Detailed information for compound 1333937

Basic information

Technical information
  • TDR Targets ID: 1333937
  • Name: (3Z)-4-oxo-2-(3-pentylimidazol-3-ium-1-yl)-3- phenylsulfonyliminonaphthalen-1-olate
  • MW: 449.522 | Formula: C24H23N3O4S
  • H donors: 1 H acceptors: 4 LogP: 4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCn1cc[n+](c1)C1=C([N-]S(=O)(=O)c2ccccc2)C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C24H23N3O4S/c1-2-3-9-14-26-15-16-27(17-26)22-21(25-32(30,31)18-10-5-4-6-11-18)23(28)19-12-7-8-13-20(19)24(22)29/h4-8,10-13,15-17H,2-3,9,14H2,1H3
  • InChiKey: CVWXODFBKWPROK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-oxo-2-(3-pentylimidazol-3-ium-1-yl)-3-phenylsulfonyliminonaphthalen-1-olate
  • (3Z)-4-oxo-2-(3-pentylimidazol-3-ium-1-yl)-3-phenylsulfonylimino-naphthalen-1-olate
  • 4-oxo-2-(3-pentylimidazol-3-ium-1-yl)-3-phenylsulfonylimino-naphthalen-1-olate
  • (3Z)-4-oxo-2-(3-pentyl-1-imidazol-3-iumyl)-3-phenylsulfonylimino-1-naphthalenolate
  • 4-oxo-2-(3-pentyl-1-imidazol-3-iumyl)-3-phenylsulfonylimino-1-naphthalenolate
  • (3Z)-2-(3-amylimidazol-3-ium-1-yl)-4-keto-3-phenylsulfonylimino-naphthalen-1-olate
  • 2-(3-amylimidazol-3-ium-1-yl)-4-keto-3-phenylsulfonylimino-naphthalen-1-olate
  • STOCK2S-32997
  • MLS000555436
  • SMR000147153

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens apoptotic peptidase activating factor 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microphthalmia-associated transcription factor Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133408 All targets in OG5_133408
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Helix-loop-helix DNA-binding domain containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0083 0.0246
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0039
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0087 0.0611
Brugia malayi topoisomerase 0.0012 0.0083 0.0246
Schistosoma mansoni smad1 5 8 and 0.001 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0087 0.0258
Brugia malayi ancient conserved domain protein 2 0.0016 0.0132 0.0399
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0083 0.0246
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0399
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0087 0.0087
Echinococcus multilocularis transcription factor eb 0.013 0.1514 0.1505
Schistosoma mansoni coup transcription factor 0.0012 0.0087 0.0087
Brugia malayi steroid hormone receptor 0.0012 0.0087 0.0258
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0087 0.0078
Brugia malayi MH1 domain containing protein 0.001 0.0059 0.0167
Loa Loa (eye worm) hypothetical protein 0.013 0.1506 0.4736
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0016 0.0132 0.0123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0607 0.0598
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0359 0.1115
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0016 0.0132 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0018 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0087 0.0078
Echinococcus granulosus caspase 2 0.0037 0.039 0.0381
Brugia malayi nuclear hormone receptor 0.0006 0.0009 0.0012
Echinococcus multilocularis caspase 2 0.0037 0.039 0.0381
Toxoplasma gondii CBS family protein 0.0016 0.0132 0.0157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0044 0.0035
Schistosoma mansoni hypothetical protein 0.0494 0.5903 0.5903
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0009 0.0009
Brugia malayi hypothetical protein 0.0006 0.0009 0.0012
Brugia malayi hypothetical protein 0.0012 0.0083 0.0246
Brugia malayi Muscleblind-like protein 0.018 0.2118 0.6667
Schistosoma mansoni smad1 5 8 and 0.001 0.0059 0.0059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0733 0.2102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0246
Echinococcus granulosus transcription factor btf3 0.0042 0.045 0.0441
Schistosoma mansoni nuclear receptor 0.0006 0.0009 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0018 0.0039
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0016 0.0132 0.0123
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0018 0.0008
Loa Loa (eye worm) chloride channel 3 0.0016 0.0132 0.0399
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0009 0.0009
Giardia lamblia Hypothetical protein 0.0016 0.0132 1
Schistosoma mansoni topbp1 0.0012 0.0083 0.0083
Schistosoma mansoni nuclear receptor 0.0006 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0246
Brugia malayi nuclear receptor RXR 0.0006 0.0009 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0009 0.0009
Trypanosoma brucei GMP reductase 0.0268 0.3174 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0059 0.0059
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0087 0.0087
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0141 0.1638 0.4951
Brugia malayi GMP reductase 0.0111 0.1284 0.4035
Onchocerca volvulus 0.0035 0.0359 0.274
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.045 0.1264
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0268 0.3174 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0039
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0087 0.0087
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0252 0.2982 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.017 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0087 0.0258
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.017 0.0281
Leishmania major basic transcription factor 3a, putative 0.0042 0.045 0.1044
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.017 0.0281
Echinococcus multilocularis nibrin 0.0012 0.0083 0.0074
Chlamydia trachomatis Mg++ transporter 0.0016 0.0132 1
Brugia malayi conserved hypotetical protein 0.0006 0.0009 0.0012
Loa Loa (eye worm) IMP dehydrogenase 1 0.0268 0.3174 1
Trypanosoma cruzi chloride channel protein, putative 0.0016 0.0132 0.0157
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0059 0.0049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0018 0.0018
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0016 0.0132 0.0132
Schistosoma mansoni chloride channel protein 0.0016 0.0132 0.0132
Brugia malayi nuclear hormone receptor 0.0012 0.0087 0.0258
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.0009 0.0012
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0016 0.0132 0.0123
Brugia malayi CBS domain containing protein 0.0016 0.0132 0.0399
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.017 0.0281
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0087 0.0087
Loa Loa (eye worm) loechrig isoform VII 0.0016 0.0132 0.0399
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0016 0.0132 0.0157
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0059 0.0049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0087 0.0258
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.018 0.2118 0.6667
Loa Loa (eye worm) Smad1 0.001 0.0059 0.0167
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0016 0.0132 0.0157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0399
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0016 0.0132 0.0123
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0083 0.1173
Entamoeba histolytica hypothetical protein 0.0042 0.045 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0087 0.0087
Schistosoma mansoni cpg binding protein 0.0035 0.0359 0.0359
Echinococcus multilocularis Smad4 0.001 0.0059 0.0049
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.017 0.0126
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0059 0.0049
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.045 0.1185
Treponema pallidum Mg2+ transport protein (mgtE) 0.0016 0.0132 1
Toxoplasma gondii CBS domain-containing protein 0.0016 0.0132 0.0157
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0016 0.0132 0.0157
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0825 0.2279
Brugia malayi hypothetical protein 0.0012 0.0083 0.0246
Echinococcus multilocularis transcription factor btf3 0.0042 0.045 0.0441
Schistosoma mansoni smad1 5 8 and 0.001 0.0059 0.0059
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.013 0.1514 0.476
Brugia malayi Cell death protein 3 precursor 0.0037 0.039 0.1215
Leishmania major guanosine monophosphate reductase 0.0268 0.3174 1
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0059 0.0167
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.168 0.5287
Brugia malayi nuclear receptor NHR-88 0.0012 0.0087 0.0258
Onchocerca volvulus Cell death protein 3 homolog 0.0037 0.039 0.299
Echinococcus granulosus transcription factor eb 0.013 0.1514 0.1505
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0252 0.2982 0.9379
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0083 0.1173
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0016 0.0132 0.0157
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.017 0.03
Brugia malayi MH2 domain containing protein 0.001 0.0059 0.0167
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5903 0.5899
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5903 0.5899
Echinococcus granulosus H:Cl exchange transporter 4 0.0016 0.0132 0.0123
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0087 0.0087
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0268 0.3174 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0258
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0087 0.0078
Mycobacterium ulcerans hypothetical protein 0.0016 0.0132 0.0157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0087 0.0258
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.017 0.0161
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0246
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0268 0.3174 0.3167
Brugia malayi nuclear receptor NHR-88 0.0006 0.0009 0.0012
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0016 0.0132 0.0157
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0087 0.0078
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0258
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0825 0.24
Schistosoma mansoni hypothetical protein 0.0205 0.241 0.241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0607 0.0607
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0059 0.0049
Loa Loa (eye worm) ICD-1 protein 0.0042 0.045 0.1402
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0039
Mycobacterium ulcerans cystathionine beta-synthase 0.0016 0.0132 0.0157
Mycobacterium ulcerans transcriptional regulator 0.0016 0.0132 0.0157
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0087 0.0258
Brugia malayi ecdysone receptor 0.0006 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Brugia malayi CLC chloride channel protein 0.0016 0.0132 0.0399
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0087 0.0258
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.017 0.017
Echinococcus multilocularis smad 0.001 0.0059 0.0049
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0268 0.3174 1
Schistosoma mansoni protein kinase subunit gamma 0.0016 0.0132 0.0132
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0111 0.1284 0.4035
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.0009 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0069 0.006
Plasmodium falciparum protein MAM3, putative 0.0016 0.0132 0.0167
Echinococcus granulosus cpg binding protein 0.0037 0.0382 0.0373
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0087 0.0611
Brugia malayi Isocitrate dehydrogenase 0.0019 0.017 0.052
Brugia malayi nuclear receptor RXR 0.0006 0.0018 0.0039
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0083 0.0074
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0087 0.0078
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0035
Echinococcus granulosus muscleblind protein 0.018 0.2118 0.211
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0083 0.0074
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0009 0.0009
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0252 0.2982 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.017 0.0281
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0087 0.0611
Schistosoma mansoni Smad4 0.001 0.0059 0.0059
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0268 0.3174 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0087 0.0078
Schistosoma mansoni caspase-7 (C14 family) 0.0037 0.039 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0059 0.0167
Brugia malayi MH1 domain containing protein 0.001 0.0059 0.0167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0828 0.0828
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0087 0.0258
Echinococcus granulosus smad 0.001 0.0059 0.0049
Schistosoma mansoni cpg binding protein 0.0037 0.0382 0.0382
Brugia malayi nuclear receptor NHR-67 0.0006 0.0009 0.0012
Loa Loa (eye worm) chloride channel protein 7 0.0016 0.0132 0.0399
Echinococcus granulosus geminin 0.0205 0.241 0.2403
Brugia malayi hypothetical protein 0.0006 0.0009 0.0012
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0016 0.0132 0.0123
Loa Loa (eye worm) GMP reductase 0.0111 0.1284 0.4035
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.045 0.1185
Brugia malayi ecdysteroid receptor 0.0012 0.0087 0.0258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0607 0.1898
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0268 0.3174 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0083 0.1173
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0087 0.0078
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0016 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0399
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0087 0.0258
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0825 0.24
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0069 0.006
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0268 0.3174 0.3174
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0016 0.0132 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0246
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0035
Mycobacterium ulcerans hypothetical protein 0.0016 0.0132 0.0157
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0087 0.0078
Brugia malayi ancient conserved domain protein 4 0.0016 0.0132 0.0399
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0258
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0825 0.0816
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0087 0.0258
Brugia malayi loechrig isoform VII 0.0016 0.0132 0.0399
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0068 0.0197
Echinococcus granulosus Smad4 0.001 0.0059 0.0049
Schistosoma mansoni smad 0.001 0.0059 0.0059
Echinococcus granulosus H:Cl exchange transporter 3 0.0016 0.0132 0.0123
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0268 0.3174 1
Schistosoma mansoni cpg binding protein 0.0037 0.0382 0.0382
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0016 0.0132 0.0157
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0268 0.3174 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0087 0.0258
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0825 0.0816
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0016 0.0132 1
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0016 0.0132 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0087 0.0087
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0016 0.0132 0.0123
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0825 0.2279
Brugia malayi tailless protein 0.0006 0.0009 0.0012
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0268 0.3174 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0246
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.017 0.0126
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0087 0.0078
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0044 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0083 0.1173
Echinococcus multilocularis apoptotic protease activating factor 1 0.0037 0.039 0.0381
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.045 0.1185
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0258
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0016 0.0132 0.0157
Brugia malayi hypothetical protein 0.0006 0.0018 0.0039
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0825 0.0825
Brugia malayi hypothetical protein 0.0037 0.039 0.1215
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0087 0.0258
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0127 0.1476 0.4506
Toxoplasma gondii IMP dehydrogenas 0.0268 0.3174 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0087 0.0258
Echinococcus multilocularis muscleblind protein 1 0.018 0.2118 0.211
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0083 0.1173
Echinococcus multilocularis muscleblind protein 0.018 0.2118 0.211
Loa Loa (eye worm) hypothetical protein 0.0012 0.0083 0.0246
Trypanosoma cruzi GMP reductase 0.0268 0.3174 1
Schistosoma mansoni chloride channel protein 0.0016 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.0009 0.0012
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.017 0.0161
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0825 0.0825
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0087 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0087 0.0258
Treponema pallidum hemolysin (tlyC) 0.0016 0.0132 1
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.017 0.0281
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.0009 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0607 0.1898
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0087 0.0258
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0087 0.0078
Echinococcus multilocularis cpg binding protein 0.0037 0.0382 0.0373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0087 0.0258
Chlamydia trachomatis CBS domain-containing protein 0.0016 0.0132 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0083 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0087 0.0258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0607 0.0598
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0258
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0258
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0016 0.0132 0.0157
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.0009 0.0012
Brugia malayi MH2 domain containing protein 0.001 0.0059 0.0167
Brugia malayi CXXC zinc finger family protein 0.0035 0.0359 0.1115
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0268 0.3174 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0083 0.1173
Toxoplasma gondii NAC domain-containing protein 0.0042 0.045 0.1185
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0087 0.0078
Brugia malayi chloride channel protein 7 0.0016 0.0132 0.0399
Trypanosoma cruzi GMP reductase 0.0268 0.3174 1
Brugia malayi beta-NAC-like protein 0.0042 0.045 0.1402
Trypanosoma cruzi chloride channel protein, putative 0.0016 0.0132 0.0157
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0127 0.1476 0.4506
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0258
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Brugia malayi Smad1 0.001 0.0059 0.0167
Schistosoma mansoni hypothetical protein 0.0205 0.241 0.241
Loa Loa (eye worm) DR-78 0.0006 0.0009 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0087 0.0078
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.045 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0825 0.24
Leishmania major inosine-5-monophosphate dehydrogenase 0.0268 0.3174 1
Onchocerca volvulus 0.0016 0.0132 0.0961
Schistosoma mansoni chloride channel protein 0.0016 0.0132 0.0132
Toxoplasma gondii CBS domain-containing protein 0.0016 0.0132 0.0157
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.017 0.0161
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0087 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0087 0.0258
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0039
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0016 0.0132 1
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0016 0.0132 0.0123
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.017 0.03
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0016 0.0132 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0087 0.0258
Echinococcus granulosus H:Cl exchange transporter 7 0.0016 0.0132 0.0123
Schistosoma mansoni DNA ligase IV 0.0012 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Schistosoma mansoni zinc finger protein 0.0006 0.0009 0.0009
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.0009 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0083 0.1173
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0087 0.0078
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.045 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.045 0.1264
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0016 0.0132 0.0157
Trypanosoma cruzi chloride channel protein, putative 0.0016 0.0132 0.0157
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0087 0.0078
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0016 0.0132 0.0157
Onchocerca volvulus 0.0012 0.0087 0.0611
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.017 0.0161
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.017 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0083 0.1173
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0087 0.0258
Mycobacterium ulcerans hypothetical protein 0.0016 0.0132 0.0157
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0009 0.0009
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0141 0.1638 0.503
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.017 0.0281
Echinococcus granulosus apoptotic protease activating factor 1 0.0037 0.039 0.0381
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0607 0.0598
Onchocerca volvulus Putative GMP reductase 0.0111 0.1284 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0268 0.3174 0.3167
Loa Loa (eye worm) hypothetical protein 0.018 0.2118 0.6667
Brugia malayi hypothetical protein 0.0006 0.0018 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.039 0.1215
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0016 0.0132 0.0123
Brugia malayi Voltage gated chloride channel family protein 0.0016 0.0132 0.0399
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0087 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0087 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0087 0.0258
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0083 0.1173
Schistosoma mansoni transcription factor btf3 0.0042 0.045 0.045
Brugia malayi MH2 domain containing protein 0.0144 0.168 0.5287
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0087 0.0087
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0132 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.168 0.5287
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0111 0.1284 0.4035
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.013 0.1506 0.4736
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0607 0.0598
Onchocerca volvulus 0.0037 0.039 0.299
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0083 0.1173
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0825 0.24
Brugia malayi DKFZp564C0469 protein 0.0012 0.0083 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0037 0.039 0.1215
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.017 0.052
Echinococcus granulosus nibrin 0.0012 0.0083 0.0074
Brugia malayi isocitrate dehydrogenase 0.0019 0.017 0.052
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.0012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0087 0.0078
Schistosoma mansoni hypothetical protein 0.0037 0.039 0.039
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0018 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.045 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0087 0.0078
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0018 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0087 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0607 0.0607
Schistosoma mansoni topbp1 0.0012 0.0083 0.0083
Onchocerca volvulus 0.0012 0.0083 0.0581
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0018 0.0018
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0087 0.0258
Echinococcus multilocularis geminin 0.0205 0.241 0.2403
Trypanosoma cruzi chloride channel protein, putative 0.0016 0.0132 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0087 0.0258
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0069 0.0202

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 5.896 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 5.896 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 5.896 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 14.241 uM PUBCHEM_BIOASSAY: MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 15.503 uM PUBCHEM_BIOASSAY: MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
EC50 (functional) = 2.582 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 3.694 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
IC50 (functional) = 13.8 uM PUBCHEM_BIOASSAY: Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489030, AID492945] ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response validation of Inhibitors of Apaf-1 using a Fluorescent Interference Counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489030, AID492945] ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.