Detailed information for compound 1302426

Basic information

Technical information
  • TDR Targets ID: 1302426
  • Name: N'-(3-morpholin-4-ylpropyl)-N-(oxolan-2-ylmet hyl)oxamide
  • MW: 299.366 | Formula: C14H25N3O4
  • H donors: 2 H acceptors: 2 LogP: -0.32 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)NCCCN1CCOCC1)NCC1CCCO1
  • InChi: 1S/C14H25N3O4/c18-13(14(19)16-11-12-3-1-8-21-12)15-4-2-5-17-6-9-20-10-7-17/h12H,1-11H2,(H,15,18)(H,16,19)
  • InChiKey: IVJMJOKEFJVJMB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N'-(3-morpholinopropyl)-N-(tetrahydrofuran-2-ylmethyl)oxamide
  • N'-(3-morpholinopropyl)-N-(2-tetrahydrofuranylmethyl)oxamide
  • N'-(3-morpholinopropyl)-N-(tetrahydrofurfuryl)oxamide
  • N'-(3-morpholin-4-ylpropyl)-N-(oxolan-2-ylmethyl)ethanediamide
  • STK100312
  • BAS 00447805
  • N-(3-Morpholin-4-yl-propyl)-N'-(tetrahydro-furan-2-ylmethyl)-oxalamide
  • MLS000569156
  • SMR000175061

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus pyruvate kinase 0.004 0.1146 0.1902
Mycobacterium ulcerans hypothetical protein 0.0029 0.0726 0.1367
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1394 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1438 0.1644
Echinococcus multilocularis Aminotransferase class III 0.0021 0.045 0.0678
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0079 0.0057
Echinococcus granulosus Aminotransferase class III 0.0021 0.045 0.0699
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0945 0.1555
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0133 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0079 0.0091
Loa Loa (eye worm) hypothetical protein 0.0101 0.3324 0.3799
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0079 0.0057
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0148 0.5012 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1438 0.1644
Loa Loa (eye worm) pyruvate kinase 0.004 0.1146 0.1309
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0993 0.1589
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0079 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0079 0.0091
Schistosoma mansoni pyruvate kinase 0.0021 0.0439 0.0659
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.6 1
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0439 0.2613
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0079 0.0091
Giardia lamblia Pyruvate kinase 0.0021 0.0439 0.2913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1438 0.2337
Echinococcus granulosus pyruvate kinase 0.0021 0.0439 0.0679
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0021 0.045 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0079 0.0091
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0726 0.1367
Onchocerca volvulus 0.0011 0.0079 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0726 0.144
Echinococcus granulosus ornithine aminotransferase 0.0021 0.045 0.0699
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0439 0.2613
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.1146 1
Brugia malayi Pre-SET motif family protein 0.0251 0.8749 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0726 0.1367
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0726 0.1367
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0993 0.1589
Schistosoma mansoni pyruvate kinase 0.004 0.1146 0.1846
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1438 0.2408
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0993 0.1589
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0079 0.0055
Plasmodium falciparum ornithine aminotransferase 0.0021 0.045 0.2995
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.5823 1
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0047 0.0053
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.6 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.1146 0.1309
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.045 0.0678
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8749 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0726 0.5039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0079 0.0091
Mycobacterium ulcerans pyruvate kinase 0.004 0.1146 0.2213
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0726 0.1367
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.1146 0.2213
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0439 0.2913
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0148 0.5012 0.4989
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0079 0.0091
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0021 0.045 0.006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0706 0.0807
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0465 0.2785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0726 0.066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Brugia malayi DKFZp564C0469 protein 0.001 0.0047 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0079 0.0091
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.6 0.6858
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.1146 0.1104
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0079 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0079 0.0091
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0079 0.0055
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.045 0.0515
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0726 0.144
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0465 0.3104
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0079 0.0055
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0993 0.1638
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.1146 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0655 0.4051
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.1146 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.1146 0.1104
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1438 0.2337
Treponema pallidum DNA ligase (lig) 0.001 0.0047 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0079 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Echinococcus multilocularis pyruvate kinase 0.004 0.1146 0.1846
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0079 0.0055
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.1146 0.1309
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0047 0.0053
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1549 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0655 0.4515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1438 0.2337
Giardia lamblia Pyruvate kinase 0.004 0.1146 0.8155
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0079 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0993 0.1589
Echinococcus multilocularis pyruvate kinase 0.0032 0.084 0.1332
Brugia malayi hypothetical protein 0.001 0.0047 0.0053
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.045 0.0678
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0655 0.5537
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0993 0.1589
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0021 0.045 0.0813
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0079 0.0091
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1549 1
Onchocerca volvulus 0.0029 0.0726 0.0682
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.045 0.0678
Mycobacterium ulcerans acetylornithine aminotransferase 0.0021 0.045 0.0813
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0021 0.045 0.006
Echinococcus multilocularis pyruvate kinase 0.004 0.1146 0.1846
Trypanosoma brucei pyruvate kinase 1 0.004 0.1146 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0079 0.0055
Echinococcus granulosus geminin 0.0168 0.5761 0.9892
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0706 0.0807
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0106 0.3506 0.5988
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0079 0.0057
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0726 0.5039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0079 0.0055
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0125 0.0136
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0079 0.0091
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0079 0.0055
Echinococcus granulosus pyruvate kinase 0.0021 0.0439 0.0679
Echinococcus multilocularis geminin 0.0168 0.5761 0.9598
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1549 0.1509
Brugia malayi topoisomerase 0.001 0.0047 0.0053
Loa Loa (eye worm) hypothetical protein 0.0027 0.0655 0.0749
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.045 0.0813
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0079 0.0055
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0655 0.5537
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1394 1
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0021 0.045 0.3673
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0079 0.0055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0106 0.3506 0.581
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0079 0.0033
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0079 0.0057
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.1146 0.1575
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1394 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0993 0.1135
Schistosoma mansoni hypothetical protein 0.0168 0.5761 0.9598
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0079 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0726 0.1367
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0079 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Onchocerca volvulus 0.0036 0.0993 0.0951
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0079 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0726 0.1367
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0079 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Loa Loa (eye worm) acetyltransferase 0.0175 0.6 0.6858
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0079 0.0091
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0021 0.045 0.0813
Loa Loa (eye worm) pyruvate kinase 0.004 0.1146 0.1309
Mycobacterium ulcerans hypothetical protein 0.0148 0.5012 1
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0021 0.045 0.0813
Echinococcus multilocularis pyruvate kinase 0.0021 0.0439 0.0659
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1549 0.1509
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0079 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0079 0.0091
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.1146 0.7316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1438 0.2408
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0079 0.0091
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.045 0.2687
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0148 0.5012 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0655 0.5537
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.1146 0.1104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0079 0.0091
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.1146 0.1104
Loa Loa (eye worm) hypothetical protein 0.004 0.1146 0.1309
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0079 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0079 0.0091
Brugia malayi hypothetical protein 0.0027 0.0655 0.0749
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Echinococcus granulosus pyruvate kinase 0.0021 0.0439 0.0679
Leishmania major pyruvate kinase 0.004 0.1146 1
Brugia malayi ecdysteroid receptor 0.0011 0.0079 0.0091
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.045 0.0813
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0079 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0079 0.0091
Plasmodium vivax SET domain protein, putative 0.0036 0.0993 0.63
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1549 0.26
Plasmodium vivax pyruvate kinase, putative 0.004 0.1146 0.7316
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0021 0.045 0.0813
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0465 0.3806
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0125 0.0132
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0079 0.0091
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0079 0.0057
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0465 0.0842
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0079 0.0057
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0079 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0993 0.1589
Loa Loa (eye worm) pyruvate kinase 0.004 0.1146 0.1309
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0079 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1438 0.2337
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Mycobacterium tuberculosis Probable aminotransferase 0.0148 0.5012 1
Leishmania major pyruvate kinase 0.004 0.1146 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0079 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.045 0.2687
Brugia malayi nuclear receptor NHR-88 0.0011 0.0079 0.0091
Brugia malayi Steroid receptor seven-up type 2 0.0106 0.3506 0.4007
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.1146 0.1104
Echinococcus multilocularis pyruvate kinase 0.0021 0.0439 0.0659
Chlamydia trachomatis pyruvate kinase 0.004 0.1146 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0726 0.5039
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1549 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0465 0.0531
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0021 0.045 0.006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0726 0.0829
Loa Loa (eye worm) nuclear hormone receptor 0.01 0.3302 0.3774
Plasmodium falciparum pyruvate kinase 0.004 0.1146 0.8155
Loa Loa (eye worm) hypothetical protein 0.0029 0.0726 0.0829
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0726 0.1367
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0726 0.0829
Loa Loa (eye worm) hypothetical protein 0.0036 0.0993 0.1135
Brugia malayi steroid hormone receptor 0.0011 0.0079 0.0091
Schistosoma mansoni hypothetical protein 0.0012 0.0125 0.0132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0079 0.0055
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0148 0.5012 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0079 0.0091
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0021 0.045 0.0813
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0726 0.1367
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0726 0.0829
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0726 0.066
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0655 0.4515
Schistosoma mansoni coup transcription factor 0.0011 0.0079 0.0055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0079 0.0055
Brugia malayi hypothetical protein 0.001 0.0047 0.0053
Schistosoma mansoni hypothetical protein 0.0168 0.5761 0.9598
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0726 0.1367
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0706 0.4896
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Echinococcus multilocularis pyruvate kinase 0.0021 0.0439 0.0659
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0079 0.0091
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0465 0.0092
Brugia malayi hypothetical protein 0.0017 0.0315 0.036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1438 0.2337
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0993 0.63
Mycobacterium ulcerans L-lysine aminotransferase 0.0021 0.045 0.0813
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0079 0.0033
Schistosoma mansoni pyruvate kinase 0.004 0.1146 0.1846
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Brugia malayi nuclear hormone receptor 0.0011 0.0079 0.0091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0726 0.0829
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0079 0.0091
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0726 0.144
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0021 0.045 0.006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0079 0.0055
Echinococcus granulosus pyruvate kinase 0.004 0.1146 0.1902
Loa Loa (eye worm) hypothetical protein 0.0011 0.0079 0.0091
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0655 0.4051
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0726 0.0829

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1259 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 6.7456 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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