Detailed information for compound 1289212

Basic information

Technical information
  • TDR Targets ID: 1289212
  • Name: STOCK2S-46720
  • MW: 399.573 | Formula: C21H25N3OS2
  • H donors: 0 H acceptors: 1 LogP: 4.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCSc1nc2sc3c(c2c(=O)n1c1ccc(cc1)C)CCN(C3)C
  • InChi: 1S/C21H25N3OS2/c1-4-5-12-26-21-22-19-18(16-10-11-23(3)13-17(16)27-19)20(25)24(21)15-8-6-14(2)7-9-15/h6-9H,4-5,10-13H2,1-3H3
  • InChiKey: DXXGLYBROFCCPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus wingless-type MMTV integration site family, member 3A Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Mus musculus GLI-Kruppel family member GLI1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis zinc finger transcription factor gli2 Get druggable targets OG5_130785 All targets in OG5_130785
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) zinc finger protein Get druggable targets OG5_130785 All targets in OG5_130785
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Zinc finger, C2H2 type family protein Get druggable targets OG5_130785 All targets in OG5_130785
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus zinc finger transcription factor gli2 Get druggable targets OG5_130785 All targets in OG5_130785
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Wnt-2 protein precursor wingless-type MMTV integration site family, member 3A 352 aa 355 aa 39.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable lipase LipE 0.0043 0.0449 0.1746
Schistosoma mansoni hypothetical protein 0.004 0.0393 0.0393
Leishmania major hypothetical protein, conserved 0.0025 0.0089 0.0144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0458 0.0458
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0969 0.0969
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0738 0.1047
Schistosoma mansoni transient receptor potential channel 4 0.0104 0.1674 0.1674
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.2344 0.9264
Schistosoma mansoni hypothetical protein 0.0112 0.1824 0.1824
Brugia malayi PHD-finger family protein 0.0032 0.0236 0.0335
Brugia malayi hypothetical protein 0.0023 0.0049 0.007
Echinococcus granulosus dnaJ subfamily B 0.0494 0.945 0.945
Loa Loa (eye worm) hypothetical protein 0.0028 0.0149 0.0211
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.2547 0.2547
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.2609 0.3703
Mycobacterium ulcerans hypothetical protein 0.0172 0.3026 0.495
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.0009 0.0102
Loa Loa (eye worm) zinc finger protein 0.0373 0.7045 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0449 0.0869
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0979 0.0979
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0393 0.0393
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0089 0.1195
Echinococcus multilocularis protein dispatched 1 0.01 0.1596 0.1596
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.6112 1
Echinococcus multilocularis jumonji domain containing protein 0.008 0.1187 0.1187
Loa Loa (eye worm) hypothetical protein 0.0043 0.0449 0.0637
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0374 0.0713
Echinococcus granulosus Aminotransferase class III 0.0021 0.0009 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.1958 0.278
Loa Loa (eye worm) hypothetical protein 0.0043 0.0449 0.0637
Echinococcus granulosus transient receptor potential gamma protein 0.0104 0.1674 0.1674
Brugia malayi PHD-finger family protein 0.0057 0.0738 0.1047
Brugia malayi Transient-receptor-potential like protein 0.0039 0.0366 0.0519
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0458 0.065
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.5227 1
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0313 0.0444
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0458 0.0458
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0449 0.0722
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0374 0.5064
Plasmodium falciparum importin beta, putative 0.0028 0.0149 0.1999
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0149 0.1438
Schistosoma mansoni ran 0.0021 0.0001 0.0001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.2414 0.2414
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0738 0.0738
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5227 0.8562
Entamoeba histolytica hypothetical protein 0.004 0.0393 0.075
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0327 0.6112 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.3489 0.3489
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.2547 0.2547
Trichomonas vaginalis glutaminase, putative 0.0326 0.6104 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.065
Trichomonas vaginalis esterase, putative 0.0043 0.0449 0.0733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0458 0.065
Loa Loa (eye worm) hypothetical protein 0.0025 0.0089 0.0127
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0458 0.0458
Brugia malayi CXXC zinc finger family protein 0.0035 0.0283 0.0402
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.5227 0.5
Trichomonas vaginalis protein kinase inhibitor, putative 0.0066 0.0905 0.1481
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.065
Echinococcus granulosus zinc finger transcription factor gli2 0.0373 0.7045 0.7045
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0508 0.0829
Mycobacterium ulcerans hypothetical protein 0.0147 0.253 0.4135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0458 0.065
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0458 0.0458
Brugia malayi Bromodomain containing protein 0.0064 0.086 0.122
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0458 0.065
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0112 0.1824 0.1824
Echinococcus granulosus snurportin 1 0.0298 0.5542 0.5542
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.3489 0.3489
Onchocerca volvulus 0.0036 0.0313 0.424
Echinococcus granulosus expressed conserved protein 0.0193 0.3437 0.3437
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0049 0.0049
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0089 0.1195
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0218 0.031
Brugia malayi glutaminase DH11.1 0.0326 0.6104 0.8665
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.007
Onchocerca volvulus Alhambra homolog 0.0057 0.0738 1
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0108 0.1743 0.2474
Echinococcus multilocularis Niemann Pick C1 protein 0.0293 0.5442 0.5442
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0354 0.6647 0.9435
Brugia malayi steroid hormone receptor 0.0043 0.0458 0.065
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0449 0.0732
Echinococcus multilocularis zinc finger transcription factor gli2 0.0373 0.7045 0.7045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.1059 0.1059
Loa Loa (eye worm) beta-lactamase 0.0043 0.0449 0.0637
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0449 0.0732
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.065
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0449 0.0449
Brugia malayi hypoxia-induced factor 1 0.0151 0.2609 0.3703
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0089 0.086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.3489 0.3489
Echinococcus granulosus Protein patched homolog 1 0.0088 0.1348 0.1348
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0458 0.065
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0188 0.3346 0.3346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0458 0.065
Echinococcus multilocularis peregrin 0.0064 0.086 0.086
Loa Loa (eye worm) hypothetical protein 0.0205 0.3685 0.523
Echinococcus granulosus single minded 2 0.0036 0.0313 0.0313
Echinococcus granulosus Niemann Pick C1 protein 0.0293 0.5442 0.5442
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0313 0.0313
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0449 0.1746
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0458 0.065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0283 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.1348 0.2206
Onchocerca volvulus 0.0043 0.0449 0.6088
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0458 0.0458
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.5227 1
Echinococcus granulosus Niemann Pick C1 protein 0.0205 0.3685 0.3685
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0449 0.0869
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.2344 0.4613
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0049 0.007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.3489 0.3489
Mycobacterium tuberculosis Conserved protein 0.0043 0.0449 0.0869
Loa Loa (eye worm) hypothetical protein 0.0047 0.0536 0.0761
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0738 0.7195
Echinococcus granulosus cpg binding protein 0.0039 0.0364 0.0364
Brugia malayi ecdysteroid receptor 0.0043 0.0458 0.065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5227 0.8562
Loa Loa (eye worm) hypothetical protein 0.0043 0.0449 0.0637
Schistosoma mansoni single-minded 0.0049 0.0566 0.0566
Plasmodium vivax importin-beta 2, putative 0.0028 0.0149 0.1999
Echinococcus multilocularis zinc finger protein 0.0027 0.0122 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0458 0.065
Loa Loa (eye worm) hypothetical protein 0.0164 0.2862 0.4062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0393 0.0393
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0738 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0458 0.065
Brugia malayi Importin beta-1 subunit 0.0028 0.0149 0.0211
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0449 0.608
Echinococcus multilocularis snurportin 1 0.0298 0.5542 0.5542
Mycobacterium tuberculosis Probable aminotransferase 0.0147 0.253 0.4979
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0149 0.0241
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0449 0.0637
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0458 0.6207
Brugia malayi hypothetical protein 0.0023 0.0049 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0449 0.0637
Echinococcus multilocularis Aminotransferase class III 0.0021 0.0009 0.0009
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0374 0.0713
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.1348 0.1913
Brugia malayi Bromodomain containing protein 0.0086 0.1311 0.1861
Onchocerca volvulus 0.0035 0.0283 0.3842
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0458 0.065
Schistosoma mansoni glutaminase 0.0326 0.6104 0.6104
Brugia malayi PAS domain containing protein 0.0049 0.0566 0.0804
Schistosoma mansoni hypothetical protein 0.0085 0.1285 0.1285
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0042 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0049 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5227 0.8562
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.3026 0.5959
Schistosoma mansoni jumonji domain containing protein 0.0149 0.2574 0.2574
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.1059 0.1059
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.2344 0.3831
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0354 0.6647 0.9435
Mycobacterium ulcerans lipase LipD 0.0043 0.0449 0.0722
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0049 0.0049
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0458 0.0458
Brugia malayi Zinc finger, C2H2 type family protein 0.0373 0.7045 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0458 0.0458
Leishmania major mitochondrial DNA polymerase beta 0.0327 0.6112 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0195 0.3489 0.4952
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0104 0.1674 0.2375
Echinococcus multilocularis transient receptor potential ion channel A 0.0101 0.1604 0.1604
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0969 0.0969
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0008 0.0091
Loa Loa (eye worm) hypothetical protein 0.0088 0.1348 0.1913
Schistosoma mansoni hypothetical protein 0.0112 0.1824 0.1824
Echinococcus multilocularis protein patched 0.0088 0.1348 0.1348
Brugia malayi Calcitonin receptor-like protein seb-1 0.0354 0.6647 0.9435
Brugia malayi nuclear receptor RXR 0.0023 0.0049 0.007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0458 0.0458
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0114 0.0114
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0738 0.0738
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0458 0.6207
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0496 0.0496
Echinococcus granulosus zinc finger protein 0.0027 0.0122 0.0122
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.0366 0.0366
Schistosoma mansoni hypothetical protein 0.0112 0.1824 0.1824
Brugia malayi hypothetical protein 0.004 0.0393 0.0558
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0041 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0449 0.0733
Brugia malayi Bromodomain containing protein 0.0045 0.0484 0.0687
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0458 0.0458
Echinococcus granulosus transient receptor potential ion channel A 0.0101 0.1604 0.1604
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0458 0.065
Loa Loa (eye worm) hypothetical protein 0.0043 0.0449 0.0637
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0313 0.0498
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0066
Brugia malayi jmjC domain containing protein 0.0188 0.3346 0.4749
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0089 0.0144
Schistosoma mansoni cpg binding protein 0.0039 0.0364 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0458 0.065
Onchocerca volvulus 0.0043 0.0449 0.6088
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0983 0.0983
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.1059 0.1059
Entamoeba histolytica hypothetical protein 0.004 0.0393 0.075
Mycobacterium ulcerans glutaminase 0.0326 0.6104 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0449 0.0637
Brugia malayi beta-lactamase family protein 0.0043 0.0449 0.0637
Echinococcus multilocularis cpg binding protein 0.0039 0.0364 0.0364
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.5227 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0449 0.0733
Loa Loa (eye worm) hypothetical protein 0.0112 0.1824 0.2589
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0049 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.2677 0.4379
Echinococcus granulosus ornithine aminotransferase 0.0021 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0298 0.5542 0.5542
Echinococcus multilocularis transient receptor potential gamma protein 0.0104 0.1674 0.1674
Loa Loa (eye worm) glutaminase 2 0.0326 0.6104 0.8665
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0458 0.065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0458 0.0458
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.0009 0.0013
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0449 0.0869
Echinococcus multilocularis dnaJ subfamily C 6 0.0066 0.0905 0.0905
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0458 0.065
Plasmodium falciparum phd finger protein, putative 0.0057 0.0738 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0112 0.1824 0.2589
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0508 0.0829
Schistosoma mansoni zinc finger protein 0.0027 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.007
Leishmania major importin beta-1 subunit, putative 0.0023 0.0043 0.0068
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.2677 0.4379
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0458 0.6207
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0508 0.0829
Brugia malayi jmjC domain containing protein 0.0074 0.1059 0.1504
Schistosoma mansoni hypothetical protein 0.0242 0.4415 0.4415
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5227 0.8562
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0114 0.0114
Echinococcus granulosus FTZ F1 alpha 0.0473 0.903 0.903
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0149 0.0241
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0089 0.0144
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0449 0.0732
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.3489 0.3489
Mycobacterium ulcerans hypothetical protein 0.0043 0.0449 0.0722
Schistosoma mansoni transient receptor potential channel 0.0104 0.1674 0.1674
Schistosoma mansoni hypothetical protein 0.0494 0.945 0.945
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0089 0.0144
Loa Loa (eye worm) hypothetical protein 0.0057 0.0738 0.1047
Brugia malayi hypothetical protein 0.0164 0.2862 0.4062
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0969 0.0969
Plasmodium falciparum ornithine aminotransferase 0.0021 0.0009 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0458 0.065
Schistosoma mansoni hypothetical protein 0.0112 0.1824 0.1824
Mycobacterium tuberculosis Conserved protein 0.0043 0.0449 0.0869
Loa Loa (eye worm) hypothetical protein 0.0242 0.4415 0.6266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5227 0.8562
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0458 0.0458
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0458 0.0458
Schistosoma mansoni hypothetical protein 0.0057 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0035 0.0296 0.042
Loa Loa (eye worm) hypothetical protein 0.0051 0.0617 0.0875
Brugia malayi nuclear receptor NHR-88 0.0043 0.0458 0.065
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0449 0.0869
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0138 0.0138
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0449 0.0733
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0458 0.0458
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0983 0.0983
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0738 0.7195
Echinococcus granulosus peregrin 0.0064 0.086 0.086
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0149 0.0149
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.1348 0.1348
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0449 0.0733
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1059 0.1059
Schistosoma mansoni hypothetical protein 0.0085 0.1285 0.1285
Brugia malayi DnaJ domain containing protein 0.0066 0.0905 0.1285
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0496 0.0811
Loa Loa (eye worm) hypothetical protein 0.0098 0.1557 0.2209
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0354 0.6647 0.9435
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0458 0.065
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0458 0.065
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0458 0.0458
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0449 0.0733
Schistosoma mansoni ran 0.0021 0.0001 0.0001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0043 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.065
Giardia lamblia PHD finger protein 15 0.0057 0.0738 0.1409
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0458 0.0458
Brugia malayi beta-lactamase family protein 0.0043 0.0449 0.0637
Brugia malayi Niemann-Pick C1 protein precursor 0.0205 0.3685 0.523
Brugia malayi nuclear hormone receptor 0.0043 0.0458 0.065
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0008 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0449 0.0449
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0112 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0066 0.0899 0.1276
Loa Loa (eye worm) hypothetical protein 0.0039 0.0366 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0458 0.065
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.945 0.945
Loa Loa (eye worm) hypothetical protein 0.0041 0.0414 0.0588
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.2677 0.4379
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0458 0.0458
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0001 0.0001
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0147 0.253 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0508 0.0829
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5227 0.8562
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0458 0.065
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0458 0.0458
Brugia malayi PHD-finger family protein 0.0023 0.0046 0.0066
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0147 0.253 0.4979
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.007
Toxoplasma gondii ABC1 family protein 0.0043 0.0449 0.4375
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.5542 0.7866
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0114 0.0114
Loa Loa (eye worm) glutaminase 0.0326 0.6104 0.8665
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0188 0.3346 0.3346
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.1348 0.1348
Echinococcus granulosus jumonji domain containing protein 0.008 0.1187 0.1187
Schistosoma mansoni importin beta-1 0.0028 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.065
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0021 0.0009 0.5
Schistosoma mansoni patched 1 0.0088 0.1348 0.1348
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.3489 0.3489
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.0068
Echinococcus multilocularis expressed conserved protein 0.0193 0.3437 0.3437
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0458 0.065
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0001 0.0002
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0042 0.0042
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0034 0.0048
Schistosoma mansoni hypothetical protein 0.0066 0.0905 0.0905
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0458 0.0458
Brugia malayi hypothetical protein 0.0025 0.0089 0.0127
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0009 0.0009
Onchocerca volvulus 0.0043 0.0458 0.6207
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0089 0.1195
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0001 0.0001
Toxoplasma gondii hypothetical protein 0.0053 0.0643 0.627
Entamoeba histolytica hypothetical protein 0.004 0.0393 0.075
Schistosoma mansoni hypothetical protein 0.0085 0.1285 0.1285
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0208 0.3748 0.3748
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0738 0.0738
Schistosoma mansoni cpg binding protein 0.0035 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0076 0.1108 0.1573
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0043 0.0068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0449 0.0449
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0566 0.0566
Echinococcus granulosus dnaJ subfamily C 6 0.0066 0.0905 0.0905
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.0009 0.0009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0458 0.0458
Leishmania major hypothetical protein, conserved 0.0043 0.0449 0.0732
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0458 0.0458
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0496 0.4836
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0275 0.5072 1
Loa Loa (eye worm) acetyltransferase 0.0148 0.2547 0.3615
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0496 0.6721
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0458 0.065
Entamoeba histolytica hypothetical protein 0.0023 0.0043 0.008
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0496 0.0811
Echinococcus granulosus GPCR family 2 0.0112 0.1824 0.1824
Entamoeba histolytica hypothetical protein 0.004 0.0393 0.075
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0049 0.007
Schistosoma mansoni bromodomain containing protein 0.0074 0.1059 0.1059
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0458 0.0458
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0449 0.0869
Schistosoma mansoni transient receptor potential channel 0.0069 0.0969 0.0969
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.0009 0.0074
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0449 0.0637
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0458 0.0458
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0449 0.0869
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0112 0.1824 0.1824
Brugia malayi beta-lactamase 0.0043 0.0449 0.0637
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.065
Mycobacterium ulcerans beta-lactamase 0.0043 0.0449 0.0722
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0969 0.0969
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.1059 0.1504
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0049 0.007
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.0366 0.0366
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0147 0.253 0.4143
Loa Loa (eye worm) DnaJ domain-containing protein 0.0066 0.0905 0.1285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5227 0.8562
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0458 0.0458
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0458 0.0458
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0195 0.3489 0.4952
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0205 0.3685 0.7049
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0449 0.0869
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0496 0.4836
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0112 0.1824 0.2589
Toxoplasma gondii histone lysine methyltransferase SET1 0.0072 0.1025 1
Brugia malayi CHE-14 protein 0.0088 0.1348 0.1913
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0021 0.0009 0.5
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0009 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0242 0.4415 0.6266
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.2547 0.3615
Onchocerca volvulus 0.0043 0.0449 0.6088
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0449 0.0722
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0362 0.0362
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.6112 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0393 0.0393
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.5227 0.8562
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0449 0.0869
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0458 0.0458
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0449 0.0449
Brugia malayi RNA, U transporter 1 0.0079 0.1176 0.1669
Schistosoma mansoni coup transcription factor 0.0043 0.0458 0.0458
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.3489 0.3489
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0458 0.065
Echinococcus multilocularis Niemann Pick C1 protein 0.0205 0.3685 0.3685
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.007
Schistosoma mansoni cpg binding protein 0.0039 0.0364 0.0364
Echinococcus granulosus importin subunit beta 1 0.0028 0.0149 0.0149
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0112 0.1824 0.1824
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0085 0.1285 0.1285
Schistosoma mansoni transient receptor potential channel 0.0069 0.0969 0.0969
Brugia malayi Latrophilin receptor protein 2 0.0112 0.1824 0.2589
Echinococcus multilocularis GPCR, family 2 0.0112 0.1824 0.1824
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0362 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0458 0.065
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0147 0.253 0.4135
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0458 0.065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0709 0.1157

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 10.8 uM PubChem BioAssay. Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 17.9 uM PubChem BioAssay. Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.