
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0027 0.0052 0.01
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0032 0.0098 0.0188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0292 0.0292
Onchocerca volvulus 0.0028 0.0057 0.011
Brugia malayi jmjC domain containing protein 0.0028 0.0059 0.0114
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0028 0.0057 0.0008
Brugia malayi Cation transporter family protein 0.0032 0.0098 0.0188
Echinococcus granulosus metabotropic glutamate receptor 5 0.0082 0.0643 0.0994
Loa Loa (eye worm) hypothetical protein 0.0156 0.1436 0.2704
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0506 0.5196 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.013 0.116 0.1176
Schistosoma mansoni hypothetical protein 0.0028 0.0057 0.0057
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.013 0.116 0.1863
Schistosoma mansoni bromodomain containing protein 0.0157 0.144 0.144
Echinococcus multilocularis chromobox protein 2 0.0218 0.2102 0.2177
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.058 0.5998 0.6315
Schistosoma mansoni hypothetical protein 0.0189 0.1786 0.1786
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0165 0.0318
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0028 0.0059 0.0012
Echinococcus multilocularis geminin 0.0189 0.1786 0.1842
Plasmodium vivax glutathione reductase, putative 0.0037 0.0154 1
Brugia malayi Cation transporter family protein 0.0032 0.0098 0.0188
Schistosoma mansoni hypothetical protein 0.0034 0.0119 0.0119
Schistosoma mansoni Protein aveugle 0.0028 0.0057 0.0057
Echinococcus granulosus fetal alzheimer antigen falz 0.0067 0.0475 0.0712
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0098
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0032 0.0098 0.0048
Echinococcus granulosus nAChR subunit 0.0032 0.0098 0.0076
Brugia malayi Bromodomain containing protein 0.0182 0.1717 0.3305
Echinococcus multilocularis Sterile alpha motif SAM 0.0028 0.0057 0.0005
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0422 0.0735
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0292 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0188
Loa Loa (eye worm) hypothetical protein 0.0506 0.5196 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0032 0.0098 0.0076
Onchocerca volvulus 0.0028 0.0057 0.011
Schistosoma mansoni lip-related protein (liprin) alpha 0.0028 0.0057 0.0057
Echinococcus granulosus histone acetyltransferase MYST2 0.0106 0.0897 0.1421
Onchocerca volvulus 0.0104 0.0871 0.1676
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0104 0.0871 0.0871
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0394 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0223 0.035
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0032 0.0098 0.0048
Schistosoma mansoni sex comb on midleg homolog 0.0294 0.2918 0.2918
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1001 0.1859
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0154 0.0215
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0032 0.0098 0.0106
Onchocerca volvulus 0.0104 0.0871 0.1676
Onchocerca volvulus 0.0264 0.2594 0.4992
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0149 0.1355 0.2191
Echinococcus granulosus histone acetyltransferase myst3 0.0049 0.0287 0.0395
Onchocerca volvulus Putative nachr subunit 0.0032 0.0098 0.0188
Echinococcus multilocularis polyhomeotic protein 2 0.0028 0.0057 0.0005
Loa Loa (eye worm) hypothetical protein 0.0104 0.0871 0.1607
Loa Loa (eye worm) hypothetical protein 0.0156 0.1431 0.2695
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0032 0.0098 0.0076
Echinococcus multilocularis histone acetyltransferase MYST2 0.0106 0.0897 0.0897
Onchocerca volvulus 0.0028 0.0057 0.011
Loa Loa (eye worm) jmjC domain-containing protein 0.0156 0.1432 0.2696
Schistosoma mansoni DNAj-like protein 0.0028 0.0057 0.0057
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0032 0.0098 0.0106
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0246 0.0393
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0028 0.0057 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0071 0.0518 0.0495
Loa Loa (eye worm) RNA binding protein 0.0062 0.0422 0.0735
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0027
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0662 0.8342
Echinococcus multilocularis nAChR subunit 0.0032 0.0098 0.0048
Echinococcus granulosus lysine specific demethylase 5A 0.0107 0.0909 0.1441
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0034 0.0124 0.012
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0032 0.0098 0.0076
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0426 0.4336 0.4336
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0032 0.0098 0.0048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Schistosoma mansoni sex comb on midleg homolog 0.0294 0.2918 0.2918
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0188
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0027
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0763 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0106 0.0897 0.1727
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0292 0.0292
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0032 0.0098 0.0188
Echinococcus granulosus geminin 0.0189 0.1786 0.2916
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0028 0.0057 0.5
Onchocerca volvulus 0.0046 0.0251 0.0484
Plasmodium vivax SET domain protein, putative 0.0033 0.0114 0.5943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0292 0.0404
Brugia malayi mbt repeat family protein 0.0306 0.3047 0.5864
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0032 0.0098 0.0106
Brugia malayi jmjC domain containing protein 0.0156 0.1432 0.2756
Schistosoma mansoni hypothetical protein 0.0028 0.0057 0.0057
Brugia malayi PHD-finger family protein 0.0072 0.0531 0.1023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0292 0.0255
Schistosoma mansoni zinc finger protein 0.0034 0.0119 0.0119
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0032 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0056 0.0354 0.0604
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0763 1
Loa Loa (eye worm) tnks protein 0.0028 0.0057 0.0027
Brugia malayi CHD4 protein 0.0034 0.0124 0.0238
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0032 0.0098 0.0188
Echinococcus granulosus glycine receptor subunit alpha 1 0.0032 0.0098 0.0076
Loa Loa (eye worm) ACC-1 protein 0.0032 0.0098 0.0106
Schistosoma mansoni phd finger protein 0.0049 0.0287 0.0287
Schistosoma mansoni hypothetical protein 0.0045 0.0246 0.0246
Onchocerca volvulus 0.0028 0.0057 0.011
Loa Loa (eye worm) hypothetical protein 0.0089 0.0714 0.1302
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0394 0.0363
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0059 0.0059
Echinococcus multilocularis glycine receptor subunit beta 0.0032 0.0098 0.0048
Echinococcus multilocularis liprin alpha 2 0.0028 0.0057 0.0005
Loa Loa (eye worm) hypothetical protein 0.0071 0.0518 0.0922
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0082 0.0643 0.0628
Schistosoma mansoni nAChR subunit 0.0032 0.0098 0.0098
Echinococcus granulosus pdz domain containing protein 0.0028 0.0057 0.0008
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0662 0.8342
Brugia malayi metabotropic glutamate receptor type 2 0.0082 0.0643 0.1238
Echinococcus granulosus histone lysine methyltransferase setb 0.0071 0.0518 0.0784
Onchocerca volvulus Poor gastrulation protein homolog 0.0027 0.0052 0.01
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0101 0.0083
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0394 0.0394
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0027 0.0052 0.01
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0422 0.0422
Brugia malayi coiled-coil like protein 1 0.0028 0.0057 0.011
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0032 0.0098 0.0106
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0662 0.8342
Loa Loa (eye worm) hypothetical protein 0.0202 0.1931 0.3664
Loa Loa (eye worm) hypothetical protein 0.0082 0.0643 0.1165
Onchocerca volvulus 0.0032 0.0098 0.0188
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0106 0.0897 0.1421
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0018
Echinococcus multilocularis histone acetyltransferase myst3 0.0049 0.0287 0.0249
Brugia malayi Metabotropic glutamate receptor precursor. 0.0043 0.0223 0.0429

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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