Detailed information for compound 1312795

Basic information

Technical information
  • TDR Targets ID: 1312795
  • Name: 1-(5-methoxy-1H-indol-3-yl)-2-[4-(4-methoxyph enyl)-3-methylpiperazin-1-yl]ethanol
  • MW: 395.495 | Formula: C23H29N3O3
  • H donors: 2 H acceptors: 1 LogP: 3.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1CCN(CC1C)CC(c1c[nH]c2c1cc(OC)cc2)O
  • InChi: 1S/C23H29N3O3/c1-16-14-25(10-11-26(16)17-4-6-18(28-2)7-5-17)15-23(27)21-13-24-22-9-8-19(29-3)12-20(21)22/h4-9,12-13,16,23-24,27H,10-11,14-15H2,1-3H3
  • InChiKey: CBRDUXXEIWYHQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(5-methoxy-1H-indol-3-yl)-2-[4-(4-methoxyphenyl)-3-methyl-piperazin-1-yl]ethanol
  • 1-(5-methoxy-1H-indol-3-yl)-2-[4-(4-methoxyphenyl)-3-methyl-1-piperazinyl]ethanol
  • STOCK2S-65921
  • MLS000037446
  • SMR000041013

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) prolyl oligopeptidase 0.0175 0.0378 0.339
Trichomonas vaginalis inositol monophosphatase, putative 0.0072 0.0128 0.2088
Echinococcus granulosus inositol monophosphatase 1 0.0072 0.0128 0.0642
Schistosoma mansoni hypothetical protein 0.0205 0.0451 0.2269
Echinococcus multilocularis smad 0.0025 0.0012 0.0012
Mycobacterium ulcerans transcriptional regulator 0.1549 0.3737 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0046 0.0231
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0051 0.0076 0.0682
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0046 0.1066
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0175 0.0378 0.19
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0041 0.0659
Echinococcus granulosus Dipeptidyl peptidase 9 0.0059 0.0094 0.0475
Brugia malayi beta-lactamase 0.0076 0.0136 0.122
Echinococcus granulosus smad 0.0025 0.0012 0.0061
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0046 0.0743
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0136 0.0684
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0059 0.0094 0.3705
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0381 0.0882 0.0882
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1988 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0118
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0036 0.0039 0.0194
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0059 0.0094 0.6149
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0286 0.0286
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0041 0.0792
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0381 0.0882 0.4437
Loa Loa (eye worm) hypothetical protein 0.0076 0.0136 0.122
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0074 0.0373
Schistosoma mansoni ets-related 0.0224 0.0498 0.2507
Toxoplasma gondii melibiase subfamily protein 0.0124 0.0253 1
Echinococcus multilocularis expressed conserved protein 0.009 0.0171 0.0171
Loa Loa (eye worm) MH2 domain-containing protein 0.0367 0.0848 0.7612
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0185 0.0932
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0012 0.0108
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0052 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0443 0.2227
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0441 0.3958
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0128 0.8548
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0046 0.0413
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0136 0.0684
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0036 0.0039 0.0347
Echinococcus granulosus tar DNA binding protein 0.0201 0.0443 0.2227
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0034 0.0034
Echinococcus multilocularis Smad4 0.0025 0.0012 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0136 0.0136
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0153 0.0767
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.0253 0.1274
Schistosoma mansoni hypothetical protein 0.0063 0.0106 0.0533
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0013 0.0066
Onchocerca volvulus Protein cycle homolog 0.0036 0.0039 0.0636
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0072 0.0128 0.5022
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0059 0.0094 0.4942
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0046 0.5
Schistosoma mansoni alpha-glucosidase 0.0143 0.03 0.1509
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0286 0.2567
Brugia malayi MH2 domain containing protein 0.0025 0.0012 0.0108
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0046 0.0046
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0109 0.0274
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1549 0.3737 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0302
Onchocerca volvulus 0.0269 0.0608 1
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0443 0.2227
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0046 0.304
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0241
Onchocerca volvulus 0.0023 0.0007 0.0115
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.0462
Schistosoma mansoni ap endonuclease 0.0039 0.0046 0.0231
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.0528 0.4739
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0007 0.012
Echinococcus granulosus geminin 0.0205 0.0451 0.2269
Brugia malayi prolyl oligopeptidase family protein 0.0059 0.0094 0.0847
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0041 0.0659
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0001 0.0008
Loa Loa (eye worm) TAR-binding protein 0.0201 0.0443 0.3973
Schistosoma mansoni hypothetical protein 0.0063 0.0106 0.0533
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.1115 0.5606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.0633 0.3184
Entamoeba histolytica hypothetical protein 0.0227 0.0506 1
Schistosoma mansoni hypothetical protein 0.0036 0.004 0.02
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0036 0.0039 0.0347
Schistosoma mansoni alpha-glucosidase 0.0143 0.03 0.1509
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0136 0.0346
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0185 0.3654
Loa Loa (eye worm) hypothetical protein 0.0137 0.0286 0.2567
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0149 0.5876
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0201 0.0443 0.3973
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0034 0.017
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0008
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0097
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.0253 0.0253
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0109 0.0274
Echinococcus granulosus GPCR family 2 0.0063 0.0106 0.0533
Loa Loa (eye worm) fli-1 protein 0.0224 0.0498 0.4471
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0061
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0357 0.3199
Leishmania major hypothetical protein, conserved 0.0081 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0149 0.1339
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0128 0.8486
Brugia malayi Ets-domain containing protein 0.0074 0.0131 0.1177
Brugia malayi Fli-1 protein 0.0224 0.0498 0.4471
Mycobacterium ulcerans TetR family transcriptional regulator 0.1549 0.3737 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0106 0.0533
Mycobacterium tuberculosis Conserved protein 0.0076 0.0136 0.0346
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0041 0.0206
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0128 0.2088
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0136 0.0346
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0063
Echinococcus multilocularis musashi 0.0053 0.008 0.008
Echinococcus multilocularis aryl hydrocarbon receptor 0.0051 0.0076 0.0076
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0059 0.0094 0.6306
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0007 0.012
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0136 0.0346
Schistosoma mansoni survival motor neuron protein 0.0097 0.0188 0.0947
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.0633 0.3184
Loa Loa (eye worm) hypothetical protein 0.0076 0.0136 0.122
Echinococcus multilocularis protein dispatched 1 0.0047 0.0066 0.0066
Brugia malayi hypothetical protein 0.0051 0.0075 0.0677
Loa Loa (eye worm) hypothetical protein 0.0096 0.0185 0.1663
Toxoplasma gondii exonuclease III APE 0.0039 0.0046 0.1786
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0188 0.1689
Schistosoma mansoni ap endonuclease 0.0039 0.0046 0.0231
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0072 0.0128 1
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0241
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.004 0.004
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0128 0.8012
Schistosoma mansoni intermediate filament proteins 0.0053 0.008 0.0402
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0061
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0106 0.0533
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0149 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0279 0.0633 0.5679
Mycobacterium leprae Probable lipase LipE 0.0076 0.0136 0.0346
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0041 0.0659
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0041 0.2696
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0052 0.0052
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0052 0.0259
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1988 1
Brugia malayi hypothetical protein 0.0227 0.0506 0.4537
Brugia malayi hypothetical protein 0.0148 0.0313 0.2804
Schistosoma mansoni hypothetical protein 0.0063 0.0106 0.0533
Onchocerca volvulus 0.0034 0.0034 0.0554
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.008 0.0717
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0185 0.0185
Mycobacterium ulcerans lipase LipD 0.0076 0.0136 0.0346
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0061
Onchocerca volvulus 0.0076 0.0136 0.2236
Onchocerca volvulus 0.0076 0.0136 0.2236
Echinococcus granulosus lamin dm0 0.0053 0.008 0.0402
Brugia malayi MH1 domain containing protein 0.0025 0.0012 0.0108
Mycobacterium ulcerans beta-lactamase 0.0076 0.0136 0.0346
Loa Loa (eye worm) RNA binding protein 0.0201 0.0443 0.3973
Echinococcus multilocularis tumor protein p63 0.0345 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.0063 0.0105 0.0943
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0072 0.0128 0.2511
Loa Loa (eye worm) hypothetical protein 0.0052 0.0078 0.0695
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0034 0.0034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0106 0.0951
Onchocerca volvulus 0.0053 0.008 0.1314
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.008 0.0717
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0136 0.2224
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0137 0.0286 0.1439
Brugia malayi prolyl oligopeptidase family protein 0.0175 0.0378 0.339
Echinococcus multilocularis lamin dm0 0.0053 0.008 0.008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0227 0.0506 0.2544
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0136 0.0346
Brugia malayi RNA binding protein 0.0201 0.0443 0.3973
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0136 0.0346
Brugia malayi Serine carboxypeptidase S28 family protein 0.002 0.0001 0.0008
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0357 0.3199
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0286 0.1438
Onchocerca volvulus Huntingtin homolog 0.0148 0.0313 0.5141
Loa Loa (eye worm) transcription factor SMAD2 0.0367 0.0848 0.7612
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0484 0.1133 0.302
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0253 0.1274
Brugia malayi beta-lactamase family protein 0.0076 0.0136 0.122
Schistosoma mansoni inositol monophosphatase 0.0072 0.0128 0.0642
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0034 0.017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0227 0.0506 0.0506
Schistosoma mansoni hypothetical protein 0.0097 0.0188 0.0947
Echinococcus granulosus tumor protein p63 0.0345 0.0794 0.3992
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0063
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0136 0.0346
Loa Loa (eye worm) intermediate filament protein 0.0053 0.008 0.0717
Schistosoma mansoni hypothetical protein 0.0227 0.0506 0.2544
Loa Loa (eye worm) hypothetical protein 0.0063 0.0106 0.0951
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0046 0.0413
Brugia malayi hypothetical protein 0.0036 0.0039 0.0347
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0046 0.0893
Schistosoma mansoni gabp alpha 0.0074 0.0131 0.066
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0149 1
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0131 0.066
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0072 0.0128 0.0324
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0253 0.1274
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0175 0.0378 0.6214
Schistosoma mansoni transcription factor LCR-F1 0.0227 0.0506 0.2544
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0059 0.0094 0.4942
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0153 0.2497
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0041 0.0659
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0149 1
Mycobacterium ulcerans short chain dehydrogenase 0.0287 0.0653 0.1731
Brugia malayi hypothetical protein 0.0155 0.033 0.2956
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0241
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0149 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0052 0.0833
Brugia malayi hypothetical protein 0.0476 0.1115 1
Brugia malayi Pre-SET motif family protein 0.0236 0.0528 0.4739
Brugia malayi TAR-binding protein 0.0201 0.0443 0.3973
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0031 0.0154
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0357 0.0357
Brugia malayi MH2 domain containing protein 0.0025 0.0012 0.0108
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0175 0.0378 0.0378
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0036 0.0038 0.0341
Echinococcus granulosus aryl hydrocarbon receptor 0.0051 0.0076 0.0382
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0153 0.0767
Schistosoma mansoni hypothetical protein 0.0205 0.0451 0.2269
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0041 0.0659
Onchocerca volvulus Huntingtin homolog 0.0148 0.0313 0.5141
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0136 0.2224
Schistosoma mansoni lamin 0.0053 0.008 0.0402
Toxoplasma gondii ABC1 family protein 0.0076 0.0136 0.5351
Entamoeba histolytica hypothetical protein 0.0227 0.0506 1
Onchocerca volvulus 0.0155 0.033 0.542
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0041 0.0659
Loa Loa (eye worm) hypothetical protein 0.0148 0.0313 0.2804
Echinococcus granulosus lamin 0.0053 0.008 0.0402
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0046 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0046 0.0105
Brugia malayi Melibiase family protein 0.0082 0.0153 0.1369
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.002 0.0001 0.0005
Brugia malayi hypothetical protein 0.0036 0.0038 0.0341
Schistosoma mansoni inositol monophosphatase 0.0072 0.0128 0.0642
Brugia malayi Smad1 0.0025 0.0012 0.0108
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0041 0.0659
Echinococcus multilocularis lamin 0.0053 0.008 0.008
Onchocerca volvulus 0.0053 0.008 0.1314
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0012 0.0012
Trichomonas vaginalis esterase, putative 0.0076 0.0136 0.2224
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0131 0.0131
Brugia malayi Ets-domain containing protein 0.0074 0.0131 0.1177
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0041 0.0792
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0136 0.0346
Loa Loa (eye worm) hypothetical protein 0.0155 0.033 0.2956
Brugia malayi hypothetical protein 0.0052 0.0079 0.0708
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0012 0.0012
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0052 0.0462
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0136 0.0346
Brugia malayi intermediate filament protein 0.0053 0.008 0.0717
Loa Loa (eye worm) inositol-1 0.0072 0.0128 0.1145
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0341
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0189 0.0951
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0128 0.2088
Brugia malayi hypothetical protein 0.0045 0.0061 0.0544
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0341
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0185 0.1663
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0041 0.0367
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0149 1
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1549 0.3737 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0034 0.017
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0357 0.1794
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0034 0.017
Mycobacterium ulcerans hypothetical protein 0.0076 0.0136 0.0346
Brugia malayi CHE-14 protein 0.0041 0.0052 0.0462
Loa Loa (eye worm) hypothetical protein 0.005 0.0074 0.0666
Loa Loa (eye worm) hypothetical protein 0.0082 0.0153 0.1369
Echinococcus multilocularis inositol monophosphatase 1 0.0072 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0053 0.008 0.0717
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0136 0.8854
Leishmania major hypothetical protein, conserved 0.0076 0.0136 0.907
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0076 0.0136 0.122
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.1115 0.1115
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0041 0.2696
Schistosoma mansoni lamin 0.0053 0.008 0.0402
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.004 0.02
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0106 0.0951
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0441 0.3958
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0253 0.1274
Loa Loa (eye worm) beta-lactamase 0.0076 0.0136 0.122
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0441 0.3958
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0036 0.0039 0.0347
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0008
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0001 0.0008
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0012 0.0061
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0136 0.122
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0008
Schistosoma mansoni smad 0.0025 0.0012 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.0633 0.3184
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0136 0.9108
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0136 0.0346
Onchocerca volvulus 0.0076 0.0136 0.2236
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0046 0.0471
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.002 0.0001 0.0005
Brugia malayi hypothetical protein 0.0081 0.0149 0.1339
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0136 0.2224
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0034 0.1298
Brugia malayi Inositol-1 0.0072 0.0128 0.1145
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0253 0.1274
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0341
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1549 0.3737 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0059 0.0094 0.6306
Brugia malayi MH1 domain containing protein 0.0025 0.0012 0.0108
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0007 0.0063
Schistosoma mansoni alpha glucosidase 0.0037 0.0041 0.0206
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1988 0.1988
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0059 0.0094 0.0475
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0149 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0034 0.017
Loa Loa (eye worm) hypothetical protein 0.0076 0.0136 0.122
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0476 0.1115 1
Mycobacterium tuberculosis Conserved protein 0.0076 0.0136 0.0346
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0046 0.2744
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0443 0.2227
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0012 0.0061
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0341
Echinococcus granulosus expressed conserved protein 0.009 0.0171 0.0861
Trichomonas vaginalis set domain proteins, putative 0.0269 0.0608 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0106 0.0951
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.0633 0.3184
Loa Loa (eye worm) hypothetical protein 0.0076 0.0136 0.122
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0136 0.9108
Echinococcus multilocularis tar DNA binding protein 0.0201 0.0443 0.0443
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0106 0.0106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0046 0.304
Onchocerca volvulus 0.0097 0.0188 0.3096
Onchocerca volvulus 0.0096 0.0186 0.3052
Mycobacterium tuberculosis Probable oxidoreductase 0.0287 0.0653 0.1731
Brugia malayi MH2 domain containing protein 0.0367 0.0848 0.7612
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.0253 0.0253
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0041 0.0659
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0007 0.012
Loa Loa (eye worm) hypothetical protein 0.0051 0.0075 0.0677
Echinococcus granulosus Smad4 0.0025 0.0012 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0443 0.2227
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0041 0.2385
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0227 0.0506 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0041 0.0659
Onchocerca volvulus 0.002 0.0001 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0041 0.0367
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.002 0.0179
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0131 0.1177
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0136 0.0346
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.002 0.0179
Onchocerca volvulus 0.005 0.0074 0.1221
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0012 0.0061
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0136 0.2224
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0381 0.0882 0.4437
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0106 0.0106
Onchocerca volvulus 0.0051 0.0075 0.124
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0357 0.0357
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0136 0.0684
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0136 0.8778
Loa Loa (eye worm) hypothetical protein 0.0201 0.0441 0.3958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.0633 0.3184
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0046 0.0743
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0046 0.0105
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0175 0.0378 0.19
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0279 0.0633 0.5679
Echinococcus granulosus intermediate filament protein 0.0053 0.008 0.0402
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0241
Echinococcus multilocularis geminin 0.0205 0.0451 0.0451
Echinococcus multilocularis protein patched 0.0041 0.0052 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0136 0.2224
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0443 0.2227
Loa Loa (eye worm) Smad1 0.0025 0.0012 0.0108
Entamoeba histolytica hypothetical protein 0.0227 0.0506 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0041 0.1584
Loa Loa (eye worm) hypothetical protein 0.005 0.0074 0.0665
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0076 0.0136 0.122
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0007 0.0063
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0136 0.122
Echinococcus multilocularis GPCR, family 2 0.0063 0.0106 0.0106
Mycobacterium tuberculosis Conserved protein 0.0076 0.0136 0.0346
Loa Loa (eye worm) hypothetical protein 0.0148 0.0313 0.2804
Brugia malayi beta-lactamase family protein 0.0076 0.0136 0.122
Loa Loa (eye worm) hypothetical protein 0.0045 0.0061 0.0544
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0059 0.0094 0.0094
Schistosoma mansoni Smad4 0.0025 0.0012 0.0061
Brugia malayi Pre-SET motif family protein 0.0034 0.0034 0.0302
Brugia malayi RNA recognition motif domain containing protein 0.0201 0.0443 0.3973
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0128 0.8548
Schistosoma mansoni hypothetical protein 0.0063 0.0106 0.0533
Schistosoma mansoni patched 1 0.0041 0.0052 0.0259

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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