Detailed information for compound 1362682

Basic information

Technical information
  • TDR Targets ID: 1362682
  • Name: 2-[2-(5,6-dihydrobenzo[b][1]benzazepin-11-yl) -2-oxoethyl]sulfanyl-N-(4-methylphenyl)acetam ide
  • MW: 416.535 | Formula: C25H24N2O2S
  • H donors: 1 H acceptors: 2 LogP: 5.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)C)CSCC(=O)N1c2ccccc2CCc2c1cccc2
  • InChi: 1S/C25H24N2O2S/c1-18-10-14-21(15-11-18)26-24(28)16-30-17-25(29)27-22-8-4-2-6-19(22)12-13-20-7-3-5-9-23(20)27/h2-11,14-15H,12-13,16-17H2,1H3,(H,26,28)
  • InChiKey: RKKLFLVKOIQFNF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-oxo-ethyl]sulfanyl-N-(4-methylphenyl)acetamide
  • 2-[[2-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-oxoethyl]thio]-N-(4-methylphenyl)acetamide
  • 2-[[2-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-keto-ethyl]thio]-N-(4-methylphenyl)acetamide
  • 2-[2-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-oxo-ethyl]sulfanyl-N-(4-methylphenyl)ethanamide
  • MLS000582836
  • STK210239
  • 2-{[2-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-2-oxoethyl]thio}-N-(4-methylphenyl)acetamide
  • SMR000201541
  • ZINC01068639

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog Get druggable targets OG5_129328 All targets in OG5_129328
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0763 0.4449
Loa Loa (eye worm) acetyltransferase 0.0175 0.0865 0.0861
Echinococcus multilocularis Immunoglobulin 0.0089 0.028 0.0584
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0072 0.0166 0.0162
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.1074 0.6337
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.016 0.0763 0.0759
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0054 0.0047 0.0083
Schistosoma mansoni tyrosine kinase 0.0051 0.0028 0.0042
Echinococcus granulosus cyclin dependent kinase 1 0.016 0.0763 0.0996
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0104 0.0387 0.2266
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.015 0.0698 0.4128
Trypanosoma brucei cdc2-related kinase 3 0.016 0.0763 0.4516
Schistosoma mansoni hypothetical protein 0.0054 0.0047 0.0083
Trypanosoma cruzi cdc2-related kinase 1 0.016 0.0763 0.4516
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0177 0.1007
Trypanosoma brucei protein kinase, putative 0.0176 0.0874 0.5179
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0581 0.3607 0.4752
Echinococcus granulosus Protein kinase C brain isozyme 0.0059 0.0077 0.009
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0277 0.1553 1
Giardia lamblia Kinase, CDC7 0.0206 0.1074 0.6401
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0149 0.0685 0.1457
Echinococcus granulosus protein kinase shaggy 0.0176 0.0874 0.1142
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0277 0.1553 0.9247
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0735 0.4651 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0059 0.0077 0.0073
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0051 0.0028 0.0042
Schistosoma mansoni nephrin 0.0102 0.037 0.0777
Brugia malayi Protein kinase domain containing protein 0.0199 0.1027 0.1002
Echinococcus granulosus epidermal growth factor receptor 0.0518 0.3183 0.4192
Brugia malayi p70 ribosomal S6 kinase beta 0.0139 0.0621 0.0595
Schistosoma mansoni tyrosine kinase 0.0447 0.2704 0.5806
Schistosoma mansoni tyrosine kinase 0.0324 0.1875 0.402
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0208 0.1084 0.142
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0072 0.0166 0.0208
Brugia malayi Furin-like cysteine rich region family protein 0.0518 0.3183 0.3164
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0059 0.0077 0.0147
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0059 0.0077 0.0073
Echinococcus multilocularis tyrosine protein kinase Abl 0.0051 0.0028 0.0042
Echinococcus multilocularis nervana 2 0.008 0.0225 0.0466
Schistosoma mansoni tyrosine kinase 0.0051 0.0028 0.0042
Schistosoma mansoni cell adhesion molecule 0.0106 0.0394 0.0831
Echinococcus granulosus protein kinase c iota type 0.0059 0.0077 0.009
Giardia lamblia Kinase, CMGC GSK 0.0176 0.0874 0.5204
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.015 0.0698 0.1485
Loa Loa (eye worm) hypothetical protein 0.0054 0.0047 0.0043
Entamoeba histolytica protein kinase, putative 0.0176 0.0874 0.2421
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0054 0.0047 0.0232
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0054 0.0047 0.0051
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0176 0.0874 0.5601
Schistosoma mansoni atypical protein kinase C 0.0059 0.0077 0.0147
Echinococcus multilocularis dual specificity protein kinase clk2 0.0277 0.1553 0.3326
Schistosoma mansoni tyrosine kinase 0.0051 0.0028 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0077 0.0147
Echinococcus multilocularis serine:threonine protein kinase N2 0.0059 0.0077 0.0147
Schistosoma mansoni serine/threonine protein kinase 0.015 0.0698 0.1485
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0295 0.1679 0.3597
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0051 0.0028 0.0042
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0072 0.0166 0.0208
Trichomonas vaginalis CAMK family protein kinase 0.0127 0.0539 0.3093
Onchocerca volvulus 0.0485 0.296 0.6325
Brugia malayi Temporarily assigned gene name protein 59 0.0054 0.0047 0.0019
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.091 0.5836 0.5834
Brugia malayi Protein kinase domain containing protein 0.0059 0.0077 0.0049
Plasmodium falciparum protein kinase, putative 0.0048 0.0009 0.0056
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0059 0.0077 0.009
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0059 0.0077 0.009
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0865 0.1843
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0051 0.0028 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0077 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0077 0.0147
Echinococcus multilocularis 0.0259 0.1434 0.3071
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.015 0.0698 0.091
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0051 0.0028 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.109 0.6431
Echinococcus multilocularis c src tyrosine kinase 0.0051 0.0028 0.0042
Brugia malayi serine/threonine-protein kinase plk-2 0.0295 0.1679 0.1655
Loa Loa (eye worm) hypothetical protein 0.0214 0.1129 0.1126
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.008 0.0225 0.0285
Schistosoma mansoni rap gtpase-activating protein 0.0054 0.0047 0.0083
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0072 0.0166 0.0339
Onchocerca volvulus 0.0176 0.0874 0.1794
Onchocerca volvulus Tyrosine kinase homolog 0.041 0.2453 0.5224
Echinococcus granulosus roundabout 2 0.0119 0.0484 0.0628
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0089 0.028 0.0584
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0051 0.0028 0.0042
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0355 0.2085 0.2741
Echinococcus granulosus nervana 2 0.008 0.0225 0.0285
Giardia lamblia Kinase, AGC PKA 0.0098 0.0343 0.2046
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0098 0.0343 0.2005
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.015 0.0698 0.4464
Loa Loa (eye worm) hypothetical protein 0.0106 0.0394 0.0391
Loa Loa (eye worm) AGC/PKA protein kinase 0.015 0.0698 0.0694
Echinococcus granulosus serine/threonine protein kinase 0.0104 0.0387 0.05
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0177 0.1088
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0051 0.0028 0.0042
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.015 0.0698 0.4128
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0077 0.0147
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0133 0.0579 0.0754
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0177 0.0362
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.015 0.0698 0.4128
Brugia malayi Hr1 repeat family protein 0.0059 0.0077 0.0049
Brugia malayi probable protein kinase 0.0201 0.1039 0.1014
Echinococcus multilocularis epidermal growth factor receptor 0.0518 0.3183 0.6838
Schistosoma mansoni serine/threonine protein kinase 0.0502 0.3078 0.6611
Schistosoma mansoni serine/threonine kinase 0.0059 0.0077 0.0147
Brugia malayi hypothetical protein 0.0054 0.0047 0.0019
Entamoeba histolytica protein kinase, putative 0.0145 0.0665 0.1842
Loa Loa (eye worm) SRC-1 0.0051 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0089 0.028 0.0276
Echinococcus multilocularis protein kinase c iota type 0.0059 0.0077 0.0147
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0665 0.3853
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0029 0.0131
Giardia lamblia Kinase, AGC PKA 0.015 0.0698 0.4158
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0183 0.092 0.1204
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.016 0.0763 0.0759
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0263 0.146 0.3126
Echinococcus multilocularis protein kinase c epsilon type 0.0059 0.0077 0.0147
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0177 0.0222
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0059 0.0077 0.009
Echinococcus granulosus c src tyrosine kinase 0.0051 0.0028 0.0026
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.015 0.0698 0.4128
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.1074 0.2295
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0177 0.5
Schistosoma mansoni tyrosine kinase 0.0324 0.1875 0.402
Schistosoma mansoni serine/threonine protein kinase 0.0581 0.3607 0.7751
Entamoeba histolytica PH domain containing protein kinase, putative 0.0157 0.0742 0.2056
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0077 0.0291
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0054 0.0047 0.0083
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0133 0.0579 0.1229
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.016 0.0763 0.0996
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0059 0.0077 0.0073
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.015 0.0698 0.091
Brugia malayi Protein kinase domain containing protein 0.016 0.0763 0.0737
Brugia malayi Protein kinase domain containing protein 0.0072 0.0166 0.0138
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0277 0.1553 0.9247
Entamoeba histolytica PH domain containing protein kinase, putative 0.0104 0.0387 0.1073
Echinococcus granulosus rho-associated protein kinase 1 0.0502 0.3078 0.4053
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1679 1
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0665 0.3853
Plasmodium falciparum protein kinase 5 0.016 0.0763 0.4912
Loa Loa (eye worm) hypothetical protein 0.0089 0.028 0.0276
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0295 0.1679 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0051 0.0028 0.0042
Echinococcus granulosus serine:threonine protein kinase N2 0.0059 0.0077 0.009
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0581 0.3607 0.7751
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0059 0.0077 0.0073
Onchocerca volvulus 0.0206 0.1074 0.223
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.015 0.0698 0.4128
Echinococcus granulosus protein kinase 0.0147 0.0672 0.0876
Entamoeba histolytica PH domain containing protein kinase, putative 0.0157 0.0742 0.2056
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0874 0.512
Schistosoma mansoni vesicular amine transporter 0.0094 0.0319 0.0669
Schistosoma mansoni tyrosine kinase 0.0518 0.3183 0.6838
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.015 0.0698 0.1485
Loa Loa (eye worm) hypothetical protein 0.0119 0.0484 0.048
Plasmodium falciparum glycogen synthase kinase 3 0.0176 0.0874 0.5625
Brugia malayi Protein kinase domain containing protein 0.091 0.5836 0.5824
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.0009 0.0024
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0072 0.0166 0.0208
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0735 0.4651 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0518 0.3183 0.3181
Schistosoma mansoni tyrosine kinase 0.0355 0.2085 0.4471
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0098 0.0343 0.2064
Loa Loa (eye worm) TK protein kinase 0.0276 0.155 0.1546
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0447 0.2704 0.3559
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.1074 0.6337
Trypanosoma cruzi cdc2-related kinase 3 0.016 0.0763 0.4516
Echinococcus multilocularis nervana 2 0.008 0.0225 0.0466
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.3457 0.4553
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0214 0.1128 0.1125
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0051 0.0028 0.0042
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0072 0.0166 0.0339
Echinococcus granulosus tyrosine protein kinase Lyn 0.0069 0.0147 0.0182
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0098 0.0343 0.0442
Leishmania major protein kinase, putative 0.0277 0.1553 0.9247
Schistosoma mansoni tyrosine kinase 0.0355 0.2085 0.4471
Echinococcus granulosus cyclin dependent kinase 5 0.016 0.0763 0.0996
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0295 0.1679 0.2205
Trypanosoma cruzi cdc2-related kinase 1 0.016 0.0763 0.4516
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0277 0.1553 0.9247
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0865 0.1843
Onchocerca volvulus 0.0206 0.1074 0.223
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0072 0.0166 0.0339
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0177 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0208 0.1084 0.2317
Echinococcus granulosus defective proboscis extension response 0.0089 0.028 0.0358
Echinococcus multilocularis roundabout 2 0.0119 0.0484 0.1024
Brugia malayi Protein kinase domain containing protein 0.0277 0.1553 0.1529
Loa Loa (eye worm) hypothetical protein 0.0168 0.0818 0.0814
Giardia lamblia Kinase, CMGC CDK 0.016 0.0763 0.4544
Schistosoma mansoni tyrosine kinase 0.0447 0.2704 0.5806
Loa Loa (eye worm) AGC/NDR protein kinase 0.0059 0.0077 0.0073
Echinococcus multilocularis neuroglian 0.0102 0.037 0.0777
Echinococcus multilocularis cyclin dependent kinase 0.016 0.0763 0.1624
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0177 0.0362
Plasmodium vivax protein kinase Crk2 0.016 0.0763 0.4815
Echinococcus granulosus epidermal growth factor receptor 0.0355 0.2085 0.2741
Echinococcus granulosus twitchin 0.0119 0.0488 0.0633
Echinococcus multilocularis cyclin dependent kinase 1 0.016 0.0763 0.1624
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0735 0.4651 0.613
Plasmodium falciparum protein serine/threonine kinase-1 0.0277 0.1553 1
Leishmania major protein kinase, putative 0.0277 0.1553 0.9247
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.015 0.0698 0.439
Echinococcus granulosus neuropeptide s receptor 0.0558 0.3457 0.4553
Loa Loa (eye worm) hypothetical protein 0.0089 0.028 0.0276
Echinococcus multilocularis 0.0149 0.0688 0.1464
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0665 0.3853
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1679 1
Schistosoma mansoni vam6/vps39 related 0.0054 0.0047 0.0083
Brugia malayi Protein kinase domain containing protein 0.0214 0.1128 0.1103
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0166 0.0339
Brugia malayi cell division control protein 2 homolog 0.016 0.0763 0.0737
Echinococcus granulosus nervana 2 0.008 0.0225 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0665 0.3853
Echinococcus granulosus tyrosine protein kinase Fyn 0.0051 0.0028 0.0026
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.1129 0.1104
Echinococcus multilocularis protein kinase shaggy 0.0176 0.0874 0.1863
Echinococcus granulosus serine threonine protein kinase nrc 0.0098 0.0343 0.0442
Brugia malayi protein kinase C II. 0.0059 0.0077 0.0049
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0089 0.028 0.0584
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1679 1
Toxoplasma gondii AGC kinase 0.015 0.0698 0.4464
Echinococcus multilocularis CDC7 cell division cycle 7 0.0206 0.1074 0.2295
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.028 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0127 0.0539 0.3093
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0831 0.1086
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0865 0.0839
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0581 0.3607 0.3605
Loa Loa (eye worm) hypothetical protein 0.0183 0.092 0.0917
Trypanosoma brucei polo-like protein kinase 0.0295 0.1679 1
Echinococcus granulosus Vam6:Vps39 protein 0.0054 0.0047 0.0051
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.015 0.0698 0.091
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0447 0.2704 0.5806
Brugia malayi Protein kinase domain containing protein 0.0447 0.2704 0.2684
Loa Loa (eye worm) hypothetical protein 0.0089 0.028 0.0276
Schistosoma mansoni serine/threonine protein kinase 0.0735 0.4651 1
Echinococcus granulosus neuroglian 0.0102 0.037 0.0477
Schistosoma mansoni tyrosine kinase 0.0051 0.0028 0.0042
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0277 0.1553 0.9247
Echinococcus multilocularis epidermal growth factor receptor 0.0355 0.2085 0.4471
Trypanosoma cruzi Protein kinase B 0.0104 0.0387 0.2266
Brugia malayi Immunoglobulin I-set domain containing protein 0.0276 0.155 0.1526
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1679 1
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0665 0.3853
Entamoeba histolytica cell division protein kinase 2, putative 0.016 0.0763 0.2115
Echinococcus granulosus protein kinase C gamma type 0.0059 0.0077 0.009
Loa Loa (eye worm) hypothetical protein 0.015 0.0698 0.0694
Echinococcus granulosus hypothetical protein 0.0259 0.1434 0.1882
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0147 0.0672 0.0669
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0077 0.0147
Loa Loa (eye worm) hypothetical protein 0.0089 0.028 0.0276
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.1074 0.6337
Onchocerca volvulus Serine\/threonine kinase homolog 0.0295 0.1679 0.3543
Loa Loa (eye worm) hypothetical protein 0.0054 0.0047 0.0043
Entamoeba histolytica protein kinase, putative 0.0139 0.0621 0.1721
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0176 0.0874 0.1863
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.3457 0.7428
Entamoeba histolytica protein kinase domain containing protein 0.0176 0.0874 0.2421
Entamoeba histolytica serine/threonine protein kinase, putative 0.0295 0.1679 0.4653
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0176 0.0874 0.087
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0735 0.4651 0.4649
Echinococcus granulosus cyclin dependent kinase 0.016 0.0763 0.0996
Echinococcus multilocularis 0.0147 0.0672 0.1429
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0177 0.5
Schistosoma mansoni tyrosine kinase 0.0263 0.146 0.3126
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0029 0.0131
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0176 0.0874 0.1863
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0735 0.4651 0.4649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.016 0.0763 0.0759
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0089 0.028 0.0584
Schistosoma mansoni tyrosine kinase 0.0061 0.0095 0.0185
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.008 0.0225 0.0466
Echinococcus multilocularis serine:threonine protein kinase 38 0.0059 0.0077 0.0147
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0665 0.3853
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1679 1
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0149 0.0685 0.0893
Trypanosoma cruzi cdc2-related kinase 3 0.016 0.0763 0.4516
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0735 0.4651 0.4636
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0077 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0763 0.1624
Trypanosoma brucei rac serine-threonine kinase, putative 0.0145 0.0665 0.3927
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0763 0.4449
Echinococcus granulosus protein kinase c epsilon type 0.0059 0.0077 0.009
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0176 0.0874 0.087
Loa Loa (eye worm) hypothetical protein 0.0119 0.0484 0.048
Brugia malayi Protein kinase domain containing protein 0.0145 0.0665 0.0638
Loa Loa (eye worm) AGC/PKN protein kinase 0.0059 0.0077 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1679 1
Echinococcus multilocularis Glutaredoxin protein 5 0.008 0.0225 0.0466
Schistosoma mansoni serine/threonine protein kinase 0.015 0.0698 0.1485
Entamoeba histolytica protein kinase domain containing protein 0.0581 0.3607 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.016 0.0763 0.4884
Schistosoma mansoni protein kinase 0.0147 0.0672 0.1429
Trichomonas vaginalis CMGC family protein kinase 0.0277 0.1553 0.9238
Echinococcus granulosus tyrosine protein kinase Fyn 0.0051 0.0028 0.0026
Giardia lamblia Kinase, PLK 0.0295 0.1679 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0644 0.064
Schistosoma mansoni tyrosine kinase 0.0324 0.1875 0.402
Loa Loa (eye worm) hypothetical protein 0.0054 0.0047 0.0043
Entamoeba histolytica cell division protein kinase 2, putative 0.016 0.0763 0.2115
Echinococcus multilocularis rho associated protein kinase 0.0502 0.3078 0.6611
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0176 0.0874 0.5179
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0051 0.0028 0.0042
Toxoplasma gondii AGC kinase 0.015 0.0698 0.4464
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0077 0.0147
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0263 0.146 0.3126
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0121 0.0555
Brugia malayi Protein kinase domain containing protein 0.0308 0.1763 0.174
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0166 0.0339
Echinococcus multilocularis Immunoglobulin 0.0089 0.028 0.0584
Brugia malayi Protein kinase domain containing protein 0.0735 0.4651 0.4636
Entamoeba histolytica protein kinase, putative 0.0059 0.0077 0.0213
Schistosoma mansoni protein kinase 0.0072 0.0166 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.0277 0.1553 0.3326
Loa Loa (eye worm) hypothetical protein 0.0244 0.1329 0.1326
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0054 0.0047 0.0232
Entamoeba histolytica PH domain containing protein kinase, putative 0.0104 0.0387 0.1073
Loa Loa (eye worm) AGC/PKA protein kinase 0.015 0.0698 0.0694
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0077 0.0147
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0098 0.0343 0.0721
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0177 0.5
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0763 0.1624
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0502 0.3076 0.3073
Echinococcus multilocularis serine:threonine protein kinase N2 0.0059 0.0077 0.0147
Schistosoma mansoni serine/threonine protein kinase 0.0295 0.1679 0.3597
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0139 0.0621 0.0617
Echinococcus granulosus Glutaredoxin protein 5 0.008 0.0225 0.0285
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0059 0.0077 0.0147
Echinococcus granulosus fibroblast growth factor receptor 4 0.0263 0.146 0.1916
Loa Loa (eye worm) AGC/AKT protein kinase 0.0145 0.0665 0.0661
Echinococcus granulosus dual specificity protein kinase clk2 0.0277 0.1553 0.2039
Entamoeba histolytica protein kinase, putative 0.0145 0.0665 0.1842
Echinococcus granulosus tyrosine protein kinase Src42A 0.0051 0.0028 0.0026
Brugia malayi hypothetical protein 0.0089 0.028 0.0252
Echinococcus granulosus CDC7 cell division cycle 7 0.0206 0.1074 0.1407
Loa Loa (eye worm) CDC7 protein kinase 0.0206 0.1074 0.1071
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0077 0.0147
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.015 0.0698 0.4128
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0098 0.0343 0.2212
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0295 0.1679 0.1675
Leishmania major protein kinase A catalytic subunit isoform 1 0.015 0.0698 0.4128
Loa Loa (eye worm) hypothetical protein 0.0259 0.1434 0.1431
Plasmodium vivax serine/threonine kinase-1, putative 0.0277 0.1553 1
Onchocerca volvulus 0.0366 0.2153 0.4574
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0263 0.146 0.1916
Trypanosoma cruzi polo-like protein kinase, putative 0.0295 0.1679 1
Echinococcus multilocularis insulin receptor 0.0447 0.2704 0.5806
Schistosoma mansoni kinase 0.0317 0.1825 0.3911
Trypanosoma brucei cdc2-related kinase 1 0.016 0.0763 0.4516
Echinococcus granulosus insulin receptor 0.0447 0.2704 0.3559
Schistosoma mansoni serine/threonine-protein kinase 0.0104 0.0387 0.0815
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0277 0.1553 0.9247
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.015 0.0698 0.1485
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.015 0.0698 0.1485
Leishmania major protein kinase A catalytic subunit 0.015 0.0698 0.4128
Echinococcus multilocularis rac serine:threonine kinase 0.0104 0.0387 0.0815
Brugia malayi Protein kinase domain containing protein 0.0059 0.0077 0.0049
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0277 0.1553 0.9247
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0059 0.0077 0.0147
Echinococcus multilocularis cyclin dependent kinase 1 0.016 0.0763 0.1624
Echinococcus multilocularis cyclin dependent kinase 5 0.016 0.0763 0.1624
Loa Loa (eye worm) TK/ALK protein kinase 0.0308 0.1763 0.1759
Onchocerca volvulus 0.0502 0.3078 0.6583
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0581 0.3607 0.3589
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1679 1
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.1128 0.2411
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0029 0.0027
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.015 0.0698 0.4128
Schistosoma mansoni serine/threonine-protein kinase 0.0104 0.0387 0.0815
Loa Loa (eye worm) hypothetical protein 0.0059 0.0077 0.0073
Loa Loa (eye worm) TK/INSR protein kinase 0.0447 0.2704 0.2701
Brugia malayi Protein kinase domain containing protein 0.0206 0.1074 0.1049
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.016 0.0763 0.4516
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.015 0.0698 0.4495
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0051 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0089 0.028 0.0276
Schistosoma mansoni protein kinase 0.0201 0.1039 0.2219
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0176 0.0874 0.1142
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0665 0.3853
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0763 0.4449
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.016 0.0763 0.4516
Leishmania major protein kinase A catalytic subunit isoform 2 0.015 0.0698 0.4128
Schistosoma mansoni serine/threonine protein kinase 0.0277 0.1553 0.3326
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0277 0.1553 0.1549
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1526 1 1
Echinococcus granulosus Immunoglobulin 0.0089 0.028 0.0358
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0059 0.0077 0.0147
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1168 0.7582 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0051 0.0028 0.0026
Echinococcus multilocularis serine threonine protein kinase 0.0059 0.0077 0.0147
Entamoeba histolytica protein kinase domain containing protein 0.0176 0.0874 0.2421
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0106 0.0394 0.0509
Plasmodium vivax glycogen synthase kinase 3, putative 0.0176 0.0874 0.5542
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0176 0.0874 0.5179
Echinococcus granulosus tyrosine protein kinase Src64B 0.0051 0.0028 0.0026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.028 0.0252
Echinococcus granulosus tyrosine protein kinase Fyn 0.0051 0.0028 0.0026
Toxoplasma gondii AGC kinase 0.0139 0.0621 0.3965
Entamoeba histolytica protein kinase 2, putative 0.0098 0.0343 0.0952
Giardia lamblia Kinase, CMGC CDK 0.016 0.0763 0.4544
Giardia lamblia Kinase, CMGC GSK 0.0176 0.0874 0.5204
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0054 0.0047 0.0083
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0051 0.0028 0.0042
Schistosoma mansoni tyrosine kinase 0.0196 0.1006 0.2149
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.0874 0.512
Brugia malayi intracellular kinase 0.0176 0.0874 0.0848
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.015 0.0698 0.0672
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.3457 0.7428
Giardia lamblia Kinase, CMGC CLK 0.0277 0.1553 0.9251
Trypanosoma cruzi polo-like protein kinase, putative 0.0295 0.1679 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0054 0.0047 0.0232
Trichomonas vaginalis AGC family protein kinase 0.015 0.0698 0.4055
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0177 0.0362
Brugia malayi Immunoglobulin I-set domain containing protein 0.0502 0.3076 0.3057
Schistosoma mansoni serine/threonine protein kinase 0.015 0.0698 0.1485
Echinococcus granulosus NDR protein kinase 0.0059 0.0077 0.009

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 4.65 uM PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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