Detailed information for compound 13523

Basic information

Technical information
  • TDR Targets ID: 13523
  • Name: 7,9-dibenzyl-8-hydroxy-1,3-dimethyl-2H-purino [7,8-a]pyrimidine-4,6-dione
  • MW: 429.471 | Formula: C24H23N5O3
  • H donors: 1 H acceptors: 4 LogP: 3.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(C)CN(c2c1n1c(=O)c(Cc3ccccc3)c(n(c1n2)Cc1ccccc1)O)C
  • InChi: 1S/C24H23N5O3/c1-26-15-27(2)23(32)19-20(26)25-24-28(14-17-11-7-4-8-12-17)21(30)18(22(31)29(19)24)13-16-9-5-3-6-10-16/h3-12,30H,13-15H2,1-2H3
  • InChiKey: LJGMAQCGTVMPEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-hydroxy-1,3-dimethyl-7,9-bis(phenylmethyl)-2H-purino[7,8-a]pyrimidine-4,6-dione
  • 7,9-dibenzyl-8-hydroxy-1,3-dimethyl-2H-purino[7,8-a]pyrimidine-4,6-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0031 0.0275 0.0819
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0382 0.038
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0167 0.2119 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0333 0.4095
Giardia lamblia Kinase, AGC AKT 0.0101 0.1226 0.569
Echinococcus granulosus expressed protein 0.0036 0.0344 0.0344
Trypanosoma cruzi heat shock protein 90, putative 0.0071 0.0809 1
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0043 0.0441 0.1896
Echinococcus multilocularis dnaJ subfamily B 0.0444 0.5867 0.5867
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0167 0.2119 0.628
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0002 0.0002
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0333 0.216
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.0048 0.0138
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0086 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0086 0.0084
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0014 0.0048 0.0048
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0086 0.0086
Entamoeba histolytica protein kinase, putative 0.0017 0.0086 0.0185
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Trypanosoma brucei heat shock protein 90, putative 0.0071 0.0809 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0002 0.0002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0137 0.0135
Brugia malayi intermediate filament protein 0.0029 0.025 0.0541
Onchocerca volvulus 0.0039 0.0378 0.1127
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Onchocerca volvulus 0.0043 0.0441 0.1312
Schistosoma mansoni rab6-interacting 0.0021 0.014 0.0138
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0017 0.0086 0.0188
Schistosoma mansoni hypothetical protein 0.0021 0.014 0.0138
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0107 0.0105
Echinococcus granulosus intermediate filament protein 0.0029 0.025 0.025
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0086 0.0187
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0004
Trypanosoma brucei metacaspase MCA2 0.0058 0.0634 0.7826
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0086 0.0543
Schistosoma mansoni intermediate filament proteins 0.0029 0.025 0.0248
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Trichomonas vaginalis set domain proteins, putative 0.0258 0.3345 1
Plasmodium vivax heat shock protein 86, putative 0.0071 0.0809 0.3675
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0233
Brugia malayi kinase, mitochondrial precursor 0.0014 0.0048 0.0101
Trypanosoma brucei heat shock protein, putative 0.0071 0.0809 1
Echinococcus multilocularis peroxidasin 0.0039 0.0378 0.0378
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0086 0.0084
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.0048 0.0138
Schistosoma mansoni lamin 0.0029 0.025 0.0248
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0029 0.0245 0.0245
Echinococcus multilocularis tumor protein p63 0.0367 0.4822 0.4822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0002 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0002 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0301 0.03
Mycobacterium ulcerans heat shock protein 90 0.0056 0.0614 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0017 0.0086 0.0086
Entamoeba histolytica heat shock protein 90, putative 0.0071 0.0809 0.3675
Entamoeba histolytica protein kinase, putative 0.0017 0.0086 0.0185
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0301 0.0301
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0002 0.0002
Schistosoma mansoni DNA polymerase eta 0.0049 0.0512 0.051
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.0441 0.5432
Brugia malayi Protein kinase domain containing protein 0.0017 0.0086 0.0184
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Trypanosoma cruzi metacaspase, putative 0.0058 0.0634 0.7826
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0086 0.0664
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.0048 0.0562
Trichomonas vaginalis heat shock protein, putative 0.0071 0.0809 0.2308
Echinococcus granulosus endoplasmin 0.0056 0.0614 0.0614
Schistosoma mansoni eyes absent homolog 0.0096 0.1149 0.1147
Trypanosoma cruzi Heat shock protein 83, putative 0.0071 0.0809 1
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0512 0.6311
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0137 0.0137
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0058 0.0634 0.1383
Echinococcus multilocularis heat shock protein 90 0.0071 0.0809 0.0809
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0002 0.0002
Trypanosoma cruzi metacaspase, putative 0.0058 0.0634 0.7826
Schistosoma mansoni hypothetical protein 0.003 0.0253 0.0251
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0017 0.0086 0.0086
Echinococcus multilocularis caspase 8 0.0058 0.0634 0.0634
Entamoeba histolytica heat shock protein 90, putative 0.0071 0.0809 0.3675
Echinococcus multilocularis protein kinase c iota type 0.0017 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Trypanosoma brucei heat shock protein, putative 0.0071 0.0809 1
Loa Loa (eye worm) heat shock protein 75 0.0029 0.0245 0.0534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Toxoplasma gondii hypothetical protein 0.0043 0.0441 0.2865
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0378 0.0826
Onchocerca volvulus 0.0019 0.0107 0.0314
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0512 0.1113
Trypanosoma cruzi heat shock protein 85, putative 0.0056 0.0614 0.7586
Loa Loa (eye worm) AGC/PKN protein kinase 0.0017 0.0086 0.0188
Echinococcus multilocularis caspase 0.0216 0.2772 0.2772
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0137 0.0299
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Trichomonas vaginalis heat shock protein, putative 0.0056 0.0614 0.1718
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0066 0.0139
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0086 0.0086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0086 0.0086
Schistosoma mansoni peroxidasin 0.0039 0.0378 0.0377
Echinococcus multilocularis serine:threonine protein kinase 38 0.0017 0.0086 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0049 0.0575
Schistosoma mansoni loxhd1 0.0021 0.014 0.0138
Loa Loa (eye worm) hypothetical protein 0.0049 0.0512 0.1116
Onchocerca volvulus 0.0052 0.0562 0.1677
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0029 0.0245 0.0951
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.014 0.014
Onchocerca volvulus 0.0019 0.0107 0.0314
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0216 0.2772 0.2772
Entamoeba histolytica protein kinase, putative 0.0017 0.0086 0.0185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0233
Brugia malayi Protein kinase domain containing protein 0.0017 0.0086 0.0184
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Loa Loa (eye worm) hypothetical protein 0.0054 0.058 0.1267
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Giardia lamblia Rab geranylgeranyltransferase 0.0043 0.0441 0.1896
Brugia malayi isocitrate dehydrogenase 0.0017 0.0086 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Echinococcus multilocularis RUN 0.0021 0.014 0.014
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0058 0.0634 0.0632
Entamoeba histolytica hypothetical protein 0.0039 0.0382 0.1614
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Echinococcus granulosus heat shock protein 90 0.0071 0.0809 0.0809
Loa Loa (eye worm) blistered cuticle protein 3 0.0039 0.0378 0.0826
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0086 0.1029
Trypanosoma cruzi metacaspase 5, putative 0.0058 0.0634 0.7826
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.0441 0.5432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0002 0.0004
Leishmania major mitochondrial DNA topoisomerase II 0.0014 0.0048 0.037
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0417 0.5144
Treponema pallidum heat shock protein 90 0.0056 0.0614 1
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0101 0.1226 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0017 0.0086 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0634 0.1777
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0043 0.0441 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0137 0.1667
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0058 0.0634 0.138
Schistosoma mansoni rab6-interacting 0.0021 0.014 0.0138
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0004
Trypanosoma brucei unspecified product 0.0014 0.0049 0.0575
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0045 0.0045
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0043 0.0441 0.1896
Echinococcus granulosus protein kinase c iota type 0.0017 0.0086 0.0086
Trypanosoma brucei heat shock protein, putative 0.0071 0.0809 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0029 0.0245 0.0727
Toxoplasma gondii hypothetical protein 0.0124 0.1531 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0019 0.0107 0.0107
Plasmodium vivax SET domain protein, putative 0.0033 0.0301 0.1224
Loa Loa (eye worm) hypothetical protein 0.0058 0.0634 0.1383
Schistosoma mansoni serine/threonine kinase 0.0017 0.0086 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0002 0.0002
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0086 0.0182
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0029 0.0245 0.0245
Plasmodium vivax heat shock protein 90, putative 0.0029 0.0245 0.0951
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0043 0.0441 0.5432
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0316 0.2049
Echinococcus granulosus transmembrane protease serine 3 0.0019 0.0107 0.0107
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0043 0.0441 0.5432
Toxoplasma gondii heat shock protein 75, putative 0.0029 0.0245 0.1585
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0378 0.0822
Brugia malayi CXXC zinc finger family protein 0.0031 0.0275 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0049 0.0575
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0019 0.0107 0.0105
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0167 0.2119 0.4622
Giardia lamblia Heat shock protein HSP 90-alpha 0.0056 0.0614 0.2735
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0056 0.0614 0.0614
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0086 0.1029
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0441 0.5432
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0014 0.0048 0.0048
Brugia malayi Hsp90 protein 0.0029 0.0245 0.0531
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.058 0.0579
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.014 0.0444
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0634 0.1777
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0378 0.0826
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.0048 0.0562
Loa Loa (eye worm) intermediate filament protein 0.0029 0.025 0.0545
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.0048 0.5
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0043 0.0441 0.1896
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0105
Loa Loa (eye worm) hypothetical protein 0.0029 0.0242 0.0529
Brugia malayi Trypsin family protein 0.0019 0.0107 0.0229
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0634 0.1777
Trypanosoma brucei unspecified product 0.0014 0.0049 0.0575
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0056 0.0614 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0048 0.0297
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0301 0.0301
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0058 0.0634 0.4128
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0107 0.0105
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0004
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0167 0.2119 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0004
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.014 0.014
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0137 0.1099
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.014 0.014
Echinococcus granulosus lamin 0.0029 0.025 0.025
Echinococcus granulosus dna polymerase kappa 0.0021 0.0137 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0002 0.0004
Onchocerca volvulus 0.0019 0.0107 0.0314
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0137 0.1573
Echinococcus granulosus RUN 0.0021 0.014 0.014
Onchocerca volvulus 0.0033 0.0301 0.0896
Entamoeba histolytica hypothetical protein 0.0039 0.0382 0.1614
Echinococcus granulosus cpg binding protein 0.0033 0.03 0.03
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0301 0.1955
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0086 0.0086
Toxoplasma gondii DNA topoisomerase 2, putative 0.0014 0.0048 0.0297
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0378 0.0822
Brugia malayi hypothetical protein 0.0096 0.1149 0.2505
Schistosoma mansoni heat shock protein 0.0029 0.0245 0.0243
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Schistosoma mansoni endoplasmin 0.0071 0.0809 0.0807
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0634 0.1777
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0137 0.0137
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0167 0.2119 0.628
Loa Loa (eye worm) hypothetical protein 0.0096 0.1149 0.2508
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0086 0.0086
Trichomonas vaginalis rotamase, putative 0.0036 0.0344 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0634 0.1777
Schistosoma mansoni hypothetical protein 0.0039 0.0382 0.038
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0634 0.1777
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Leishmania major hypothetical protein, conserved 0.0014 0.0048 0.037
Echinococcus granulosus caspase 3 0.0158 0.1992 0.1992
Echinococcus granulosus Mastin 0.0019 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0512 0.6311
Echinococcus multilocularis musashi 0.0029 0.025 0.025
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0043 0.0441 0.5432
Brugia malayi Trypsin family protein 0.0019 0.0107 0.0229
Brugia malayi Blistered cuticle protein 3 0.0039 0.0378 0.0822
Echinococcus granulosus heat shock protein 90 0.0056 0.0614 0.0614
Onchocerca volvulus 0.0021 0.014 0.0413
Trypanosoma brucei rac serine-threonine kinase, putative 0.0017 0.0086 0.1038
Brugia malayi Trypsin family protein 0.0019 0.0107 0.0229
Leishmania major DNA topoisomerase ii 0.0014 0.0048 0.037
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.0245 0.0951
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0378 0.0822
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0107 0.0105
Toxoplasma gondii AGC kinase 0.0017 0.0086 0.0548
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0081
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0137 0.027
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0301 0.03
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Echinococcus multilocularis expressed protein 0.0036 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0167 0.2119 0.4624
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.0809 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.0048 0.0048
Brugia malayi hypothetical protein 0.0019 0.0107 0.0229
Trypanosoma cruzi metacaspase, putative 0.0058 0.0634 0.7826
Trypanosoma brucei heat shock protein, putative 0.0071 0.0809 1
Brugia malayi Peroxidasin 0.0039 0.0378 0.0822
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0086 0.0182
Echinococcus multilocularis caspase 2 0.0058 0.0634 0.0634
Schistosoma mansoni rotamase 0.0036 0.0344 0.0343
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Toxoplasma gondii heat shock protein 90, putative 0.0071 0.0809 0.5275
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0043 0.0441 0.0441
Entamoeba histolytica hypothetical protein 0.0039 0.0382 0.1614
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0014 0.0048 0.0741
Trypanosoma cruzi metacaspase, putative 0.0058 0.0634 0.7826
Brugia malayi Trypsin-like protease protein 5 0.0019 0.0107 0.0229
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0017 0.0086 0.0086
Trypanosoma cruzi metacaspase 5, putative 0.0058 0.0634 0.7826
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0118 0.1454 0.1454
Echinococcus granulosus protein quaking 0.003 0.0253 0.0253
Schistosoma mansoni lipoxygenase 0.0089 0.1052 0.105
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Plasmodium vivax metacaspase 1, putative 0.0058 0.0634 0.2829
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.014 0.014
Onchocerca volvulus 0.0019 0.0107 0.0314
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0048 0.0297
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0107 0.0105
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0333 0.1376
Trypanosoma brucei metacaspase 0.0058 0.0634 0.7826
Schistosoma mansoni polycystin 1-related 0.0021 0.014 0.0138
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0017 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0029 0.025 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0634 0.1777
Leishmania major heat shock protein, putative 0.0029 0.0245 0.198
Onchocerca volvulus 0.0258 0.3345 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0014 0.0048 0.0048
Echinococcus granulosus enteropeptidase 0.0019 0.0107 0.0107
Brugia malayi Doublecortin family protein 0.0021 0.014 0.0301
Loa Loa (eye worm) hypothetical protein 0.0033 0.0301 0.0658
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0382 0.0382
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0137 0.0137
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.0048 0.0562
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0086 0.0183
Loa Loa (eye worm) trypsin family protein 0.0019 0.0107 0.0233
Onchocerca volvulus 0.0029 0.025 0.0741
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Schistosoma mansoni hypothetical protein 0.0052 0.0562 0.0561
Trypanosoma brucei Metacaspase-4 0.0058 0.0634 0.7826
Brugia malayi hypothetical protein 0.003 0.0253 0.0549
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0137 0.043
Schistosoma mansoni lipoxygenase 0.0127 0.1568 0.1566
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.0245 0.0951
Schistosoma mansoni pyruvate dehydrogenase 0.0014 0.0048 0.0046
Brugia malayi Temporarily assigned gene name protein 44 0.003 0.0253 0.0549
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0002 0.0002
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0378 0.0822
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.0048 0.0048
Schistosoma mansoni caspase-3 (C14 family) 0.0216 0.2772 0.2771
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0441 0.5432
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0014 0.0048 0.0101
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0086 0.0543
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0002 0.0002
Trypanosoma brucei metacaspase MCA3 0.0058 0.0634 0.7826
Trichomonas vaginalis heat shock protein, putative 0.0043 0.044 0.1188
Onchocerca volvulus 0.0019 0.0107 0.0314
Onchocerca volvulus 0.0021 0.014 0.0413
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0137 0.1573
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.014 0.014
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0333 0.4095
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0344 0.0748
Onchocerca volvulus 0.0029 0.025 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0014 0.0048 0.0562
Trypanosoma brucei developmentally regulated phosphoprotein 0.0014 0.0048 0.0562
Loa Loa (eye worm) AGC/AKT protein kinase 0.0017 0.0086 0.0188
Schistosoma mansoni DNA topoisomerase II 0.0014 0.0048 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0301 0.0301
Onchocerca volvulus 0.0039 0.0378 0.1127
Brugia malayi Hr1 repeat family protein 0.0017 0.0086 0.0184
Echinococcus granulosus protein kinase C gamma type 0.0017 0.0086 0.0086
Loa Loa (eye worm) TOPoisomerase family member 0.0014 0.0048 0.0104
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0043 0.0441 0.3579
Brugia malayi hypothetical protein 0.0021 0.014 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0002 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.014 0.0444
Plasmodium vivax endoplasmin, putative 0.0071 0.0809 0.3675
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0086 0.0084
Leishmania major developmentally regulated phosphoprotein-like protein 0.0014 0.0048 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0049 0.0575
Brugia malayi Cell death protein 3 precursor 0.0058 0.0634 0.138
Trypanosoma brucei heat shock protein, putative 0.0071 0.0809 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0724 0.0723
Schistosoma mansoni endoplasmin 0.0071 0.0809 0.0807
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0014 0.0048 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.1454 0.1453
Plasmodium vivax heat shock protein, putative 0.0029 0.0245 0.0951
Mycobacterium ulcerans hypothetical protein 0.0019 0.0107 0.1041
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0167 0.2119 0.2117
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0086 0.1029
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0086 0.1029
Plasmodium falciparum endoplasmin, putative 0.0043 0.044 0.1891
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0004
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Onchocerca volvulus 0.0039 0.0378 0.1127
Loa Loa (eye worm) hypothetical protein 0.0257 0.333 0.7268
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0562 0.1224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Schistosoma mansoni peroxidasin 0.0039 0.0378 0.0377
Schistosoma mansoni cpg binding protein 0.0033 0.03 0.0298
Loa Loa (eye worm) AGC/NDR protein kinase 0.0017 0.0086 0.0188
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0233
Trichomonas vaginalis rotamase, putative 0.0035 0.0333 0.0864
Echinococcus granulosus peroxidasin 0.0039 0.0378 0.0378
Schistosoma mansoni microtubule-associated protein tau 0.0749 1 1
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0101 0.1226 0.2674
Trypanosoma brucei unspecified product 0.0021 0.0137 0.1667
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0233
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0017 0.0086 0.0086
Echinococcus granulosus heat shock protein 0.0071 0.0809 0.0809
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0014 0.0048 0.0562
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0634 0.1777
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0137 0.0295
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.025 0.0545
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0301 0.03
Toxoplasma gondii Hsp90 domain-containing protein 0.0029 0.0245 0.1585
Echinococcus multilocularis protein kinase c epsilon type 0.0017 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0216 0.2772 0.2772
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0118 0.1454 0.1454
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.333 0.333
Echinococcus multilocularis glycoprotein Antigen 5 0.0019 0.0107 0.0107
Brugia malayi Protein kinase domain containing protein 0.0017 0.0086 0.0184
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0127 0.1568 0.1568
Toxoplasma gondii heat shock protein HSP90 0.0071 0.0809 0.5275
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0634 0.1777
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0275 0.0601
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0043 0.0441 0.0962
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0378 0.0826
Brugia malayi Endoplasmin precursor 0.0071 0.0809 0.1762
Brugia malayi hypothetical protein 0.0039 0.0378 0.0822
Trichomonas vaginalis heat shock protein, putative 0.0056 0.0614 0.1718
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0017 0.0086 0.0188
Onchocerca volvulus 0.0054 0.058 0.173
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0634 0.1777
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0014 0.0048 0.0741
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0634 0.1777
Brugia malayi p70 ribosomal S6 kinase beta 0.0017 0.0086 0.0184
Echinococcus multilocularis cpg binding protein 0.0033 0.03 0.03
Echinococcus granulosus dna polymerase eta 0.0049 0.0512 0.0512
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0127 0.1568 0.1568
Brugia malayi hypothetical protein 0.0039 0.0382 0.0831
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0043 0.0441 0.0958
Schistosoma mansoni cpg binding protein 0.0033 0.03 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0634 0.1777
Echinococcus multilocularis caspase 3 0.0158 0.1992 0.1992
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Echinococcus multilocularis lamin dm0 0.0029 0.025 0.025
Onchocerca volvulus 0.0019 0.0107 0.0314
Trypanosoma brucei heat shock protein, putative 0.0071 0.0809 1
Loa Loa (eye worm) tumor suppressor 0.0349 0.4582 1
Brugia malayi Pre-SET motif family protein 0.0227 0.2923 0.6377
Trypanosoma brucei heat shock protein 90, putative 0.0071 0.0809 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0014 0.0048 0.0562
Schistosoma mansoni heat shock protein 0.0071 0.0809 0.0807
Echinococcus multilocularis endoplasmin 0.0056 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0333 0.2698
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0669 0.4362
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0167 0.2119 0.2119
Loa Loa (eye worm) hypothetical protein 0.0017 0.0086 0.0188
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0048 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0382 0.0382
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0137 0.1573
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.0634 0.0632
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0137 0.027
Echinococcus granulosus hypothetical protein 0.003 0.0253 0.0253
Echinococcus multilocularis microtubule associated protein 2 0.0749 1 1
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.0048 0.0562
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0137 0.1573
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0019 0.0107 0.0107
Leishmania major DNA polymerase eta, putative 0.0049 0.0512 0.4159
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0017 0.0086 0.0086
Plasmodium falciparum heat shock protein 90 0.0071 0.0809 0.3675
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0118 0.1454 0.3174
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0002 0.0002
Trypanosoma brucei DNA topoisomerase ii 0.0014 0.0048 0.0562
Onchocerca volvulus Peroxidase homolog 0.0039 0.0378 0.1127
Brugia malayi tumor suppressor. 0.0349 0.4582 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0066 0.0143
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0378 0.0826
Echinococcus multilocularis protein quaking 0.003 0.0253 0.0253
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0167 0.2119 1
Brugia malayi protein kinase C II. 0.0017 0.0086 0.0184
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0058 0.0634 0.4128
Echinococcus granulosus glycoprotein Antigen 5 0.0019 0.0107 0.0107
Trichomonas vaginalis endoplasmin, putative 0.0043 0.044 0.1188
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.0048 0.0562
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0344 0.0899
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0441 0.5432
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0048 0.0297
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0086 0.0086
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.333 0.333
Plasmodium falciparum metacaspase 1 0.0058 0.0634 0.2829
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0017 0.0081 0.0101
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0107 0.0105
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0014 0.0048 0.0741
Loa Loa (eye worm) hypothetical protein 0.0021 0.014 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Onchocerca volvulus Chorion peroxidase homolog 0.0039 0.0378 0.1127
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0017 0.0086 0.0188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Schistosoma mansoni hypothetical protein 0.0444 0.5867 0.5867
Echinococcus multilocularis enteropeptidase 0.0019 0.0107 0.0107
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0245 0.0597
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0634 0.2829
Echinococcus multilocularis heat shock protein 90 0.0056 0.0614 0.0614
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0137 0.1667
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Schistosoma mansoni atypical protein kinase C 0.0017 0.0086 0.0084
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0019 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0104
Echinococcus granulosus Protein kinase C brain isozyme 0.0017 0.0086 0.0086
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0056 0.0614 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0019 0.0107 0.0105
Echinococcus granulosus caspase 8 0.0058 0.0634 0.0634
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.0809 1
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Echinococcus granulosus lamin dm0 0.0029 0.025 0.025
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0043 0.0441 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0137 0.1667
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0058 0.0634 0.4128
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0124 0.1531 0.4499
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0107 0.0105
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0056 0.0614 0.4999
Trypanosoma brucei heat shock protein, putative 0.0071 0.0809 1
Echinococcus granulosus caspase 2 0.0058 0.0634 0.0634
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0276 0.0276
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0378 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0634 0.1777
Giardia lamblia Heat shock protein HSP 90-alpha 0.0071 0.0809 0.3675
Loa Loa (eye worm) doublecortin family protein 0.0021 0.014 0.0305
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0344 0.0752
Brugia malayi hypothetical protein 0.0257 0.333 0.7267
Trypanosoma cruzi heat shock protein, putative 0.0029 0.0245 0.3005
Echinococcus granulosus caspase 0.0216 0.2772 0.2772
Schistosoma mansoni heat shock protein 0.0071 0.0809 0.0807
Schistosoma mansoni cpg binding protein 0.0031 0.0275 0.0274
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.0809 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.003 0.0253 0.0251
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0634 0.1777
Trypanosoma brucei heat shock protein 84, putative 0.0029 0.0245 0.3005
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.0634 0.189
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0039 0.0378 0.0826
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0004
Brugia malayi Probable DNA topoisomerase II 0.0014 0.0048 0.0101
Echinococcus multilocularis heat shock protein 0.0071 0.0809 0.0809
Trypanosoma brucei Heat shock protein 83, putative 0.0071 0.0809 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0056 0.0614 1
Schistosoma mansoni survival motor neuron protein 0.0052 0.0562 0.0561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0301 0.03
Trichomonas vaginalis heat shock protein, putative 0.0056 0.0614 0.1718
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0045 0.0045
Echinococcus multilocularis dna polymerase eta 0.0049 0.0512 0.0512
Onchocerca volvulus Peroxidase homolog 0.0039 0.0378 0.1127
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0378 0.1127
Giardia lamblia Rab geranylgeranyltransferase 0.0167 0.2119 1
Loa Loa (eye worm) heat shock protein 90 0.0071 0.0809 0.1766
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0333 0.4095
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0316 0.3885
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0002 0.0002
Echinococcus granulosus NDR protein kinase 0.0017 0.0086 0.0086
Giardia lamblia DINP protein human, muc B family 0.0021 0.0137 0.043
Echinococcus granulosus protein kinase c epsilon type 0.0017 0.0086 0.0086
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0002 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0634 0.1777
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0002 0.0004
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0086 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0043 0.0441 0.1191
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0086 0.0084
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.2923 0.6379
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.025 0.0541
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0086 0.0678
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0043 0.0441 0.0441
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0002 0.0002
Leishmania major metacaspase, putative 0.0058 0.0634 0.5158
Onchocerca volvulus Dual oxidase homolog 0.0039 0.0378 0.1127
Trypanosoma brucei heat shock protein, putative 0.0071 0.0809 1
Echinococcus multilocularis transmembrane protease serine 3 0.0019 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0233
Leishmania major DNA polymerase kappa, putative 0.0021 0.0137 0.1099
Giardia lamblia Grp94/Hsp90 0.0056 0.0614 0.2735
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.0441 0.5432
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0167 0.2119 0.628
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0104
Entamoeba histolytica hypothetical protein 0.0039 0.0382 0.1614
Brugia malayi hypothetical protein 0.0021 0.014 0.0301
Loa Loa (eye worm) hypothetical protein 0.0096 0.1149 0.2508
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0002 0.0002
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0019 0.0107 0.0229
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0014 0.0048 0.0101
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0086 0.0086
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0086 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0233
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0167 0.2119 0.2119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0233
Loa Loa (eye worm) hypothetical protein 0.0021 0.014 0.0305
Trypanosoma brucei metacaspase 5, putative 0.0058 0.0634 0.7826
Echinococcus multilocularis lamin 0.0029 0.025 0.025
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0002 0.0002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0002 0.0002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0107 0.0105
Plasmodium falciparum metacaspase-like protein 0.0058 0.0634 0.2829
Echinococcus granulosus tumor protein p63 0.0367 0.4822 0.4822
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0104
Echinococcus multilocularis serine threonine protein kinase 0.0017 0.0086 0.0086
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0019 0.0107 0.0107
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0378 0.1127
Echinococcus granulosus dnaJ subfamily B 0.0444 0.5867 0.5867
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0002 0.0002
Schistosoma mansoni lamin 0.0029 0.025 0.0248
Loa Loa (eye worm) hypothetical protein 0.003 0.0253 0.0553
Brugia malayi Trypsin family protein 0.0019 0.0107 0.0229
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0086 0.0084
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.0048 0.0562
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0137 0.1667
Brugia malayi heat shock protein 90 0.0071 0.0809 0.1762
Entamoeba histolytica protein kinase, putative 0.0017 0.0086 0.0185
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.014 0.014
Leishmania major heat shock protein 83-1 0.0071 0.0809 0.659
Brugia malayi Pre-SET motif family protein 0.0033 0.0301 0.0654
Leishmania major DNA polymerase eta, putative 0.0034 0.0316 0.256
Schistosoma mansoni caspase-7 (C14 family) 0.0216 0.2772 0.2771
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0765 0.0763
Loa Loa (eye worm) endoplasmin 0.0071 0.0809 0.1766
Echinococcus multilocularis Mastin 0.0019 0.0107 0.0107
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0167 0.2119 0.4624
Trypanosoma cruzi heat shock protein 90, putative 0.0056 0.0614 0.7586
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.0048 0.5

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 5 % Antiinflammatory activity against reverse passive Arthus reaction-synovitis in rat at dose of 50 mg/kg per orally. ChEMBL. 2496230
Inhibition (functional) = 34 % Prophylactic antiinflammatory activity against adjuvant arthritic rat at dose of 25 mg/kg in noninjected 1 degree paw . ChEMBL. 2496230
Inhibition (functional) = 46 % Prophylactic antiinflammatory activity against adjuvant arthritic rat at dose of 50 mg/kg in noninjected 1 degree paw . ChEMBL. 2496230
Inhibition (functional) = 49 % Prophylactic antiinflammatory activity against adjuvant arthritic rat at dose of 25 mg/kg in noninjected 2 degree paw . ChEMBL. 2496230
Inhibition (functional) = 63 % Prophylactic antiinflammatory activity against adjuvant arthritic rat at dose of 50 mg/kg in noninjected 2 degree paw . ChEMBL. 2496230

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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