Detailed information for compound 1347963

Basic information

Technical information
  • TDR Targets ID: 1347963
  • Name: N-[2-[(3,4-dichlorophenyl)amino]-2-oxoethyl]- N-methylcyclopentanecarboxamide
  • MW: 329.222 | Formula: C15H18Cl2N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(C(=O)C1CCCC1)C)Nc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C15H18Cl2N2O2/c1-19(15(21)10-4-2-3-5-10)9-14(20)18-11-6-7-12(16)13(17)8-11/h6-8,10H,2-5,9H2,1H3,(H,18,20)
  • InChiKey: WKTFDIMMTPUNRE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(3,4-dichlorophenyl)amino]-2-oxo-ethyl]-N-methyl-cyclopentanecarboxamide
  • N-[2-[(3,4-dichlorophenyl)amino]-2-keto-ethyl]-N-methyl-cyclopentanecarboxamide
  • T5322953
  • ZINC03422965

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0257 0.1556 0.885
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0071 0.0259 0.0259
Schistosoma mansoni inositol monophosphatase 0.0037 0.0024 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0192 0.0192
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0192 0.0178
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0014 0.0014
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0259 0.0259
Giardia lamblia Encystation-specific protease 0.0051 0.0119 0.0578
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Brugia malayi neuropeptide F receptor 0.0071 0.0259 0.0259
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0143 0.0251
Echinococcus multilocularis tumor protein p63 0.0408 0.2605 0.2595
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0071 0.0259 0.0259
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0277 0.0817
Echinococcus granulosus G protein coupled receptor 139 0.0071 0.0259 0.0253
Trypanosoma cruzi cysteine peptidase, putative 0.0283 0.1736 0.3609
Brugia malayi Cathepsin L-like precursor 0.0055 0.0143 0.0143
Echinococcus granulosus cathepsin L cysteine protease 0.0106 0.0499 0.0494
Schistosoma mansoni hypothetical protein 0.0071 0.0259 0.0259
Schistosoma mansoni amine GPCR 0.0071 0.0259 0.0259
Schistosoma mansoni cathepsin F (C01 family) 0.0186 0.1056 0.1056
Echinococcus multilocularis cysteine protease 0.0186 0.1056 0.1043
Echinococcus granulosus brain tumor protein 0.0038 0.0031 0.0026
Echinococcus granulosus cathepsin L cysteine proteinase 0.0186 0.1056 0.1051
Onchocerca volvulus Cathepsin F homolog 0.0186 0.1056 0.6012
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0083 0.0342 0.067
Trypanosoma brucei calpain-like protein, putative 0.0083 0.0342 0.1856
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0071 0.0259 0.0259
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0119 0.0119
Plasmodium falciparum glutathione reductase 0.0047 0.0093 0.0883
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0074 0.0277 0.0277
Brugia malayi Melatonin receptor type 1A 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus g protein coupled receptor 0.0071 0.0259 0.0253
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0106 0.0499 0.0499
Schistosoma mansoni growth hormone secretagogue receptor 0.0071 0.0259 0.0259
Echinococcus granulosus calpain 7 C02 family 0.0083 0.0342 0.0337
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0516 0.1607
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0259 0.0245
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0071 0.0259 0.0253
Brugia malayi fibroinase precursor 0.0051 0.0119 0.0119
Brugia malayi G protein-coupled receptor 0.0071 0.0259 0.0259
Brugia malayi hypothetical protein 0.0071 0.0259 0.0259
Giardia lamblia Cathepsin B precursor 0.0051 0.0119 0.0578
Giardia lamblia Cathepsin L precursor 0.0051 0.0119 0.0578
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0259 0.0259
Echinococcus granulosus neuropeptide receptor A26 0.0071 0.0259 0.0253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0277 0.0277
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0259 0.0245
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0277 0.0272
Onchocerca volvulus 0.006 0.0179 0.1021
Echinococcus multilocularis hypothetical protein 0.0083 0.0342 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0119 0.0549
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0259 0.0253
Brugia malayi Cathepsin L-like precursor 0.0186 0.1056 0.1056
Plasmodium vivax vivapain-2 0.0186 0.1056 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0392 0.0392
Trypanosoma cruzi cysteine peptidase, putative 0.0283 0.1736 0.3609
Schistosoma mansoni amine GPCR 0.0071 0.0259 0.0259
Echinococcus granulosus cathepsin b 0.0718 0.4767 0.4764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0259 0.0259
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0093 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0051 0.0119 0.0549
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0083 0.0342 0.1856
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0071 0.0259 0.0259
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0014 0.0014
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0186 0.1056 0.1043
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0718 0.4767 0.4767
Brugia malayi ORL1-like opioid receptor 0.0071 0.0259 0.0259
Plasmodium falciparum plasmepsin I 0.0144 0.0764 0.724
Echinococcus granulosus cysteine protease 0.0106 0.0499 0.0494
Brugia malayi cathepsin B-like cysteine proteinase 0.0718 0.4767 0.4767
Echinococcus multilocularis cathepsin L 0.0106 0.0499 0.0485
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0277 0.1464
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0259 0.0253
Plasmodium falciparum serine repeat antigen 7 0.0051 0.0119 0.1128
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Plasmodium vivax unspecified product 0.0051 0.0119 0.1128
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0119 0.0119
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.0038 0.0031 0.0031
Echinococcus multilocularis cathepsin L 0.0051 0.0119 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Brugia malayi RE15519p 0.0071 0.0259 0.0259
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.147 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.1501 0.1501
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0143 0.0143
Onchocerca volvulus 0.0071 0.0259 0.1473
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0071 0.0259 0.0245
Schistosoma mansoni calpain C (C02 family) 0.0083 0.0342 0.0342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0392 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Echinococcus multilocularis snurportin 1 0.0304 0.1883 0.1872
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Onchocerca volvulus 0.0071 0.0259 0.1473
Loa Loa (eye worm) hypothetical protein 0.0074 0.0277 0.0277
Echinococcus granulosus cathepsin l1 0.0186 0.1056 0.1051
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0259 0.0253
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0051 0.0119 0.1128
Onchocerca volvulus 0.0286 0.1756 1
Schistosoma mansoni calpain (C02 family) 0.0083 0.0342 0.0342
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0106 0.0499 0.0499
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Schistosoma mansoni cathepsin F (C01 family) 0.0131 0.0676 0.0676
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0083 0.0342 0.067
Schistosoma mansoni opsin-like receptor 0.0071 0.0259 0.0259
Brugia malayi B-box type zinc-finger protein ncl-1 0.0038 0.0031 0.0031
Echinococcus granulosus calpain A 0.023 0.1366 0.1361
Echinococcus granulosus neuropeptides capa receptor 0.0071 0.0259 0.0253
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0144 0.0764 0.0764
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.0259 0.0259
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0051 0.0119 0.1006
Brugia malayi Cathepsin L-like precursor 0.0186 0.1056 0.1056
Schistosoma mansoni peptidylglycine monooxygenase 0.0781 0.52 0.52
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0718 0.4767 1
Loa Loa (eye worm) calpain family protein 1 0.022 0.1296 0.1296
Mycobacterium ulcerans lipase LipD 0.0074 0.0277 1
Onchocerca volvulus 0.0186 0.1056 0.6012
Toxoplasma gondii cathepsin B 0.0257 0.1556 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0031 0.0031
Echinococcus multilocularis tripartite motif containing protein 3 0.0038 0.0031 0.0017
Plasmodium vivax vivapain-1 0.0106 0.0499 0.4725
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0119 0.0119
Leishmania major cathepsin L-like protease 0.0283 0.1736 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0024 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.1501 0.1501
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.1056 0.1056
Brugia malayi Dopamine receptor 0.0071 0.0259 0.0259
Plasmodium falciparum plasmepsin VI 0.0144 0.0764 0.724
Loa Loa (eye worm) hypothetical protein 0.0162 0.0892 0.0892
Trypanosoma cruzi cysteine proteinase, putative 0.0106 0.0499 0.1001
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0071 0.0259 0.0259
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0259 0.0245
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0051 0.0119 0.0119
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.3048 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0051 0.0119 0.1128
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0277 0.0535
Loa Loa (eye worm) inositol-1 0.0037 0.0024 0.0024
Schistosoma mansoni neuropeptide receptor 0.0071 0.0259 0.0259
Schistosoma mansoni dopamine-beta-monooxygenase 0.0781 0.52 0.52
Entamoeba histolytica cysteine proteinase 2 0.0106 0.0499 0.4652
Loa Loa (eye worm) hypothetical protein 0.0036 0.0014 0.0014
Brugia malayi B-box zinc finger family protein 0.0038 0.0031 0.0031
Echinococcus granulosus calpain A 0.0083 0.0342 0.0337
Brugia malayi neuropeptide F receptor 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0051 0.0119 0.0119
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0083 0.0342 0.1856
Loa Loa (eye worm) hypothetical protein 0.0051 0.0119 0.0119
Plasmodium vivax vivapain-3 0.0106 0.0499 0.4725
Schistosoma mansoni neuropeptide receptor 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0131 0.0676 0.3765
Echinococcus multilocularis G-protein coupled receptor, putative 0.0071 0.0259 0.0245
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0051 0.0119 0.1128
Schistosoma mansoni cathepsin F (C01 family) 0.0186 0.1056 0.1056
Echinococcus granulosus g protein coupled receptor 0.0071 0.0259 0.0253
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Brugia malayi hypothetical protein 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Echinococcus multilocularis serotonin receptor 0.0071 0.0259 0.0245
Plasmodium vivax unspecified product 0.0106 0.0499 0.4725
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0051 0.0119 0.0578
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0024 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0277 0.0535
Trypanosoma brucei calpain-like protein, putative 0.0083 0.0342 0.1856
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0024 0.001
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0186 0.1056 0.1056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0392 0.0392
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0259 0.0253
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.07 0.4638 0.4638
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Leishmania major cathepsin L-like protease 0.0283 0.1736 1
Brugia malayi Dopamine receptor protein 2 0.0071 0.0259 0.0259
Leishmania major kinesin, putative 0.0058 0.0168 0.0841
Giardia lamblia Cathepsin B precursor 0.0051 0.0119 0.0578
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0259 0.0253
Schistosoma mansoni peptidyl-glycine monooxygenase 0.147 1 1
Brugia malayi B-box zinc finger family protein 0.0038 0.0031 0.0031
Echinococcus multilocularis calpain A 0.023 0.1366 0.1353
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0259 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0131 0.0676 0.3765
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0051 0.0119 0.1128
Loa Loa (eye worm) TYRA-2 protein 0.0071 0.0259 0.0259
Echinococcus granulosus neuropeptide receptor 0.0071 0.0259 0.0253
Brugia malayi hypothetical protein 0.0071 0.0259 0.0259
Schistosoma mansoni myosin xvIII 0.0071 0.0259 0.0259
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0144 0.0764 0.0751
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Plasmodium falciparum serine repeat antigen 2 0.0051 0.0119 0.1128
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0277 0.1464
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0259 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Leishmania major cysteine peptidase A (CPA) 0.0186 0.1056 0.6027
Giardia lamblia Cathepsin B precursor 0.0257 0.1556 1
Schistosoma mansoni neuropeptide receptor 0.0071 0.0259 0.0259
Trypanosoma cruzi major cysteine proteinase, putative 0.0149 0.0799 0.1634
Brugia malayi GnHR receptor homolog 0.0071 0.0259 0.0259
Echinococcus granulosus sex peptide receptor 0.0071 0.0259 0.0253
Entamoeba histolytica cysteine protease, putative 0.0051 0.0119 0.1006
Loa Loa (eye worm) fibroinase 0.0186 0.1056 0.1056
Echinococcus multilocularis cathepsin b 0.0718 0.4767 0.4759
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0071 0.0259 0.0259
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0024 0.0154
Onchocerca volvulus 0.0071 0.0259 0.1473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0119 0.0549
Toxoplasma gondii cathepsin CPC2 0.0051 0.0119 0.0765
Brugia malayi glutathione reductase 0.0047 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0036 0.0014 0.0014
Echinococcus granulosus serotonin receptor 0.0071 0.0259 0.0253
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0259 0.0259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0259 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0119 0.0549
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0229 0.1356 0.2808
Loa Loa (eye worm) G-protein coupled receptor 0.0071 0.0259 0.0259
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1245 0.8436 0.8433
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0392 0.0378
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus neuropeptide s receptor 0.0071 0.0259 0.0253
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus cathepsin L 0.0051 0.0119 0.0114
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Giardia lamblia Cathepsin L precursor 0.0051 0.0119 0.0578
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0071 0.0259 0.0253
Leishmania major cathepsin L-like protease 0.0186 0.1056 0.6027
Schistosoma mansoni cathepsin s 0.0055 0.0143 0.0143
Trypanosoma brucei calpain-like protein, putative 0.0083 0.0342 0.1856
Giardia lamblia Cathepsin B precursor 0.0051 0.0119 0.0578
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0226 0.1336 0.1336
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0144 0.0764 0.0759
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0051 0.0119 0.0549
Onchocerca volvulus 0.0186 0.1056 0.6012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0277 0.0277
Entamoeba histolytica cysteine protease, putative 0.0051 0.0119 0.1006
Toxoplasma gondii cathepsin CPL 0.0186 0.1056 0.6782
Schistosoma mansoni inositol monophosphatase 0.0037 0.0024 0.0024
Brugia malayi Thioredoxin reductase 0.0047 0.0093 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0277 0.1464
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0051 0.0119 0.1128
Brugia malayi cathepsin F-like cysteine proteinase 0.0055 0.0143 0.0143
Echinococcus granulosus orexin receptor type 2 0.0071 0.0259 0.0253
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Entamoeba histolytica cysteine proteinase, putative 0.0106 0.0499 0.4652
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0119 0.0119
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.0119 0.0578
Brugia malayi Cathepsin L-like precursor 0.0131 0.0676 0.0676
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0071 0.0259 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Leishmania major hypothetical protein, conserved 0.0074 0.0277 0.1481
Loa Loa (eye worm) hypothetical protein 0.0137 0.0718 0.0718
Onchocerca volvulus 0.0051 0.0119 0.0678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Loa Loa (eye worm) hypothetical protein 0.022 0.1296 0.1296
Toxoplasma gondii aspartyl protease ASP1 0.0144 0.0764 0.491
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0186 0.1056 1
Brugia malayi Hypothetical RING finger protein F54G8.4 in chromosome III 0.0038 0.0031 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0392 0.0387
Brugia malayi beta-lactamase family protein 0.0074 0.0277 0.0277
Onchocerca volvulus 0.0186 0.1056 0.6012
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0259 0.0259
Brugia malayi Cathepsin L-like cysteine proteinase 0.0131 0.0676 0.0676
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0277 0.1481
Giardia lamblia Cysteine protease 0.0051 0.0119 0.0578
Leishmania major cathepsin L-like protease 0.0283 0.1736 1
Brugia malayi calpain family protein 1 0.022 0.1296 0.1296
Giardia lamblia Hypothetical protein 0.0051 0.0119 0.0578
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.022 0.1296 0.1296
Brugia malayi hypothetical protein 0.07 0.4638 0.4638
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.023 0.1366 0.1361
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0277 0.0264
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.023 0.1366 0.1353
Schistosoma mansoni hypothetical protein 0.0038 0.0031 0.0031
Echinococcus granulosus cathepsin b 0.0718 0.4767 0.4764
Trichomonas vaginalis esterase, putative 0.0074 0.0277 0.1464
Loa Loa (eye worm) calpain 0.0083 0.0342 0.0342
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Onchocerca volvulus 0.0186 0.1056 0.6012
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1056 0.5957
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.06 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0071 0.0259 0.0259
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0277 0.0817
Loa Loa (eye worm) hypothetical protein 0.0051 0.0119 0.0119
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0192 0.0192
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Brugia malayi Cathepsin L-like precursor 0.0186 0.1056 0.1056
Brugia malayi Pre-SET motif family protein 0.0036 0.0014 0.0014
Schistosoma mansoni cathepsin B (C01 family) 0.0051 0.0119 0.0119
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0093 0.0206
Schistosoma mansoni amine GPCR 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0119 0.0549
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0259 0.0253
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus multilocularis calpain 7 (C02 family) 0.0083 0.0342 0.0328
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0071 0.0259 0.0245
Schistosoma mansoni cathepsin D (A01 family) 0.0424 0.2714 0.2714
Entamoeba histolytica cysteine protease, putative 0.0051 0.0119 0.1006
Loa Loa (eye worm) B-box zinc finger family protein 0.0038 0.0031 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Loa Loa (eye worm) RING finger protein nhl-1 0.0038 0.0031 0.0031
Brugia malayi follicle stimulating hormone receptor 0.0071 0.0259 0.0259
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Trypanosoma brucei kinesin, putative 0.0058 0.0168 0.0841
Brugia malayi Tachykinin-like peptides receptor 99D 0.0071 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Brugia malayi MH2 domain containing protein 0.0249 0.1501 0.1501
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0119 0.0549
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0589 0.3868 0.386
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0143
Schistosoma mansoni Mername-AA248 (C02 family) 0.0083 0.0342 0.0342
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0083 0.0342 0.067
Toxoplasma gondii thioredoxin reductase 0.0047 0.0093 0.0599
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0259 0.0259
Entamoeba histolytica cysteine proteinase, putative 0.0106 0.0499 0.4652
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0259 0.0259
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.0259 0.0253
Brugia malayi cathepsin Z-like cysteine proteinase 0.0051 0.0119 0.0119
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0718 0.4767 0.4767
Toxoplasma gondii preprocathepsin c precursor, putative 0.0051 0.0119 0.0765
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0119 0.0549
Schistosoma mansoni peptidylglycine monooxygenase 0.0038 0.0031 0.0031
Echinococcus granulosus somatostatin receptor 0.0071 0.0259 0.0253
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0277 1
Echinococcus granulosus g-protein coupled receptor 0.0071 0.0259 0.0253
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0038 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.006 0.0179 0.0179
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0071 0.0259 0.0259
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0259 0.0245
Schistosoma mansoni opsin-like receptor 0.0071 0.0259 0.0259
Trypanosoma brucei cysteine peptidase C (CPC) 0.0257 0.1556 0.8954
Loa Loa (eye worm) hypothetical protein 0.0718 0.4767 0.4767
Echinococcus granulosus calpain 5 0.0083 0.0342 0.0337
Echinococcus multilocularis cysteine protease 0.0186 0.1056 0.1043
Plasmodium falciparum serine repeat antigen 6 0.0051 0.0119 0.1128
Echinococcus multilocularis dro:myosuppressin receptor 0.0071 0.0259 0.0245
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0144 0.0764 0.491
Brugia malayi sulfakinin receptor protein 0.07 0.4638 0.4638
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0259 0.0259
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0257 0.1556 0.1556
Brugia malayi RNA, U transporter 1 0.0081 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1056 0.5957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0277 0.0277
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0186 0.1056 0.1043
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0071 0.0259 0.1473
Loa Loa (eye worm) glutathione reductase 0.0047 0.0093 0.0093
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Trypanosoma cruzi cruzipain precursor, putative 0.0055 0.0143 0.0251
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0051 0.0119 0.1128
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0384 0.2441 0.2441
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0051 0.0119 0.0549
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0259 0.0259
Plasmodium falciparum serine repeat antigen 9 0.0051 0.0119 0.1128
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus tachykinin peptides receptor 99D 0.1245 0.8436 0.8435
Echinococcus granulosus g protein coupled receptor 0.0071 0.0259 0.0253
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.147 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0106 0.0499 0.4652
Schistosoma mansoni hypothetical protein 0.0071 0.0259 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0119 0.0549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1056 0.5957
Schistosoma mansoni histamine h1 receptor 0.0071 0.0259 0.0259
Entamoeba histolytica hypothetical protein 0.0038 0.0031 0.0159
Mycobacterium tuberculosis Conserved protein 0.0074 0.0277 0.0817
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0259 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0259 0.0259
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0516 0.1607
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.1056 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0119 0.0549
Brugia malayi Serotonin receptor 0.0071 0.0259 0.0259
Brugia malayi hypothetical protein 0.0071 0.0259 0.0259
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0781 0.52 0.52
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0074 0.0277 0.0277
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0257 0.1556 0.3231
Loa Loa (eye worm) RNA binding protein 0.0062 0.0192 0.0192
Echinococcus multilocularis sex peptide receptor 0.0071 0.0259 0.0245
Giardia lamblia Cathepsin B precursor 0.0051 0.0119 0.0578
Schistosoma mansoni neuropeptide F-like receptor 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1056 0.5957
Giardia lamblia Hypothetical protein 0.0051 0.0119 0.0578
Giardia lamblia Cathepsin B precursor 0.0257 0.1556 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.0119 0.0578
Echinococcus multilocularis calpain 0.0083 0.0342 0.0328
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0143
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0396 0.2522 0.2522
Loa Loa (eye worm) hypothetical protein 0.147 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0516 0.7394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0106 0.0499 0.2774
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0277 0.0817
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0083 0.0342 0.067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0083 0.0342 0.067
Echinococcus granulosus snurportin 1 0.0304 0.1883 0.1879
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Brugia malayi RNA binding protein 0.0062 0.0192 0.0192
Onchocerca volvulus 0.0186 0.1056 0.6012
Onchocerca volvulus 0.0071 0.0259 0.1473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0499 0.2742
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0038 0.0031 0.0041
Brugia malayi beta-lactamase family protein 0.0074 0.0277 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0071 0.0259 0.0259
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0014 0.0093
Onchocerca volvulus 0.0071 0.0259 0.1473
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0259 0.0245
Echinococcus granulosus alpha 1A adrenergic receptor 0.0071 0.0259 0.0253
Echinococcus multilocularis cathepsin L cysteine protease 0.0186 0.1056 0.1043
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus tm gpcr rhodopsin 0.0071 0.0259 0.0253
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0051 0.0119 0.1128
Plasmodium vivax serine-repeat antigen (SERA) 0.0051 0.0119 0.1128
Echinococcus granulosus neuropeptide receptor 0.0071 0.0259 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0259 0.0245
Loa Loa (eye worm) calpain family protein 1 0.0162 0.0892 0.0892
Giardia lamblia Cathepsin L precursor 0.0051 0.0119 0.0578
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0257 0.1556 0.8954
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus neuropeptide FF receptor 2 0.0071 0.0259 0.0253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1056 0.5957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0119 0.0549
Entamoeba histolytica cysteine protease, putative 0.0186 0.1056 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0051 0.0119 0.0119
Echinococcus multilocularis serotonin receptor 0.0071 0.0259 0.0245
Onchocerca volvulus 0.0036 0.0014 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0277 0.1464
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0186 0.1056 0.5957
Plasmodium vivax unspecified product 0.0055 0.0143 0.1355
Brugia malayi hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) B-box zinc finger family protein 0.0038 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0131 0.0676 0.0676
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0051 0.0119 0.1128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Plasmodium vivax vivapain-2 0.0186 0.1056 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0058 0.0168 0.1474
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0051 0.0119 0.0549
Brugia malayi calpain 7 0.0083 0.0342 0.0342
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0144 0.0764 0.4275
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0119 0.0549
Trypanosoma cruzi kinesin, putative 0.0058 0.0168 0.0303
Entamoeba histolytica protein kinase, putative 0.0058 0.0168 0.1474
Echinococcus granulosus peptide allatostatin:somatostatin 0.0071 0.0259 0.0253
Echinococcus granulosus neuropeptide Y receptor 0.0071 0.0259 0.0253
Brugia malayi hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus cathepsin l cysteine peptidase 0.0186 0.1056 0.1051
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Echinococcus multilocularis brain tumor protein 0.0038 0.0031 0.0017
Onchocerca volvulus 0.0071 0.0259 0.1473
Plasmodium falciparum serine repeat antigen 5 0.0051 0.0119 0.1128
Onchocerca volvulus 0.0071 0.0259 0.1473
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1242 0.8414 0.8414
Brugia malayi larval opioid receptor 0.0071 0.0259 0.0259
Onchocerca volvulus 0.0074 0.0277 0.158
Loa Loa (eye worm) calpain 5 0.0058 0.0168 0.0168
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0051 0.0119 0.1128
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0051 0.0119 0.0119
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0516 0.1607
Brugia malayi Cathepsin L-like precursor 0.0131 0.0676 0.0676
Brugia malayi Pre-SET motif family protein 0.0251 0.1514 0.1514
Echinococcus multilocularis calpain 5 0.0083 0.0342 0.0328
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0259 0.0245
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0718 0.4767 0.4767
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0071 0.0259 0.0259
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0071 0.0259 0.0259
Brugia malayi G protein-coupled receptor F59B2.13 0.0071 0.0259 0.0259
Onchocerca volvulus 0.0071 0.0259 0.1473
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0071 0.0259 0.0259
Onchocerca volvulus 0.0137 0.0718 0.409
Entamoeba histolytica cysteine proteinase, putative 0.0131 0.0676 0.6354
Brugia malayi AKH receptor 0.0071 0.0259 0.0259
Onchocerca volvulus 0.0074 0.0277 0.158
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0119 0.0201
Onchocerca volvulus 0.0071 0.0259 0.1473
Toxoplasma gondii cathepsin CPC1 0.0051 0.0119 0.0765
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Entamoeba histolytica cysteine protease, putative 0.0051 0.0119 0.1006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0259 0.0245
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0071 0.0259 0.0245
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.06 0.1885
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0144 0.0764 0.0764
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0259 0.0253
Loa Loa (eye worm) NCL-1 protein 0.0038 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0038 0.0031 0.0031
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0119 0.0678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0499 0.2742
Brugia malayi cathepsin L-like cysteine proteinase 0.0051 0.0119 0.0119
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0179 0.0179
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0277 0.2629
Trypanosoma cruzi cysteine proteinase, putative 0.0106 0.0499 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Giardia lamblia Cysteine protease 0.0051 0.0119 0.0578
Loa Loa (eye worm) hypothetical protein 0.0144 0.0764 0.0764
Echinococcus multilocularis cathepsin b 0.0718 0.4767 0.4759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0071 0.0259 0.0245
Schistosoma mansoni amine GPCR 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Onchocerca volvulus 0.0131 0.0676 0.385
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1514 0.1514
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0071 0.0259 0.0245
Leishmania major cathepsin L-like protease 0.0186 0.1056 0.6027
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0499 0.0499
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.0119 0.0578
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0093 0.0883
Trypanosoma brucei trypanothione reductase 0.0047 0.0093 0.0405
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0192 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0106 0.0499 0.2774
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0071 0.0259 0.0259
Schistosoma mansoni adenoreceptor 0.0071 0.0259 0.0259
Brugia malayi Serotonin receptor 0.0071 0.0259 0.0259
Echinococcus multilocularis g protein coupled receptor 0.0071 0.0259 0.0245
Echinococcus granulosus hypothetical protein 0.0071 0.0259 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0014 0.0014
Plasmodium vivax aspartyl proteinase, putative 0.0144 0.0764 0.724
Brugia malayi Cathepsin L-like precursor 0.0186 0.1056 0.1056
Mycobacterium ulcerans beta-lactamase 0.0074 0.0277 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0071 0.0259 0.0259
Trypanosoma cruzi cysteine peptidase, putative 0.0283 0.1736 0.3609
Giardia lamblia Cysteine protease 0.0051 0.0119 0.0578
Loa Loa (eye worm) beta-lactamase 0.0074 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0195 0.1123 0.1123
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.0259 0.0253
Entamoeba histolytica hypothetical protein 0.0051 0.0119 0.1006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0259 0.0245
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0051 0.0119 0.1128
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0083 0.0342 0.1856
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0119 0.0119
Brugia malayi cathepsin L-like precursor 0.0131 0.0676 0.0676
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0119 0.0119
Mycobacterium ulcerans hypothetical protein 0.0074 0.0277 1
Schistosoma mansoni hypothetical protein 0.0038 0.0031 0.0031
Schistosoma mansoni calpain-7 (C02 family) 0.0083 0.0342 0.0342
Entamoeba histolytica cysteine proteinase, putative 0.0186 0.1056 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0192 0.0192
Schistosoma mansoni biogenic amine receptor 0.0071 0.0259 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0259 0.0259
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0071 0.0259 0.0259
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Loa Loa (eye worm) hypothetical protein 0.0051 0.0119 0.0119
Schistosoma mansoni alpha-1 adrenergic receptor 0.0071 0.0259 0.0259
Entamoeba histolytica cysteine protease, putative 0.0051 0.0119 0.1006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1056 0.5957
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0392 0.0392
Echinococcus granulosus tar DNA binding protein 0.0062 0.0192 0.0187
Mycobacterium tuberculosis Probable reductase 0.0108 0.0516 0.1607
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0093 0.0146
Onchocerca volvulus 0.0186 0.1056 0.6012
Schistosoma mansoni neuropeptide receptor 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0083 0.0342 0.067
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0119 0.0119
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0055 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0259 0.0253
Echinococcus multilocularis somatostatin receptor 0.0071 0.0259 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0106 0.0499 0.4652
Onchocerca volvulus 0.0186 0.1056 0.6012
Brugia malayi hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus cathepsin l1 0.0131 0.0676 0.0671
Onchocerca volvulus Cathepsin L homolog 0.0186 0.1056 0.6012
Echinococcus granulosus dro:myosuppressin receptor 0.0071 0.0259 0.0253
Plasmodium falciparum cysteine proteinase falcipain 3 0.0186 0.1056 1
Brugia malayi calpain 5 0.0058 0.0168 0.0168
Onchocerca volvulus 0.0071 0.0259 0.1473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0083 0.0342 0.067
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0071 0.0259 0.0259
Plasmodium falciparum plasmepsin IV 0.0144 0.0764 0.724
Echinococcus multilocularis neuropeptide receptor 0.0071 0.0259 0.0245
Brugia malayi Inositol-1 0.0037 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0014 0.0014
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0051 0.0119 0.1128
Schistosoma mansoni cathepsin D (A01 family) 0.0424 0.2714 0.2714
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.06 0.1885
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0186 0.1056 1
Brugia malayi cathepsin L precursor 0.0051 0.0119 0.0119
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0014 0.0009
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0051 0.0119 0.1128
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0074 0.0277 0.0277
Giardia lamblia Cathepsin L precursor 0.0051 0.0119 0.0578
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0119 0.0549
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1056 0.5957
Schistosoma mansoni brat protein 0.0038 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Schistosoma mansoni cathepsin S (C01 family) 0.0051 0.0119 0.0119
Giardia lamblia Cathepsin B precursor 0.0051 0.0119 0.0578
Echinococcus multilocularis allatostatin A receptor 0.0071 0.0259 0.0245
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0071 0.0259 0.0245
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0277 0.0817
Brugia malayi G-protein coupled receptor 0.0071 0.0259 0.0259
Plasmodium falciparum serine repeat antigen 4 0.0051 0.0119 0.1128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0119 0.0119
Mycobacterium tuberculosis Conserved protein 0.0074 0.0277 0.0817
Echinococcus multilocularis neuropeptides capa receptor 0.0071 0.0259 0.0245
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0051 0.0119 0.0119
Mycobacterium tuberculosis Conserved protein 0.0074 0.0277 0.0817
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0106 0.0499 0.1001
Loa Loa (eye worm) hypothetical protein 0.0131 0.0676 0.0676
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0259 0.0253
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0277 0.0817
Brugia malayi hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) cysteine protease 0.0186 0.1056 0.1056
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0083 0.0342 0.067
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0259 0.0253
Loa Loa (eye worm) hypothetical protein 0.0074 0.0277 0.0277
Plasmodium vivax plasmepsin IV, putative 0.0144 0.0764 0.724
Echinococcus granulosus tumor protein p63 0.0408 0.2605 0.2601
Brugia malayi G-protein coupled receptor 0.0071 0.0259 0.0259
Schistosoma mansoni opsin-like receptor 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0119 0.0549
Echinococcus multilocularis calpain family protein 1, d 0.0162 0.0892 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0119 0.0119
Leishmania major cathepsin L-like protease 0.0186 0.1056 0.6027
Giardia lamblia Cathepsin L precursor 0.0051 0.0119 0.0578
Onchocerca volvulus Cathepsin L homolog 0.0186 0.1056 0.6012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0277 0.0817
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.06 0.1885
Plasmodium falciparum cysteine proteinase falcipain 1 0.0106 0.0499 0.4725
Plasmodium falciparum thioredoxin reductase 0.0047 0.0093 0.0883
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0131 0.0676 0.0676
Schistosoma mansoni amine GPCR 0.0071 0.0259 0.0259
Trypanosoma cruzi cysteine protease, putative 0.0106 0.0499 0.1001
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0259 0.0245
Onchocerca volvulus 0.0071 0.0259 0.1473
Onchocerca volvulus 0.0071 0.0259 0.1473
Echinococcus granulosus fmrfamide receptor 0.0071 0.0259 0.0253
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0071 0.0259 0.0259
Loa Loa (eye worm) melatonin receptor type 1A 0.0071 0.0259 0.0259
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0083 0.0342 0.067
Onchocerca volvulus 0.0071 0.0259 0.1473
Onchocerca volvulus 0.0071 0.0259 0.1473
Echinococcus granulosus 7TM GPCR rhodopsin 0.0071 0.0259 0.0253
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0051 0.0119 0.1128
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0277 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0093 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0259 0.0245
Trypanosoma cruzi cysteine peptidase, putative 0.0106 0.0499 0.1001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0259 0.0253
Echinococcus multilocularis G protein coupled receptor 139 0.0071 0.0259 0.0245
Onchocerca volvulus 0.0074 0.0277 0.158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Giardia lamblia Cysteine protease 0.0051 0.0119 0.0578
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Echinococcus multilocularis fmrfamide receptor 0.0071 0.0259 0.0245
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0071 0.0259 0.0259
Toxoplasma gondii ABC1 family protein 0.0074 0.0277 0.1783
Brugia malayi calpain family protein 1 0.022 0.1296 0.1296
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0106 0.0499 0.0499
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0083 0.0342 0.067
Echinococcus granulosus calpain 0.0083 0.0342 0.0337
Echinococcus multilocularis brain tumor protein 0.0038 0.0031 0.0017
Loa Loa (eye worm) hypothetical protein 0.0186 0.1056 0.1056
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.1883 0.1883
Echinococcus multilocularis neuropeptide Y receptor 0.0071 0.0259 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Echinococcus granulosus cathepsin L 0.0106 0.0499 0.0494
Echinococcus multilocularis cathepsin L cysteine protease 0.0186 0.1056 0.1043
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.023 0.1366 0.1366
Plasmodium falciparum serine repeat antigen 3 0.0051 0.0119 0.1128
Brugia malayi cathepsin Z-like cysteine proteinase 0.0051 0.0119 0.0119
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0093 0.0079
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0119 0.0119
Trypanosoma brucei antigen, putative 0.0083 0.0342 0.1856
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0304 0.1883 0.1883
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Brugia malayi Cathepsin L-like precursor 0.0186 0.1056 0.1056
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0192 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1056 0.5957
Plasmodium vivax SET domain protein, putative 0.0036 0.0014 0.0137
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0071 0.0259 0.0245
Entamoeba histolytica cysteine protease, putative 0.0106 0.0499 0.4652
Loa Loa (eye worm) neuropeptide F receptor 0.0071 0.0259 0.0259
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0051 0.0119 0.1006
Loa Loa (eye worm) cathepsin B 0.0257 0.1556 0.1556
Plasmodium vivax serine-repeat antigen (SERA) 0.0051 0.0119 0.1128
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0083 0.0342 0.1856
Schistosoma mansoni calpain-7 (C02 family) 0.0083 0.0342 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0119 0.0549
Entamoeba histolytica cysteine protease, putative 0.0051 0.0119 0.1006
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0071 0.0259 0.0245
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0277 0.1464
Trypanosoma cruzi cruzipain precursor, putative 0.0283 0.1736 0.3609
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0071 0.0259 0.0245
Loa Loa (eye worm) ctsf protein 0.0186 0.1056 0.1056
Echinococcus granulosus allatostatin A receptor 0.0071 0.0259 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0186 0.1056 0.5957
Plasmodium vivax calpain, putative 0.0083 0.0342 0.3237
Echinococcus granulosus tripartite motif containing protein 3 0.0038 0.0031 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0283 0.1736 1
Echinococcus multilocularis neuropeptide receptor A26 0.0071 0.0259 0.0245
Giardia lamblia Cathepsin B precursor 0.0257 0.1556 1
Leishmania major cathepsin L-like protease 0.0186 0.1056 0.6027
Echinococcus multilocularis neuropeptide FF receptor 2 0.0071 0.0259 0.0245
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0071 0.0259 0.0253
Giardia lamblia Cathepsin L-like protease 0.0051 0.0119 0.0578
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0083 0.0342 0.1856
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0499 0.0499
Echinococcus granulosus tm gpcr rhodopsin 0.0589 0.3868 0.3865
Plasmodium vivax glutathione reductase, putative 0.0047 0.0093 0.0883
Leishmania major trypanothione reductase 0.0047 0.0093 0.0405
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0392 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1056 0.5957
Echinococcus multilocularis g-protein coupled receptor 0.0071 0.0259 0.0245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0031 0.0031
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0051 0.0119 0.0119
Giardia lamblia Cathepsin L-like protease 0.0051 0.0119 0.0578
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.023 0.1366 0.1366
Onchocerca volvulus 0.0071 0.0259 0.1473
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1756 1
Brugia malayi hypothetical protein 0.0036 0.0014 0.0014
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0024 0.0019
Plasmodium falciparum serine repeat antigen 8 0.0051 0.0119 0.1128
Brugia malayi TAR-binding protein 0.0062 0.0192 0.0192
Brugia malayi beta-lactamase 0.0074 0.0277 0.0277
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0071 0.0259 0.0245
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.1056 0.2175
Giardia lamblia Cathepsin L precursor 0.0051 0.0119 0.0578
Plasmodium falciparum plasmepsin II 0.0144 0.0764 0.724
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0392 0.0378
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Schistosoma mansoni cathepsin C 0.0051 0.0119 0.0119
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0277 0.0277
Brugia malayi putative neuropeptide receptor 0.0071 0.0259 0.0259
Schistosoma mansoni biogenic amine receptor 0.0071 0.0259 0.0259
Echinococcus granulosus 7tm_1 domain containing protein 0.0071 0.0259 0.0253
Entamoeba histolytica cysteine proteinase, putative 0.0186 0.1056 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0516 0.1607
Trypanosoma cruzi kinesin, putative 0.0058 0.0168 0.0303
Echinococcus multilocularis neuropeptide s receptor 0.0071 0.0259 0.0245
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0516 0.1607
Leishmania major cathepsin L-like protease 0.0186 0.1056 0.6027
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0192 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0392 0.0392
Plasmodium falciparum serine repeat antigen 1 0.0051 0.0119 0.1128
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0718 0.4767 0.4767
Brugia malayi putative neuropeptide receptor NPR1 0.0071 0.0259 0.0259
Echinococcus multilocularis orexin receptor type 2 0.0071 0.0259 0.0245
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0051 0.0119 0.0119
Brugia malayi B-box type zinc-finger protein ncl-1 0.0038 0.0031 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1056 0.5957
Trypanosoma brucei calpain-like protein, putative 0.0083 0.0342 0.1856
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0119 0.0549
Brugia malayi hypothetical protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0038 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0071 0.0259 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0119 0.0549
Onchocerca volvulus 0.0071 0.0259 0.1473
Entamoeba histolytica cysteine proteinase, putative 0.0106 0.0499 0.4652
Onchocerca volvulus Neuropeptide F receptor homolog 0.0071 0.0259 0.1473
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0277 0.0817
Schistosoma mansoni biogenic amine receptor 0.0071 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0071 0.0259 0.0259
Onchocerca volvulus 0.0071 0.0259 0.1473
Brugia malayi Dopamine receptor protein 1 0.0071 0.0259 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0071 0.0259 0.0253
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0192 0.0192
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0781 0.52 0.52
Loa Loa (eye worm) hypothetical protein 0.0051 0.0119 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0071 0.0259 0.0245
Loa Loa (eye worm) hypothetical protein 0.0074 0.0277 0.0277
Brugia malayi Cathepsin L-like precursor 0.0186 0.1056 0.1056

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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