Detailed information for compound 1353592

Basic information

Technical information
  • TDR Targets ID: 1353592
  • Name: MLS000770154
  • MW: 407.386 | Formula: C20H20F3N3O3
  • H donors: 0 H acceptors: 3 LogP: 2.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)COc1cccc(c1)C(=O)C
  • InChi: 1S/C20H20F3N3O3/c1-14(27)15-3-2-4-17(11-15)29-13-19(28)26-9-7-25(8-10-26)18-6-5-16(12-24-18)20(21,22)23/h2-6,11-12H,7-10,13H2,1H3
  • InChiKey: PCQWIJAFZTWDHF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • SMR000343635
  • T5308671

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens insulin-degrading enzyme Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis ENSANGP00000016000 Get druggable targets OG5_126910 All targets in OG5_126910
Cryptosporidium parvum peptidaseinsulinase-like peptidase Get druggable targets OG5_126910 All targets in OG5_126910
Echinococcus multilocularis nardilysin Get druggable targets OG5_126910 All targets in OG5_126910
Brugia malayi insulin-degrading enzyme Get druggable targets OG5_126910 All targets in OG5_126910
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 Get druggable targets OG5_126910 All targets in OG5_126910
Toxoplasma gondii sporozoite developmental protein Get druggable targets OG5_126910 All targets in OG5_126910
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus 3'partial|nardilysin Get druggable targets OG5_126910 All targets in OG5_126910
Candida albicans likely protease similar to S. cerevisiae STE23 (YLR389C) involved in a-factor maturation Get druggable targets OG5_126910 All targets in OG5_126910
Neospora caninum M16 family peptidase, putative Get druggable targets OG5_126910 All targets in OG5_126910
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus nardilysin Get druggable targets OG5_126910 All targets in OG5_126910
Neospora caninum Peptidase M16 domain protein, related Get druggable targets OG5_126910 All targets in OG5_126910
Trypanosoma brucei peptidase, putative Get druggable targets OG5_126910 All targets in OG5_126910
Chlamydia trachomatis insulinase family protease III Get druggable targets OG5_126910 All targets in OG5_126910
Echinococcus multilocularis nardilysin Get druggable targets OG5_126910 All targets in OG5_126910
Schistosoma mansoni insulysin (M16 family) Get druggable targets OG5_126910 All targets in OG5_126910
Schistosoma mansoni nardilysin (M16 family) Get druggable targets OG5_126910 All targets in OG5_126910
Trypanosoma congolense peptidase, putative Get druggable targets OG5_126910 All targets in OG5_126910
Leishmania donovani phosphoglycan beta 1,3 galactosyltransferase 5 Get druggable targets OG5_126910 All targets in OG5_126910
Schistosoma mansoni insulysin unit 3 (M16 family) Get druggable targets OG5_126910 All targets in OG5_126910
Schistosoma mansoni nardilysin (M16 family) Get druggable targets OG5_126910 All targets in OG5_126910
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 Get druggable targets OG5_126910 All targets in OG5_126910
Leishmania infantum phosphoglycan beta 1,3 galactosyltransferase 5 Get druggable targets OG5_126910 All targets in OG5_126910
Schistosoma japonicum ko:K01408 insulysin [EC3.4.24.56], putative Get druggable targets OG5_126910 All targets in OG5_126910
Schistosoma mansoni insulysin unit 3 (M16 family) Get druggable targets OG5_126910 All targets in OG5_126910
Trypanosoma brucei gambiense peptidase, putative,metallo-peptidase, Clan ME, Family M16, putative Get druggable targets OG5_126910 All targets in OG5_126910
Schistosoma japonicum ko:K01408 insulysin [EC3.4.24.56], putative Get druggable targets OG5_126910 All targets in OG5_126910
Echinococcus multilocularis insulin degrading enzyme Get druggable targets OG5_126910 All targets in OG5_126910
Schistosoma japonicum ko:K01411 nardilysin [EC3.4.24.61], putative Get druggable targets OG5_126910 All targets in OG5_126910
Loa Loa (eye worm) insulin-degrading enzyme Get druggable targets OG5_126910 All targets in OG5_126910
Echinococcus multilocularis nardilysin Get druggable targets OG5_126910 All targets in OG5_126910
Toxoplasma gondii insulysin, putative Get druggable targets OG5_126910 All targets in OG5_126910
Cryptosporidium hominis involved in a-factor processing; Ste23p Get druggable targets OG5_126910 All targets in OG5_126910
Trypanosoma cruzi peptidase, putative Get druggable targets OG5_126910 All targets in OG5_126910
Cryptosporidium parvum peptidaseinsulinase-like peptidase Get druggable targets OG5_126910 All targets in OG5_126910
Candida albicans likely protease similar to S. cerevisiae STE23 (YLR389C) involved in a-factor maturation Get druggable targets OG5_126910 All targets in OG5_126910
Trypanosoma cruzi peptidase, putative Get druggable targets OG5_126910 All targets in OG5_126910
Toxoplasma gondii peptidase M16 inactive domain-containing protein Get druggable targets OG5_126910 All targets in OG5_126910
Echinococcus granulosus insulin degrading enzyme Get druggable targets OG5_126910 All targets in OG5_126910
Leishmania braziliensis phosphoglycan beta 1,3 galactosyltransferase 5 Get druggable targets OG5_126910 All targets in OG5_126910
Trypanosoma congolense peptidase, putative Get druggable targets OG5_126910 All targets in OG5_126910
Leishmania braziliensis phosphoglycan beta 1,3 galactosyltransferase 5 Get druggable targets OG5_126910 All targets in OG5_126910
Leishmania mexicana peptidase, putative,metallo-peptidase, Clan ME, Family M16 Get druggable targets OG5_126910 All targets in OG5_126910
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.041 0.0704
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.128 0.219
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0081 0.2682 0.4266
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0432 0.0534
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.128 0.127
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0081 0.2682 0.4266
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.041 0.1529
Loa Loa (eye worm) hypothetical protein 0.0011 0.0185 0.0175
Schistosoma mansoni hypothetical protein 0.0036 0.1089 0.1722
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.3922 0.8844
Echinococcus multilocularis insulin degrading enzyme 0.0081 0.2682 0.2673
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3411 1
Echinococcus granulosus 3'partial|nardilysin 0.0081 0.2682 0.2673
Echinococcus multilocularis nibrin 0.0011 0.0183 0.0172
Onchocerca volvulus 0.002 0.0514 0.0614
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0193 0.0182
Schistosoma mansoni smad1 5 8 and 0.0009 0.0118 0.017
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0193 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.4381 1
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.128 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0264 0.057
Brugia malayi topoisomerase 0.0011 0.0183 0.0172
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0044 0.1374 0.1364
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0432 0.0534
Echinococcus granulosus survival motor neuron protein 1 0.0286 1 1
Loa Loa (eye worm) matrixin family protein 0.002 0.0514 0.0503
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0266 0.0256
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.041 0.0704
Echinococcus multilocularis smad 0.0009 0.0118 0.0107
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0193 0.0182
Brugia malayi hypothetical protein 0.0017 0.0428 0.0418
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.128 0.3398
Schistosoma mansoni DNA helicase recq1 0.0011 0.0185 0.0278
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.3922 0.8906
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0193 0.029
Loa Loa (eye worm) hypothetical protein 0.002 0.0514 0.0503
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0723 0.1674
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.041 0.0637
Giardia lamblia DNA damage repair protein 0.0013 0.0264 0.0252
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0118 0.0107
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0024 0.0668 0.0657
Brugia malayi isocitrate dehydrogenase 0.0017 0.041 0.0399
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0432 0.1613
Schistosoma mansoni insulysin (M16 family) 0.0045 0.1405 0.2227
Leishmania major DNA polymerase kappa, putative 0.0041 0.128 0.3227
Trypanosoma brucei unspecified product 0.0028 0.0823 0.1982
Schistosoma mansoni survival motor neuron protein 0.0058 0.1886 0.2995
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.3922 0.8844
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0769 0.1815
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.1611 0.3025
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1886 0.1877
Brugia malayi polk-prov protein 0.0013 0.0264 0.0254
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0723 0.0713
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.041 0.0463
Trypanosoma brucei peptidase, putative 0.0081 0.2682 0.7741
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3411 1
Schistosoma mansoni hypothetical protein 0.0036 0.1089 0.1722
Echinococcus granulosus dna polymerase eta 0.0068 0.2252 0.2243
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.1089 0.1079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.128 0.3398
Echinococcus multilocularis geminin 0.0181 0.6272 0.6268
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.128 0.127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.1089 0.1079
Brugia malayi Smad1 0.0009 0.0118 0.0107
Schistosoma mansoni topbp1 0.0011 0.0183 0.0275
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.3922 0.8844
Loa Loa (eye worm) hypothetical protein 0.0011 0.0183 0.0172
Trypanosoma brucei polo-like protein kinase 0.0101 0.3411 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0432 0.0673
Loa Loa (eye worm) matrixin family protein 0.0044 0.1374 0.1364
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0432 0.1747
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0193 0.0182
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0427 0.1706
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0118 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0432 0.0773
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0182
Loa Loa (eye worm) hypothetical protein 0.0286 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0193 0.0182
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0193 0.029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0193 0.0182
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0185 0.0175
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0432 0.0056
Schistosoma mansoni nardilysin (M16 family) 0.0081 0.2682 0.4266
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.128 0.127
Schistosoma mansoni hypothetical protein 0.0181 0.6272 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.041 0.1529
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0432 0.1747
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.128 0.3398
Onchocerca volvulus Matrilysin homolog 0.002 0.0514 0.0614
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.1089 0.1079
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0264 0.0252
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.3411 0.3404
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.041 0.159
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0193 0.029
Schistosoma mansoni nardilysin (M16 family) 0.0081 0.2682 0.4266
Mycobacterium leprae PROBABLE HYDROLASE 0.0024 0.0668 0.1154
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0185 0.0175
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.128 0.3398
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0264 0.0252
Plasmodium falciparum glutathione reductase 0.0018 0.0432 0.1747
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0419 0.1563
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0193 0.0182
Echinococcus multilocularis Smad4 0.0009 0.0118 0.0107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.1089 0.1079
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0432 0.0422
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0264 0.0252
Schistosoma mansoni hypothetical protein 0.0036 0.1089 0.1722
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0432 0.0773
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0044 0.1374 0.1364
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0118 0.0107
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0185 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0193 0.0182
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0432 0.0773
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0193 0.0182
Toxoplasma gondii insulysin, putative 0.0077 0.254 0.9473
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0193 0.0182
Plasmodium vivax glutathione reductase, putative 0.0051 0.1611 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.3411 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0118 0.017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0823 0.1982
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0432 0.0773
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.3922 0.8844
Brugia malayi hypothetical protein 0.0027 0.0769 0.0759
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.3411 0.3404
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0264 0.0252
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0769 0.1815
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0193 0.0182
Brugia malayi Thioredoxin reductase 0.0051 0.1611 0.1602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0193 0.0182
Loa Loa (eye worm) insulin-degrading enzyme 0.0081 0.2682 0.2673
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.3411 0.3404
Plasmodium falciparum glutathione reductase 0.0051 0.1611 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.128 0.3398
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0193 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0193 0.0182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1552 0.1543
Schistosoma mansoni DNA polymerase eta 0.0068 0.2252 0.3579
Schistosoma mansoni smad1 5 8 and 0.0009 0.0118 0.017
Giardia lamblia DINP protein human, muc B family 0.0041 0.128 0.3398
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0183 0.0536
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0432 0.0773
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.128 0.2027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0432 0.0773
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0193 0.0182
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.1611 0.1602
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0193 0.0182
Loa Loa (eye worm) hypothetical protein 0.002 0.0514 0.0503
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.002 0.0514 0.0803
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.3411 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.3411 1
Brugia malayi MH2 domain containing protein 0.0009 0.0118 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0193 0.0182
Echinococcus granulosus bloom syndrome protein 0.0026 0.0723 0.0713
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0193 0.0182
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0432 0.0422
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0193 0.029
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0183 0.0172
Brugia malayi hypothetical protein 0.0162 0.5572 0.5567
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0723 0.1674
Schistosoma mansoni kinase 0.0051 0.1639 0.26
Schistosoma mansoni hypothetical protein 0.0078 0.2576 0.4097
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0297 0.0352
Loa Loa (eye worm) hypothetical protein 0.0011 0.0183 0.0172
Loa Loa (eye worm) hypothetical protein 0.0068 0.2252 0.2243
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1552 0.1543
Echinococcus granulosus 5'partial|nardilysin 0.0036 0.1084 0.1074
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0769 0.1815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0193 0.0182
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0432 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0193 0.0182
Brugia malayi insulin-degrading enzyme 0.0081 0.2682 0.2673
Loa Loa (eye worm) hypothetical protein 0.0129 0.4417 0.4411
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0193 0.0182
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0118 0.0107
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0432 0.1613
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0193 0.029
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.041 0.0399
Toxoplasma gondii peptidase M16 inactive domain-containing protein 0.0049 0.1547 0.5768
Loa Loa (eye worm) hypothetical protein 0.0024 0.0668 0.0657
Loa Loa (eye worm) hypothetical protein 0.002 0.0514 0.0503
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0432 0.0534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1552 0.1543
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0193 0.0182
Trypanosoma brucei unspecified product 0.0041 0.128 0.3398
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0193 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Loa Loa (eye worm) hypothetical protein 0.0027 0.0769 0.0759
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0264 0.0252
Schistosoma mansoni hypothetical protein 0.0036 0.1089 0.1722
Loa Loa (eye worm) hypothetical protein 0.0113 0.3858 0.3851
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.041 0.0704
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0612 0.3004
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.3411 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.3411 0.3404
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0769 0.4103
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0264 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0823 0.1982
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0264 0.0986
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0185 0.0175
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0185 0.0175
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.1611 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0432 0.2275
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.2252 0.6409
Schistosoma mansoni hypothetical protein 0.0181 0.6272 1
Brugia malayi nuclear hormone receptor 0.0011 0.0193 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0193 0.0182
Schistosoma mansoni hypothetical protein 0.0058 0.1886 0.2995
Chlamydia trachomatis insulinase family protease III 0.0081 0.2682 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0769 0.4103
Echinococcus multilocularis nardilysin 0.0081 0.2682 0.2673
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0432 0.0422
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0183 0.0682
Trypanosoma cruzi peptidase, putative 0.0081 0.2682 0.7741
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0432 0.2275
Echinococcus multilocularis dna polymerase eta 0.0068 0.2252 0.2243
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.128 0.3752
Brugia malayi Matrixin family protein 0.002 0.0514 0.0503
Toxoplasma gondii toxolysin TLN4 0.0036 0.1084 0.4041
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0432 0.0534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0432 0.0773
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.041 0.0399
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.2576 0.2568
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.041 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0193 0.0182
Entamoeba histolytica hypothetical protein 0.0011 0.0183 0.0536
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0183 0.0275
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.1236 0.461
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.1611 0.4425
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0185 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3411 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0193 0.0182
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.1611 0.1602
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1552 0.1543
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0193 0.0182
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0193 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0264 0.0252
Schistosoma mansoni family M16 unassigned peptidase (M16 family) 0.0032 0.0942 0.1487
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3411 1
Treponema pallidum NADH oxidase 0.0018 0.0432 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.128 0.127
Onchocerca volvulus Matrix metalloproteinase homolog 0.0044 0.1374 0.221
Echinococcus multilocularis nardilysin 0.0049 0.1547 0.1537
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0432 0.0773
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.3411 0.543
Brugia malayi Matrixin family protein 0.002 0.0514 0.0503
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3411 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1552 0.1543
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.1611 0.1602
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0239 0.0228
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0432 0.1747
Brugia malayi Matrixin family protein 0.002 0.0514 0.0503
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.3858 0.3851
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.4362 0.4356
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0185 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0823 0.1982
Loa Loa (eye worm) Smad1 0.0009 0.0118 0.0107
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.041 0.0399
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0432 0.2275
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0024 0.0668 0.0648
Schistosoma mansoni smad 0.0009 0.0118 0.017
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.128 0.3398
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0432 0.1747
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1552 0.1543
Schistosoma mansoni topbp1 0.0011 0.0183 0.0275
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.128 0.3398
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.3922 0.8844
Trypanosoma brucei trypanothione reductase 0.0051 0.1611 0.4425
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0193 0.0182
Loa Loa (eye worm) matrix metalloproteinase 0.002 0.0514 0.0503
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0185 0.0017
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.2252 0.6409
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0239 0.0228
Brugia malayi hypothetical protein 0.0011 0.0183 0.0172
Schistosoma mansoni smad1 5 8 and 0.0009 0.0118 0.017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.3858 0.3851
Giardia lamblia Kinase, PLK 0.0101 0.3411 1
Trichomonas vaginalis CAMK family protein kinase 0.005 0.1591 0.4363
Leishmania major DNA polymerase eta, putative 0.004 0.1236 0.3088
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0193 0.0182
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.1089 0.1079
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0193 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1552 0.2462
Echinococcus granulosus insulin degrading enzyme 0.0081 0.2682 0.2673
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.128 0.3398
Echinococcus granulosus geminin 0.0181 0.6272 0.6268
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.128 0.3398
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0182
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0193 0.029
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0432 0.0773
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0769 0.4103
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.128 0.219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0193 0.0182
Brugia malayi MH2 domain containing protein 0.0128 0.4362 0.4356
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0118 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0264 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0193 0.0182
Brugia malayi nuclear receptor NHR-88 0.0011 0.0193 0.0182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0182
Brugia malayi steroid hormone receptor 0.0011 0.0193 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0193 0.0182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0183 0.0172
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0264 0.0252
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0297 0.0869
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.2252 0.2243
Toxoplasma gondii thioredoxin reductase 0.0051 0.1611 0.6008
Plasmodium falciparum thioredoxin reductase 0.0018 0.0432 0.1747
Loa Loa (eye worm) hypothetical protein 0.0078 0.2576 0.2568
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1552 0.2462
Onchocerca volvulus Matrilysin homolog 0.0044 0.1374 0.221
Brugia malayi Matrixin family protein 0.002 0.0514 0.0503
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0264 0.057
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3411 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0182
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0193 0.0182
Toxoplasma gondii sporozoite developmental protein 0.0081 0.2682 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0264 0.0252
Brugia malayi Isocitrate dehydrogenase 0.0017 0.041 0.0399
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0432 0.0773
Loa Loa (eye worm) hypothetical protein 0.0011 0.0193 0.0182
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0264 0.0986
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0193 0.029
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0264 0.0405
Brugia malayi hypothetical protein 0.0011 0.0183 0.0172
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0193 0.0182
Brugia malayi Latrophilin receptor protein 2 0.0036 0.1089 0.1079
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0185 0.0691
Schistosoma mansoni Smad4 0.0009 0.0118 0.017
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0432 0.0999
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0193 0.0182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0183 0.0172
Brugia malayi glutathione reductase 0.0051 0.1611 0.1602
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.128 0.3227
Echinococcus granulosus nardilysin 0.0081 0.2682 0.2673
Loa Loa (eye worm) hypothetical protein 0.0013 0.0264 0.0254
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0432 0.0773
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.4381 1
Echinococcus granulosus Smad4 0.0009 0.0118 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0193 0.0182
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.128 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.041 0.0399
Echinococcus multilocularis survival motor neuron protein 1 0.0286 1 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0297 0.0102
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.1089 0.1079
Echinococcus multilocularis nardilysin 0.0081 0.2682 0.2673
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.041 0.0399
Trypanosoma cruzi peptidase, putative 0.0081 0.2682 0.7741
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0266 0.0256
Loa Loa (eye worm) hypothetical protein 0.0036 0.1089 0.1079
Loa Loa (eye worm) hypothetical protein 0.0162 0.5572 0.5567
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0193 0.029
Echinococcus granulosus nibrin 0.0011 0.0183 0.0172
Trichomonas vaginalis CAMK family protein kinase 0.005 0.1591 0.4363
Loa Loa (eye worm) hypothetical protein 0.0011 0.0183 0.0172
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0297 0.0352
Echinococcus granulosus smad 0.0009 0.0118 0.0107
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0769 0.2867
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0081 0.2682 0.7682
Schistosoma mansoni hypothetical protein 0.0012 0.0239 0.0364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0193 0.0182
Onchocerca volvulus 0.0058 0.1886 0.3161
Loa Loa (eye worm) RecQ helicase 0.0026 0.0723 0.0713
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0723 0.0713
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0297 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0193 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0432 0.0773
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0118 0.0107
Schistosoma mansoni DNA helicase recq5 0.0011 0.0185 0.0278
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0183 0.0682
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0264 0.0252
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0183 0.0172
Mycobacterium ulcerans hydrolase 0.0024 0.0668 0.4418
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0193 0.029
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.053 0.083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1552 0.2462
Brugia malayi MH2 domain containing protein 0.0009 0.0118 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0432 0.0773
Leishmania major hypothetical protein, conserved 0.0027 0.0769 0.1604
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0432 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.4381 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.041 0.0399
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0185 0.0691
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.041 0.0399
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0193 0.0182
Brugia malayi MH1 domain containing protein 0.0009 0.0118 0.0107
Plasmodium falciparum thioredoxin reductase 0.0051 0.1611 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.3858 0.3851
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0193 0.0182
Brugia malayi ecdysteroid receptor 0.0011 0.0193 0.0182
Brugia malayi Matrixin family protein 0.002 0.0514 0.0503
Schistosoma mansoni DNA ligase IV 0.0011 0.0183 0.0275
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.1236 0.3263
Echinococcus granulosus dna polymerase kappa 0.0041 0.128 0.127
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0185 0.0175
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.128 0.2027
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.041 0.159
Toxoplasma gondii hypothetical protein 0.0032 0.0942 0.3514
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.4381 1
Mycobacterium ulcerans hypothetical protein 0.0013 0.0264 0.0742
Loa Loa (eye worm) hypothetical protein 0.0011 0.0183 0.0172
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0193 0.0182
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0432 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0193 0.0182
Onchocerca volvulus 0.0162 0.5572 1
Brugia malayi DKFZp564C0469 protein 0.0011 0.0183 0.0172
Onchocerca volvulus 0.0011 0.0193 0.0019
Schistosoma mansoni coup transcription factor 0.0011 0.0193 0.029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0432 0.0773
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0432 1
Mycobacterium tuberculosis Probable reductase 0.0115 0.3922 0.8844
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0193 0.0182
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0183 0.0172
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0193 0.029
Trypanosoma brucei unspecified product 0.0028 0.0823 0.1982
Leishmania major trypanothione reductase 0.0051 0.1611 0.428
Leishmania major DNA polymerase eta, putative 0.0068 0.2252 0.6316
Brugia malayi MH1 domain containing protein 0.0009 0.0118 0.0107
Onchocerca volvulus 0.0011 0.0198 0.0027
Loa Loa (eye worm) glutathione reductase 0.0051 0.1611 0.1602
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0081 0.2682 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.128 0.3398
Echinococcus granulosus GPCR family 2 0.0036 0.1089 0.1079
Echinococcus multilocularis dna polymerase kappa 0.0041 0.128 0.127
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.4362 0.4356
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0193 0.029
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0193 0.0182
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.3411 0.599
Echinococcus multilocularis GPCR, family 2 0.0036 0.1089 0.1079
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3411 1
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0183 0.0172

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 19.156 um PUBCHEM_BIOASSAY: Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE). (Class of assay: confirmatory) [Related pubchem assays: 434962 (Primary screen (IDE inhibitors in singlicate)), 449730 (Counterscreen (Cytotoxicity in triplicate)), 435028 (Confirmation (IDE inhibitors in triplicate)), 434984 (Summary (IDE inhibitors))] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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