Detailed information for compound 1329230

Basic information

Technical information
  • TDR Targets ID: 1329230
  • Name: 2-(2-fluorophenyl)-N-(1-phenylethyl)quinazoli n-4-amine
  • MW: 343.397 | Formula: C22H18FN3
  • H donors: 1 H acceptors: 2 LogP: 5.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccccc1)Nc1nc(nc2c1cccc2)c1ccccc1F
  • InChi: 1S/C22H18FN3/c1-15(16-9-3-2-4-10-16)24-22-18-12-6-8-14-20(18)25-21(26-22)17-11-5-7-13-19(17)23/h2-15H,1H3,(H,24,25,26)
  • InChiKey: PTEHHMVRHOYERK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-fluorophenyl)-N-(1-phenylethyl)-4-quinazolinamine
  • [2-(2-fluorophenyl)quinazolin-4-yl]-(1-phenylethyl)amine
  • EU-0042208
  • Oprea1_292575

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens acid phosphatase 1, soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans C terminus of potential Low molecular weight phosphoTyrosine Phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) phosphotyrosine protein phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Onchocerca volvulus Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA Get druggable targets OG5_127571 All targets in OG5_127571
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) acid phosphatase 1, soluble 112 aa 107 aa 24.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0651 0.7612
Echinococcus granulosus pyruvate kinase 0.0067 0.0713 0.1216
Onchocerca volvulus 0.0084 0.0925 0.3142
Echinococcus multilocularis survival motor neuron protein 1 0.0488 0.5863 0.5863
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0148 0.0212
Loa Loa (eye worm) hypothetical protein 0.0128 0.146 0.246
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0252 0.0252
Brugia malayi CXXC zinc finger family protein 0.0035 0.0319 0.0505
Loa Loa (eye worm) hypothetical protein 0.0084 0.0925 0.1543
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0315 0.3873
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0223 0.0223
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.3712 0.6317
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0344 0.055
Leishmania major pyruvate kinase 0.0067 0.0713 0.8455
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0252 0.2181
Onchocerca volvulus 0.0056 0.0575 0.1761
Echinococcus granulosus pyruvate kinase 0.0067 0.0713 0.1216
Trichomonas vaginalis ran, putative 0.0021 0.0157 0.0027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0184 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3712 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0157 0.0898
Brugia malayi Inositol-1 0.0076 0.0827 0.1375
Echinococcus multilocularis cpg binding protein 0.0037 0.0343 0.0343
Toxoplasma gondii ABC1 family protein 0.0073 0.0783 0.946
Schistosoma mansoni hypothetical protein 0.0312 0.3708 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0217 0.2014
Schistosoma mansoni hypothetical protein 0.0074 0.0803 0.2164
Onchocerca volvulus 0.0035 0.0319 0.0748
Loa Loa (eye worm) STAT protein 0.0161 0.1861 0.3147
Loa Loa (eye worm) hypothetical protein 0.0073 0.0783 0.1301
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.266 0.7047
Trichomonas vaginalis esterase, putative 0.0073 0.0783 0.1782
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0713 0.1586
Schistosoma mansoni hypothetical protein 0.0099 0.1112 0.2998
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.1253 0.2105
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0324 0.0514
Brugia malayi hypothetical protein 0.0019 0.013 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1035 0.2791
Mycobacterium ulcerans pyruvate kinase 0.0067 0.0713 0.2137
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0184 0.0169
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0252 0.2884
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0213
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0148 0.1597
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0783 0.1782
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0783 0.1336
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0803 0.0803
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0651 0.1886
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0184 0.1262
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0148 0.0212
Schistosoma mansoni lamin 0.0056 0.0575 0.1551
Loa Loa (eye worm) inositol-1 0.0076 0.0827 0.1375
Plasmodium falciparum importin beta, putative 0.0029 0.0252 0.2579
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0024 0.0061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0563 0.0923
Schistosoma mansoni inositol monophosphatase 0.0076 0.0827 0.223
Schistosoma mansoni DNA helicase recq1 0.0021 0.0148 0.0399
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.24 0.6317
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0651 0.1021
Brugia malayi hypothetical protein 0.0488 0.5863 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0148 0.0212
Echinococcus granulosus pyruvate kinase 0.0034 0.0315 0.0537
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0091 0.0951
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0259 0.0403
Echinococcus granulosus pyruvate kinase 0.0034 0.0315 0.0537
Schistosoma mansoni survival motor neuron protein 0.0099 0.1112 0.2998
Loa Loa (eye worm) hypothetical protein 0.0128 0.146 0.246
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.24 0.6317
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0259 0.0402
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0182
Giardia lamblia Pyruvate kinase 0.0034 0.0315 0.0665
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0091 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0217 0.2403
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0344 0.3988
Onchocerca volvulus 0.0056 0.0575 0.1761
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1035 0.1731
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0184 0.0102
Schistosoma mansoni ran 0.0021 0.0157 0.0425
Echinococcus granulosus geminin 0.0172 0.2006 0.3422
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2534 0.6695
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3712 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0783 0.1301
Loa Loa (eye worm) hypothetical protein 0.0076 0.0823 0.1369
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0827 1
Leishmania major hypothetical protein, conserved 0.0073 0.0783 0.9406
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0783 0.1782
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0148 0.1597
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0091 0.09
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0024 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1035 0.2791
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0091 0.0156
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0091 0.0115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0651 0.1886
Schistosoma mansoni inositol monophosphatase 0.0076 0.0827 0.223
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0019 0.013 0.035
Echinococcus granulosus lamin dm0 0.0056 0.0575 0.0981
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0026 0.0004
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0156 0.1807 0.3131
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0157 0.1717
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0713 0.1181
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0067 0.0074
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0067 0.0713 0.1135
Mycobacterium ulcerans beta-lactamase 0.0073 0.0783 0.2419
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0783 0.0783
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0019 0.005
Brugia malayi RNA, U transporter 1 0.0083 0.091 0.1518
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0747 0.1681
Schistosoma mansoni intermediate filament proteins 0.0056 0.0575 0.1551
Echinococcus granulosus survival motor neuron protein 1 0.0488 0.5863 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0091 0.0116
Onchocerca volvulus Huntingtin homolog 0.0128 0.146 0.5258
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0651 0.1756
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0217 0.2403
Brugia malayi beta-lactamase 0.0073 0.0783 0.13
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0182
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0344 0.3988
Schistosoma mansoni hypothetical protein 0.0035 0.0324 0.0874
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0019 0.013 0.0181
Echinococcus granulosus cpg binding protein 0.0037 0.0343 0.0586
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0783 0.1262
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0783 0.1301
Echinococcus granulosus GPCR family 2 0.0035 0.0324 0.0553
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0226 0.266 0.4514
Entamoeba histolytica hypothetical protein 0.0074 0.0803 0.2968
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0783 0.2112
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0315 0.3663
Schistosoma mansoni hypothetical protein 0.0035 0.0324 0.0874
Leishmania major pyruvate kinase 0.0067 0.0713 0.8455
Echinococcus granulosus importin subunit beta 1 0.0029 0.0252 0.0429
Brugia malayi hypothetical protein 0.0074 0.0803 0.1333
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0344 0.0927
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0699 0.8417
Leishmania major importin beta-1 subunit, putative 0.0024 0.0184 0.1262
Echinococcus granulosus pyruvate kinase 0.0034 0.0315 0.0537
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0157 0.0269
Echinococcus granulosus lamin 0.0056 0.0575 0.0981
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0783 0.1262
Entamoeba histolytica hypothetical protein 0.0024 0.0184 0.0627
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0783 0.1262
Onchocerca volvulus 0.0027 0.0231 0.0399
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.266 1
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0324 0.0514
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0324 0.0553
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0148 0.0907
Echinococcus multilocularis lamin dm0 0.0056 0.0575 0.0575
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0823 0.1368
Schistosoma mansoni hypothetical protein 0.0172 0.2006 0.541
Echinococcus granulosus snurportin 1 0.0312 0.3708 0.6325
Schistosoma mansoni cpg binding protein 0.0037 0.0343 0.0926
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0026
Echinococcus multilocularis pyruvate kinase 0.0067 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0073 0.0783 0.1301
Giardia lamblia Pyruvate kinase 0.0067 0.0713 0.2251
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0148 0.0767
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0344 0.0344
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0713 0.1181
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0344 0.1231
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0713 0.8586
Loa Loa (eye worm) hypothetical protein 0.0056 0.0575 0.0945
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0226 0.266 1
Chlamydia trachomatis pyruvate kinase 0.0067 0.0713 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1035 0.2791
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0157 0.0228
Leishmania major hypothetical protein, conserved 0.0026 0.0217 0.1703
Schistosoma mansoni hypothetical protein 0.0076 0.0823 0.2219
Mycobacterium leprae Probable lipase LipE 0.0073 0.0783 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0344 0.3434
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0344 0.0587
Schistosoma mansoni lamin 0.0056 0.0575 0.1551
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0148 0.0148
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0344 0.0781
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0925 0.0925
Schistosoma mansoni hypothetical protein 0.0172 0.2006 0.541
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1035 0.1035
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0783 0.9456
Trypanosoma brucei pyruvate kinase 1, putative 0.0067 0.0713 0.8455
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0091 0.0091
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0827 0.1905
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0091 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3712 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3712 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0827 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0827 0.1905
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0651 0.7827
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0713 0.1181
Entamoeba histolytica hypothetical protein 0.0074 0.0803 0.2968
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0157 0.1062
Onchocerca volvulus 0.0073 0.0783 0.2582
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0182
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0019 0.013 0.0182
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0226 0.266 0.4514
Loa Loa (eye worm) hypothetical protein 0.0073 0.0783 0.1301
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.24 0.6317
Schistosoma mansoni importin beta-1 0.0029 0.0252 0.0679
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0713 0.2306
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0184 0.2166
Echinococcus multilocularis lamin 0.0056 0.0575 0.0575
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0231 0.0355
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.24 0.6317
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0344 0.055
Toxoplasma gondii pyruvate kinase PyK1 0.0067 0.0713 0.8594
Plasmodium vivax pyruvate kinase, putative 0.0067 0.0713 0.9085
Mycobacterium ulcerans hypothetical protein 0.0073 0.0783 0.2419
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0217 0.2449
Onchocerca volvulus 0.0073 0.0783 0.2582
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.0465 0.0757
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.24 0.6317
Entamoeba histolytica hypothetical protein 0.0074 0.0803 0.2968
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0925 0.2493
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0827 0.141
Mycobacterium ulcerans lipase LipD 0.0073 0.0783 0.2419
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.266 0.7047
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.1253 0.2104
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.24 0.8972
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0148 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3712 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0783 0.1782
Echinococcus multilocularis pyruvate kinase 0.0034 0.0315 0.0315
Brugia malayi pyruvate kinase 0.0014 0.0067 0.0073
Echinococcus multilocularis pyruvate kinase 0.0034 0.0315 0.0315
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0925 0.1542
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0148 0.1546
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0827 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0211 0.032
Onchocerca volvulus Huntingtin homolog 0.0128 0.146 0.5258
Loa Loa (eye worm) beta-lactamase 0.0073 0.0783 0.1301
Schistosoma mansoni cpg binding protein 0.0035 0.0319 0.086
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0184 0.1493
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0713 0.8586
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0344 0.3434
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0827 0.0827
Loa Loa (eye worm) hypothetical protein 0.0073 0.0783 0.1301
Loa Loa (eye worm) hypothetical protein 0.0027 0.0231 0.0355
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0223 0.038
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0344 0.0927
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0827 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0217 0.2589
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0827 0.2596
Echinococcus multilocularis geminin 0.0172 0.2006 0.2006
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0157 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0651 0.1886
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0184 0.2049
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0091 0.09
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0039 0.0067
Mycobacterium tuberculosis Conserved protein 0.0073 0.0783 0.1262
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0231 0.0231
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0142 0.0202
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0344 0.0587
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0344 0.0548
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0231 0.0394
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0713 0.2306
Plasmodium falciparum pyruvate kinase 0.0067 0.0713 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0747 0.1681
Schistosoma mansoni hypothetical protein 0.0012 0.0039 0.0105
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0148 0.0252
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0344 0.055
Echinococcus multilocularis pyruvate kinase 0.0067 0.0713 0.0713
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0827 0.306
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0713 0.2306
Entamoeba histolytica hypothetical protein 0.0074 0.0803 0.2968
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0729 0.1164
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0344 0.0344
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0184 0.2
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0651 0.1756
Schistosoma mansoni hypothetical protein 0.0035 0.0324 0.0874
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0783 0.2419
Brugia malayi hypothetical protein 0.0026 0.0217 0.033
Loa Loa (eye worm) hypothetical protein 0.0035 0.0324 0.0515
Loa Loa (eye worm) hypothetical protein 0.0073 0.0783 0.1301
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0184 0.1262
Echinococcus multilocularis GPCR, family 2 0.0035 0.0324 0.0324
Schistosoma mansoni hypothetical protein 0.0035 0.0324 0.0874
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0783 0.2112
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0024 0.0019
Schistosoma mansoni pyruvate kinase 0.0067 0.0713 0.1923
Echinococcus granulosus bloom syndrome protein 0.0021 0.0148 0.0252
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0827 1
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0148 0.0148
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0464 0.5572 1
Schistosoma mansoni pyruvate kinase 0.0067 0.0713 0.1923
Brugia malayi Pyruvate kinase, M2 isozyme 0.0067 0.0713 0.118
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0729 0.9098
Loa Loa (eye worm) hypothetical protein 0.0037 0.0344 0.0548
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0039 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2534 0.6695
Brugia malayi hypothetical protein 0.0019 0.013 0.0181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0211 0.032
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3712 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0783 0.1262
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0344 0.0344
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0575 0.0945
Entamoeba histolytica hypothetical protein 0.0024 0.0184 0.0627
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0803 0.2164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1035 0.1765
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0783 0.1262
Loa Loa (eye worm) hypothetical protein 0.0111 0.1253 0.2105
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0157 0.0229
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0091 0.0091
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0091 0.0247
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0184 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0091 0.0115
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0713 0.1586
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.266 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.00000000017883
Loa Loa (eye worm) RecQ helicase 0.0021 0.0148 0.0213
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0091 0.0844
Plasmodium vivax importin-beta 2, putative 0.0029 0.0252 0.3049
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0783 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0067 0.0713 0.118
Trypanosoma brucei pyruvate kinase 1 0.0067 0.0713 0.8455
Entamoeba histolytica Ran family GTPase 0.0021 0.0157 0.0525
Leishmania major hypothetical protein, conserved 0.007 0.0747 0.8914
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0783 0.2419
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0184 0.0102
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0651 0.1111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0795 0.2144
Loa Loa (eye worm) hypothetical protein 0.0488 0.5863 1
Echinococcus multilocularis pyruvate kinase 0.0053 0.0541 0.0541
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0019 0.013 0.0181
Loa Loa (eye worm) hypothetical protein 0.0027 0.0223 0.0341
Leishmania major GTP-binding protein, putative 0.0021 0.0157 0.0898
Echinococcus multilocularis snurportin 1 0.0312 0.3708 0.3708
Loa Loa (eye worm) hypothetical protein 0.0047 0.0465 0.0757
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.3708 0.631
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0783 0.1782
Schistosoma mansoni ran 0.0021 0.0157 0.0425
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0148 0.0148
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0783 0.1262
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0044
Schistosoma mansoni pyruvate kinase 0.0034 0.0315 0.0849
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0783 0.9456
Onchocerca volvulus 0.0073 0.0783 0.2582
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0157 0.0157
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0157 0.1666
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.1112 0.1863
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.24 0.6317
Brugia malayi beta-lactamase family protein 0.0073 0.0783 0.13
Loa Loa (eye worm) hypothetical protein 0.0067 0.0713 0.1181
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.266 0.7047
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0575 0.0945
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0783 0.1262
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0783 0.1782
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0252 0.2181
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.266 0.7047
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0575 0.0944
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1035 0.1732
Brugia malayi hypothetical protein 0.0027 0.0231 0.0354
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0226 0.266 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0803 0.1369
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0148 0.0489
Onchocerca volvulus 0.0099 0.1112 0.3882
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0344 0.0587
Brugia malayi hypothetical protein 0.0017 0.0102 0.0134
Loa Loa (eye worm) hypothetical protein 0.0026 0.0217 0.0331
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0217 0.2014
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.24 0.6317
Schistosoma mansoni DNA helicase recq5 0.0021 0.0148 0.0399
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0157 0.1815
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0217 0.1703
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0091 0.0844
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0324 0.0515
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0157 0.1666
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0148 0.0767
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.007 0.0747 0.8914
Mycobacterium leprae Probable pyruvate kinase PykA 0.0067 0.0713 0.8833
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0747 0.9005
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.3712 0.6316
Echinococcus granulosus intermediate filament protein 0.0056 0.0575 0.0981
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0319 0.0506
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0827 0.1905
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0024 0.0064
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0783 0.13
Mycobacterium tuberculosis Conserved protein 0.0073 0.0783 0.1262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1035 0.1765
Loa Loa (eye worm) hypothetical protein 0.0029 0.0252 0.0391
Brugia malayi Importin beta-1 subunit 0.0029 0.0252 0.039
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.266 0.7047
Schistosoma mansoni cpg binding protein 0.0037 0.0343 0.0926
Echinococcus multilocularis pyruvate kinase 0.0034 0.0315 0.0315
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.266 0.7047
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0925 0.1577
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0067 0.0073
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0019 0.013 0.0181
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.1253 0.2104
Brugia malayi beta-lactamase family protein 0.0073 0.0783 0.13
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0324 0.0324
Brugia malayi hypothetical protein 0.0128 0.146 0.2459
Onchocerca volvulus 0.0226 0.266 1
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0783 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0324 0.0324
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0184 0.2049
Brugia malayi STAT protein, DNA binding domain containing protein 0.0161 0.1861 0.3146
Brugia malayi intermediate filament protein 0.0056 0.0575 0.0944
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0747 0.9005
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0827 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0783 0.1262
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.0465 0.1692
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0324 0.0553
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0783 0.9406
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0315 0.3592
Echinococcus multilocularis musashi 0.0056 0.0575 0.0575
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0651 0.0651
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1035 0.1035
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0148 0.0907
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0148 0.0213

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 5.48 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 80 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 3.6588 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Primary Screen Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 2101 ] ChEMBL. No reference
Potency (functional) = 3.6588 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays: 2613, 2592, 2593, 2589, 2596, 2588, 2587, 2597, 2578, 2595, 2577, 2590, 2101 ] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.