TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.418 | Formula: C22H18N6O
H donors: 2 H acceptors: 4 LogP: 3.67 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1nc(oc1c1ccc2c(c1)c(ncn2)NCc1ncc[nH]1)c1ccccc1
InChi: 1S/C22H18N6O/c1-14-20(29-22(28-14)15-5-3-2-4-6-15)16-7-8-18-17(11-16)21(27-13-26-18)25-12-19-23-9-10-24-19/h2-11,13H,12H2,1H3,(H,23,24)(H,25,26,27)
InChiKey: SSONSSSFMAFGAP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	Starlite/ChEMBL	No references
Homo sapiens	CDC-like kinase 4	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Cryptosporidium parvum	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	CMGC/CLK protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium vivax	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania mexicana		Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Giardia lamblia	Kinase, CMGC CLK	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase minibrain, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Neospora caninum	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium berghei	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126990	All targets in OG5_126990
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei	kinetoplastid kinetochore protein 19	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus granulosus	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Theileria parva	serine/threonine protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus multilocularis	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase Doa, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium falciparum	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Babesia bovis	protein serine/threonine kinase 1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	kinetoplastid kinetochore protein 10	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium knowlesi	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	ko:K08823 CDC-like kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania donovani	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Cryptosporidium hominis	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis		Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium yoelii	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	oxidoreductase	0.0005	0.0007	0.0007
Loa Loa (eye worm)	oxidoreductase	0.0005	0.0007	0.0007
Onchocerca volvulus		0.0005	0.0007	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0108	0.3815	1
Echinococcus granulosus	Smad4	0.0008	0.0132	0.0328
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0074	0.2539	0.6649
Onchocerca volvulus		0.0005	0.0007	0.5
Entamoeba histolytica	protein kinase, putative	0.0108	0.3815	1
Brugia malayi	Protein kinase domain containing protein	0.0074	0.2539	0.2539
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0005	0.0007	0.5
Brugia malayi	hypothetical protein	0.0005	0.0007	0.0007
Onchocerca volvulus		0.0005	0.0007	0.5
Brugia malayi	MH1 domain containing protein	0.0008	0.0132	0.0132
Brugia malayi	Dehydrogenases, short chain protein 2	0.0005	0.0007	0.0007
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0005	0.0007	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0074	0.2539	0.6649
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Mycobacterium leprae	Probable oxidoreductase	0.0005	0.0007	0.5
Loa Loa (eye worm)	dehydrogenase	0.0005	0.0007	0.0007
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0132	0.0328
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0074	0.2539	0.2539
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Loa Loa (eye worm)	oxidoreductase	0.0005	0.0007	0.0007
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0108	0.3815	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Brugia malayi	oxidoreductase	0.0005	0.0007	0.0007
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0005	0.0007	0.0007
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0108	0.3815	1
Echinococcus multilocularis		0.0072	0.2498	0.6542
Onchocerca volvulus		0.0005	0.0007	0.5
Brugia malayi	dehydrogenases, short chain protein 9	0.0005	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Plasmodium falciparum	protein serine/threonine kinase-1	0.0074	0.2539	1
Onchocerca volvulus		0.0005	0.0007	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Brugia malayi	MH1 domain containing protein	0.0008	0.0132	0.0132
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0132	0.0328
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0069	0.2354	0.2354
Echinococcus granulosus	dual specificity	0.0108	0.3815	1
Onchocerca volvulus		0.0005	0.0007	0.5
Onchocerca volvulus		0.0005	0.0007	0.5
Entamoeba histolytica	hypothetical protein	0.0108	0.3815	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0132	0.0132
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0005	0.0007	0.5
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0005	0.0007	0.0007
Loa Loa (eye worm)	oxidoreductase	0.0005	0.0007	0.0007
Onchocerca volvulus		0.0005	0.0007	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Echinococcus granulosus	hypothetical protein	0.0072	0.2498	0.6542
Brugia malayi	Dehydrogenases, short chain protein 30	0.0005	0.0007	0.0007
Brugia malayi	MH2 domain containing protein	0.0008	0.0132	0.0132
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0005	0.0007	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Loa Loa (eye worm)	oxidoreductase	0.0005	0.0007	0.0007
Brugia malayi	Retinol dehydrogenase 12	0.0005	0.0007	0.0007
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Onchocerca volvulus		0.0005	0.0007	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.2539	1
Brugia malayi	dehydrogenases, short chain protein 2	0.0005	0.0007	0.0007
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0064	0.2185	0.2185
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Echinococcus multilocularis	dual specificity	0.0108	0.3815	1
Brugia malayi	hypothetical protein	0.0005	0.0007	0.0007
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0074	0.2539	0.6649
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0005	0.0007	0.5
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0132	0.0328
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0132	0.0328
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0005	0.0007	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0074	0.2539	0.6649
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Loa Loa (eye worm)	Smad1	0.0008	0.0132	0.0132
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Loa Loa (eye worm)	oxidoreductase	0.0005	0.0007	0.0007
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.2354	1
Onchocerca volvulus		0.0005	0.0007	0.5
Onchocerca volvulus		0.0005	0.0007	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Leishmania major	protein kinase, putative	0.0074	0.2539	0.6649
Onchocerca volvulus		0.0005	0.0007	0.5
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0132	0.0328
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0277	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2498	0.2498
Echinococcus multilocularis	smad	0.0008	0.0132	0.0328
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0005	0.0007	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.2539	0.6649
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.2354	0.6164
Plasmodium vivax	serine/threonine kinase-1, putative	0.0074	0.2539	1
Brugia malayi	MH2 domain containing protein	0.0008	0.0132	0.0132
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0132	0.0132
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0069	0.2354	1
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0074	0.2539	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0069	0.2354	0.6164
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3774	0.3774
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0132	0.0328
Schistosoma mansoni	Smad4	0.0008	0.0132	0.0328
Echinococcus granulosus	smad	0.0008	0.0132	0.0328
Echinococcus multilocularis	Smad4	0.0008	0.0132	0.0328
Loa Loa (eye worm)	oxidoreductase	0.0005	0.0007	0.0007
Loa Loa (eye worm)	dehydrogenase	0.0005	0.0007	0.0007
Schistosoma mansoni	serine/threonine protein kinase	0.0108	0.3815	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0005	0.0007	0.0007
Schistosoma mansoni	smad	0.0008	0.0132	0.0328
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.2539	0.6649
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0005	0.0007	0.5
Loa Loa (eye worm)	oxidoreductase	0.0005	0.0007	0.0007
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0108	0.3815	1
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0074	0.2539	0.6649
Loa Loa (eye worm)	hypothetical protein	0.0107	0.3774	0.3774
Onchocerca volvulus		0.0005	0.0007	0.5
Echinococcus granulosus	dual specificity protein kinase clk2	0.0074	0.2539	0.6649
Onchocerca volvulus	Sepiapterin reductase homolog	0.0005	0.0007	0.5
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.2354	0.6164
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Brugia malayi	Smad1	0.0008	0.0132	0.0132
Leishmania major	protein kinase, putative	0.0074	0.2539	0.6649
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.4159	0.4159
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0074	0.2539	0.6649
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0074	0.2539	0.6649
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0005	0.0007	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.2354	1
Giardia lamblia	Kinase, CMGC CLK	0.0074	0.2539	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0069	0.2354	0.6164
Entamoeba histolytica	protein kinase, putative	0.0108	0.3815	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0132	0.0328
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0108	0.3815	0.3815
Loa Loa (eye worm)	oxidoreductase	0.0005	0.0007	0.0007
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0108	0.3815	0.3815
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0108	0.3815	1
Brugia malayi	MH2 domain containing protein	0.0118	0.4159	0.4159
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.4159	0.4159
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0132	0.0328
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0005	0.0007	0.0007

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.4631 uM	PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1379, AID1770, AID1983, AID1997, AID2710, AID488872, AID488883, AID488887, AID493206, AID504421, AID504424, AID504427, AID504428, AID504429, AID504430]	ChEMBL.	No reference
Potency (functional)	3.6751 uM	PUBCHEM_BIOASSAY: Assay for Inhibitors of Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (Kinase-Glo assay). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1770, AID1997, AID488872, AID488883, AID488887, AID493206]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1476977

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1357023