Detailed information for compound 1312918

Basic information

Technical information
  • TDR Targets ID: 1312918
  • Name: N-(5-imidazo[1,2-a]pyrimidin-2-yl-2-methoxyph enyl)cyclopentanecarboxamide
  • MW: 336.388 | Formula: C19H20N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)C1CCCC1)c1cn2c(n1)nccc2
  • InChi: 1S/C19H20N4O2/c1-25-17-8-7-14(16-12-23-10-4-9-20-19(23)22-16)11-15(17)21-18(24)13-5-2-3-6-13/h4,7-13H,2-3,5-6H2,1H3,(H,21,24)
  • InChiKey: XKDASXLFBFFWTR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-imidazo[1,2-a]pyrimidin-2-yl-2-methoxy-phenyl)cyclopentanecarboxamide
  • N-[5-(2-imidazo[1,2-a]pyrimidinyl)-2-methoxyphenyl]cyclopentanecarboxamide
  • SMR000028317
  • UNM000003193002
  • MLS000045945

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major p-glycoprotein 0.0105 0.2124 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0488 0.123
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0193 0.1142
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0211 0.0878
Entamoeba histolytica P-glycoprotein 6, putative 0.0033 0.0488 0.1115
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0484 0.2156
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.1039 0.0964
Trypanosoma brucei trypanothione reductase 0.0057 0.1039 1
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0033 0.0488 0.2212
Toxoplasma gondii sugar transporter ST1 0.0015 0.0084 0.0091
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0105 0.2124 0.9823
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0158
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0158
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0217 0.0641
Brugia malayi P-glycoprotein-like protein 0.0033 0.0488 0.2174
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0105 0.2124 0.9823
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0174 0.0229
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0283 0.0961
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0174 0.0396
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0021 0.0211 0.0878
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0193 0.1142
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0084 0.0283
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0283 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0193 0.0169
Brugia malayi ABC transporter family protein 0.0033 0.0488 0.2174
Echinococcus granulosus multidrug resistance protein 1 0.0073 0.1405 0.6466
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0085 0.1661 0.7798
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0211 0.0485
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.1355 0.6232
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0105 0.2124 0.9823
Brugia malayi jmjC domain containing protein 0.0071 0.1355 0.6231
Echinococcus multilocularis ATP binding cassette sub family B 0.0104 0.2098 0.9706
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0174 0.0704
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0105 0.2124 0.9828
Loa Loa (eye worm) hypothetical protein 0.0021 0.0211 0.0495
Loa Loa (eye worm) hypothetical protein 0.0026 0.0333 0.0818
Echinococcus multilocularis expressed conserved protein 0.0012 0.0024 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0484 0.1927
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0193 0.0438
Plasmodium vivax glutathione reductase, putative 0.0057 0.1039 0.0964
Echinococcus granulosus multidrug resistance protein 1 0.0073 0.1405 0.6466
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0105 0.2124 0.9828
Brugia malayi major facilitator superfamily protein 0.0015 0.0084 0.028
Entamoeba histolytica ABC transporter, putative 0.0033 0.0488 0.1115
Loa Loa (eye worm) hypothetical protein 0.01 0.2006 0.525
Loa Loa (eye worm) hypothetical protein 0.0033 0.0484 0.1218
Echinococcus multilocularis multidrug resistance protein 1 0.0105 0.2124 0.9828
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0084 0.0285
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0193 0.0525
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0211 0.0485
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0493 0.4287
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0033 0.0488 0.0709
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0493 0.4287
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0033 0.0488 0.4236
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.1398 0.6329
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0174 0.0941
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0033 0.0488 0.4236
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0469 0.1008
Plasmodium falciparum multidrug resistance protein 2 0.0033 0.0488 0.0466
Toxoplasma gondii ABC transporter, putative 0.0033 0.0488 0.0709
Loa Loa (eye worm) hypothetical protein 0.0019 0.0174 0.0396
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0484 0.0461
Echinococcus granulosus multidrug resistance associated protein 7 0.0033 0.0488 0.2177
Brugia malayi Sugar transporter family protein 0.0015 0.0084 0.028
Schistosoma mansoni voltage-gated potassium channel 0.009 0.1794 0.4596
Schistosoma mansoni protein kinase 0.0033 0.0484 0.1194
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0174 0.0389
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0493 0.4287
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0283 0.1217
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0193 0.1142
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0105 0.2124 0.9823
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4287
Echinococcus multilocularis ATP binding cassette sub family B 0.0033 0.0488 0.2177
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4287
Brugia malayi hypothetical protein 0.0033 0.0488 0.2174
Brugia malayi jmjC domain containing protein 0.0019 0.0174 0.07
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0493 0.1973
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0032 0.0462 0.1139
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 0.58
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0373 0.0907
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0211 0.0485
Plasmodium falciparum multidrug resistance protein 1 0.0105 0.2124 0.2105
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0105 0.2124 0.9828
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0283
Entamoeba histolytica P-glycoprotein-2 0.0105 0.2124 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0105 0.2124 0.9823
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0084 0.0264
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0211 0.0878
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0589 0.0566
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0033 0.0488 0.4236
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Schistosoma mansoni smdr2 0.0105 0.2124 0.5452
Leishmania major protein kinase, putative 0.0033 0.0484 0.219
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.2699 0.8833
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0033 0.0488 0.4236
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.2699 0.891
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0105 0.2124 0.9823
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0074 0.0233
Echinococcus granulosus sodium channel protein 0.0085 0.1661 0.7665
Echinococcus granulosus voltage gated potassium channel 0.0028 0.0373 0.1639
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0438 0.1942
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0033 0.0488 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.3028 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.1355 0.3457
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0283 0.026
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0028 0.0373 0.1639
Toxoplasma gondii sugar transporter ST3 0.0015 0.0084 0.0091
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0105 0.2124 0.9828
Schistosoma mansoni multidrug resistance protein 0.0105 0.2124 0.5452
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0283 0.1235
Trypanosoma cruzi hexose transporter 0.0033 0.0493 0.4287
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0283 0.0288
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0105 0.2124 0.9823
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.3028 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Brugia malayi ABC transporter transmembrane region family protein 0.0033 0.0488 0.2174
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0484 0.0461
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0283
Leishmania major trypanothione reductase 0.0057 0.1039 0.4836
Brugia malayi Cyclic-nucleotide gated cation channel 0.0021 0.0211 0.0874
Leishmania major glucose transporter, lmgt1 0.0033 0.0493 0.2236
Schistosoma mansoni voltage-gated potassium channel 0.009 0.1794 0.4596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0488 0.0709
Trichomonas vaginalis taga, putative 0.0105 0.2124 0.9823
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0493 0.1973
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0105 0.2124 0.556
Mycobacterium tuberculosis Probable reductase 0.013 0.2699 0.891
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3649 0.3633
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0193 0.0525
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0484 0.0404
Schistosoma mansoni multidrug resistance protein 0.0033 0.0488 0.1206
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0193 0.3947
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0211 0.0612
Loa Loa (eye worm) hypothetical protein 0.0033 0.0488 0.123
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0283 0.4932
Echinococcus multilocularis ATP binding cassette sub family B 0.0033 0.0488 0.2177
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0155
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0032 0.0462 0.9359
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.3028 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0174 0.0396
Plasmodium falciparum ABC transporter B family member 7, putative 0.0033 0.0488 0.0466
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0193 0.0804
Echinococcus granulosus ATP binding cassette sub family B 0.0033 0.0488 0.2177
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0084 0.1714
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0193 0.2696
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.216 1
Brugia malayi ABC transporter transmembrane region family protein 0.0032 0.0462 0.2053
Schistosoma mansoni multidrug resistance protein 0.0033 0.0488 0.1206
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0033 0.0488 0.2212
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0193 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0493 0.1973
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0589 0.5288
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0105 0.2124 0.9823
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0193 0.0804
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.1355 0.3525
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0283 0.1334
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0484 0.1218
Leishmania major glucose transporter, lmgt3 0.0033 0.0493 0.2236
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0438 0.1942
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.1039 0.3424
Schistosoma mansoni protein kinase 0.0033 0.0484 0.1194
Entamoeba histolytica ATP-binding cassette protein, putative 0.0033 0.0488 0.1115
Echinococcus granulosus multidrug resistance protein 1 0.0105 0.2124 0.9828
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0589 0.2691
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0211 0.0612
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0211 0.0878
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0193 0.1142
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0493 0.1973
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0469 0.1155
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0997 0.4555
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0488 0.1949
Plasmodium falciparum ABC transporter B family member 3, putative 0.0033 0.0488 0.0466
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0493 0.1973
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0084 0.0283
Toxoplasma gondii ABC transporter family protein 0.0033 0.0488 0.0709
Entamoeba histolytica P-glycoprotein-2 0.0105 0.2124 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0105 0.2124 0.3207
Giardia lamblia MRP-like ABC transporter 0.0033 0.0488 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.2156
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0154 0.0731
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.2156
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.2699 0.891
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0484 0.0404
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.2156
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0469 0.1855
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0105 0.2124 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0193 0.0908
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0193 0.1142
Brugia malayi jmjC domain containing protein 0.0071 0.1355 0.6231
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0033 0.0488 0.0408
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.1039 0.4754
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0202 0.0656
Leishmania major p-glycoprotein e 0.0033 0.0488 0.2212
Loa Loa (eye worm) hypothetical protein 0.0032 0.0469 0.1178
Schistosoma mansoni smdr1 0.0033 0.0488 0.1206
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0193 0.3947
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0083 0.1631 0.4256
Leishmania major pentamidine resistance protein 1 0.0033 0.0488 0.2212
Giardia lamblia Hypothetical protein 0.0032 0.0462 0.9359
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0193 0.2696
Plasmodium falciparum multidrug resistance-associated protein 2 0.0033 0.0488 0.0466
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0033 0.0488 1
Loa Loa (eye worm) ABC transporter 0.0033 0.0488 0.123
Echinococcus granulosus ATP binding cassette sub family B 0.0033 0.0488 0.2177
Schistosoma mansoni glucose transport protein 0.0107 0.216 0.5548
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0687
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0589 0.5288
Plasmodium vivax CDK-related protein kinase 6, putative 0.0452 1 1
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0174 0.0389
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0033 0.0488 0.4236
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0211 0.0878
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0033 0.0488 0.2212
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.3028 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0032 0.0462 0.9359
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0484 0.0461
Schistosoma mansoni glucose transport protein 0.0107 0.216 0.5548
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0997 0.2527
Entamoeba histolytica P-glycoprotein-2, putative 0.0032 0.0462 0.0974
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0193 0.079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0997 0.4557
Loa Loa (eye worm) hypothetical protein 0.0105 0.2124 0.556
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0024 0.0004
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.216 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0021 0.0211 0.0878
Echinococcus multilocularis sodium channel protein 0.0085 0.1661 0.7665
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0174 0.0704
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4287
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0174 0.0389
Echinococcus multilocularis multidrug resistance associated protein 1 0.0033 0.0488 0.2177
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0193 0.0258
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0105 0.2124 0.7008
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0469 0.9517
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0084 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0462 0.1824
Loa Loa (eye worm) hypothetical protein 0.0179 0.38 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.2124 0.556
Toxoplasma gondii sugar transporter ST2 0.0015 0.0084 0.0091
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4287
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.1355 0.6232
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0084 0.028
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0033 0.0488 0.4236
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0105 0.2124 0.9823
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0373 0.0907
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0589 0.0863
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0174 0.0229
Loa Loa (eye worm) hypothetical protein 0.0028 0.0373 0.0925
Plasmodium vivax multidrug resistance protein 1, putative 0.0105 0.2124 0.2057
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0193 0.011
Brugia malayi multidrug resistance related protein 1 0.0033 0.0488 0.2174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Loa Loa (eye worm) ABC transporter 0.0033 0.0488 0.123
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0484 0.2153
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0105 0.2124 0.9823
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0193 0.0794
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0193 0.0169
Loa Loa (eye worm) hypothetical protein 0.0019 0.0174 0.0396
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.1355 0.6232
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0283
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0997 0.4557
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3649 0.5536
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0179 0.38 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0484 0.0703
Trichomonas vaginalis ABC transporter, putative 0.0105 0.2124 0.9823
Entamoeba histolytica ATP-binding cassette protein, putative 0.0033 0.0488 0.1115
Brugia malayi ABC transporter 0.0032 0.0462 0.2053
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0469 0.2086
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0283
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0024 0.0004
Schistosoma mansoni multidrug resistance protein 0.0032 0.0462 0.1139
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.2156
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0488 0.0709
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0084 0.028
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0211 0.0485
Echinococcus multilocularis multidrug resistance protein 1 0.0073 0.1405 0.6466
Plasmodium vivax ABC transporter B family member 3, putative 0.0033 0.0488 0.0408
Plasmodium vivax ABC transporter B family member 7, putative 0.0033 0.0488 0.0408
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0283 0.2089
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0174 0.0704
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0174 0.0704
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0493 0.1973
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0997 0.2577
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0174 0.0704
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.2699 0.891
Entamoeba histolytica P-glycoprotein-5 0.0105 0.2124 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0488 0.0709
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0283 0.1214
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0493 0.4287
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0105 0.2124 0.9828
Plasmodium vivax ABC transporter B family member 6, putative 0.0033 0.0488 0.0408
Plasmodium falciparum thioredoxin reductase 0.0057 0.1039 0.1018
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0493 0.4287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0997 0.2527
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0174 0.0396
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.2156
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0283
Entamoeba histolytica protein kinase, putative 0.0033 0.0484 0.109
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0105 0.2124 0.3207
Plasmodium falciparum ABC transporter B family member 4, putative 0.0033 0.0488 0.0466
Brugia malayi Sugar transporter family protein 0.0015 0.0084 0.028
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0469 0.0944
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0033 0.0488 0.0408
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0484 0.0703
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0211 0.0485
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0033 0.0488 0.4236
Schistosoma mansoni protein kinase 0.0033 0.0484 0.1194
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0211 0.0495
Brugia malayi jmjC domain containing protein 0.0019 0.0174 0.07
Entamoeba histolytica ATP-binding cassette protein, putative 0.0033 0.0488 0.1115
Leishmania major hypothetical protein, conserved 0.0015 0.0084 0.0285
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0488 0.0709
Loa Loa (eye worm) multidrug resistance protein 3 0.0105 0.2124 0.556
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0193 0.0804
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0193 0.1142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0997 0.4557
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0033 0.0488 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0997 0.4557
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0033 0.0488 0.1603
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0105 0.2124 0.9823
Brugia malayi ABC transporter transmembrane region family protein 0.0033 0.0488 0.2174
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0469 0.1155
Schistosoma mansoni hypothetical protein 0.0107 0.216 0.5548
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0105 0.2124 0.9823
Trichomonas vaginalis ABC transporter, putative 0.0105 0.2124 0.9823
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0033 0.0488 0.2212
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0193 0.1142
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0589 0.2691
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0484 0.4188
Echinococcus granulosus phd:f box containing protein 0.0019 0.0174 0.0704
Brugia malayi hypothetical protein 0.0015 0.0084 0.028
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0084 0.0283
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0589 0.5288
Echinococcus multilocularis 0.0033 0.0488 0.2177
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0174 0.0704
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0105 0.2124 0.9823
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0493 0.4287
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0033 0.0488 0.4236
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0193 0.0625
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0084 0.0264
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0083 0.1631 0.7524
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0083 0.1631 0.7524
Loa Loa (eye worm) hypothetical protein 0.0033 0.0488 0.123
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.216 1
Brugia malayi ABC transporter family protein 0.0033 0.0488 0.2174
Trypanosoma cruzi multidrug resistance protein E, putative 0.0033 0.0488 0.4236
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0105 0.2124 0.9828
Entamoeba histolytica multidrug resistance protein, putative 0.0033 0.0488 0.1115
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0493 0.2236
Echinococcus granulosus General substrate transporter 0.0092 0.1821 0.841
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0105 0.2124 0.9823
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.216 0.3263
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0193 0.3947
Loa Loa (eye worm) hypothetical protein 0.0032 0.0469 0.1178
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.1355 0.3457
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0033 0.0488 0.2212
Entamoeba histolytica P-glyco protein 6, putative 0.0105 0.2124 1
Brugia malayi ABC transporter family protein 0.0033 0.0488 0.2174
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.216 1
Trichomonas vaginalis abcb9, putative 0.0105 0.2124 0.9823
Brugia malayi Cam kinase protein 1 0.0033 0.0484 0.2153
Echinococcus granulosus multidrug resistance protein 1 0.0105 0.2124 0.9828
Echinococcus multilocularis voltage gated potassium channel 0.0028 0.0373 0.1639
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0084 0.1714
Echinococcus granulosus multidrug resistance protein 1 0.0105 0.2124 0.9828
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0193 0.1142
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.2006 0.9363
Brugia malayi multidrug resistance protein 3 0.0105 0.2124 0.9828
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.216 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0202 0.0656
Schistosoma mansoni multidrug resistance protein 0.0033 0.0488 0.1206
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0033 0.0488 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.38 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0105 0.2124 0.9823
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0174 0.0941
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0462 0.1824
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0469 0.2086
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.014 0.03
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0033 0.0488 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0484 0.1194
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0024 0.0004
Loa Loa (eye worm) ABC transporter 0.0033 0.0488 0.123
Plasmodium vivax ABC transporter B family member 5, putative 0.0033 0.0488 0.0408
Brugia malayi glutathione reductase 0.0057 0.1039 0.4752
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0105 0.2124 0.9823
Echinococcus multilocularis General substrate transporter 0.0092 0.1821 0.841
Plasmodium falciparum ABC transporter B family member 6, putative 0.0033 0.0488 0.0466
Trypanosoma brucei glucose transporter 2A 0.0033 0.0493 0.4287
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0211 0.0878
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0033 0.0488 0.2212
Mycobacterium ulcerans sugar transporter 0.0015 0.0084 0.1714
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0211 0.0485
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0084 0.006
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0174 0.0389
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0073 0.1405 0.6363
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0174 0.015
Brugia malayi ABC transporter family protein 0.0105 0.2124 0.9828
Entamoeba histolytica protein kinase, putative 0.0033 0.0484 0.109
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0033 0.0488 0.2212
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0193 0.1142
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.1039 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0105 0.2124 0.9823
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0193 0.1142
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0084 0.0155
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0211 0.0878
Schistosoma mansoni multidrug resistance protein 0.0105 0.2124 0.5452
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.014 0.03
Schistosoma mansoni multidrug resistance protein 0.0033 0.0488 0.1206
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0283
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.1039 0.2689
Leishmania major glucose transporter, lmgt2 0.0033 0.0493 0.2236
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0033 0.0488 0.1603
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0462 0.1824
Giardia lamblia ABC transporter, putative 0.0033 0.0488 1
Leishmania major ABC-thiol transporter 0.0033 0.0488 0.2212
Plasmodium falciparum hexose transporter 0.0107 0.216 0.2142
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0033 0.0488 0.2174
Schistosoma mansoni multidrug resistance protein 0.0033 0.0488 0.1206
Plasmodium falciparum protein kinase 7 0.0301 0.6571 0.6563
Loa Loa (eye worm) hypothetical protein 0.0179 0.38 1
Trichomonas vaginalis abcb9, putative 0.0105 0.2124 0.9823
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0105 0.2124 0.9823
Treponema pallidum NADH oxidase 0.002 0.0193 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0105 0.2124 0.9828
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0105 0.2124 0.9828
Loa Loa (eye worm) hypothetical protein 0.0019 0.0174 0.0396
Trichomonas vaginalis ABC transporter, putative 0.0105 0.2124 0.9823
Brugia malayi jmjC domain containing protein 0.0019 0.0174 0.07
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0033 0.0488 0.1013
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.1355 0.6232
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0021 0.0211 0.0878
Entamoeba histolytica hypothetical protein 0.0033 0.0488 0.1115
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0083 0.1631 0.7523
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0021 0.0211 0.0878
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0193 0.1142
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0084 0.0283
Onchocerca volvulus 0.0105 0.2124 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0104 0.2098 0.9706
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0283 0.2089
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0488 0.0709
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0193 0.0794
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0469 0.2083
Loa Loa (eye worm) hypothetical protein 0.0032 0.0462 0.1161
Entamoeba histolytica ATP-binding cassette protein, putative 0.0033 0.0488 0.1115
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.2006 0.9363
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0033 0.0488 0.1013
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0105 0.2124 0.9828
Trypanosoma brucei multidrug resistance protein E 0.0033 0.0488 0.4236
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0084 0.028
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0488 0.0709
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0105 0.2124 1
Loa Loa (eye worm) sugar transporter 0.0107 0.216 0.5658
Schistosoma mansoni jumonji domain containing protein 0.0071 0.1355 0.3457
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.216 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.2156
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0105 0.2124 0.9823
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4287
Echinococcus multilocularis multidrug resistance protein 1 0.0105 0.2124 0.9828
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0193 0.1142
Echinococcus multilocularis multidrug resistance associated protein 7 0.0033 0.0488 0.2177
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0211 0.0495
Loa Loa (eye worm) hypothetical protein 0.0104 0.2098 0.5491
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0105 0.2124 0.9823
Brugia malayi jmjC domain containing protein 0.0019 0.0174 0.07
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0484 0.0404
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0105 0.2124 0.9823
Entamoeba histolytica P-glycoprotein 5, putative 0.0105 0.2124 1
Trichomonas vaginalis ABC transporter, putative 0.0105 0.2124 0.9823
Brugia malayi major facilitator superfamily protein 0.0015 0.0084 0.028
Echinococcus multilocularis ATP binding cassette sub family B 0.0033 0.0488 0.2177
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0283 0.0396
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0028 0.0373 0.1639
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0997 0.2527
Plasmodium vivax ABC transporter B family member 4, putative 0.0033 0.0488 0.0408
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0484 0.0703
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0193 0.0804
Loa Loa (eye worm) hypothetical protein 0.0032 0.0462 0.1161
Brugia malayi hypothetical protein 0.0015 0.0084 0.028
Toxoplasma gondii hypothetical protein 0.0179 0.38 0.5768
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4287
Brugia malayi Thioredoxin reductase 0.0057 0.1039 0.4752
Echinococcus granulosus multidrug resistance associated protein 1 0.0033 0.0488 0.2177
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 0.58
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0033 0.0488 0.123
Entamoeba histolytica P-glycoprotein 5, putative 0.0032 0.0462 0.0974
Schistosoma mansoni multidrug resistance protein 0.0105 0.2124 0.5452
Plasmodium vivax JmjC domain containing protein 0.0019 0.0174 0.0091
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0042 0.0046
Plasmodium falciparum glutathione reductase 0.002 0.0193 0.0169
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0283 0.0673
Trypanosoma brucei glucose transporter 1E 0.0033 0.0493 0.4287
Plasmodium falciparum multidrug resistance-associated protein 1 0.0033 0.0488 0.0466
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0469 0.2083
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3649 0.3595
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0283 0.1217
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0105 0.2124 0.9823
Leishmania major hypothetical protein, conserved 0.0019 0.0174 0.0713
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0493 0.1973
Brugia malayi Sugar transporter family protein 0.0107 0.216 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4287
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0174 0.0704
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.2156
Entamoeba histolytica P-glycoprotein-2, putative 0.0105 0.2124 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0283 0.0673
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0074 0.0233
Trypanosoma brucei p-glycoprotein 0.0033 0.0488 0.4236
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0484 0.0461
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0283
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0174 0.0389
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.216 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0484 0.1218
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0155
Loa Loa (eye worm) hypothetical protein 0.0073 0.1397 0.3637
Echinococcus granulosus ATP binding cassette sub family B 0.0032 0.0462 0.2056
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.1398 0.6329
Brugia malayi ABC transporter 0.0033 0.0488 0.2174
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0033 0.0488 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0033 0.0488 1
Plasmodium falciparum thioredoxin reductase 0.002 0.0193 0.0169
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0174 0.0704
Trypanosoma brucei glucose transporter, putative 0.0033 0.0493 0.4287
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.2699 0.891
Toxoplasma gondii thioredoxin reductase 0.0057 0.1039 0.1551
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0033 0.0488 1
Schistosoma mansoni glucose transport protein 0.0107 0.216 0.5548
Entamoeba histolytica P-glycoprotein-1 0.0105 0.2124 1
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0084 0.1714
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0484 0.0461
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0589 0.051
Brugia malayi hypothetical protein 0.0015 0.0084 0.028
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0174 0.0941
Loa Loa (eye worm) sugar transporter 0.0015 0.0084 0.0158
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0484 0.0404
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0174 0.0704
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0462 0.1824
Toxoplasma gondii protein kinase, putative 0.0301 0.6571 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0193 0.1142
Schistosoma mansoni glucose transporter 0.0015 0.0084 0.0155
Plasmodium vivax hexose transporter 0.0107 0.216 0.2094
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0283
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0193 0.2696
Echinococcus multilocularis ATP binding cassette sub family B 0.0033 0.0488 0.2177
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0033 0.0488 0.1206
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0155
Plasmodium vivax multidrug resistance protein 2, putative 0.0033 0.0488 0.0408
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.1039 0.4754
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0024 0.0004
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.216 1
Entamoeba histolytica P-glycoprotein 6, putative 0.0033 0.0488 0.1115
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0158
Trichomonas vaginalis abcb9, putative 0.0105 0.2124 0.9823
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.216 1
Plasmodium falciparum ABC transporter B family member 5, putative 0.0033 0.0488 0.0466
Loa Loa (eye worm) glutathione reductase 0.0057 0.1039 0.2689
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.2699 0.891
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0028 0.0373 0.1636
Giardia lamblia Multidrug resistance-associated protein 1 0.0033 0.0488 1
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0193 0.0258
Plasmodium falciparum glutathione reductase 0.0057 0.1039 0.1018
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.0024 0.0004
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0085 0.1661 0.7665
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.0211 0.0878

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) 66.7 uM PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0033 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.0037 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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