Detailed information for compound 1349207

Basic information

Technical information
  • TDR Targets ID: 1349207
  • Name: 2-[5-(3-methoxyphenyl)tetrazol-2-yl]acetic ac id
  • MW: 234.211 | Formula: C10H10N4O3
  • H donors: 1 H acceptors: 5 LogP: 1.45 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1nnn(n1)CC(=O)O
  • InChi: 1S/C10H10N4O3/c1-17-8-4-2-3-7(5-8)10-11-13-14(12-10)6-9(15)16/h2-5H,6H2,1H3,(H,15,16)
  • InChiKey: GNGONLZPSUVJAK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[5-(3-methoxyphenyl)-2-tetrazolyl]acetic acid
  • 2-[5-(3-methoxyphenyl)-1,2,3,4-tetrazol-2-yl]ethanoic acid
  • [5-(3-Methoxy-phenyl)-tetrazol-2-yl]-acetic acid
  • Oprea1_012233
  • ASN 15364443
  • ST5370022
  • MLS000035727
  • SMR000003010

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.062 0.4981
Echinococcus granulosus translational activator gcn1 0.0007 0.0104 0.0051
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0005 0.0067 0.0014
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0574 0.0612
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0256 0.0658
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.062 0.193
Brugia malayi tumor suppressor. 0.0319 0.8561 1
Plasmodium vivax sentrin-specific protease 1, putative 0.0046 0.1176 1
Plasmodium vivax sentrin-specific protease 2, putative 0.0013 0.0272 0.2308
Giardia lamblia Sentrin specific protease, putative 0.0013 0.0272 0.3667
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0624 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.293 1
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0013 0.0272 0.5
Entamoeba histolytica hypothetical protein 0.0028 0.069 0.5619
Echinococcus multilocularis sentrin specific protease 1 0.0046 0.1176 0.1129
Loa Loa (eye worm) hypothetical protein 0.0005 0.0067 0.0014
Schistosoma mansoni hypothetical protein 0.0372 1 1
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0005 0.0067 0.0014
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0869 0.7228
Plasmodium falciparum sentrin-specific protease 1 0.0046 0.1176 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0869 0.082
Trypanosoma cruzi hypothetical protein 0.0013 0.0272 0.0714
Entamoeba histolytica hypothetical protein 0.0036 0.0891 0.743
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.1176 0.1129
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.293 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.069 0.5619
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0624 0.5024
Echinococcus multilocularis flap endonuclease GEN 1 0.0005 0.0067 0.0014
Schistosoma mansoni hypothetical protein 0.0027 0.0656 0.0606
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0574 0.4878
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0272 0.1842
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0574 0.4567
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0624 0.0574
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0272 0.0257
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0624 0.5024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0272 0.022
Echinococcus granulosus sentrin specific protease 8 0.0013 0.0272 0.022
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0272 0.1842
Leishmania major importin beta-1 subunit, putative 0.0028 0.069 0.2176
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.1176 1
Echinococcus granulosus flap endonuclease GEN 1 0.0005 0.0067 0.0014
Echinococcus granulosus importin 5 0.0007 0.0104 0.0051
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.062 0.193
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.062 0.0666
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0272 0.1842
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0574 0.1769
Echinococcus multilocularis snurportin 1 0.0372 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.062 0.5268
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0574 0.0523
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.293 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0869 0.28
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.0104 0.0051
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0007 0.0104 0.0127
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0574 0.0612
Entamoeba histolytica Ran family GTPase 0.0026 0.062 0.4981
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.1176 0.132
Leishmania major GTP-binding protein, putative 0.0026 0.062 0.193
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0624 0.1946
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.062 0.9914
Echinococcus granulosus hypothetical protein 0.0027 0.0656 0.0606
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0624 0.1946
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0869 0.28
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.1176 0.1129
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.293 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0574 0.4878
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.293 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0256 0.0204
Treponema pallidum ATP-dependent DNA helicase 0.0012 0.0256 0.5
Echinococcus granulosus flap endonuclease 1 0.0026 0.0624 0.0574
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0256 0.2174
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0272 0.0257
Plasmodium vivax importin-beta 2, putative 0.0035 0.0869 0.7386
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0574 0.4567
Toxoplasma gondii HEAT repeat-containing protein 0.0007 0.0104 0.0328
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0624 0.5024
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0574 0.1769
Echinococcus granulosus geminin 0.0168 0.4476 0.4446
Brugia malayi Flap endonuclease-1 0.0026 0.0624 0.0671
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0624 0.0574
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0891 0.0843
Loa Loa (eye worm) hypothetical protein 0.0024 0.0574 0.0523
Entamoeba histolytica hypothetical protein 0.0036 0.0891 0.743
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0272 0.1842
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.293 1
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0104 0.0127
Brugia malayi Importin beta-1 subunit 0.0035 0.0869 0.0959
Echinococcus granulosus importin subunit beta 1 0.0035 0.0869 0.082
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0574 0.4567
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0012 0.0243 0.2067
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0111 0.293 1
Echinococcus multilocularis translational activator gcn1 0.0007 0.0104 0.0051
Schistosoma mansoni DNA helicase recq1 0.0024 0.0574 0.0523
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0272 0.1842
Leishmania major hypothetical protein, conserved 0.0007 0.0104 0.0127
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0574 0.0523
Plasmodium vivax transportin, putative 0.0007 0.0104 0.088
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0272 0.022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.069 0.5619
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0013 0.0272 0.1842
Loa Loa (eye worm) hypothetical protein 0.0012 0.0256 0.0204
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.062 0.057
Schistosoma mansoni flap endonuclease-1 0.0023 0.0557 0.0507
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0574 0.4567
Loa Loa (eye worm) RecQ helicase 0.0024 0.0574 0.0523
Schistosoma mansoni DNA helicase recq5 0.0024 0.0574 0.0523
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0013 0.0272 0.0714
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0256 0.0204
Echinococcus multilocularis exonuclease 1 0.0005 0.0067 0.0014
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0574 0.0523
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0272 0.1842
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.293 1
Onchocerca volvulus 0.0013 0.0272 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0256 0.0658
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.062 0.057
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.062 0.5268
Loa Loa (eye worm) hypothetical protein 0.0013 0.0272 0.022
Loa Loa (eye worm) XPG I-region family protein 0.0005 0.0067 0.0014
Echinococcus multilocularis protein quaking 0.0027 0.0656 0.0606
Schistosoma mansoni importin-beta 2 0.0007 0.0104 0.0051
Loa Loa (eye worm) hypothetical protein 0.0005 0.0067 0.0014
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0272 0.022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.293 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.069 0.2176
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0256 0.17
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0272 0.1842
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0891 0.0843
Schistosoma mansoni hypothetical protein 0.0027 0.0656 0.0606
Trypanosoma brucei calpain-like protein, putative 0.0111 0.293 1
Echinococcus multilocularis sentrin specific protease 8 0.0013 0.0272 0.022
Echinococcus granulosus protein quaking 0.0027 0.0656 0.0606
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0656 0.0708
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0111 0.293 1
Schistosoma mansoni ran 0.0026 0.062 0.057
Echinococcus granulosus sentrin specific protease 7 0.0013 0.0272 0.022
Echinococcus multilocularis sentrin specific protease 7 0.0013 0.0272 0.022
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0046 0.1176 1
Brugia malayi kap beta 3 protein 0.0007 0.0104 0.0059
Schistosoma mansoni hypothetical protein 0.0036 0.0891 0.0843
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0624 0.1946
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0243 0.0191
Echinococcus multilocularis geminin 0.0168 0.4476 0.4446
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0111 0.293 1
Plasmodium falciparum flap endonuclease 1 0.0026 0.0624 0.5309
Loa Loa (eye worm) hypothetical protein 0.0035 0.0869 0.082
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0624 0.5309
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0272 0.022
Schistosoma mansoni importin beta-1 0.0035 0.0869 0.082
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0272 0.1842
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.062 0.057
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.293 1
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0272 0.0257
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0574 0.0523
Loa Loa (eye worm) hypothetical protein 0.0046 0.1176 0.1129
Brugia malayi XPG I-region family protein 0.0005 0.0067 0.0017
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0272 0.022
Echinococcus multilocularis transportin 1 0.0007 0.0104 0.0051
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0005 0.0067 0.0014
Entamoeba histolytica HEAT repeat domain containing protein 0.0007 0.0104 0.0328
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0243 0.1586
Loa Loa (eye worm) hypothetical protein 0.0027 0.0656 0.0606
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0574 0.0612
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.0104 0.0051
Schistosoma mansoni exonuclease 0.0005 0.0067 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0891 0.0843
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0013 0.0272 0.0714
Schistosoma mansoni hypothetical protein 0.0168 0.4476 0.4446
Entamoeba histolytica hypothetical protein 0.0036 0.0891 0.743
Loa Loa (eye worm) tumor suppressor 0.0319 0.8561 0.8554
Plasmodium vivax exonuclease I, putative 0.0005 0.0067 0.0571
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0272 0.1842
Echinococcus granulosus exonuclease 1 0.0005 0.0067 0.0014
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0891 0.743
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0574 0.1769
Echinococcus granulosus transportin 1 0.0007 0.0104 0.0051
Echinococcus multilocularis importin 5 0.0007 0.0104 0.0051
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.293 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0272 0.1842
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0272 0.1842
Schistosoma mansoni ran 0.0026 0.062 0.057
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0272 0.1842
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0272 0.1842
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0574 0.4567
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0013 0.0272 0.0714
Plasmodium falciparum importin beta, putative 0.0035 0.0869 0.7386
Toxoplasma gondii HEAT repeat-containing protein 0.0007 0.0104 0.0328
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0013 0.0272 0.5
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0574 0.909
Echinococcus granulosus sentrin specific protease 1 0.0046 0.1176 0.1129
Trichomonas vaginalis Sentrin-specific protease, putative 0.0013 0.0272 0.1842
Trypanosoma brucei calpain, putative 0.0111 0.293 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.0574 0.0523
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0574 0.0523
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0574 0.4567
Trichomonas vaginalis hypothetical protein 0.0007 0.0104 0.0328
Trypanosoma brucei hypothetical protein 0.0111 0.293 1
Plasmodium falciparum DNA repair protein RAD2, putative 0.0005 0.0067 0.0571
Brugia malayi hypothetical protein 0.0027 0.0656 0.0708
Plasmodium falciparum transportin 0.0007 0.0104 0.088
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0243 0.1586
Trypanosoma brucei SUMO1/Ulp2, putative 0.0013 0.0272 0.0714
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.293 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0574 0.0523
Plasmodium falciparum exonuclease I, putative 0.0005 0.0067 0.0571
Trichomonas vaginalis importin beta-1, putative 0.0028 0.069 0.5619
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0272 0.1842
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.062 0.193
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.293 1
Plasmodium vivax DNA repair protein RAD2, putative 0.0005 0.0067 0.0571
Brugia malayi RNA, U transporter 1 0.0099 0.2609 0.3004
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0046 0.1176 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0272 0.1842
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0005 0.0067 0.0014
Trichomonas vaginalis ran, putative 0.0026 0.062 0.4981
Schistosoma mansoni hypothetical protein 0.0168 0.4476 0.4446
Brugia malayi hypothetical protein 0.0036 0.0891 0.0985
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0272 0.1842
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0256 0.17

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2995 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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