Detailed information for compound 1349476

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.391 | Formula: C21H19F2N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.25 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1cccc(c1)n1cccc1)CC(=O)Nc1c(F)cccc1F
  • InChi: 1S/C21H19F2N3O2/c1-2-25(14-19(27)24-20-17(22)9-6-10-18(20)23)21(28)15-7-5-8-16(13-15)26-11-3-4-12-26/h3-13H,2,14H2,1H3,(H,24,27)
  • InChiKey: XBGIHAMPWYIRHT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens APOBEC3A and APOBEC3B deletion hybrid Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0006 0.0761
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0015 0.0014
Onchocerca volvulus 0.0043 0.002 0.0514
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0006 0.0283
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0001 0.0169
Brugia malayi Bromodomain containing protein 0.0035 0.0015 0.0619
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0006 0.353
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0016 0.0001 0.0169
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0006 0.0322
Brugia malayi jmjC domain containing protein 0.0115 0.007 0.3167
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.003 0.1939
Onchocerca volvulus 0.0196 0.0125 1
Mycobacterium ulcerans glutaminase 0.033 0.0217 0.0211
Mycobacterium tuberculosis Conserved protein 0.0043 0.002 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.002 0.0939
Onchocerca volvulus 0.0043 0.002 0.0514
Plasmodium vivax hypothetical protein, conserved 0.0043 0.002 0.0019
Brugia malayi 6-phosphofructokinase 0.0131 0.0081 0.3674
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0016 0.0001 0.0169
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0036 0.2308
Entamoeba histolytica phosphoinositide kinase, putative 0.0016 0.0001 0.0169
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0024 0.154
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0006 0.0005
Loa Loa (eye worm) glutaminase 0.033 0.0217 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.002 0.0939
Mycobacterium ulcerans lipase LipD 0.0043 0.002 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.002 0.2529
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.002 0.1245
Loa Loa (eye worm) RecQ helicase 0.0026 0.0008 0.0319
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.3714
Trichomonas vaginalis esterase, putative 0.0043 0.002 0.0939
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0006 0.0283
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0006 0.0761
Loa Loa (eye worm) glutaminase 2 0.033 0.0217 1
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.002 0.1245
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Schistosoma mansoni glutaminase 0.033 0.0217 0.9273
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.002 0.0035
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0015 0.1847
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.002 0.0882
Leishmania major hypothetical protein, conserved 0.0043 0.002 0.2529
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0006 0.0761
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0081 0.5352
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0016 0.0001 0.0169
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Brugia malayi mbt repeat family protein 0.0058 0.003 0.1331
Echinococcus multilocularis peregrin 0.0035 0.0015 0.0901
Loa Loa (eye worm) hypothetical protein 0.0182 0.0116 0.5304
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0015 0.0013
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0015 0.0014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.002 0.1285
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0015 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.3714
Mycobacterium tuberculosis Conserved protein 0.0043 0.002 0.0035
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0153
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.003 0.1234
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0081 0.3674
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.002 0.0939
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.003 0.1939
Plasmodium falciparum phd finger protein, putative 0.0035 0.0015 0.0013
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0015 0.0686
Loa Loa (eye worm) beta-lactamase 0.0043 0.002 0.0882
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0015 0.0901
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0081 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0006 0.0322
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.002 0.0854
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0016 0.0001 0.0169
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.015 1
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.4565 1 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.002 0.0939
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0081 0.0075
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.003 0.1939
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.007 0.4613
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0001 0.0169
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0024 0.154
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0081 0.3407
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0015 0.0014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0006 0.0761
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.003 0.1234
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.007 0.4613
Brugia malayi PHD-finger family protein 0.0035 0.0015 0.0619
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.002 0.0035
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0005 0.0135
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Onchocerca volvulus 0.0182 0.0116 0.9143
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0008 0.0379
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0015 0.0014
Brugia malayi glutaminase DH11.1 0.033 0.0217 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0081 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.002 0.0792
Schistosoma mansoni ap endonuclease 0.0023 0.0006 0.0205
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.3714
Mycobacterium ulcerans hypothetical protein 0.0043 0.002 0.0014
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0015 0.0014
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0006 0.0221
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.003 0.1331
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.003 0.1234
Mycobacterium tuberculosis Conserved protein 0.0043 0.002 0.0035
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0015 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.002 0.0792
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0081 0.006
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0006 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.002 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.002 0.2529
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.002 0.0035
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0006 0.0005
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0003 0.0001
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.003 0.1939
Brugia malayi phosphofructokinase 0.0131 0.0081 0.3674
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.002 0.0035
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0016 0.0001 0.0169
Onchocerca volvulus 0.0058 0.003 0.139
Brugia malayi mbt repeat family protein 0.0058 0.003 0.1331
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Toxoplasma gondii ABC1 family protein 0.0043 0.002 0.0019
Brugia malayi 6-phosphofructokinase 0.0131 0.0081 0.3674
Onchocerca volvulus 0.0043 0.002 0.0514
Brugia malayi beta-lactamase family protein 0.0043 0.002 0.0882
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0015 0.0619
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0006 0.0761
Brugia malayi jmjC domain containing protein 0.0043 0.002 0.0854
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.002 0.0035
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.4565 1 1
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0001 0.0169
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0036 0.2308
Loa Loa (eye worm) MBCTL1 0.0066 0.0036 0.1585
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0053 0.2238
Brugia malayi beta-lactamase 0.0043 0.002 0.0882
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0036 0.1585
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0081 0.3407
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.003 0.139
Brugia malayi Pip kinase protein 2 0.0196 0.0125 0.5743
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.0125 0.5325
Giardia lamblia PHD finger protein 15 0.0035 0.0015 0.987
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0008 0.0464
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0081 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0036 0.1585
Loa Loa (eye worm) hypothetical protein 0.006 0.0032 0.1419
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0081 0.3674
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0081 0.0183
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0016 0.0001 0.0169
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.0125 0.5325
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0015 0.0901
Loa Loa (eye worm) pip kinase 2 0.0196 0.0125 0.5743
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.004 0.1811
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.4565 1 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0015 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.002 0.1285
Loa Loa (eye worm) hypothetical protein 0.0058 0.003 0.1331
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0081 0.0075
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.0125 0.8365
Schistosoma mansoni hypothetical protein 0.0035 0.0015 0.0574
Mycobacterium ulcerans beta-lactamase 0.0043 0.002 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.015 1
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0001 0.0063
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0619
Brugia malayi hypothetical protein 0.0182 0.0116 0.5304
Trichomonas vaginalis glutaminase, putative 0.033 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0002 0.0001
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0001 0.0063
Echinococcus granulosus peregrin 0.0035 0.0015 0.0901
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0081 0.5352
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.0125 0.8365
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0006 0.0221
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.002 0.0818
Echinococcus granulosus bloom syndrome protein 0.0026 0.0008 0.0464
Brugia malayi beta-lactamase family protein 0.0043 0.002 0.0882
Schistosoma mansoni ap endonuclease 0.0023 0.0006 0.0205
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0016 0.0001 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.002 0.2529
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0015 0.0574
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.4565 1 1
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.5955 0.4083 1
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 1.4565 1 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0036 0.147
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0016 0.0001 0.0169
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0008 0.0379
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0181 0.043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.002 0.0818
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.002 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.002 0.0939
Schistosoma mansoni hypothetical protein 0.0355 0.0234 1
Toxoplasma gondii exonuclease III APE 0.0023 0.0006 0.0005
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0036 0.2308
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0081 0.3674
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 1.4565 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0081 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0196 0.0125 0.5743
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.3714
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.002 0.0014
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 1.4565 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0081 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0036 0.2308
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0015 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.002 0.0882
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0008 0.0319
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0081 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 15.9 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
IC50 (functional) = 27.4 uM PUBCHEM_BIOASSAY: Dose response confirmation of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 34.8 uM PUBCHEM_BIOASSAY: Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
IC50 (functional) 100 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9012 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 2.9935 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 4.2943 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.6213 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485292] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 21.5227 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 42.5615 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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