Detailed information for compound 1349476

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.391 | Formula: C21H19F2N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.25 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1cccc(c1)n1cccc1)CC(=O)Nc1c(F)cccc1F
  • InChi: 1S/C21H19F2N3O2/c1-2-25(14-19(27)24-20-17(22)9-6-10-18(20)23)21(28)15-7-5-8-16(13-15)26-11-3-4-12-26/h3-13H,2,14H2,1H3,(H,24,27)
  • InChiKey: XBGIHAMPWYIRHT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APOBEC3A and APOBEC3B deletion hybrid Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutaminase 2 0.033 0.0217 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0015 0.0013
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0036 0.2308
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 1.4565 1 1
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0016 0.0001 0.0169
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0081 0.3407
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0016 0.0001 0.0169
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0081 0.3674
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0081 0.0075
Mycobacterium ulcerans beta-lactamase 0.0043 0.002 0.0014
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0005 0.0135
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0006 0.0761
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0001 0.0063
Brugia malayi beta-lactamase family protein 0.0043 0.002 0.0882
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 1.4565 1 1
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.003 0.1939
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0081 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0015 0.0686
Trichomonas vaginalis esterase, putative 0.0043 0.002 0.0939
Loa Loa (eye worm) RecQ helicase 0.0026 0.0008 0.0319
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0008 0.0379
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0015 0.1847
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0036 0.2308
Onchocerca volvulus 0.0182 0.0116 0.9143
Mycobacterium tuberculosis Conserved protein 0.0043 0.002 0.0035
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.002 0.0035
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Schistosoma mansoni hypothetical protein 0.0035 0.0015 0.0574
Onchocerca volvulus 0.0043 0.002 0.0514
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0081 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0015 0.0014
Brugia malayi jmjC domain containing protein 0.0115 0.007 0.3167
Schistosoma mansoni glutaminase 0.033 0.0217 0.9273
Brugia malayi 6-phosphofructokinase 0.0131 0.0081 0.3674
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0036 0.147
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.002 0.0854
Loa Loa (eye worm) hypothetical protein 0.0066 0.0036 0.1585
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.002 0.0818
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Plasmodium vivax hypothetical protein, conserved 0.0043 0.002 0.0019
Mycobacterium ulcerans hypothetical protein 0.0043 0.002 0.0014
Plasmodium falciparum phd finger protein, putative 0.0035 0.0015 0.0013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.002 0.0014
Mycobacterium ulcerans glutaminase 0.033 0.0217 0.0211
Schistosoma mansoni ap endonuclease 0.0023 0.0006 0.0205
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0006 0.0761
Brugia malayi Bromodomain containing protein 0.0035 0.0015 0.0619
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Echinococcus granulosus bloom syndrome protein 0.0026 0.0008 0.0464
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0081 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.002 0.0818
Entamoeba histolytica phosphoinositide kinase, putative 0.0016 0.0001 0.0169
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.002 0.0882
Loa Loa (eye worm) beta-lactamase 0.0043 0.002 0.0882
Brugia malayi phosphofructokinase 0.0131 0.0081 0.3674
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.002 0.0035
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.002 0.1245
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.4565 1 1
Brugia malayi Pip kinase protein 2 0.0196 0.0125 0.5743
Brugia malayi jmjC domain containing protein 0.0043 0.002 0.0854
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0024 0.154
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.4565 1 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0081 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.002 0.2529
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0006 0.0283
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0016 0.0001 0.0169
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.003 0.1939
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.003 0.1234
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.3714
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.003 0.1939
Brugia malayi mbt repeat family protein 0.0058 0.003 0.1331
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.003 0.1234
Mycobacterium tuberculosis Conserved protein 0.0043 0.002 0.0035
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0081 0.5352
Loa Loa (eye worm) glutaminase 0.033 0.0217 1
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.3714
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0006 0.0283
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Echinococcus granulosus peregrin 0.0035 0.0015 0.0901
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Loa Loa (eye worm) MBCTL1 0.0066 0.0036 0.1585
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0008 0.0319
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0024 0.154
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0015 0.0013
Onchocerca volvulus 0.0043 0.002 0.0514
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.002 0.1245
Leishmania major hypothetical protein, conserved 0.0043 0.002 0.2529
Brugia malayi beta-lactamase family protein 0.0043 0.002 0.0882
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.002 0.0035
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0081 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.002 0.0939
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0015 0.0014
Brugia malayi glutaminase DH11.1 0.033 0.0217 1
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0053 0.2238
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.007 0.4613
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0006 0.0221
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.015 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0006 0.353
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.002 0.1285
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.002 0.0792
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0006 0.0761
Giardia lamblia PHD finger protein 15 0.0035 0.0015 0.987
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0036 0.1585
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0001 0.0169
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Toxoplasma gondii exonuclease III APE 0.0023 0.0006 0.0005
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0015 0.0619
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0036 0.2308
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0008 0.0379
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0015 0.0014
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.0125 0.5325
Loa Loa (eye worm) hypothetical protein 0.0182 0.0116 0.5304
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.3714
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0015 0.0901
Onchocerca volvulus 0.0058 0.003 0.139
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.003 0.1939
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.003 0.1234
Onchocerca volvulus 0.0196 0.0125 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0006 0.0322
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0016 0.0001 0.0169
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.002 0.0792
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0181 0.043
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0015 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0058 0.003 0.1331
Mycobacterium ulcerans lipase LipD 0.0043 0.002 0.0014
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0015 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0081 0.3714
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Echinococcus multilocularis peregrin 0.0035 0.0015 0.0901
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.0125 0.8365
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0016 0.0001 0.0169
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0006 0.0005
Toxoplasma gondii ABC1 family protein 0.0043 0.002 0.0019
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.003 0.139
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0006 0.0761
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0016 0.0001 0.0169
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Schistosoma mansoni ap endonuclease 0.0023 0.0006 0.0205
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0081 0.3674
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0015 0.0901
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0016 0.0001 0.0169
Brugia malayi mbt repeat family protein 0.0058 0.003 0.1331
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0008 0.0464
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0081 0.006
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0015 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.002 0.0939
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0006 0.0005
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0001 0.0063
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0081 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.002 0.0882
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.007 0.4613
Schistosoma mansoni hypothetical protein 0.0355 0.0234 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.015 1
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0081 0.5352
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.002 0.0939
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0015 0.0014
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0015 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.002 0.2529
Brugia malayi PHD-finger family protein 0.0035 0.0015 0.0619
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.004 0.1811
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0016 0.0001 0.0169
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0015 0.0574
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.002 0.2529
Brugia malayi 6-phosphofructokinase 0.0131 0.0081 0.3674
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.002 0.1285
Loa Loa (eye worm) hypothetical protein 0.0196 0.0125 0.5743
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.002 0.0939
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.4565 1 1
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0081 0.3407
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0001 0.0169
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 1.4565 1 1
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.4565 1 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0015 0.0009
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0081 0.0075
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.002 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.002 0.0035
Trichomonas vaginalis glutaminase, putative 0.033 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0153
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0006 0.0221
Brugia malayi beta-lactamase 0.0043 0.002 0.0882
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.003 0.1331
Mycobacterium tuberculosis Conserved protein 0.0043 0.002 0.0035
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0081 0.3674
Brugia malayi hypothetical protein 0.0182 0.0116 0.5304
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0619
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.002 0.0014
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0006 0.0322
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0015 0.0686
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0081 0.0183
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.5955 0.4083 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0001 0.0169
Loa Loa (eye worm) pip kinase 2 0.0196 0.0125 0.5743
Onchocerca volvulus 0.0043 0.002 0.0514
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0003 0.0001
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.002 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0032 0.1419
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.0125 0.8365
Loa Loa (eye worm) hypothetical protein 0.0043 0.002 0.0882
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0006 0.0761
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0015 0.0014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0002 0.0001
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0001 0.0169
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.002 0.0035
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0036 0.2308
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.002 0.0939
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.0125 0.5325

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 15.9 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
IC50 (functional) = 27.4 uM PUBCHEM_BIOASSAY: Dose response confirmation of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 34.8 uM PUBCHEM_BIOASSAY: Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493011, AID493024] ChEMBL. No reference
IC50 (functional) 100 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9012 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 2.9935 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 4.2943 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.6213 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485292] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 21.5227 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 42.5615 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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