Detailed information for compound 1350756

Basic information

Technical information
  • TDR Targets ID: 1350756
  • Name: 4-nitro-2-[(1-phenyltetrazol-5-yl)sulfanylmet hyl]phenol
  • MW: 329.334 | Formula: C14H11N5O3S
  • H donors: 1 H acceptors: 6 LogP: 3.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1CSc1nnnn1c1ccccc1)[N+](=O)[O-]
  • InChi: 1S/C14H11N5O3S/c20-13-7-6-12(19(21)22)8-10(13)9-23-14-15-16-17-18(14)11-4-2-1-3-5-11/h1-8,20H,9H2
  • InChiKey: RTRMUAMTMGCKOT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-nitro-2-[[(1-phenyl-5-tetrazolyl)thio]methyl]phenol
  • 4-nitro-2-[[(1-phenyltetrazol-5-yl)thio]methyl]phenol
  • 4-nitro-2-[(1-phenyl-1,2,3,4-tetrazol-5-yl)sulfanylmethyl]phenol
  • SMR000502674
  • STK067850
  • MLS001183961

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 5 (sodium/choline cotransporter), member 7 Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis high affinity choline transporter 1 Get druggable targets OG5_131601 All targets in OG5_131601
Brugia malayi GH02984p Get druggable targets OG5_131601 All targets in OG5_131601
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma japonicum IPR001734,Na+/solute symporter,domain-containing Get druggable targets OG5_131601 All targets in OG5_131601
Echinococcus granulosus high affinity choline transporter 1 Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma mansoni high-affinity choline transporter Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma japonicum High affinity choline transporter 1, putative Get druggable targets OG5_131601 All targets in OG5_131601
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum serine/threonine protein kinase, putative 0.0437 0.0838 0.7478
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0538 0.1126 0.1126
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Echinococcus granulosus tyrosine protein kinase HCK 0.0266 0.0347 0.0743
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0287 0.0406 0.1387
Schistosoma mansoni hypothetical protein 0.0157 0.0033 0.0086
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0573 0.1226 0.2626
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0435 0.0831 0.0837
Echinococcus multilocularis 0.033 0.053 0.053
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.0218 0.0559
Echinococcus granulosus protein kinase 0.033 0.053 0.1134
Onchocerca volvulus 0.3609 0.9926 1
Brugia malayi Protein kinase domain containing protein 0.0186 0.0118 0.0119
Loa Loa (eye worm) SRC-1 0.0412 0.0766 0.0772
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Loa Loa (eye worm) hypothetical protein 0.0455 0.0889 0.0896
Brugia malayi Protein kinase domain containing protein 0.3609 0.9926 1
Plasmodium falciparum protein serine/threonine kinase-1 0.0529 0.11 1
Schistosoma mansoni vesicular amine transporter 0.0287 0.0408 0.1049
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Loa Loa (eye worm) AGC/PKN protein kinase 0.0163 0.0051 0.0051
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0437 0.0838 0.5722
Brugia malayi putative serine/threonine kinase SADA gamma 0.0166 0.0059 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.0178 0.0803
Loa Loa (eye worm) hypothetical protein 0.0268 0.0352 0.0355
Onchocerca volvulus 0.0326 0.0519 0.0491
Brugia malayi Stress-activated protein kinase jnk-1 0.1079 0.2676 0.2696
Loa Loa (eye worm) hypothetical protein 0.0455 0.0889 0.0896
Onchocerca volvulus Tyrosine kinase homolog 0.1402 0.3603 0.3608
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0059 0.0152
Echinococcus multilocularis serine:threonine protein kinase N2 0.0163 0.0051 0.0051
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0538 0.1126 0.1126
Loa Loa (eye worm) TK/ROR protein kinase 0.0188 0.0123 0.0124
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Loa Loa (eye worm) TK protein kinase 0.0622 0.1366 0.1376
Loa Loa (eye worm) hypothetical protein 0.0235 0.0258 0.026
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Loa Loa (eye worm) CAMK protein kinase 0.0163 0.005 0.0051
Schistosoma mansoni titin 0.0163 0.005 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0431 0.082 0.2108
Brugia malayi Tyrosine-protein kinase abl-1 0.0511 0.1048 0.1055
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1038 0.2557 1
Echinococcus multilocularis MAM 0.0157 0.0033 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0706 0.1608 0.4133
Echinococcus granulosus dual specificity testis-specific protein kinase 0.103 0.2537 0.5431
Brugia malayi Protein kinase domain containing protein 0.0179 0.0099 0.0099
Entamoeba histolytica protein kinase domain containing protein 0.0166 0.0062 0.0344
Brugia malayi Protein kinase domain containing protein 0.0801 0.188 0.1894
Echinococcus multilocularis activated cdc42 kinase 1 0.0831 0.1964 0.1964
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0693 0.157 0.3362
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0624 0.1374 0.2941
Schistosoma mansoni tyrosine kinase 0.0297 0.0436 0.112
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0193 0.0138 0.0316
Entamoeba histolytica casein kinase, putative 0.0274 0.037 0.2483
Plasmodium falciparum protein kinase 5 0.0302 0.045 0.3753
Echinococcus granulosus cyclin dependent kinase 7 0.0404 0.0741 0.1587
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0801 0.188 0.188
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.0218 0.0559
Plasmodium falciparum calcium-dependent protein kinase 2 0.0207 0.0178 0.1141
Echinococcus multilocularis high affinity choline transporter 1 0.042 0.0787 0.0787
Echinococcus granulosus hypothetical protein 0.0462 0.0909 0.1945
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0207 0.0179 0.0478
Echinococcus multilocularis cyclin dependent kinase 0.0302 0.045 0.045
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0412 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.0462 0.0909 0.0915
Echinococcus granulosus serine:threonine kinase SAD 1 0.0166 0.0059 0.0127
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0287 0.0406 0.1387
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0587 0.1268 0.2715
Brugia malayi Hr1 repeat family protein 0.0163 0.0051 0.0051
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0624 0.1374 0.1384
Echinococcus granulosus high affinity choline transporter 1 0.042 0.0787 0.1686
Trypanosoma brucei cdc2-related kinase 3 0.0302 0.045 0.1563
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0163 0.0051 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0653 0.1455 0.374
Loa Loa (eye worm) hypothetical protein 0.028 0.0386 0.0389
Brugia malayi protein kinase C II. 0.0221 0.0218 0.0219
Onchocerca volvulus 0.0186 0.0118 0.0086
Brugia malayi casein kinase I 0.0274 0.037 0.0373
Loa Loa (eye worm) TK/FAK protein kinase 0.152 0.3938 0.3968
Echinococcus multilocularis mitogen activated protein kinase 11 0.1038 0.2557 0.2557
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0716 0.1637 0.1649
Plasmodium vivax serine/threonine kinase-1, putative 0.0529 0.11 1
Brugia malayi Tyrosine-protein kinase abl-1 0.042 0.0789 0.0795
Loa Loa (eye worm) hypothetical protein 0.0193 0.0138 0.0139
Loa Loa (eye worm) hypothetical protein 0.0455 0.0889 0.0896
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Onchocerca volvulus 0.0455 0.0889 0.0865
Brugia malayi probable protein kinase 0.0523 0.1083 0.1091
Echinococcus granulosus twitchin 0.0438 0.084 0.1798
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0163 0.0051 0.0051
Echinococcus multilocularis tyrosine protein kinase Abl 0.0511 0.1048 0.1048
Echinococcus granulosus dual specificity protein kinase clk2 0.0529 0.11 0.2355
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0337 0.0549 0.1176
Entamoeba histolytica cell division protein kinase 2, putative 0.0319 0.05 0.3381
Echinococcus multilocularis cyclin dependent kinase 9 0.0184 0.0112 0.0112
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0437 0.0838 0.7351
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Leishmania major protein kinase, putative 0.0529 0.11 0.4166
Loa Loa (eye worm) hypothetical protein 0.0337 0.0549 0.0553
Echinococcus multilocularis protein KINase family member (kin 25) 0.0384 0.0684 0.0684
Entamoeba histolytica protein kinase, putative 0.0152 0.0021 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0059 0.0152
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2056 0.5475 0.5516
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0207 0.0178 0.1213
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0287 0.0406 0.1387
Brugia malayi Protein kinase domain containing protein 0.2056 0.5475 0.5516
Echinococcus granulosus aurora kinase A 0.0437 0.0838 0.1793
Schistosoma mansoni serine/threonine protein kinase 0.0587 0.1268 0.3259
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0544 0.1145 0.2451
Echinococcus granulosus cyclin dependent kinase 1 0.0302 0.045 0.0963
Echinococcus multilocularis transfer RNA-Thr 0.0831 0.1964 0.1964
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Onchocerca volvulus 0.0639 0.1416 0.1398
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0404 0.0741 0.0747
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0171 0.0074 0.0059
Brugia malayi Protein kinase domain containing protein 0.0335 0.0544 0.0548
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0412 0.0766 0.0766
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0302 0.045 0.3803
Loa Loa (eye worm) hypothetical protein 0.2061 0.5491 0.5532
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0779 0.1816 0.1816
Schistosoma mansoni tyrosine kinase 0.0297 0.0436 0.112
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Echinococcus granulosus tyrosine protein kinase Blk 0.0348 0.0583 0.1248
Trypanosoma brucei protein kinase, putative 0.0171 0.0074 0.0059
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0099 0.0301
Brugia malayi Protein kinase domain containing protein 0.034 0.0557 0.0562
Schistosoma mansoni vam6/vps39 related 0.0193 0.0138 0.0356
Echinococcus granulosus defective proboscis extension response 0.0287 0.0408 0.0874
Schistosoma mansoni tyrosine kinase 0.0533 0.1111 0.2855
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0171 0.0074 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.1079 0.2676 0.6879
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0146 0.0004 0.0004
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0207 0.0178 0.0179
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0287 0.0406 0.1387
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0163 0.0051 0.0051
Echinococcus granulosus titin 0.0163 0.005 0.0108
Schistosoma mansoni protein kinase 0.0274 0.037 0.0952
Echinococcus multilocularis cyclin dependent kinase 5 0.0302 0.045 0.045
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0936 0.2267 0.2284
Loa Loa (eye worm) hypothetical protein 0.0289 0.0412 0.0415
Trichomonas vaginalis AGC family protein kinase 0.0437 0.0838 0.4961
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0051 0.0131
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Entamoeba histolytica protein kinase , putative 0.0437 0.0838 0.5722
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0302 0.045 0.0453
Entamoeba histolytica protein kinase, putative 0.0437 0.0838 0.5722
Schistosoma mansoni tyrosine kinase 0.025 0.0302 0.0776
Brugia malayi Protein kinase domain containing protein 0.0831 0.1964 0.1979
Echinococcus granulosus cyclin dependent kinase 0.0302 0.045 0.0963
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0486 0.0976 0.209
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0287 0.0408 0.1049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0412 0.0766 0.0766
Echinococcus multilocularis protein kinase c iota type 0.0221 0.0218 0.0218
Echinococcus granulosus dual specificity 0.0653 0.1455 0.3115
Echinococcus granulosus tyrosine protein kinase Fyn 0.0412 0.0766 0.1641
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0437 0.0838 0.1793
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0529 0.11 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0302 0.045 0.1563
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0653 0.1455 0.1466
Brugia malayi hypothetical protein 0.1321 0.3371 0.3396
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0207 0.0178 0.0179
Echinococcus granulosus casein kinase I delta 0.0274 0.037 0.0793
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0412 0.0766 0.0766
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0529 0.11 0.4166
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0529 0.11 0.1108
Giardia lamblia Kinase, AGC AKT 0.0435 0.0831 0.4724
Plasmodium vivax casein kinase 1, putative 0.0274 0.037 0.2633
Schistosoma mansoni serine/threonine protein kinase 0.0437 0.0838 0.2153
Schistosoma mansoni serine/threonine protein kinase 0.0318 0.0497 0.1276
Brugia malayi hypothetical protein 0.0193 0.0138 0.0139
Echinococcus granulosus Protein kinase C brain isozyme 0.0221 0.0218 0.0466
Schistosoma mansoni protein kinase 0.0418 0.0783 0.2012
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1038 0.2557 0.2576
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0146 0.0004 0.0011
Loa Loa (eye worm) TKL/LRRK protein kinase 0.026 0.0328 0.0331
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0207 0.0178 0.0694
Brugia malayi Protein kinase domain containing protein 0.0533 0.1111 0.1119
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0412 0.0766 0.0766
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0437 0.0838 0.5722
Brugia malayi Immunoglobulin I-set domain containing protein 0.0163 0.005 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.005 0.013
Loa Loa (eye worm) hypothetical protein 0.0268 0.0352 0.0355
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0653 0.1455 0.5587
Schistosoma mansoni tyrosine kinase 0.0297 0.0436 0.112
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0653 0.1455 0.5587
Echinococcus granulosus cyclin dependent kinase 9 0.0166 0.0062 0.0132
Echinococcus multilocularis rho associated protein kinase 0.0706 0.1608 0.1608
Onchocerca volvulus 0.1215 0.3065 0.3064
Schistosoma mansoni protein kinase 0.103 0.2537 0.652
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0193 0.0138 0.0356
Schistosoma mansoni protein kinase C mu 0.0393 0.071 0.1826
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0287 0.0406 0.1387
Echinococcus granulosus growth factor receptor bound protein 2 0.0153 0.0024 0.0052
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0287 0.0406 0.0869
Loa Loa (eye worm) IKK protein kinase 0.3609 0.9926 1
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0099 0.0301
Brugia malayi Cam kinase protein 1 0.0207 0.0178 0.0179
Leishmania major protein kinase, putative 0.0437 0.0838 0.3116
Entamoeba histolytica protein kinase, putative 0.0179 0.0099 0.0599
Entamoeba histolytica protein kinase domain containing protein 0.0486 0.0976 0.6683
Echinococcus granulosus tyrosine protein kinase Src64B 0.0412 0.0766 0.1641
Echinococcus granulosus fibroblast growth factor receptor 4 0.0538 0.1126 0.241
Schistosoma mansoni serine/threonine protein kinase 0.0302 0.045 0.1156
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0099 0.0301
Echinococcus granulosus casein kinase I delta 0.0274 0.037 0.0793
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Brugia malayi cell division control protein 2 homolog 0.0302 0.045 0.0453
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0529 0.11 0.4166
Schistosoma mansoni hypothetical protein 0.0157 0.0033 0.0086
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0186 0.0118 0.0118
Brugia malayi Protein kinase domain containing protein 0.0186 0.0118 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.0741 0.1906
Echinococcus multilocularis casein kinase i 0.0274 0.037 0.037
Brugia malayi Protein kinase domain containing protein 0.026 0.0328 0.0331
Brugia malayi hypothetical protein 0.0268 0.0352 0.0355
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0051 0.0131
Entamoeba histolytica protein kinase domain containing protein 0.0653 0.1455 1
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0166 0.0059 0.006
Schistosoma mansoni protein kinase 0.0624 0.1374 0.3531
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0531 0.1105 0.1105
Trichomonas vaginalis STE family protein kinase 0.0518 0.107 0.6427
Trypanosoma cruzi casein kinase, putative 0.0274 0.037 0.1245
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0716 0.1637 0.6314
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0418 0.0783 0.0789
Onchocerca volvulus 0.0343 0.0567 0.0539
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.026 0.0328 0.0328
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0207 0.0178 0.0694
Echinococcus multilocularis c src tyrosine kinase 0.025 0.0302 0.0302
Echinococcus multilocularis dual specificity testis specific protein kinase 0.103 0.2537 0.2537
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0318 0.0497 0.1063
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.026 0.033 0.033
Trypanosoma brucei casein kinase I, isoform 2 0.0274 0.037 0.1245
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0287 0.0408 0.0408
Echinococcus granulosus casein kinase I alpha 0.0274 0.037 0.0793
Schistosoma mansoni tyrosine kinase 0.0384 0.0684 0.1758
Schistosoma mansoni tyrosine kinase 0.0193 0.0138 0.0354
Onchocerca volvulus 0.0706 0.1608 0.1592
Schistosoma mansoni serine/threonine protein kinase 0.0302 0.045 0.1156
Leishmania major protein kinase, putative 0.0171 0.0074 0.0059
Toxoplasma gondii casein kinase I 0.0274 0.037 0.3044
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0188 0.0123 0.0263
Trypanosoma cruzi cdc2-related kinase 1 0.0302 0.045 0.1563
Echinococcus granulosus tyrosine protein kinase Fyn 0.0412 0.0766 0.1641
Brugia malayi Protein kinase domain containing protein 0.0186 0.0118 0.0119
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0287 0.0406 0.1387
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0335 0.0544 0.0548
Brugia malayi hypothetical protein 0.0186 0.0118 0.0119
Entamoeba histolytica protein kinase domain containing protein 0.0437 0.0838 0.5722
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.026 0.033 0.0706
Giardia lamblia Kinase, CK1 Casein kinase 0.0274 0.037 0.1708
Brugia malayi p70 ribosomal S6 kinase beta 0.0163 0.0051 0.0051
Echinococcus granulosus tyrosine protein kinase Srms 0.0186 0.0118 0.0253
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.045 0.2516
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0381 0.0676 0.0676
Echinococcus granulosus tyrosine kinase 0.0186 0.0118 0.0253
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0207 0.0178 0.1213
Echinococcus multilocularis cyclin dependent kinase 1 0.0302 0.045 0.045
Entamoeba histolytica serine/threonine protein kinase, putative 0.0166 0.0059 0.0328
Echinococcus granulosus titin 0.0163 0.005 0.0108
Brugia malayi Protein kinase domain containing protein 0.0163 0.0051 0.0051
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0529 0.11 0.4166
Trypanosoma cruzi aurora B kinase, putative 0.0437 0.0838 0.3116
Schistosoma mansoni adapter molecule crk 0.0146 0.0004 0.0011
Brugia malayi protein unc-22 0.0163 0.005 0.0051
Leishmania major protein kinase, putative 0.0207 0.0178 0.0476
Echinococcus multilocularis casein kinase I alpha 0.0274 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0343 0.0567 0.0571
Brugia malayi cyclin-dependent kinase 7 homolog 0.0421 0.0791 0.0797
Brugia malayi SH2 domain containing protein 0.0186 0.0118 0.0119
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0486 0.0976 0.2509
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0171 0.0074 0.0059
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0486 0.0976 0.3671
Brugia malayi SH2 domain containing protein 0.0186 0.0118 0.0119
Onchocerca volvulus 0.0193 0.0138 0.0106
Echinococcus multilocularis dual specificity protein kinase clk2 0.0529 0.11 0.11
Onchocerca volvulus 0.0186 0.0118 0.0086
Echinococcus granulosus TGF beta receptor type 1 0.0381 0.0676 0.1448
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.147 0.3797 0.8129
Entamoeba histolytica protein kinase, putative 0.0207 0.0178 0.1151
Onchocerca volvulus 0.0186 0.0118 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0326 0.0519 0.0523
Loa Loa (eye worm) hypothetical protein 0.0193 0.0138 0.0139
Echinococcus granulosus Immunoglobulin 0.0287 0.0408 0.0874
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0531 0.1105 0.2367
Entamoeba histolytica protein kinase domain containing protein 0.0171 0.0074 0.043
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0335 0.0544 0.0548
Onchocerca volvulus 0.0186 0.0118 0.0086
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0287 0.0406 0.0409
Entamoeba histolytica PH domain containing protein kinase, putative 0.0303 0.0454 0.306
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0207 0.0178 0.0476
Echinococcus multilocularis serine:threonine protein kinase 38 0.0163 0.0051 0.0051
Echinococcus granulosus MAM 0.0157 0.0033 0.0072
Trichomonas vaginalis AGC family protein kinase 0.018 0.0101 0.0316
Brugia malayi P38 map kinase family protein 2 0.1038 0.2557 0.2576
Loa Loa (eye worm) hypothetical protein 0.028 0.0386 0.0389
Loa Loa (eye worm) hypothetical protein 0.0236 0.026 0.0262
Schistosoma mansoni atypical protein kinase C 0.0221 0.0218 0.0559
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0186 0.0118 0.0253
Echinococcus granulosus cyclin dependent kinase 5 0.0302 0.045 0.0963
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0274 0.037 0.0373
Brugia malayi serine/threonine kinase 12 0.0437 0.0838 0.0844
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0287 0.0406 0.0406
Echinococcus multilocularis protein kinase shaggy 0.0486 0.0976 0.0976
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Schistosoma mansoni vav2 0.0157 0.0035 0.009
Loa Loa (eye worm) hypothetical protein 0.042 0.079 0.0795
Echinococcus granulosus TGF-beta receptor type-1 0.0381 0.0676 0.1448
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0146 0.0004 0.0004
Echinococcus multilocularis roundabout 2 0.0432 0.0823 0.0823
Trichomonas vaginalis CK1 family protein kinase 0.0274 0.037 0.2014
Trichomonas vaginalis AGC family protein kinase 0.0437 0.0838 0.4961
Schistosoma mansoni protein kinase 0.103 0.2537 0.652
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0412 0.0766 0.0766
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0062 0.0158
Echinococcus granulosus tyrosine protein kinase Fyn 0.0412 0.0766 0.1641
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0287 0.0406 0.2993
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0193 0.0138 0.0316
Entamoeba histolytica protein kinase, putative 0.0163 0.0051 0.0269
Echinococcus multilocularis dual specificity 0.0653 0.1455 0.1455
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0171 0.0074 0.0222
Entamoeba histolytica protein kinase, putative 0.0163 0.0051 0.0269
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0587 0.1268 0.1277
Trypanosoma brucei aurora B kinase 0.0437 0.0838 0.3116
Echinococcus granulosus casein kinase i 0.0274 0.037 0.0793
Echinococcus multilocularis twitchin 0.0151 0.0017 0.0017
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0573 0.1226 0.1226
Echinococcus multilocularis serine threonine protein kinase 0.0163 0.0051 0.0051
Echinococcus multilocularis neuroglian 0.0371 0.0649 0.0649
Trypanosoma cruzi casein kinase, putative 0.0274 0.037 0.1245
Schistosoma mansoni serine/threonine kinase 0.0163 0.0051 0.0131
Trypanosoma cruzi casein kinase, putative 0.0274 0.037 0.1245
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0287 0.0408 0.1049
Entamoeba histolytica protein kinase domain containing protein 0.0486 0.0976 0.6683
Loa Loa (eye worm) hypothetical protein 0.042 0.0787 0.0793
Loa Loa (eye worm) TK protein kinase 0.0266 0.0347 0.035
Echinococcus granulosus NCK adaptor protein 0.0146 0.0004 0.0009
Trypanosoma cruzi cdc2-related kinase 1 0.0302 0.045 0.1563
Loa Loa (eye worm) hypothetical protein 0.0287 0.0408 0.0411
Plasmodium falciparum calcium-dependent protein kinase 1 0.0207 0.0178 0.1141
Plasmodium falciparum NIMA related kinase 1 0.0518 0.107 0.9711
Giardia lamblia Kinase, CMGC CLK 0.0529 0.11 0.6487
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0207 0.0178 0.0178
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0529 0.11 0.4166
Echinococcus multilocularis insulin receptor 0.0533 0.1111 0.1111
Brugia malayi protein-tyrosine kinase 0.0348 0.0583 0.0587
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0163 0.0051 0.0051
Brugia malayi Temporarily assigned gene name protein 59 0.0193 0.0138 0.0139
Loa Loa (eye worm) hypothetical protein 0.0831 0.1964 0.1979
Loa Loa (eye worm) hypothetical protein 0.0287 0.0406 0.0409
Brugia malayi Protein kinase domain containing protein 0.0186 0.0118 0.0119
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0207 0.0178 0.0694
Entamoeba histolytica cell division protein kinase 2, putative 0.0302 0.045 0.3035
Schistosoma mansoni protein kinase 0.033 0.053 0.1362
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0302 0.045 0.0453
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0573 0.1226 0.1236
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0207 0.0178 0.0381
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0302 0.045 0.0963
Loa Loa (eye worm) hypothetical protein 0.0299 0.0442 0.0446
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.0049 0.0127
Echinococcus multilocularis 0.0462 0.0909 0.0909
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0318 0.0497 0.0497
Brugia malayi Serine/threonine-protein kinase SULU 0.1321 0.3371 0.3396
Echinococcus multilocularis tyrosine protein kinase Blk 0.0348 0.0583 0.0583
Entamoeba histolytica protein kinase, putative 0.0152 0.0021 0.0059
Echinococcus multilocularis mitogen activated protein kinase 14 0.1038 0.2557 0.2557
Loa Loa (eye worm) AGC/AKT protein kinase 0.0179 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0193 0.0138 0.0356
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0653 0.1455 0.5587
Schistosoma mansoni serine/threonine protein kinase 0.0274 0.037 0.0952
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1655 0.4327 0.4359
Echinococcus granulosus dual specificity mitogen activated protein 0.0716 0.1637 0.3504
Toxoplasma gondii aurora kinase 0.0437 0.0838 0.7498
Brugia malayi GH02984p 0.042 0.0787 0.0793
Brugia malayi Immunoglobulin I-set domain containing protein 0.0622 0.1366 0.1376
Schistosoma mansoni tyrosine kinase 0.0412 0.0766 0.197
Loa Loa (eye worm) hypothetical protein 0.0268 0.0352 0.0355
Brugia malayi hypothetical protein 0.0299 0.0442 0.0446
Brugia malayi Protein kinase domain containing protein 0.0529 0.11 0.1108
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0587 0.1268 0.1268
Loa Loa (eye worm) hypothetical protein 0.0146 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0538 0.1126 0.2893
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0412 0.0766 0.0766
Trichomonas vaginalis AGC family protein kinase 0.0287 0.0406 0.2239
Schistosoma mansoni tyrosine kinase 0.0193 0.0138 0.0354
Echinococcus multilocularis casein kinase I delta 0.0274 0.037 0.037
Schistosoma mansoni tyrosine kinase 0.025 0.0302 0.0776
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0099 0.0301
Loa Loa (eye worm) TK/EGFR protein kinase 0.0297 0.0436 0.0439
Echinococcus granulosus cyclin dependent kinase 9 0.0184 0.0112 0.0239
Trichomonas vaginalis STE family protein kinase 0.0716 0.1637 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0186 0.0118 0.0737
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0779 0.1816 0.1829
Onchocerca volvulus 0.0186 0.0118 0.0086
Echinococcus multilocularis casein kinase I alpha 0.0274 0.037 0.037
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0518 0.107 0.9696
Trichomonas vaginalis CMGC family protein kinase 0.0486 0.0976 0.5836
Echinococcus multilocularis TGF beta receptor type 1 0.0381 0.0676 0.0676
Echinococcus multilocularis epidermal growth factor receptor 0.0297 0.0436 0.0436
Schistosoma mansoni serine/threonine protein kinase 0.0779 0.1816 0.4667
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0287 0.0406 0.0406
Brugia malayi serine/threonine-protein kinase PAK 7 0.087 0.2076 0.2092
Loa Loa (eye worm) hypothetical protein 0.0207 0.0178 0.0179
Plasmodium falciparum calcium-dependent protein kinase 3 0.0207 0.0178 0.1141
Echinococcus multilocularis tyrosine protein kinase shark 0.0186 0.0118 0.0118
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0538 0.1126 0.241
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0486 0.0976 0.0984
Loa Loa (eye worm) AGC/PKA protein kinase 0.0287 0.0406 0.0409
Leishmania major casein kinase, putative 0.0274 0.037 0.1245
Giardia lamblia Kinase, CMGC GSK 0.0486 0.0976 0.5677
Schistosoma mansoni growth factor receptor-bound protein 0.0146 0.0004 0.0011
Trichomonas vaginalis STE family protein kinase 0.0716 0.1637 1
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1038 0.2557 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0207 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0186 0.0118 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0936 0.2267 0.5826
Loa Loa (eye worm) AGC/NDR protein kinase 0.0163 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0157 0.0033 0.0034
Trypanosoma brucei protein kinase, putative 0.0486 0.0976 0.3671
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0412 0.0766 0.0766
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0779 0.1816 0.1802
Onchocerca volvulus 0.0163 0.005 0.0017
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0287 0.0406 0.3383
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0412 0.0766 0.0766
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0629 0.1387 0.1398
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0193 0.0138 0.0356
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0302 0.045 0.0453
Loa Loa (eye worm) hypothetical protein 0.0456 0.0892 0.0898
Entamoeba histolytica protein kinase, putative 0.0437 0.0838 0.5722
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.045 0.2516
Schistosoma mansoni protein kinase 0.0693 0.157 0.4036
Brugia malayi Protein kinase domain containing protein 0.0779 0.1816 0.1829
Brugia malayi serine/threonine protein kinase 6 0.0437 0.0838 0.0844
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0207 0.0178 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0437 0.0838 0.0838
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0274 0.037 0.0373
Giardia lamblia Kinase, NEK 0.0518 0.107 0.629
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1079 0.2676 0.2676
Loa Loa (eye worm) hypothetical protein 0.0384 0.0684 0.0689
Schistosoma mansoni tyrosine kinase 0.0237 0.0264 0.0678
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0518 0.107 0.9713
Brugia malayi Immunoglobulin I-set domain containing protein 0.0209 0.0184 0.0186
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0412 0.0766 0.1641
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0486 0.0976 0.0976
Echinococcus granulosus epidermal growth factor receptor 0.0297 0.0436 0.0933
Entamoeba histolytica protein kinase, putative 0.0653 0.1455 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1038 0.2557 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0033 0.0034
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0274 0.037 0.0373
Echinococcus granulosus activated cdc42 kinase 1 0.0831 0.1964 0.4206
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.0263 0.0676
Brugia malayi Protein kinase domain containing protein 0.0936 0.2267 0.2284
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0163 0.0051 0.0051
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0188 0.0123 0.0123
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.033 0.053 0.0534
Entamoeba histolytica protein kinase, putative 0.0266 0.0347 0.2321
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0529 0.11 0.4166
Echinococcus multilocularis titin 0.0163 0.005 0.005
Giardia lamblia Kinase, CMGC CDK 0.0302 0.045 0.223
Echinococcus granulosus casein kinase I alpha 0.0274 0.037 0.0793
Schistosoma mansoni tyrosine kinase 0.0186 0.0118 0.0304
Onchocerca volvulus 0.0207 0.0179 0.0147
Echinococcus granulosus activin receptor type 0.1775 0.4671 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0251 0.0305 0.0305
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0302 0.045 0.1563
Plasmodium falciparum calcium-dependent protein kinase 5 0.0207 0.0178 0.1141
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0437 0.0838 0.5722
Echinococcus granulosus Vam6:Vps39 protein 0.0193 0.0138 0.0296
Loa Loa (eye worm) gastrulation defective protein 1 0.0869 0.2075 0.2091
Brugia malayi SRC-1 0.0412 0.0766 0.0772
Schistosoma mansoni nephrin 0.0383 0.0682 0.1754
Loa Loa (eye worm) hypothetical protein 0.0586 0.1263 0.1273
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0693 0.157 0.157
Entamoeba histolytica protein kinase, putative 0.0179 0.0099 0.0599
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0221 0.0218 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0529 0.11 0.2828
Onchocerca volvulus 0.0186 0.0118 0.0086
Entamoeba histolytica protein kinase, putative 0.0207 0.0178 0.1151
Entamoeba histolytica p21-activated kinase 0.0152 0.0021 0.0059
Echinococcus granulosus tyrosine protein kinase ABL1 0.0867 0.2068 0.4428
Schistosoma mansoni tyrosine kinase 0.0533 0.1111 0.2855
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Trichomonas vaginalis AGC family protein kinase 0.0437 0.0838 0.4961
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.1321 0.3371 0.3371
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.0218 0.0559
Schistosoma mansoni protein kinase 0.0437 0.0838 0.2153
Brugia malayi Variant SH3 domain containing protein 0.0146 0.0004 0.0004
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0274 0.037 0.1245
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0653 0.1455 0.5587
Plasmodium falciparum casein kinase 1 0.0274 0.037 0.2988
Trichomonas vaginalis CK1 family protein kinase 0.0274 0.037 0.2014
Echinococcus granulosus tyrosine kinase 0.0348 0.0583 0.1248
Loa Loa (eye worm) hypothetical protein 0.0193 0.0138 0.0139
Schistosoma mansoni tyrosine kinase 0.0931 0.2251 0.5785
Schistosoma mansoni tyrosine kinase 0.0193 0.0138 0.0354
Schistosoma mansoni rap gtpase-activating protein 0.0193 0.0138 0.0356
Giardia lamblia Kinase, CMGC GSK 0.0486 0.0976 0.5677
Echinococcus granulosus rho-associated protein kinase 1 0.0706 0.1608 0.3443
Schistosoma mansoni serine/threonine protein kinase 0.0318 0.0497 0.1276
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0157 0.0033 0.0034
Leishmania major protein kinase, putative 0.0529 0.11 0.4166
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0207 0.0178 0.1213
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0193 0.0138 0.0138
Schistosoma mansoni protein kinase 0.0171 0.0074 0.019
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0779 0.1816 0.1829
Schistosoma mansoni tyrosine kinase 0.0785 0.1833 0.471
Echinococcus multilocularis protein tyrosine kinase 0.1503 0.3891 0.3891
Brugia malayi intracellular kinase 0.0486 0.0976 0.0984
Loa Loa (eye worm) AUR protein kinase 0.0437 0.0838 0.0844
Giardia lamblia Kinase, NEK 0.0518 0.107 0.629
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0287 0.0406 0.0406
Schistosoma mansoni growth factor receptor-bound protein 0.0153 0.0024 0.0062
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0544 0.1145 0.1145
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0384 0.0684 0.1465
Schistosoma mansoni kinase 0.0166 0.0062 0.0158
Loa Loa (eye worm) TK/FER protein kinase 0.0186 0.0118 0.0119
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0779 0.1816 0.3887
Echinococcus granulosus casein kinase I alpha 0.0274 0.037 0.0793
Echinococcus granulosus NDR protein kinase 0.0163 0.0051 0.0109
Brugia malayi Furin-like cysteine rich region family protein 0.0297 0.0436 0.0439
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0163 0.005 0.0051
Loa Loa (eye worm) hypothetical protein 0.0586 0.1263 0.1273
Echinococcus granulosus raf serine:threonine protein kinase 0.0162 0.0049 0.0106
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0221 0.0218 0.0218
Echinococcus multilocularis cyclin dependent kinase 7 0.0404 0.0741 0.0741
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Giardia lamblia Aurora kinase 0.0437 0.0838 0.4768
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0801 0.188 0.1894
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0452 0.0879 0.3279
Schistosoma mansoni cell adhesion molecule 0.0348 0.0583 0.1499
Plasmodium falciparum protein kinase, putative 0.0171 0.0074 0.0142
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0486 0.0976 0.0984
Loa Loa (eye worm) hypothetical protein 0.0727 0.1666 0.1679
Onchocerca volvulus 0.0168 0.0067 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.1655 0.4327 0.4359
Trichomonas vaginalis STE family protein kinase 0.0716 0.1637 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.022 0.0214 0.0459
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0988 0.2414 0.5169
Plasmodium vivax glycogen synthase kinase 3, putative 0.0486 0.0976 0.8751
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.026 0.0329 0.0704
Schistosoma mansoni protein kinase 0.0693 0.157 0.4036
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0716 0.1637 0.6314
Loa Loa (eye worm) TK/ABL protein kinase 0.0867 0.2068 0.2084
Loa Loa (eye worm) hypothetical protein 0.042 0.079 0.0795
Giardia lamblia Kinase, STE STE20 0.0716 0.1637 1
Trichomonas vaginalis CMGC family protein kinase 0.0529 0.11 0.6617
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0988 0.2414 0.2414
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0406 0.1043
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0287 0.0406 0.0869
Echinococcus multilocularis activin receptor type 0.1775 0.4671 0.4671
Echinococcus granulosus protein kinase c epsilon type 0.0221 0.0218 0.0466
Loa Loa (eye worm) AGC/PKA protein kinase 0.0287 0.0406 0.0409
Echinococcus multilocularis mitogen activated protein kinase 14 0.1038 0.2557 0.2557
Echinococcus granulosus tyrosine protein kinase Src42A 0.0412 0.0766 0.1641
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0486 0.0976 0.3671
Echinococcus granulosus protein tyrosine kinase 0.1503 0.3891 0.833
Echinococcus granulosus protein kinase c iota type 0.0221 0.0218 0.0466
Echinococcus multilocularis cyclin dependent kinase 1 0.0302 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0618 0.1356 0.1366
Echinococcus granulosus activated cdc42 kinase 1 0.0831 0.1964 0.4206
Echinococcus multilocularis protein kinase c epsilon type 0.0221 0.0218 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0531 0.1105 0.2841
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.1321 0.3371 0.3396
Onchocerca volvulus 0.0274 0.037 0.0341
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0348 0.0583 0.0583
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1038 0.2557 1
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Brugia malayi bone morphogenetic protein type 1 receptor 0.0418 0.0783 0.0789
Entamoeba histolytica hypothetical protein 0.0653 0.1455 1
Trichomonas vaginalis AGC family protein kinase 0.0518 0.107 0.6427
Loa Loa (eye worm) hypothetical protein 0.0364 0.0628 0.0633
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0163 0.0051 0.0109
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0163 0.0051 0.0051
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0193 0.0138 0.0316
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0207 0.0178 0.0381
Loa Loa (eye worm) TK/ALK protein kinase 0.2322 0.6238 0.6284
Leishmania major protein kinase A catalytic subunit isoform 1 0.0287 0.0406 0.1387
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0573 0.1226 0.1236
Loa Loa (eye worm) AUR protein kinase 0.0437 0.0838 0.0844
Echinococcus granulosus serine:threonine protein kinase TAO1 0.1321 0.3371 0.7217
Entamoeba histolytica protein kinase, putative 0.0486 0.0976 0.6683
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Trichomonas vaginalis CK1 family protein kinase 0.0274 0.037 0.2014
Echinococcus granulosus tyrosine protein kinase Lyn 0.0479 0.0958 0.2051
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0624 0.1374 0.1374
Schistosoma mansoni tyrosine kinase 0.1503 0.3891 1
Schistosoma mansoni high-affinity choline transporter 0.042 0.0787 0.2024
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0193 0.0138 0.0296
Echinococcus granulosus mitogen activated protein kinase 11 0.1038 0.2557 0.5475
Schistosoma mansoni protein kinase 0.0381 0.0676 0.1738
Entamoeba histolytica casein kinase 1, putative 0.0274 0.037 0.2483
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0531 0.1105 0.1114
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0406 0.1043
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0207 0.0178 0.0179
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0529 0.11 0.4166
Echinococcus multilocularis Immunoglobulin 0.0287 0.0408 0.0408
Echinococcus multilocularis dual specificity mitogen activated protein 0.0716 0.1637 0.1637
Loa Loa (eye worm) AUR protein kinase 0.0437 0.0838 0.0844
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0099 0.0301
Echinococcus multilocularis tyrosine protein kinase Srms 0.0348 0.0583 0.0583
Echinococcus granulosus tyrosine protein kinase Src42A 0.0251 0.0305 0.0653
Echinococcus granulosus neuroglian 0.0371 0.0649 0.1388
Trichomonas vaginalis CAMK family protein kinase 0.0166 0.0059 0.0053
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0166 0.0062 0.0062
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0716 0.1637 0.1649
Giardia lamblia Kinase, NEK 0.0518 0.107 0.629
Trypanosoma cruzi casein kinase, putative 0.0274 0.037 0.1245
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0867 0.2068 0.2068
Echinococcus granulosus epidermal growth factor receptor 0.0297 0.0436 0.0933
Echinococcus granulosus protein kinase C gamma type 0.0163 0.0051 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0529 0.11 0.2828
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0486 0.0976 0.882
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0587 0.1268 0.1277
Leishmania major protein kinase A catalytic subunit 0.0287 0.0406 0.1387
Echinococcus multilocularis aurora kinase A 0.0437 0.0838 0.0838
Echinococcus multilocularis cyclin dependent kinase 9 0.0166 0.0062 0.0062
Echinococcus granulosus mitogen activated protein kinase 14 0.1038 0.2557 0.5475
Echinococcus multilocularis epidermal growth factor receptor 0.0297 0.0436 0.0436
Echinococcus granulosus serine:threonine protein kinase N2 0.0163 0.0051 0.0109
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1079 0.2676 0.2696
Brugia malayi Protein kinase domain containing protein 0.0624 0.1374 0.1384
Brugia malayi casein kinase 1, delta 0.0274 0.037 0.0373
Echinococcus granulosus protein kinase shaggy 0.0486 0.0976 0.209
Echinococcus multilocularis casein kinase I alpha 0.0274 0.037 0.037
Giardia lamblia Kinase, AGC PKA 0.0287 0.0406 0.1941
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0099 0.0301
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.0741 0.1906
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.087 0.2076 0.2092
Echinococcus multilocularis serine:threonine protein kinase N2 0.0163 0.0051 0.0051
Echinococcus granulosus c-Jun N-terminal kinases 0.1079 0.2676 0.573
Brugia malayi hypothetical protein 0.0157 0.0033 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0801 0.188 0.4833
Schistosoma mansoni protein kinase 0.0716 0.1637 0.4206
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0287 0.0406 0.0406
Trypanosoma cruzi cdc2-related kinase 3 0.0302 0.045 0.1563
Trypanosoma brucei rac serine-threonine kinase, putative 0.0179 0.0099 0.0157
Brugia malayi protein C17H12.11 0.0268 0.0352 0.0355
Trypanosoma cruzi casein kinase, putative 0.0274 0.037 0.1245
Brugia malayi serine/threonine-protein kinase 6 0.0437 0.0838 0.0844
Entamoeba histolytica PH domain containing protein kinase, putative 0.0303 0.0454 0.306
Trypanosoma cruzi cdc2-related kinase 3 0.0302 0.045 0.1563
Echinococcus granulosus c src tyrosine kinase 0.025 0.0302 0.0647
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0456 0.0892 0.1909
Schistosoma mansoni serine/threonine protein kinase 0.0629 0.1387 0.3566
Schistosoma mansoni tyrosine kinase 0.0173 0.0079 0.0204
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0486 0.0977 0.0984
Echinococcus multilocularis cyclin dependent kinase 19 0.0936 0.2267 0.2267
Brugia malayi Protein kinase domain containing protein 0.0163 0.0051 0.0051
Brugia malayi Protein kinase domain containing protein 0.0186 0.0118 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0017 0.0042
Schistosoma mansoni protein kinase 0.0693 0.157 0.4036
Toxoplasma gondii AGC kinase 0.0287 0.0406 0.3383
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.022 0.0214 0.0214
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0335 0.0544 0.0548
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0099 0.0301
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0059 0.0152
Brugia malayi Protein kinase domain containing protein 0.2323 0.624 0.6287
Plasmodium vivax protein kinase Crk2 0.0302 0.045 0.3437
Loa Loa (eye worm) hypothetical protein 0.0299 0.0442 0.0446
Trichomonas vaginalis AGC family protein kinase 0.0437 0.0838 0.4961
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0212 0.0191 0.0193
Brugia malayi Sex muscle abnormal protein 5 0.0146 0.0004 0.0004
Loa Loa (eye worm) TK protein kinase 0.0348 0.0583 0.0587
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0209 0.0184 0.0186
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.025 0.0302 0.0776
Trichomonas vaginalis AGC family protein kinase 0.0179 0.0099 0.0301
Plasmodium falciparum calcium-dependent protein kinase 4 0.0207 0.0178 0.1141
Onchocerca volvulus 0.0486 0.0976 0.0953
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0412 0.0766 0.1641
Echinococcus multilocularis casein kinase I delta 0.0274 0.037 0.037
Plasmodium falciparum glycogen synthase kinase 3 0.0486 0.0976 0.8811
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0393 0.071 0.0716
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.0178 0.0458
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0348 0.0583 0.1248
Echinococcus multilocularis mitogen activated protein kinase 11 0.1038 0.2557 0.2557
Toxoplasma gondii histone kinase SNF1, putative 0.0166 0.0059 0.0081
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0573 0.1226 0.1236
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0801 0.188 0.4024
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0166 0.0059 0.0059
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0287 0.0406 0.1387
Leishmania major protein kinase A catalytic subunit isoform 2 0.0287 0.0406 0.1387
Trichomonas vaginalis CMGC family protein kinase 0.0486 0.0976 0.5836
Brugia malayi C1-like domain containing protein 0.0393 0.071 0.0716
Brugia malayi Fibronectin type III domain containing protein 0.0299 0.0442 0.0446
Entamoeba histolytica protein kinase, putative 0.0653 0.1455 1
Brugia malayi Variant SH3 domain containing protein 0.0146 0.0004 0.0004
Brugia malayi Protein kinase domain containing protein 0.0653 0.1455 0.1466
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0779 0.1816 0.1829
Brugia malayi Protein kinase domain containing protein 0.0302 0.045 0.0453
Brugia malayi Protein kinase domain containing protein 0.152 0.3938 0.3968
Schistosoma mansoni nck2/grb4 0.0146 0.0004 0.0011
Schistosoma mansoni protein kinase 0.0523 0.1083 0.2784
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0406 0.1043
Echinococcus multilocularis tyrosine protein kinase HCK 0.0266 0.0347 0.0347
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0287 0.0406 0.0869
Loa Loa (eye worm) hypothetical protein 0.0299 0.0442 0.0446
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0207 0.0178 0.0381
Loa Loa (eye worm) hypothetical protein 0.0514 0.1056 0.1064
Onchocerca volvulus 0.0268 0.0352 0.0322
Brugia malayi cyclin-dependent kinase 9 0.0166 0.0062 0.0062
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0629 0.1387 0.1398
Schistosoma mansoni tyrosine kinase 0.0412 0.0766 0.197
Echinococcus multilocularis growth factor receptor bound protein 2 0.0146 0.0004 0.0004
Echinococcus multilocularis NCK adaptor protein 0.0153 0.0024 0.0024
Plasmodium vivax calcium-dependent protein kinase, putative 0.0207 0.0178 0.0694
Loa Loa (eye worm) hypothetical protein 0.0287 0.0408 0.0411
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0486 0.0977 0.0984
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0716 0.1637 0.6314
Brugia malayi Immunoglobulin I-set domain containing protein 0.0299 0.0442 0.0446
Echinococcus multilocularis tyrosine kinase 0.0186 0.0118 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0059 0.0152
Echinococcus multilocularis raf serine:threonine protein kinase 0.0162 0.0049 0.0049
Echinococcus granulosus insulin receptor 0.0533 0.1111 0.2378
Loa Loa (eye worm) TK/INSR protein kinase 0.0533 0.1111 0.1119
Loa Loa (eye worm) hypothetical protein 0.0166 0.0059 0.006
Echinococcus granulosus roundabout 2 0.0432 0.0823 0.1763
Giardia lamblia Kinase, CMGC CDK 0.0302 0.045 0.223
Echinococcus multilocularis Immunoglobulin 0.0287 0.0408 0.0408
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.045 0.2516
Toxoplasma gondii AGC kinase 0.0287 0.0406 0.3383
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0297 0.0436 0.0933
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0393 0.071 0.0716
Echinococcus granulosus tyrosine protein kinase shark 0.0186 0.0118 0.0253
Echinococcus granulosus cyclin dependent kinase 19 0.0936 0.2267 0.4853
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0287 0.0406 0.333
Trypanosoma brucei cdc2-related kinase 1 0.0302 0.045 0.1563
Schistosoma mansoni serine/threonine protein kinase 0.1321 0.3371 0.8664
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0051 0.0131

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 12.02264435 uM PUBCHEM_BIOASSAY: Dose responses of compounds that inhibit the Choline Transporter (CHT) - 5 point CRC. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488975, AID488997, AID493221, AID493222] ChEMBL. No reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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