Detailed information for compound 1321302

Basic information

Technical information
  • TDR Targets ID: 1321302
  • Name: N-[(3Z)-3-[1-cyano-2-[2-(4-methoxyphenyl)ethy lamino]-2-oxoethylidene]isoindol-1-yl]thiophe ne-2-carboxamide
  • MW: 456.516 | Formula: C25H20N4O3S
  • H donors: 2 H acceptors: 3 LogP: 3.72 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCNC(=O)/C(=C/1\N=C(c2c1cccc2)NC(=O)c1cccs1)/C#N
  • InChi: 1S/C25H20N4O3S/c1-32-17-10-8-16(9-11-17)12-13-27-24(30)20(15-26)22-18-5-2-3-6-19(18)23(28-22)29-25(31)21-7-4-14-33-21/h2-11,14H,12-13H2,1H3,(H,27,30)(H,28,29,31)/b22-20-
  • InChiKey: VCCGQFJXGMRRHV-XDOYNYLZSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(3Z)-3-[1-cyano-2-[2-(4-methoxyphenyl)ethylamino]-2-oxo-ethylidene]isoindol-1-yl]thiophene-2-carboxamide
  • N-[(3Z)-3-[1-cyano-2-[2-(4-methoxyphenyl)ethylamino]-2-oxoethylidene]-1-isoindolyl]-2-thiophenecarboxamide
  • N-[(3Z)-3-[1-cyano-2-keto-2-[2-(4-methoxyphenyl)ethylamino]ethylidene]isoindol-1-yl]thiophene-2-carboxamide
  • Thiophene-2-carboxylic acid {3-[1-cyano-1-[2-(4-methoxy-phenyl)-ethylcarbamoyl]-meth-(Z)-ylidene]-3H-isoindol-1-yl}-amide
  • MLS000331037
  • SMR000221098

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 1 0.018 0.1097 0.1754
Brugia malayi ecdysteroid receptor 0.0012 0.0012 0.0016
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0115 0.5956
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.3277
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5312 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.002 0.0028
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0012 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0031
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0004 0.0007
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0004 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0012 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0063 0.3384
Brugia malayi Carboxylesterase family protein 0.0011 0.0004 0.0006
Trichomonas vaginalis ran, putative 0.0026 0.0098 0.5084
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0324 0.1206
Entamoeba histolytica Ran family GTPase 0.0026 0.0098 0.5251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.002 0.1043
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.0012 0.5
Brugia malayi Cathepsin L-like precursor 0.0014 0.002 0.0028
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0004 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0012 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0012 0.0016
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.002 0.1043
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0063 0.0119
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0012 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0063 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0098 0.0323
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0012 0.0022
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0063 0.0236
Onchocerca volvulus 0.002 0.0063 0.0059
Leishmania major cathepsin L-like protease 0.002 0.0063 0.0192
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0012 0.0018
Echinococcus granulosus expressed protein 0.004 0.0193 0.0364
Leishmania major GTP-binding protein, putative 0.0026 0.0098 0.0323
Plasmodium vivax telomerase reverse transcriptase, putative 0.0426 0.2683 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0063 0.0059
Loa Loa (eye worm) fibroinase 0.002 0.0063 0.0253
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0012 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0063 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0012 0.0016
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0004 0.0008
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1776 0.3344
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.043 0.1603
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0098 0.0403
Leishmania major cathepsin L-like protease 0.0077 0.043 0.1566
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0012 0.0016
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1776 0.284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0012 0.0022
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0187 1
Plasmodium falciparum telomerase reverse transcriptase 0.0426 0.2683 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0068
Echinococcus granulosus acetylcholinesterase 0.0066 0.0356 0.0671
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0187 0.0697
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0063 0.0253
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0063 0.0236
Brugia malayi Cathepsin L-like precursor 0.0014 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0286 0.1776 0.7611
Onchocerca volvulus 0.002 0.0063 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0012 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0012 0.0031
Loa Loa (eye worm) cysteine protease 0.002 0.0063 0.0253
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0012 0.0018
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0426 0.2683 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0115 0.0429
Echinococcus multilocularis snurportin 1 0.0372 0.2332 0.3729
Echinococcus multilocularis neuroligin 0.0011 0.0004 0.0007
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0098 0.0366
Brugia malayi RNA, U transporter 1 0.0099 0.0572 0.0789
Brugia malayi STAT protein, DNA binding domain containing protein 0.028 0.1739 0.2399
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0158 0.0545
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0031
Leishmania major cathepsin L-like protease 0.0077 0.043 0.1566
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5312 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0063 0.3384
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0012 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5312 0.8494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.3277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.3277
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0187 0.0656
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0063 0.0101
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0356 0.1512
Onchocerca volvulus Cathepsin L homolog 0.002 0.0063 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0012 0.0031
Plasmodium falciparum importin beta, putative 0.0035 0.0158 0.0587
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0004 0.5
Leishmania major cathepsin L-like protease 0.002 0.0063 0.0192
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0012 0.0022
Echinococcus multilocularis muscleblind protein 0.018 0.1097 0.1754
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0087
Leishmania major cathepsin L-like protease 0.002 0.0063 0.0192
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0187 0.0656
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0012 0.0016
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0004 0.0008
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0098 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0012 0.0016
Schistosoma mansoni coup transcription factor 0.0012 0.0012 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.018 0.1097 0.4695
Loa Loa (eye worm) STAT protein 0.028 0.1739 0.7452
Leishmania major cathepsin L-like protease 0.002 0.0063 0.0192
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0004 0.0008
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.002 0.1077
Echinococcus granulosus neuroligin 0.0011 0.0004 0.0008
Brugia malayi Importin beta-1 subunit 0.0035 0.0158 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0063 0.3277
Leishmania major cathepsin L-like protease 0.002 0.0063 0.0192
Brugia malayi cathepsin L-like precursor 0.0014 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0253
Toxoplasma gondii cathepsin CPL 0.002 0.0063 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0012 0.0044
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2332 1
Plasmodium vivax vivapain-2 0.002 0.0063 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0012 0.0018
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0098 0.0366
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0387 0.1442
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0004 0.5
Onchocerca volvulus 0.002 0.0063 0.0059
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0012 0.0044
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0356 0.0671
Schistosoma mansoni hypothetical protein 0.0205 0.1254 0.236
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0012 0.0016
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0187 0.0697
Echinococcus granulosus neuropeptide s receptor 0.0558 0.3538 0.6659
Onchocerca volvulus 0.0012 0.0012 0.0007
Onchocerca volvulus 0.002 0.0063 0.0059
Onchocerca volvulus 0.002 0.0063 0.0059
Echinococcus granulosus acetylcholinesterase 0.0066 0.0356 0.0671
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0063 0.0119
Brugia malayi hypothetical protein 0.0286 0.1776 0.245
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0012 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Loa Loa (eye worm) hypothetical protein 0.0066 0.0356 0.1512
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0004 0.0008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0098 0.0366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0012 0.0031
Echinococcus multilocularis cysteine protease 0.002 0.0063 0.0101
Leishmania major cysteine peptidase A (CPA) 0.002 0.0063 0.0192
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0012 0.0022
Leishmania major telomerase reverse transcriptase, putative 0.0426 0.2683 1
Loa Loa (eye worm) ctsf protein 0.002 0.0063 0.0253
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0012 0.0016
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0356 0.057
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0004 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0012 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.3538 0.5656
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0063 0.0119
Echinococcus granulosus importin subunit beta 1 0.0035 0.0158 0.0297
Brugia malayi Carboxylesterase family protein 0.0011 0.0004 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0063 0.3277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0012 0.0022
Schistosoma mansoni survival motor neuron protein 0.0058 0.0309 0.0581
Trichomonas vaginalis rotamase, putative 0.004 0.0193 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0012 0.0018
Onchocerca volvulus 0.002 0.0063 0.0059
Toxoplasma gondii RNA-directed DNA polymerase 0.0426 0.2683 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0068
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0356 0.057
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0004 0.0224
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0012 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0012 0.0016
Entamoeba histolytica hypothetical protein 0.0028 0.0115 0.6151
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0193 1
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.3538 0.6659
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0004 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.043 0.1603
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0158 0.0587
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0012 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Echinococcus multilocularis geminin 0.0205 0.1254 0.2005
Brugia malayi Carboxylesterase family protein 0.0011 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0372 0.2332 0.4391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0012 0.0031
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0193 0.0266
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0426 0.2683 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0658
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0063 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Brugia malayi nuclear hormone receptor 0.0012 0.0012 0.0016
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0087
Onchocerca volvulus 0.0058 0.0309 0.0305
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0012 0.0007
Brugia malayi Carboxylesterase family protein 0.0011 0.0004 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0063 0.3384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0012 0.0031
Schistosoma mansoni ran 0.0026 0.0098 0.0185
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0012 0.0016
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0004 0.0007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0063 0.0101
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0098 0.0185
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0356 0.057
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0031
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0356 0.0671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Giardia lamblia Telomerase catalytic subunit 0.0426 0.2683 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.3277
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0012 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.3277
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0004 0.0224
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0098 0.0366
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0115 0.5956
Echinococcus granulosus cathepsin l1 0.0014 0.002 0.0038
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0063 0.0087
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0012 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0158 0.0587
Brugia malayi steroid hormone receptor 0.0012 0.0012 0.0016
Brugia malayi Carboxylesterase family protein 0.0066 0.0356 0.0492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Trichomonas vaginalis rotamase, putative 0.0039 0.0187 0.9682
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0012 0.0022
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.3538 0.5656
Schistosoma mansoni gliotactin 0.0011 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.018 0.1097 0.4695
Echinococcus granulosus muscleblind protein 0.018 0.1097 0.2065
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6254 1
Schistosoma mansoni acetylcholinesterase 0.0011 0.0004 0.0008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0187 0.0697
Brugia malayi Telomerase reverse transcriptase 0.1134 0.725 1
Echinococcus multilocularis expressed protein 0.004 0.0193 0.0309
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0012 0.0018
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0063 0.0101
Echinococcus multilocularis cysteine protease 0.002 0.0063 0.0101
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0012 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.3277
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0012 0.0022
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0012 0.0022
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0012 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Brugia malayi nuclear receptor NHR-88 0.0012 0.0012 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Echinococcus granulosus snurportin 1 0.0372 0.2332 0.4391
Echinococcus granulosus cathepsin l1 0.002 0.0063 0.0119
Onchocerca volvulus Cathepsin F homolog 0.002 0.0063 0.0059
Onchocerca volvulus 0.002 0.0063 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.3277
Onchocerca volvulus 0.0014 0.002 0.0016
Schistosoma mansoni hypothetical protein 0.0205 0.1254 0.236
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0193 0.0811
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0012 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0004 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.3277
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0098 0.0135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0012 0.0016
Schistosoma mansoni rotamase 0.004 0.0193 0.0364
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0012 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0115 0.5956
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0004 0.0007
Brugia malayi Carboxylesterase family protein 0.0066 0.0356 0.0492
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.0012 0.0044
Echinococcus granulosus geminin 0.0205 0.1254 0.236
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0031
Brugia malayi hypothetical protein 0.0011 0.0004 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0012 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0012 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.002 0.0038
Plasmodium vivax importin-beta 2, putative 0.0035 0.0158 0.0587
Brugia malayi Cathepsin L-like precursor 0.002 0.0063 0.0087
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0012 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.043 0.1603
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Leishmania major cathepsin L-like protease 0.0077 0.043 0.1566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Schistosoma mansoni hypothetical protein 0.0058 0.0309 0.0581
Schistosoma mansoni importin beta-1 0.0035 0.0158 0.0297
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0309 0.0426
Leishmania major importin beta-1 subunit, putative 0.0028 0.0115 0.0386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0031
Loa Loa (eye worm) carboxylesterase 0.0066 0.0356 0.1512
Plasmodium vivax vivapain-2 0.002 0.0063 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0063 0.3277
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0158 0.0252
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0012 0.0022
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0012 0.0018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0012 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0063 0.3277
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0063 0.0253
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0004 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0012 0.0018
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0063 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.043 0.1603
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0098 0.0366
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0068
Schistosoma mansoni ran 0.0026 0.0098 0.0185
Loa Loa (eye worm) hypothetical protein 0.0066 0.0356 0.1512
Trypanosoma brucei telomerase reverse transcriptase 0.0426 0.2683 1
Brugia malayi Muscleblind-like protein 0.018 0.1097 0.1513
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.043 0.1603

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 2.8184 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3225 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 19.0115 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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