Detailed information for compound 1358809

Basic information

Technical information
  • TDR Targets ID: 1358809
  • Name: 3,5,6,8-tetrahydroxy-1-methyl-9,10-dioxo-7-[( 2R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2- yl]oxyanthracene-2-carboxylic acid
  • MW: 508.386 | Formula: C22H20O14
  • H donors: 9 H acceptors: 12 LogP: 0.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCC1O[C@H](Oc2c(O)c3c(c(c2O)O)C(=O)c2c(C3=O)c(C)c(c(c2)O)C(=O)O)C(C(C1O)O)O
  • InChi: 1S/C22H20O14/c1-4-8-5(2-6(24)9(4)21(33)34)12(25)10-11(14(8)27)16(29)20(18(31)15(10)28)36-22-19(32)17(30)13(26)7(3-23)35-22/h2,7,13,17,19,22-24,26,28-32H,3H2,1H3,(H,33,34)/t7?,13?,17?,19?,22-/m1/s1
  • InChiKey: FTZKEIWUUDUSNG-LEZIZJMNSA-N  


Substructure search Similarity search

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Synonyms

  • 3,5,6,8-tetrahydroxy-1-methyl-9,10-dioxo-7-[(2R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-anthracene-2-carboxylic acid
  • 3,5,6,8-tetrahydroxy-1-methyl-9,10-dioxo-7-[[(2R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-2-anthracenecarboxylic acid
  • 3,5,6,8-tetrahydroxy-9,10-diketo-1-methyl-7-[(2R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-anthracene-2-carboxylic acid
  • 3,5,6,8-tetrahydroxy-1-methyl-9,10-dioxo-7-[(2R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-anthracene-2-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photuris pennsylvanica Luciferase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferase   552 aa 559 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferase   552 aa 461 aa 26.0 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Leishmania mexicana long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative Luciferase   552 aa 472 aa 21.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferase   552 aa 505 aa 22.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferase   552 aa 514 aa 23.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferase   552 aa 473 aa 24.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferase   552 aa 460 aa 24.6 %
Onchocerca volvulus Luciferase   552 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 515 aa 21.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferase   552 aa 446 aa 22.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferase   552 aa 510 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferase   552 aa 442 aa 21.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferase   552 aa 491 aa 25.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferase   552 aa 613 aa 20.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferase   552 aa 492 aa 25.2 %
Schistosoma mansoni long-chain-fatty-acid--CoA ligase Luciferase   552 aa 526 aa 22.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferase   552 aa 464 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferase   552 aa 525 aa 22.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferase   552 aa 508 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 546 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 473 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 470 aa 25.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferase   552 aa 473 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 486 aa 24.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferase   552 aa 445 aa 20.9 %
Brugia malayi AMP-binding enzyme family protein Luciferase   552 aa 492 aa 24.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferase   552 aa 605 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 540 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 480 aa 21.7 %
Onchocerca volvulus Luciferase   552 aa 553 aa 24.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferase   552 aa 485 aa 23.7 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferase   552 aa 476 aa 25.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferase   552 aa 501 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferase   552 aa 467 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 531 aa 22.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 581 aa 21.3 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferase   552 aa 580 aa 21.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferase   552 aa 554 aa 21.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferase   552 aa 478 aa 22.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferase   552 aa 474 aa 24.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 448 aa 23.0 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferase   552 aa 476 aa 24.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 486 aa 25.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferase   552 aa 514 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferase   552 aa 550 aa 24.9 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 530 aa 21.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferase   552 aa 525 aa 22.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 451 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 546 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferase   552 aa 518 aa 26.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferase   552 aa 541 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 530 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 496 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferase   552 aa 483 aa 21.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferase   552 aa 491 aa 23.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferase   552 aa 500 aa 23.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferase   552 aa 533 aa 21.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 472 aa 24.4 %
Babesia bovis acetyl-CoA synthetase, putative Luciferase   552 aa 545 aa 21.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferase   552 aa 510 aa 23.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferase   552 aa 486 aa 25.9 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 557 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 530 aa 22.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferase   552 aa 470 aa 24.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferase   552 aa 536 aa 23.1 %
Toxoplasma gondii propionate-CoA ligase Luciferase   552 aa 503 aa 21.7 %
Giardia lamblia Long chain fatty acid CoA ligase 5 Luciferase   552 aa 491 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 481 aa 20.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferase   552 aa 459 aa 25.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferase   552 aa 480 aa 24.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferase   552 aa 468 aa 20.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferase   552 aa 537 aa 20.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferase   552 aa 531 aa 24.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferase   552 aa 480 aa 21.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferase   552 aa 445 aa 22.2 %
Plasmodium vivax long-chain fatty acid CoA ligase, putative Luciferase   552 aa 453 aa 24.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferase   552 aa 478 aa 24.1 %
Theileria parva acetyl-coenzyme A synthetase, putative Luciferase   552 aa 580 aa 22.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferase   552 aa 493 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferase   552 aa 476 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferase   552 aa 509 aa 22.0 %
Cryptosporidium hominis acyl-CoA synthetase Luciferase   552 aa 460 aa 25.0 %
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) Luciferase   552 aa 512 aa 22.7 %
Onchocerca volvulus Luciferase   552 aa 487 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 529 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferase   552 aa 570 aa 21.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferase   552 aa 570 aa 21.6 %
Neospora caninum hypothetical protein Luciferase   552 aa 529 aa 22.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferase   552 aa 476 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 588 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 481 aa 25.6 %
Brugia malayi AMP-binding enzyme family protein Luciferase   552 aa 482 aa 24.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferase   552 aa 523 aa 25.0 %
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative Luciferase   552 aa 544 aa 21.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferase   552 aa 470 aa 23.4 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferase   552 aa 503 aa 22.3 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 557 aa 21.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferase   552 aa 481 aa 23.7 %
Mycobacterium tuberculosis Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 483 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 458 aa 22.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferase   552 aa 546 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferase   552 aa 467 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferase   552 aa 446 aa 22.4 %
Onchocerca volvulus Matrilysin homolog Luciferase   552 aa 499 aa 22.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferase   552 aa 492 aa 25.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 516 aa 26.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0744 0.2692
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0082 0.0082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.02 0.0874
Echinococcus granulosus eukaryotic initiation factor 4A 0.0221 0.2542 0.2542
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0221 0.2542 0.2542
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0112 0.0058
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.02 0.0874
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0716 0.0716
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0082 0.0323
Brugia malayi AMP-binding enzyme family protein 0.0029 0.02 0.0787
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0221 0.2542 1
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0413 0.0413
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0822 0.0822
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.415 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0221 0.2542 1
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0082 0.0082
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1951 0.7582
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0822 0.3147
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.415 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0082 0.0198
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0082 0.0082
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0082 0.0082
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0601 0.2265
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0082 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.415 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0822 0.3147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.415 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.044
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0221 0.2542 1
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0082 0.0082
Plasmodium vivax RNA helicase-1, putative 0.0221 0.2542 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.02 0.0787
Echinococcus granulosus phd:f box containing protein 0.0019 0.0082 0.0082
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0112 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0744 0.3711
Brugia malayi jmjC domain containing protein 0.0019 0.0082 0.0323
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0323
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0221 0.2542 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0822 0.0822
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.02 0.0419
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0221 0.2542 0.5471
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.415 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0601 0.2265
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0744 0.3711
Brugia malayi Cytochrome P450 family protein 0.0015 0.0032 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.02 0.0874
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0744 0.2837
Brugia malayi MAP kinase sur-1 0.0062 0.0601 0.2363
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0082 0.0082
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0716 0.0716
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1951 1
Brugia malayi jmjC domain containing protein 0.0019 0.0082 0.0323
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0082 0.0082
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0413 0.0413
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0082 0.0082
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0221 0.2542 0.2542
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.02 0.0668
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1951 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0601 0.2108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.044
Brugia malayi eukaryotic initiation factor 4A 0.0221 0.2542 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0221 0.2542 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0082 0.0323
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0822 0.3147
Brugia malayi jmjC domain containing protein 0.0071 0.0716 0.2818
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0601 0.2265
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0601 0.2363
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0221 0.2542 0.5471
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.02 0.0874
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0032 0.0127
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0716 0.0716
Brugia malayi Cytochrome P450 family protein 0.0015 0.0032 0.0127
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0716 0.0716
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0221 0.2542 0.2542
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0082 0.0198
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0744 0.0744
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0744 0.3711
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.044
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0221 0.2542 0.5471
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0112 0.0121
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.02 0.0874
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0822 0.1575
Brugia malayi jmjC domain containing protein 0.0019 0.0082 0.0323
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0221 0.2542 0.5471
Brugia malayi jmjC domain containing protein 0.0019 0.0082 0.0323
Onchocerca volvulus 0.0029 0.02 0.0787
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0112 0.0121
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0082 0.0082
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0082 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0029 0.02 0.0787
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0716 0.0716
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0601 0.0601
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0601 0.0601
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0716 0.0716
Trypanosoma brucei protein kinase, putative 0.0062 0.0601 0.2265
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.415 1
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0221 0.2542 0.2542
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0744 0.2645
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0082 0.0082
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0601 0.2265
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0082 0.0323
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0221 0.2542 0.593
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0822 0.3147
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.044
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0221 0.2542 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.02 0.0419
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0029 0.02 0.0787
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0082 0.0082
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0601 0.0601
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.415 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0822 0.3234
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0601 0.2265
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.415 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0601 0.2265
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0032 0.0127
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0744 0.0744
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0082 0.0082
Leishmania major hypothetical protein, conserved 0.0019 0.0082 0.0198
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0112 0.0415
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.02 0.0874
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0032 0.0127
Brugia malayi AMP-binding enzyme family protein 0.0029 0.02 0.0787
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0323
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0822 0.0822
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0221 0.2542 0.2542
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.415 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0716 0.2818
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.02 0.0874
Brugia malayi jmjC domain containing protein 0.0071 0.0716 0.2818
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.02 0.0668
Mycobacterium ulcerans hypothetical protein 0.0029 0.02 0.0874
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0082 0.0198
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0716 0.0716
Leishmania major eukaryotic initiation factor 4a, putative 0.0221 0.2542 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.0221 0.2542 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.02 0.0787
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.02 0.0668
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.044
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0601 0.2265
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.415 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0822 0.3234
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0221 0.2542 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.415 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0082 0.0323
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0744 0.0744
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0221 0.2542 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.415 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0063 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Counterscreen for Luciferase (Kinase-Glo TM) Inhibition. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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