TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 326.35 | Formula: C17H18N4O3
H donors: 2 H acceptors: 3 LogP: 2.65 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1c(C)nc2n(c1=O)C(C)CCC2=NNc1ccccc1
InChi: 1S/C17H18N4O3/c1-10-8-9-13(20-19-12-6-4-3-5-7-12)15-18-11(2)14(17(23)24)16(22)21(10)15/h3-7,10,19H,8-9H2,1-2H3,(H,23,24)
InChiKey: PTMLSROVUJDKCJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0688	0.3067	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0023	0.0047
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0131	0.0523	0.2023
Onchocerca volvulus		0.0062	0.021	0.0614
Loa Loa (eye worm)	hypothetical protein	0.007	0.0248	0.074
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0131	0.0523	0.2023
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0131	0.0523	0.2023
Loa Loa (eye worm)	transcription factor SMAD2	0.0125	0.0496	0.1556
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0139	0.3737
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0025	0.0009
Brugia malayi	excitatory GABA receptor EXP-1A	0.0131	0.0523	0.2023
Loa Loa (eye worm)	ACC-1 protein	0.0131	0.0523	0.1642
Brugia malayi	Pre-SET motif family protein	0.0432	0.1898	0.7589
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0023	0.0047
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.006	0.0202	0.0632
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0096	0.5
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0027	0.005	0.0137
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0152	0.0619	0.1998
Schistosoma mansoni	neurotransmitter gated ion channel	0.007	0.0248	0.0808
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0131	0.0523	0.2023
Trypanosoma cruzi	phytoene synthase, putative	0.0688	0.3067	0.3067
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0062	0.021	0.0684
Echinococcus granulosus	intermediate filament protein	0.0056	0.0182	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0131	0.0523	0.2023
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Echinococcus multilocularis	glycine receptor subunit beta	0.0131	0.0523	0.1681
Leishmania major	hypothetical protein, conserved	0.0688	0.3067	0.3067
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0046	0.0075
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0023	0.0074
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0131	0.0523	0.1681
Brugia malayi	hypothetical protein	0.0469	0.2068	0.8278
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0139	0.0426
Echinococcus granulosus	synaptic vesicular amine transporter	0.0563	0.2493	0.8125
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.008	0.0291	0.0949
Schistosoma mansoni	thyroid hormone receptor	0.0153	0.0623	0.2032
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0131	0.0523	0.1642
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0131	0.0523	0.1681
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0374	0.1632	0.5286
Loa Loa (eye worm)	GoLoco domain-containing protein family protein	0.0025	0.0041	0.0061
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0374	0.1632	0.5308
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0023	0.0047
Loa Loa (eye worm)	hypothetical protein	0.008	0.0291	0.0881
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.006	0.0202	0.0725
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0131	0.0523	0.1704
Loa Loa (eye worm)	bromodomain containing protein	0.0022	0.0028	0.0017
Schistosoma mansoni	intermediate filament proteins	0.0056	0.0182	0.0595
Schistosoma mansoni	hypothetical protein	0.0022	0.0025	0.0083
Echinococcus multilocularis	lamin dm0	0.0056	0.0182	0.0569
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0131	0.0523	0.2023
Schistosoma mansoni	lamin	0.0056	0.0182	0.0595
Schistosoma mansoni	nAChR subunit	0.0131	0.0523	0.1704
Loa Loa (eye worm)	intermediate filament protein	0.0056	0.0182	0.0524
Onchocerca volvulus		0.0131	0.0523	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.006	0.0202	0.0632
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.007	0.0248	0.0911
Onchocerca volvulus		0.0037	0.0096	0.0241
Brugia malayi	Bromodomain containing protein	0.0044	0.0126	0.042
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0096	0.5
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0098	0.0294
Brugia malayi	Cation transporter family protein	0.0131	0.0523	0.2023
Mycobacterium ulcerans	phytoene synthase, CrtB	0.0688	0.3067	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0041	0.0061
Echinococcus granulosus	glycine receptor subunit beta	0.0131	0.0523	0.1681
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0131	0.0523	0.1681
Trichomonas vaginalis	set domain proteins, putative	0.0492	0.217	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0131	0.0523	0.2023
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.008	0.0291	0.0924
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0354	0.154	0.5022
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0062	0.021	0.0684
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0131	0.0523	0.2023
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Schistosoma mansoni	nAChR subunit	0.006	0.0202	0.0658
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Echinococcus multilocularis	zinc finger protein	0.0024	0.0037	0.0094
Brugia malayi	Raf kinase	0.009	0.0335	0.1266
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0096	0.0314
Brugia malayi	hypothetical protein	0.006	0.0202	0.0725
Brugia malayi	beta-lactamase family protein	0.0037	0.0096	0.0297
Schistosoma mansoni	hypothetical protein	0.0025	0.0041	0.0134
Echinococcus granulosus	nAChR subunit	0.007	0.0248	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0147	0.0409
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.006	0.0202	0.0725
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0035	0.0086
Echinococcus multilocularis	raf serine:threonine protein kinase	0.009	0.0335	0.1069
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0131	0.0523	0.2023
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0023	0.0047
Schistosoma mansoni	acetylcholine receptor-related	0.006	0.0202	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0182	0.0524
Echinococcus granulosus	lamin dm0	0.0056	0.0182	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0096	0.0241
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0374	0.1632	0.6513
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0374	0.1632	0.5308
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0131	0.0523	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0023	0.0047
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0023	0.0047
Schistosoma mansoni	vesicular amine transporter	0.0563	0.2493	0.813
Schistosoma mansoni	nAChR subunit	0.0131	0.0523	0.1704
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0008	0.0027
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0023	0.0047
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Schistosoma mansoni	nAChR subunit	0.0131	0.0523	0.1704
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0096	0.0241
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0023	0.0074
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0131	0.0523	0.1681
Onchocerca volvulus		0.0131	0.0523	0.1642
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0131	0.0523	0.1681
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0152	0.0619	0.202
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Onchocerca volvulus		0.0354	0.154	0.4985
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0131	0.0523	0.1642
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0035	0.0086
Echinococcus granulosus	nAChR subunit	0.0131	0.0523	0.1681
Brugia malayi	PHD-finger family protein	0.003	0.0063	0.0161
Schistosoma mansoni	acetylcholine receptor subunit beta	0.006	0.0202	0.0658
Loa Loa (eye worm)	acetyltransferase	0.0152	0.0619	0.196
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0096	0.0241
Onchocerca volvulus		0.006	0.0202	0.0588
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.0228	0.072
Echinococcus granulosus	Squalene phytoene synthase	0.0688	0.3067	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0023	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0027	0.005	0.009
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0131	0.0523	0.1681
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0374	0.1632	0.5308
Brugia malayi	Intermediate filament tail domain containing protein	0.0056	0.0182	0.0646
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0131	0.0523	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0469	0.2068	0.6719
Brugia malayi	GoLoco motif family protein	0.0025	0.0041	0.0075
Brugia malayi	Cation transporter family protein	0.0131	0.0523	0.2023
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0098	0.0294
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0023	0.0074
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0131	0.0523	0.1681
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.007	0.0248	0.0911
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0131	0.0523	0.1681
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0008	0.0027
Schistosoma mansoni	lamin	0.0056	0.0182	0.0595
Brugia malayi	Pre-SET motif family protein	0.0062	0.021	0.0757
Onchocerca volvulus		0.0037	0.0096	0.0241
Echinococcus granulosus	G protein signaling modulator 2	0.0025	0.0041	0.0107
Leishmania major	hypothetical protein, conserved	0.0037	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0178	0.0509
Plasmodium vivax	SET domain protein, putative	0.0062	0.021	1
Echinococcus multilocularis	nAChR subunit	0.007	0.0248	0.0783
Loa Loa (eye worm)	abnormal catecholamine distribution protein 1	0.0563	0.2493	0.8116
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0023	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0138	0.0379
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0131	0.0523	0.1704
Brugia malayi	beta-lactamase	0.0037	0.0096	0.0297
Echinococcus multilocularis	G protein signaling modulator 2	0.0025	0.0041	0.0107
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0096	0.0096
Onchocerca volvulus		0.0469	0.2068	0.6719
Brugia malayi	intermediate filament protein	0.0056	0.0182	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Schistosoma mansoni	neurotransmitter gated ion channel	0.006	0.0202	0.0658
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0374	0.1632	0.5308
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0096	0.0241
Brugia malayi	cytoplasmic intermediate filament protein	0.003	0.0064	0.0166
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0023	0.0074
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0023	0.0047
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0688	0.3067	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0248	0.074
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0237	0.1008	0.3069
Schistosoma mansoni	zinc finger protein	0.0024	0.0037	0.0121
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0023	0.0047
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Schistosoma mansoni	nAChR subunit	0.006	0.0202	0.0658
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.006	0.0199	0.0624
Onchocerca volvulus		0.0056	0.0182	0.0524
Schistosoma mansoni	hypothetical protein	0.0132	0.0527	0.172
Loa Loa (eye worm)	acetylcholine receptor protein	0.006	0.0202	0.0588
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0096	0.0314
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0023	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0354	0.154	0.4985
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.006	0.0202	0.0632
Onchocerca volvulus		0.0056	0.0182	0.0524
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0096	0.0096
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0131	0.0523	0.1642
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0023	0.0047
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0354	0.154	0.5022
Onchocerca volvulus		0.0131	0.0523	0.1642
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0023	0.0047
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0096	0.0297
Brugia malayi	MH2 domain containing protein	0.0125	0.0496	0.1917
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0131	0.0523	0.1681
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0132	0.0527	0.1697
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0131	0.0523	0.2023
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0111	0.5
Echinococcus multilocularis	musashi	0.0056	0.0182	0.0569
Schistosoma mansoni	nAChR subunit	0.0131	0.0523	0.1704
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.006	0.0202	0.0632
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0131	0.0523	0.1704
Brugia malayi	beta-lactamase family protein	0.0037	0.0096	0.0297
Echinococcus granulosus	zinc finger protein	0.0024	0.0037	0.0094
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0131	0.0523	0.2023
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0023	0.0074
Schistosoma mansoni	neurotransmitter gated ion channel	0.006	0.0202	0.0658
Onchocerca volvulus		0.007	0.0248	0.074
Schistosoma mansoni	coup transcription factor	0.0021	0.0023	0.0074
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0131	0.0523	0.2023
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0335	0.1094
Loa Loa (eye worm)	hypothetical protein	0.007	0.0248	0.074
Loa Loa (eye worm)	raf kinase	0.009	0.0335	0.1027
Loa Loa (eye worm)	hypothetical protein	0.007	0.0248	0.074
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0131	0.0523	0.1681
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0432	0.1898	0.6159
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Trypanosoma cruzi	squalene synthase, putative	0.2208	1	1
Brugia malayi	Bromodomain containing protein	0.0082	0.0301	0.1128
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0027	0.005	0.0137
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0293	0.1265	0.4082
Echinococcus multilocularis	Squalene phytoene synthase	0.0688	0.3067	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0131	0.0523	0.2023
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.006	0.0202	0.0632
Brugia malayi	acetyltransferase, GNAT family protein	0.0152	0.0619	0.2415
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0035	0.0113
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0688	0.3067	1
Trypanosoma cruzi	squalene synthase, putative	0.2208	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0248	0.074
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0145	0.0589	0.1899
Loa Loa (eye worm)	hypothetical protein	0.007	0.0248	0.074
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0023	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0153	0.0623	0.201
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0056	0.0182	0.0524
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.007	0.0248	0.0911
Onchocerca volvulus		0.006	0.0202	0.0588
Onchocerca volvulus		0.0492	0.217	0.7054
Loa Loa (eye worm)	hypothetical protein	0.0374	0.1632	0.5286
Schistosoma mansoni	nAChR subunit	0.0131	0.0523	0.1704
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Schistosoma mansoni	nAChR subunit	0.0131	0.0523	0.1704
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0131	0.0523	0.1642
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0131	0.0523	0.2023
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0131	0.0523	0.1681
Loa Loa (eye worm)	hypothetical protein	0.007	0.0248	0.074
Echinococcus granulosus	lamin	0.0056	0.0182	0.0569
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.006	0.0202	0.0725
Onchocerca volvulus	Putative nachr subunit	0.0374	0.1632	0.5286
Entamoeba histolytica	hypothetical protein	0.007	0.0248	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.006	0.0202	0.0588
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.006	0.0202	0.0725
Onchocerca volvulus		0.0354	0.154	0.4985
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.007	0.0248	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0354	0.154	0.4985
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0264	0.0794
Trypanosoma brucei	squalene synthase, putative	0.2208	1	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0062	0.021	0.0658
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0023	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0096	0.0241
Brugia malayi	hypothetical protein	0.006	0.0202	0.0725
Echinococcus granulosus	raf serine:threonine protein kinase	0.009	0.0335	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0096	0.0241
Schistosoma mansoni	thyroid hormone receptor	0.0153	0.0623	0.2032
Onchocerca volvulus		0.006	0.0202	0.0588
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.006	0.0202	0.0588
Onchocerca volvulus		0.007	0.0248	0.074
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.0228	0.072
Echinococcus granulosus	histone lysine methyltransferase setb	0.008	0.0291	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0046	0.0075
Schistosoma mansoni	hypothetical protein	0.0688	0.3067	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0023	0.0047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.008	0.0291	0.0949
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.003	0.0064	0.0135
Brugia malayi	hypothetical protein	0.006	0.0202	0.0725
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0096	0.0287
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0023	0.0047
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0111	0.5
Brugia malayi	hypothetical protein	0.006	0.0202	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0131	0.0523	0.1642
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0131	0.0523	0.1704
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0139	0.0204
Loa Loa (eye worm)	hypothetical protein	0.006	0.0202	0.0588
Onchocerca volvulus		0.0037	0.0096	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0131	0.0523	0.1681
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0139	0.3737
Brugia malayi	Abnormal catecholamine distribution protein 1	0.0563	0.2493	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0023	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0523	0.1642
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0374	0.1632	0.5308
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0096	0.0241
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0131	0.0523	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0096	0.0241
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0023	0.0074
Brugia malayi	Cation transporter family protein	0.0354	0.154	0.6142
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0139	0.3737
Echinococcus granulosus	glycine receptor subunit beta	0.0131	0.0523	0.1681
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0139	0.0204
Echinococcus multilocularis	lamin	0.0056	0.0182	0.0569
Schistosoma mansoni	nAChR subunit	0.0131	0.0523	0.1704
Brugia malayi	GoLoco motif family protein	0.0025	0.0041	0.0075
Onchocerca volvulus		0.0354	0.154	0.4985
Echinococcus multilocularis	synaptic vesicular amine transporter	0.0563	0.2493	0.8125
Brugia malayi	hypothetical protein	0.006	0.0202	0.0725
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.006	0.0202	0.0725
Loa Loa (eye worm)	hypothetical protein	0.007	0.0248	0.074
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0062	0.021	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0132	0.0527	0.1697
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0374	0.1632	0.5308
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.006	0.0202	0.0725
Echinococcus multilocularis	nAChR subunit	0.0131	0.0523	0.1681
Loa Loa (eye worm)	MH2 domain-containing protein	0.0125	0.0496	0.1556
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0023	0.0074
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.007	0.0248	0.0808
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0023	0.0074
Echinococcus multilocularis	glycine receptor subunit beta	0.0131	0.0523	0.1681
Loa Loa (eye worm)	LGC-31 protein	0.0131	0.0523	0.1642
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0131	0.0523	0.2023
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0096	0.0287
Loa Loa (eye worm)	GABA receptor subunit	0.007	0.0248	0.074
Schistosoma mansoni	bromodomain containing protein	0.007	0.0246	0.0801
Loa Loa (eye worm)	hypothetical protein	0.004	0.011	0.0287
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.007	0.0248	0.0808
Loa Loa (eye worm)	ACC-1 protein	0.0131	0.0523	0.1642

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	> 100 uM kg-1	Antiallergic activity in rat reaginic passive cutaneous anaphylaxis (PCA) test upon intravenous administration	ChEMBL.	6876080
ID50 (functional)	> 320 uM kg-1	Antiallergic activity in rat reaginic passive cutaneous anaphylaxis (PCA) test upon peroral administration	ChEMBL.	6876080

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL274037

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 13305