Detailed information for compound 1302426

Basic information

Technical information
  • TDR Targets ID: 1302426
  • Name: N'-(3-morpholin-4-ylpropyl)-N-(oxolan-2-ylmet hyl)oxamide
  • MW: 299.366 | Formula: C14H25N3O4
  • H donors: 2 H acceptors: 2 LogP: -0.32 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)NCCCN1CCOCC1)NCC1CCCO1
  • InChi: 1S/C14H25N3O4/c18-13(14(19)16-11-12-3-1-8-21-12)15-4-2-5-17-6-9-20-10-7-17/h12H,1-11H2,(H,15,18)(H,16,19)
  • InChiKey: IVJMJOKEFJVJMB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N'-(3-morpholinopropyl)-N-(tetrahydrofuran-2-ylmethyl)oxamide
  • N'-(3-morpholinopropyl)-N-(2-tetrahydrofuranylmethyl)oxamide
  • N'-(3-morpholinopropyl)-N-(tetrahydrofurfuryl)oxamide
  • N'-(3-morpholin-4-ylpropyl)-N-(oxolan-2-ylmethyl)ethanediamide
  • STK100312
  • BAS 00447805
  • N-(3-Morpholin-4-yl-propyl)-N'-(tetrahydro-furan-2-ylmethyl)-oxalamide
  • MLS000569156
  • SMR000175061

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0079 0.0057
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1394 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0106 0.3506 0.581
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0079 0.0091
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1394 1
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.1146 0.1104
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.1146 0.1309
Mycobacterium ulcerans hypothetical protein 0.0148 0.5012 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Loa Loa (eye worm) pyruvate kinase 0.004 0.1146 0.1309
Schistosoma mansoni coup transcription factor 0.0011 0.0079 0.0055
Mycobacterium tuberculosis Probable aminotransferase 0.0148 0.5012 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1549 1
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0021 0.045 0.0813
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0655 0.4515
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0079 0.0091
Echinococcus granulosus ornithine aminotransferase 0.0021 0.045 0.0699
Schistosoma mansoni pyruvate kinase 0.0021 0.0439 0.0659
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0021 0.045 0.006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0079 0.0055
Loa Loa (eye worm) nuclear hormone receptor 0.01 0.3302 0.3774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0079 0.0091
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.1146 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0439 0.2613
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0079 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0106 0.3506 0.5988
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0079 0.0091
Brugia malayi Pre-SET motif family protein 0.0036 0.0993 0.1135
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.045 0.2687
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0655 0.5537
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0726 0.1367
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.1146 0.1104
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.1146 0.1104
Echinococcus granulosus pyruvate kinase 0.0021 0.0439 0.0679
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0079 0.0055
Brugia malayi hypothetical protein 0.0017 0.0315 0.036
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0079 0.0057
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0726 0.0829
Plasmodium falciparum pyruvate kinase 0.004 0.1146 0.8155
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Schistosoma mansoni pyruvate kinase 0.004 0.1146 0.1846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0079 0.0091
Plasmodium falciparum ornithine aminotransferase 0.0021 0.045 0.2995
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0726 0.066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1438 0.2337
Leishmania major pyruvate kinase 0.004 0.1146 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1549 0.1509
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.1146 0.1309
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1438 0.1644
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0079 0.0033
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0079 0.0055
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0079 0.0055
Echinococcus granulosus pyruvate kinase 0.0021 0.0439 0.0679
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0021 0.045 0.0813
Brugia malayi steroid hormone receptor 0.0011 0.0079 0.0091
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0079 0.0033
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0706 0.4896
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0079 0.0055
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0993 0.1638
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0726 0.1367
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0726 0.0829
Echinococcus multilocularis pyruvate kinase 0.0021 0.0439 0.0659
Plasmodium vivax SET domain protein, putative 0.0036 0.0993 0.63
Brugia malayi topoisomerase 0.001 0.0047 0.0053
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.045 0.0678
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1549 0.1509
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0021 0.045 0.3673
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0079 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0726 0.0829
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0079 0.0057
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Echinococcus multilocularis pyruvate kinase 0.004 0.1146 0.1846
Brugia malayi nuclear receptor NHR-88 0.0011 0.0079 0.0091
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.1146 0.2213
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0465 0.2785
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0021 0.045 0.006
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0655 0.4051
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0655 0.4515
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0726 0.1367
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0125 0.0132
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.045 0.0678
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0655 0.5537
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1549 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0125 0.0136
Leishmania major pyruvate kinase 0.004 0.1146 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0079 0.0091
Brugia malayi ecdysteroid receptor 0.0011 0.0079 0.0091
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0079 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0079 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0079 0.0091
Onchocerca volvulus 0.0011 0.0079 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0079 0.0055
Echinococcus multilocularis geminin 0.0168 0.5761 0.9598
Brugia malayi Pre-SET motif family protein 0.0251 0.8749 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0079 0.0055
Echinococcus multilocularis pyruvate kinase 0.0021 0.0439 0.0659
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0726 0.066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0993 0.1589
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0726 0.144
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0079 0.0091
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8749 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1394 1
Echinococcus granulosus Aminotransferase class III 0.0021 0.045 0.0699
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0079 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0079 0.0091
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0079 0.0055
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0079 0.0057
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0148 0.5012 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0079 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0079 0.0055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0726 0.1367
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Mycobacterium ulcerans L-lysine aminotransferase 0.0021 0.045 0.0813
Brugia malayi Steroid receptor seven-up type 2 0.0106 0.3506 0.4007
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.1146 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0079 0.0091
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.045 0.0678
Loa Loa (eye worm) hypothetical protein 0.0029 0.0726 0.0829
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1438 0.2337
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0079 0.0091
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0465 0.0842
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0439 0.2613
Echinococcus granulosus pyruvate kinase 0.004 0.1146 0.1902
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.1146 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1549 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.3324 0.3799
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0079 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0726 0.1367
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0079 0.0055
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0465 0.0092
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0655 0.4051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0655 0.5537
Onchocerca volvulus 0.0029 0.0726 0.0682
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0079 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1438 0.2337
Brugia malayi hypothetical protein 0.0027 0.0655 0.0749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1438 0.2337
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0993 0.63
Treponema pallidum DNA ligase (lig) 0.001 0.0047 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0726 0.5039
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.1146 0.7316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1438 0.2337
Brugia malayi hypothetical protein 0.001 0.0047 0.0053
Echinococcus multilocularis pyruvate kinase 0.004 0.1146 0.1846
Loa Loa (eye worm) hypothetical protein 0.004 0.1146 0.1309
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0465 0.3806
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0993 0.1589
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0148 0.5012 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0079 0.0057
Trypanosoma brucei pyruvate kinase 1 0.004 0.1146 1
Mycobacterium ulcerans pyruvate kinase 0.004 0.1146 0.2213
Echinococcus granulosus pyruvate kinase 0.004 0.1146 0.1902
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0079 0.0091
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0079 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0726 0.5039
Brugia malayi nuclear hormone receptor 0.0011 0.0079 0.0091
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0993 0.1589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0079 0.0091
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.6 0.6858
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0079 0.0091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0079 0.0057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0726 0.1367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0079 0.0091
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0945 0.1555
Plasmodium vivax pyruvate kinase, putative 0.004 0.1146 0.7316
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0148 0.5012 1
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.1146 0.1104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0079 0.0091
Brugia malayi hypothetical protein 0.001 0.0047 0.0053
Giardia lamblia Pyruvate kinase 0.004 0.1146 0.8155
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0726 0.5039
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0021 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0993 0.1135
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0079 0.0055
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0726 0.1367
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0726 0.144
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.045 0.0515
Echinococcus granulosus pyruvate kinase 0.0021 0.0439 0.0679
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0021 0.045 0.0813
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0021 0.045 0.006
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0079 0.0055
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0726 0.1367
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0079 0.0057
Schistosoma mansoni hypothetical protein 0.0012 0.0125 0.0132
Giardia lamblia Pyruvate kinase 0.0021 0.0439 0.2913
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1438 0.2408
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.6 1
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0021 0.045 0.0813
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.1146 0.1575
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.045 0.0813
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.045 0.0813
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.5823 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0993 0.1589
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0079 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0726 0.144
Onchocerca volvulus 0.0036 0.0993 0.0951
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0047 0.0053
Loa Loa (eye worm) pyruvate kinase 0.004 0.1146 0.1309
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0021 0.045 0.006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0047 0.0053
Schistosoma mansoni hypothetical protein 0.0168 0.5761 0.9598
Loa Loa (eye worm) hypothetical protein 0.0028 0.0706 0.0807
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0133 0.0152
Loa Loa (eye worm) hypothetical protein 0.0027 0.0655 0.0749
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0021 0.045 0.0813
Chlamydia trachomatis pyruvate kinase 0.004 0.1146 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0726 0.1367
Brugia malayi DKFZp564C0469 protein 0.001 0.0047 0.0053
Loa Loa (eye worm) hypothetical protein 0.0029 0.0726 0.0829
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0706 0.0807
Echinococcus granulosus geminin 0.0168 0.5761 0.9892
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0079 0.0055
Mycobacterium ulcerans hypothetical protein 0.0029 0.0726 0.1367
Echinococcus multilocularis Aminotransferase class III 0.0021 0.045 0.0678
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0079 0.0091
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0148 0.5012 0.4989
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0993 0.1589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1438 0.2408
Loa Loa (eye worm) acetyltransferase 0.0175 0.6 0.6858
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Schistosoma mansoni pyruvate kinase 0.004 0.1146 0.1846
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0726 0.0829
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0079 0.0055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1438 0.1644
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1549 0.26
Echinococcus multilocularis pyruvate kinase 0.0021 0.0439 0.0659
Echinococcus multilocularis pyruvate kinase 0.0032 0.084 0.1332
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.1146 0.1104
Loa Loa (eye worm) pyruvate kinase 0.004 0.1146 0.1309
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0993 0.1589
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0439 0.2913
Schistosoma mansoni hypothetical protein 0.0168 0.5761 0.9598
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0079 0.0055
Mycobacterium ulcerans acetylornithine aminotransferase 0.0021 0.045 0.0813
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0079 0.0055
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0465 0.3104
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.045 0.2687
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0079 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0079 0.0091
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.6 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1259 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 6.7456 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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