Detailed information for compound 1343643

Basic information

Technical information
  • TDR Targets ID: 1343643
  • Name: N-[4-(1H-benzimidazol-2-yl)phenyl]-2-methyl-4 -nitropyrazole-3-carboxamide
  • MW: 362.342 | Formula: C18H14N6O3
  • H donors: 2 H acceptors: 5 LogP: 2.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cnn(c1C(=O)Nc1ccc(cc1)c1nc2c([nH]1)cccc2)C
  • InChi: 1S/C18H14N6O3/c1-23-16(15(10-19-23)24(26)27)18(25)20-12-8-6-11(7-9-12)17-21-13-4-2-3-5-14(13)22-17/h2-10H,1H3,(H,20,25)(H,21,22)
  • InChiKey: VMHHZDBQXJXGAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(1H-benzimidazol-2-yl)phenyl]-2-methyl-4-nitro-pyrazole-3-carboxamide
  • N-[4-(1H-benzimidazol-2-yl)phenyl]-2-methyl-4-nitro-3-pyrazolecarboxamide
  • Oprea1_423976
  • BAS 03421708
  • ST027159
  • 2-Methyl-4-nitro-2H-pyrazole-3-carboxylic acid [4-(1H-benzoimidazol-2-yl)-phenyl]-amide
  • MLS000551122
  • SMR000178023
  • Oprea1_361394
  • ZINC00911868

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0021 0.0096 0.1084
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0096 0.0094
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0096 0.0113
Onchocerca volvulus 0.0021 0.0096 0.1084
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0126 0.0147
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0096 0.0113
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0005 0.0043
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0002 0.000008579
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0002 0.00000040868
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0005 0.0004
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0096 0.0333
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0096 0.0113
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi neuropeptide F receptor 0.0021 0.0096 0.0333
Echinococcus multilocularis expressed conserved protein 0.0112 0.1033 0.1032
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0096 0.0111
Chlamydia trachomatis DNA ligase 0.0012 0.0002 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0012
Echinococcus granulosus orexin receptor type 2 0.0021 0.0096 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi DOMON domain containing protein 0.0048 0.0378 0.133
Loa Loa (eye worm) hypothetical protein 0.0286 0.283 1
Onchocerca volvulus 0.0096 0.0871 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0096 0.0113
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0096 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0005 0.0012
Brugia malayi Uncoordinated protein 44 0.0015 0.0034 0.0113
Schistosoma mansoni amine GPCR 0.0021 0.0096 0.0113
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0088 0.0784 0.0782
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0096 0.0333
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8492 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0076 0.0263
Echinococcus granulosus jun protein 0.0088 0.0784 0.0921
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0096 0.0094
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0076 0.597
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0096 0.0094
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0096 0.0333
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0096 0.0333
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0034 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0005 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0406 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0096 0.0111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0005 0.0003
Brugia malayi putative neuropeptide receptor 0.0021 0.0096 0.0333
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0096 0.0094
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0096 0.0094
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0096 0.0094
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0076 0.0088
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Onchocerca volvulus 0.0021 0.0096 0.1084
Brugia malayi G-protein coupled receptor 0.0021 0.0096 0.0333
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0126 1
Schistosoma mansoni neuropeptide receptor 0.0021 0.0096 0.0113
Echinococcus multilocularis serotonin receptor 0.0021 0.0096 0.0094
Schistosoma mansoni topbp1 0.0012 0.0002 0.0002
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0002 0.5
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1108 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0096 0.0111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0096 0.0113
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0126 0.0125
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0076 0.0074
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0406 0.143
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0096 0.0094
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0076 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.0096 0.1084
Brugia malayi ecdysteroid receptor 0.0012 0.0005 0.0012
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0002 0.0127
Loa Loa (eye worm) RecQ helicase 0.0024 0.0126 0.044
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0002 0.0002
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0096 0.0094
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0252 0.2486 0.2927
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1635 0.1634
Loa Loa (eye worm) DOMON domain-containing protein 0.0048 0.0378 0.133
Brugia malayi DOMON domain containing protein 0.0048 0.0378 0.133
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0096 0.0111
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0076 0.6021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0096 0.0113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0005 0.0012
Echinococcus granulosus bloom syndrome protein 0.0024 0.0126 0.0147
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0124 0.1163 0.4106
Loa Loa (eye worm) ShTK domain-containing protein 0.0096 0.0871 0.3072
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0005 0.0006
Brugia malayi Dopamine receptor 0.0021 0.0096 0.0333
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0034 0.0113
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0096 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni neuropeptide receptor 0.0021 0.0096 0.0113
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0002 0.0014
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0096 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0096 0.0113
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0096 0.0113
Onchocerca volvulus 0.0096 0.0871 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0096 0.0094
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0126 0.044
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0096 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0005 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0005 0.0003
Schistosoma mansoni DNA ligase IV 0.0012 0.0002 0.0002
Echinococcus multilocularis Ankyrin 0.0015 0.0035 0.0033
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0005 0.0006
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0096 0.0094
Schistosoma mansoni hypothetical protein 0.0021 0.0096 0.0113
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0126 1
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0096 0.0094
Brugia malayi GnHR receptor homolog 0.0021 0.0096 0.0333
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0096 0.0094
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0096 0.0094
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0096 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0005 0.0012
Onchocerca volvulus 0.0021 0.0096 0.1084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0005 0.0012
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0059 0.0488 0.0574
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0096 0.0094
Schistosoma mansoni opsin-like receptor 0.0021 0.0096 0.0113
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1127 0.1327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0005 0.0012
Onchocerca volvulus 0.0096 0.0871 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0096 0.0111
Schistosoma mansoni hypothetical protein 0.0058 0.0481 0.0566
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0051 0.0406 0.143
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0126 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0088 0.0784 0.0921
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0252 0.2486 0.8783
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0012
Brugia malayi G-protein coupled receptor 0.0021 0.0096 0.0333
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0096 0.0094
Brugia malayi hypothetical protein 0.0069 0.059 0.2079
Schistosoma mansoni hypothetical protein 0.0071 0.0614 0.0723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0005 0.0012
Schistosoma mansoni biogenic amine receptor 0.0021 0.0096 0.0113
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0096 0.0111
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0126 0.1138
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1635 0.1924
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0126 0.044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0096 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0096 0.0111
Entamoeba histolytica hypothetical protein 0.0012 0.0002 0.0014
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0059 0.0488 0.0486
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi Serotonin receptor 0.0021 0.0096 0.0333
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0126 0.044
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0096 0.0111
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8492 1
Echinococcus granulosus g protein coupled receptor 0.0021 0.0096 0.0111
Echinococcus multilocularis jun protein 0.0088 0.0784 0.0782
Onchocerca volvulus 0.0021 0.0096 0.1084
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0005 0.0257
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0096 0.0094
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0406 0.0476
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0481 0.1694
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0096 0.0113
Schistosoma mansoni biogenic amine receptor 0.0021 0.0096 0.0113
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0002 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0096 0.0094
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0252 0.2486 0.2926
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0096 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0096 0.0113
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0096 0.0111
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0096 0.0094
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0096 0.0333
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0096 0.0113
Brugia malayi steroid hormone receptor 0.0012 0.0005 0.0012
Echinococcus granulosus death domain containing protein 0.0015 0.0034 0.0038
Echinococcus granulosus Ankyrin 0.0015 0.0035 0.0039
Onchocerca volvulus 0.0048 0.0378 0.433
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni amine GPCR 0.0021 0.0096 0.0113
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.283 0.2829
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0096 0.0111
Brugia malayi AKH receptor 0.0021 0.0096 0.0333
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0005 0.0038
Brugia malayi ShTK domain containing protein 0.0096 0.0871 0.3072
Brugia malayi Dopamine receptor protein 2 0.0021 0.0096 0.0333
Loa Loa (eye worm) tyrosinase 1 0.0096 0.0871 0.3072
Loa Loa (eye worm) hypothetical protein 0.0252 0.2486 0.8783
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0005 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Onchocerca volvulus 0.0059 0.0488 0.5592
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0002 0.000008579
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0005 0.0003
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0126 0.0147
Onchocerca volvulus 0.0048 0.0378 0.433
Loa Loa (eye worm) DOMON domain-containing protein 0.0048 0.0378 0.133
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0096 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0005 0.0012
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0096 0.0333
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0076 0.597
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0005 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0005 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0034 0.0113
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0005 0.0006
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0059 0.0488 0.0572
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0096 0.0094
Echinococcus granulosus serotonin receptor 0.0021 0.0096 0.0111
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0126 1
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0076 0.0263
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0005 0.0006
Brugia malayi isocitrate dehydrogenase 0.0019 0.0076 0.0263
Brugia malayi DOMON domain containing protein 0.0048 0.0378 0.133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0096 0.0113
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0035 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.0096 0.1084
Brugia malayi Melatonin receptor type 1A 0.0021 0.0096 0.0333
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0096 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0012
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0011
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0126 0.044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0005 0.0012
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0076 0.6021
Schistosoma mansoni amine GPCR 0.0021 0.0096 0.0113
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0096 0.0113
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0059 0.0488 0.5592
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0096 0.0871 0.3072
Echinococcus granulosus allatostatin A receptor 0.0021 0.0096 0.0111
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8492 0.8492
Onchocerca volvulus 0.0021 0.0096 0.1084
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0096 0.0111
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0096 0.0113
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0076 0.0074
Brugia malayi sulfakinin receptor protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi bZIP transcription factor family protein 0.0088 0.0784 0.2766
Schistosoma mansoni opsin-like receptor 0.0021 0.0096 0.0113
Schistosoma mansoni tyrosinase precursor 0.0096 0.0871 0.1025
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0076 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0096 0.0113
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1108 0.1303
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0096 0.0113
Schistosoma mansoni DNA helicase recq5 0.0024 0.0126 0.0148
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0126 1
Onchocerca volvulus 0.0021 0.0096 0.1084
Treponema pallidum ATP-dependent DNA helicase 0.0012 0.0005 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0481 0.0566
Echinococcus multilocularis sex peptide receptor 0.0021 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0119 0.1108 0.391
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0012
Onchocerca volvulus 0.0021 0.0096 0.1084
Onchocerca volvulus 0.0059 0.0488 0.5592
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0096 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0005 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0076 0.0074
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0096 0.0094
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0128 0.1202 0.4243
Schistosoma mansoni amine GPCR 0.0021 0.0096 0.0113
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0126 1
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0096 0.0871 0.3072
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0096 0.0111
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0005 0.0003
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0096 0.0113
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0096 0.0111
Echinococcus granulosus neuropeptide receptor 0.0021 0.0096 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0096 0.0094
Echinococcus granulosus somatostatin receptor 0.0021 0.0096 0.0111
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0076 0.597
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0096 0.0333
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0096 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0096 0.0111
Brugia malayi hypothetical protein 0.0286 0.283 1
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni coup transcription factor 0.0012 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni dopamine-beta-monooxygenase 0.0478 0.4815 0.567
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0005 0.0012
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0005 0.0632
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0005 0.0012
Schistosoma mansoni netrin receptor unc5 0.0015 0.0034 0.004
Schistosoma mansoni peptidylglycine monooxygenase 0.0252 0.2486 0.2927
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0096 0.0113
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0096 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0005 0.0003
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0096 0.0111
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0126 0.0125
Brugia malayi larval opioid receptor 0.0021 0.0096 0.0333
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0096 0.0111
Loa Loa (eye worm) hypothetical protein 0.0062 0.0525 0.1849
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0021 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0005 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0005 0.0012
Schistosoma mansoni tyrosinase precursor 0.0096 0.0871 0.1025
Onchocerca volvulus 0.0012 0.0005 0.0038
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0005 0.0004
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0034 0.004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0005 0.0004
Brugia malayi nuclear receptor NHR-88 0.0012 0.0005 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0096 0.0871 0.3072
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0096 0.0333
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0005 0.0006
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0096 0.0333
Schistosoma mansoni myosin xvIII 0.0021 0.0096 0.0113
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0096 0.0871 0.3072
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0096 0.0111
Schistosoma mansoni jun-related protein 0.0071 0.0614 0.0723
Onchocerca volvulus 0.0021 0.0096 0.1084
Schistosoma mansoni hypothetical protein 0.0021 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0085 0.0759 0.2678
Loa Loa (eye worm) DOMON domain-containing protein 0.0048 0.0378 0.133
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0012
Brugia malayi Protein kinase domain containing protein 0.0015 0.0034 0.0113
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0005 0.0003
Onchocerca volvulus 0.0021 0.0096 0.1084
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0096 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0002 0.000008579
Onchocerca volvulus 0.0021 0.0096 0.1084
Echinococcus multilocularis protein dispatched 1 0.0058 0.0481 0.0479
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0096 0.0111
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0096 0.0113
Echinococcus granulosus g protein coupled receptor 0.0021 0.0096 0.0111
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0002 0.0127
Onchocerca volvulus 0.0021 0.0096 0.1084
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0002 0.0211
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0096 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0252 0.2486 0.2485
Schistosoma mansoni patched 1 0.0051 0.0406 0.0478
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0011
Onchocerca volvulus 0.0059 0.0488 0.5592
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0005 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0005 0.0006
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0034 0.0032
Echinococcus granulosus hypothetical protein 0.0021 0.0096 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0096 0.0113
Echinococcus multilocularis somatostatin receptor 0.0021 0.0096 0.0094
Echinococcus granulosus expressed conserved protein 0.0112 0.1033 0.1215
Onchocerca volvulus 0.0058 0.0481 0.5514
Schistosoma mansoni amine GPCR 0.0021 0.0096 0.0113
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1108 0.391
Schistosoma mansoni adenoreceptor 0.0021 0.0096 0.0113
Echinococcus granulosus fmrfamide receptor 0.0021 0.0096 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0096 0.0333
Schistosoma mansoni opsin-like receptor 0.0021 0.0096 0.0113
Brugia malayi RE15519p 0.0021 0.0096 0.0333
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0096 0.0094
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0096 0.0094
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0005 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0096 0.0111
Echinococcus multilocularis serotonin receptor 0.0021 0.0096 0.0094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0005 0.0006
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0126 1
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0096 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0096 0.0094
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0096 0.0333
Onchocerca volvulus 0.0021 0.0096 0.1084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0096 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0113
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0005 0.0006
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0005 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0096 0.0094
Echinococcus granulosus neuropeptide receptor 0.0021 0.0096 0.0111
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0049 0.0383 0.1349
Schistosoma mansoni topbp1 0.0012 0.0002 0.0002
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0096 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0005 0.0004
Brugia malayi ORL1-like opioid receptor 0.0021 0.0096 0.0333
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0126 0.3078
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni biogenic amine receptor 0.0021 0.0096 0.0113
Schistosoma mansoni hypothetical protein 0.0049 0.0387 0.0456
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1108 0.1106
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0096 0.0111
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0096 0.0333
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0126 0.3078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0096 0.0871 0.3072
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0126 0.3078
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0406 0.0405
Brugia malayi CHE-14 protein 0.0051 0.0406 0.143
Echinococcus granulosus sex peptide receptor 0.0021 0.0096 0.0111
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0406 0.0476
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0673 0.0671
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0096 0.0111
Brugia malayi Common central domain of tyrosinase family protein 0.0096 0.0871 0.3072
Loa Loa (eye worm) hypothetical protein 0.0252 0.2486 0.8783
Schistosoma mansoni neuropeptide receptor 0.0021 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0034 0.0369
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0005 0.0006
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0096 0.0113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0005 0.0012
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0096 0.0094
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0096 0.0094
Schistosoma mansoni hypothetical protein 0.0049 0.0387 0.0456
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0096 0.0333
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0673 0.079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0012
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0126 0.044
Brugia malayi Serotonin receptor 0.0021 0.0096 0.0333
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0096 0.0094
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0096 0.0111
Onchocerca volvulus 0.0021 0.0096 0.1084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0118
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0096 0.0333
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0076 0.597
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0096 0.0113
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0096 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0096 0.0113
Schistosoma mansoni hypothetical protein 0.0049 0.0387 0.0456
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0005 0.0006
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0096 0.0333
Schistosoma mansoni hypothetical protein 0.0049 0.0387 0.0456
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0096 0.0871 0.3072
Brugia malayi nuclear hormone receptor 0.0012 0.0005 0.0012
Onchocerca volvulus 0.0069 0.059 0.6766
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0096 0.0111
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0126 0.0125
Onchocerca volvulus 0.0059 0.0488 0.5592
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0076 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus granulosus g protein coupled receptor 0.0021 0.0096 0.0111
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0076 0.0074
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0076 0.597
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0076 0.0074
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0002 0.5
Schistosoma mansoni neuropeptide receptor 0.0021 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0005 0.0012
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi Death domain containing protein 0.0015 0.0034 0.0113
Loa Loa (eye worm) ShTK domain-containing protein 0.0096 0.0871 0.3072
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0096 0.0111
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0005 0.0381
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0096 0.0333
Schistosoma mansoni DNA helicase recq1 0.0024 0.0126 0.0148
Onchocerca volvulus 0.0021 0.0096 0.1084
Brugia malayi Dopamine receptor protein 1 0.0021 0.0096 0.0333
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0096 0.0111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0034 0.0038
Onchocerca volvulus 0.0021 0.0096 0.1084
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0005 0.0006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0126 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0096 0.0113
Schistosoma mansoni hypothetical protein 0.0021 0.0096 0.0113
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.004
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0096 0.0111
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0096 0.0094
Brugia malayi G protein-coupled receptor 0.0021 0.0096 0.0333
Echinococcus multilocularis protein patched 0.0051 0.0406 0.0405
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0005 0.0004
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.283 0.3332
Onchocerca volvulus 0.0096 0.0871 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0005 0.0038
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0005 0.0003
Schistosoma mansoni histamine h1 receptor 0.0021 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0333
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0096 0.0333
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0252 0.2486 0.8783
Brugia malayi neuropeptide F receptor 0.0021 0.0096 0.0333
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0002 0.00000034704
Onchocerca volvulus 0.0021 0.0096 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0005 0.0012
Brugia malayi hypothetical protein 0.0021 0.0096 0.0333
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0096 0.0094

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 3.2643 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1714 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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