Detailed information for compound 138049

Basic information

Technical information
  • TDR Targets ID: 138049
  • Name: 1,3-thiazolidine-2,4-dione
  • MW: 117.126 | Formula: C3H3NO2S
  • H donors: 1 H acceptors: 2 LogP: 0.07 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1SCC(=O)N1
  • InChi: 1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
  • InChiKey: ZOBPZXTWZATXDG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • thiazolidine-2,4-dione
  • thiazolidine-2,4-quinone
  • 2,4-thiazolidinedione
  • 2295-31-0
  • 39131-10-7
  • NSC6745
  • Thiazolidinedione
  • Thiazolidinedione-2,4
  • Usaf ek-5496
  • WLN: T5SVMV EHJ
  • AIDS-019667
  • EINECS 218-941-2
  • ZINC01083110
  • BRN 0110700
  • SBB000047
  • NSC 6745
  • 375004_ALDRICH
  • thiazolidinedione deriv. 21
  • 4-27-00-03144 (Beilstein Handbook Reference)
  • AIDS019667
  • AI3-61185
  • 2,4(3H,5H)-Thiazoledione
  • 2,4-Dioxothiazolidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Chromo domain 0.0023 0.0002 0.0002
Brugia malayi TAR-binding protein 0.0254 0.0226 0.3835
Brugia malayi CHD4 protein 0.0027 0.0006 0.0099
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0038
Onchocerca volvulus 0.0048 0.0026 0.0362
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0002 0.0118
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0006 0.0057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0618 0.0578 0.9816
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0036 0.0507
Loa Loa (eye worm) phosphofructokinase 0.0215 0.0189 0.3201
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.02 0.02
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0002 0.0038
Echinococcus multilocularis tumor protein p63 0.0329 0.0299 0.0299
Echinococcus granulosus geminin 0.0681 0.064 0.064
Entamoeba histolytica hypothetical protein 0.0078 0.0055 0.2913
Echinococcus multilocularis GPCR, family 2 0.0195 0.0169 0.0169
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.2919 0.2808 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0067 0.1019
Onchocerca volvulus 0.0062 0.004 0.0563
Echinococcus granulosus tumor protein p63 0.0329 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0038
Echinococcus multilocularis zinc finger protein 0.0038 0.0017 0.0017
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.0023 0.0023
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0036 0.5
Echinococcus granulosus chromobox protein 1 0.0141 0.0117 0.0117
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0067 1
Schistosoma mansoni hypothetical protein 0.0078 0.0055 0.0827
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0012 0.0012
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0002 0.0613
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0018 0.0018
Leishmania major ATP-dependent phosphofructokinase 0.0215 0.0189 1
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0189 0.2777
Echinococcus multilocularis thymidine phosphorylase 1.034 1 1
Schistosoma mansoni hypothetical protein 0.0195 0.0169 0.2618
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0002 0.033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0195 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0038
Echinococcus multilocularis SAM and MBT domain containing protein 0.0094 0.007 0.007
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0021 0.0854
Trichomonas vaginalis set domain proteins, putative 0.0716 0.0673 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.0189 0.3201
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0055 0.0055
Trichomonas vaginalis chromobox protein, putative 0.0141 0.0117 0.1706
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0021 0.0362
Schistosoma mansoni hypothetical protein 0.0195 0.0169 0.2618
Brugia malayi Pre-SET motif family protein 0.0629 0.0589 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0002 0.0002
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0048 0.0048
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0106 0.0083 0.1409
Echinococcus granulosus histone lysine methyltransferase setb 0.0124 0.01 0.01
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0048 0.0813
Schistosoma mansoni ran 0.0043 0.0021 0.03
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0036 0.0507
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0048 0.0048
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0094 0.007 0.1017
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2452 0.2356 0.2356
Loa Loa (eye worm) hypothetical protein 0.008 0.0057 0.0971
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0254 0.0226 0.3835
Brugia malayi beta-lactamase family protein 0.007 0.0048 0.0813
Echinococcus multilocularis chromobox protein 2 0.0023 0.0002 0.0002
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.0189 1
Plasmodium vivax hypothetical protein, conserved 0.007 0.0048 0.7131
Echinococcus multilocularis tar DNA binding protein 0.0254 0.0226 0.0226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.01 0.1527
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.0189 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0124 0.01 0.01
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0002 0.033
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0019 0.0323
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0021 0.0021
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0002 0.0038
Schistosoma mansoni hypothetical protein 0.0422 0.0389 0.6064
Loa Loa (eye worm) hypothetical protein 0.0195 0.0169 0.2872
Leishmania major importin beta-1 subunit, putative 0.0047 0.0026 0.1085
Schistosoma mansoni tar DNA-binding protein 0.0254 0.0226 0.3508
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0369 0.0337 0.0337
Trypanosoma cruzi ISWI complex protein 0.003 0.0009 0.0174
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0813
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0449 0.0415 0.0369
Echinococcus granulosus GPCR family 2 0.0195 0.0169 0.0169
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0018 0.5001
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0057 0.081
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0012 0.0012
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0036 1
Brugia malayi 6-phosphofructokinase 0.0215 0.0189 0.3201
Brugia malayi beta-lactamase family protein 0.007 0.0048 0.0813
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0002 0.033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.02 0.02
Brugia malayi Protein cec-1. 0.0023 0.0002 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.02 0.02
Echinococcus multilocularis chromobox protein 1 0.0141 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0813
Loa Loa (eye worm) hypothetical protein 0.0075 0.0053 0.0895
Brugia malayi Calcitonin receptor-like protein seb-1 0.0618 0.0578 0.9816
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0002 0.0002
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0036 0.5389
Loa Loa (eye worm) hypothetical protein 0.0422 0.0389 0.6602
Onchocerca volvulus 0.0716 0.0673 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0002 0.033
Onchocerca volvulus 0.0113 0.009 0.1302
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0117 0.0093 0.0093
Echinococcus granulosus 6 phosphofructokinase 0.0215 0.0189 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0254 0.0226 0.3508
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0048 0.0813
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0106 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.004 0.0018 0.0249
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0618 0.0578 0.9816
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0034 0.0476
Schistosoma mansoni hypothetical protein 0.0681 0.064 1
Schistosoma mansoni hypothetical protein 0.0195 0.0169 0.2618
Brugia malayi hypothetical protein 0.0036 0.0014 0.0244
Echinococcus multilocularis polycomb protein SCMH1 0.0094 0.007 0.007
Brugia malayi 6-phosphofructokinase 0.0215 0.0189 0.3201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.02 0.3102
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0629 0.0589 1
Brugia malayi Importin beta-1 subunit 0.0058 0.0036 0.0615
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.2919 0.2808 0.2774
Schistosoma mansoni zinc finger protein 0.0038 0.0017 0.0232
Mycobacterium ulcerans glutaminase 0.0273 0.0244 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0036 0.0507
Brugia malayi hypothetical protein 0.0023 0.0002 0.0038
Loa Loa (eye worm) hypothetical protein 0.0079 0.0057 0.096
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0048 0.0681
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0048 0.0717
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.02 0.3102
Entamoeba histolytica hypothetical protein 0.0078 0.0055 0.2913
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0038
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.0189 0.2923
Plasmodium vivax importin-beta 2, putative 0.0058 0.0036 0.5389
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0048 0.0681
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0036 0.5389
Brugia malayi phosphofructokinase 0.0215 0.0189 0.3201
Schistosoma mansoni hypothetical protein 0.0569 0.0531 0.8289
Brugia malayi hypothetical protein 0.0036 0.0014 0.0244
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0813
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0034 0.0476
Schistosoma mansoni importin beta-1 0.0058 0.0036 0.0533
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0036 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0215 0.0189 0.051
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0002 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0036 0.0507
Leishmania major GTP-binding protein, putative 0.0043 0.0021 0.0854
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0038
Echinococcus granulosus snurportin 1 0.0621 0.0582 0.0582
Onchocerca volvulus 0.0094 0.007 0.1017
Loa Loa (eye worm) hypothetical protein 0.0048 0.0026 0.045
Loa Loa (eye worm) hypothetical protein 0.0094 0.007 0.1196
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0036 0.0507
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0038
Loa Loa (eye worm) hypothetical protein 0.0618 0.0578 0.9816
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0215 0.0189 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0195 0.0169 0.0169
Brugia malayi hypothetical protein 0.0027 0.0006 0.0097
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0369 0.0337 0.0337
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0002 0.0118
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0018 0.2695
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0048 0.0048
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0006 0.0099
Loa Loa (eye worm) hypothetical protein 0.0062 0.004 0.0679
Schistosoma mansoni hypothetical protein 0.0621 0.0582 0.9091
Schistosoma mansoni chromobox protein 0.0141 0.0117 0.1796
Brugia malayi Latrophilin receptor protein 2 0.0195 0.0169 0.2872
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0093 0.1576
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.007 0.107
Echinococcus granulosus chromobox protein 1 0.0141 0.0117 0.0117
Brugia malayi Heterochromatin protein 1 0.0141 0.0117 0.1982
Leishmania major hypothetical protein, conserved 0.003 0.0009 0.0174
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0048 0.0717
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0036 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0813
Echinococcus multilocularis geminin 0.0681 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0124 0.01 0.1691
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.0104
Brugia malayi beta-lactamase 0.007 0.0048 0.0813
Loa Loa (eye worm) hypothetical protein 0.0058 0.0036 0.0615
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0195 0.0169 0.0169
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0023 0.0002 0.0118
Plasmodium falciparum importin beta, putative 0.0058 0.0036 0.9999
Loa Loa (eye worm) hypothetical protein 0.0139 0.0114 0.1938
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0021 0.5887
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0021 0.0362
Schistosoma mansoni glutaminase 0.0273 0.0244 0.3793
Echinococcus granulosus tar DNA binding protein 0.0254 0.0226 0.0226
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0021 0.3173
Echinococcus multilocularis chromobox protein 1 0.0141 0.0117 0.0117
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0002 0.033
Entamoeba histolytica hypothetical protein 0.0078 0.0055 0.2913
Loa Loa (eye worm) beta-lactamase 0.007 0.0048 0.0813
Onchocerca volvulus 0.007 0.0048 0.0681
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0036 0.0036
Brugia malayi hypothetical protein 0.0078 0.0055 0.0933
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.007 0.107
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0012 0.0157
Brugia malayi SET domain containing protein 0.0026 0.0005 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0048 0.0681
Loa Loa (eye worm) heterochromatin protein 1 0.0141 0.0117 0.1982
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0067 0.0067
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0055 0.0827
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0048 0.2308
Brugia malayi glutaminase DH11.1 0.0273 0.0244 0.4143
Loa Loa (eye worm) TAR-binding protein 0.0254 0.0226 0.3835
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0048 0.0681
Echinococcus granulosus polycomb protein SCMH1 0.0094 0.007 0.007
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0036 0.192
Echinococcus multilocularis 6 phosphofructokinase 0.0215 0.0189 0.0189
Entamoeba histolytica hypothetical protein 0.0078 0.0055 0.2913
Mycobacterium ulcerans thymidine phosphorylase 1.034 1 1
Trichomonas vaginalis chromobox protein, putative 0.0141 0.0117 0.1706
Echinococcus granulosus importin subunit beta 1 0.0058 0.0036 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0227 0.02 0.3396
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0021 0.0854
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.2919 0.2808 0.2774
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0036 0.5389
Brugia malayi Pre-SET motif family protein 0.009 0.0067 0.1141
Mycobacterium ulcerans 6-phosphofructokinase 0.0215 0.0189 0.0141
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0026 0.0348
Echinococcus granulosus Chromo domain 0.0023 0.0002 0.0002
Brugia malayi RNA, U transporter 1 0.0166 0.014 0.238
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0062 0.0897
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0013 0.0227
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0036 0.0507
Schistosoma mansoni tar DNA-binding protein 0.0254 0.0226 0.3508
Loa Loa (eye worm) glutaminase 0.0273 0.0244 0.4143
Schistosoma mansoni ran 0.0043 0.0021 0.03
Trichomonas vaginalis esterase, putative 0.007 0.0048 0.0681
Trypanosoma brucei ISWI complex protein 0.003 0.0009 0.0174
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.0189 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0307
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.0189 0.2923
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 1.034 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0002 0.0118
Entamoeba histolytica Ran family GTPase 0.0043 0.0021 0.1131
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0006 0.1576
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0189 0.2777
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0113 0.009 0.137
Echinococcus multilocularis histone acetyltransferase MYST2 0.0106 0.0083 0.0083
Onchocerca volvulus 0.0023 0.0002 0.000000054549
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0117 0.0093 0.0093
Brugia malayi chromobox protein homolog 3 0.0079 0.0057 0.096
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0018 0.0307
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0018 0.0307
Schistosoma mansoni hypothetical protein 0.0681 0.064 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.01 0.1527
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0813
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0002 0.0613
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0026 0.0381
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0026 0.1085
Trypanosoma cruzi ISWI complex protein 0.003 0.0009 0.0174
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0036 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0057 0.081
Schistosoma mansoni hypothetical protein 0.004 0.0019 0.0263
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.0062 0.0897
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0048 0.0681
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0189 0.2777
Brugia malayi RNA binding protein 0.0254 0.0226 0.3835
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0813
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0021 0.0854
Brugia malayi PHD-finger family protein 0.0049 0.0027 0.0461
Schistosoma mansoni chromobox protein 0.0141 0.0117 0.1796
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0048 0.0048
Onchocerca volvulus 0.007 0.0048 0.0681
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0036 0.1668
Plasmodium vivax SET domain protein, putative 0.009 0.0067 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0021 0.3173
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0018 0.2695
Echinococcus granulosus SAM and MBT domain containing protein 0.0094 0.007 0.007
Echinococcus granulosus chromobox protein 2 0.0023 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0048 0.2308
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.0189 0.3201
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0621 0.0582 0.9878
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0093 0.1576
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0106 0.0083 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0422 0.0389 0.6602
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0012 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0062 0.0897
Entamoeba histolytica hypothetical protein 0.0047 0.0026 0.1355
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0036 0.5389
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0215 0.0189 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.02 0.02
Schistosoma mansoni bromodomain containing protein 0.0124 0.01 0.1534
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0036 0.0507
Schistosoma mansoni zinc finger protein 0.003 0.0009 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0002 0.033
Loa Loa (eye worm) MBCTL1 0.0106 0.0083 0.1409
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0079 0.0057 0.081
Schistosoma mansoni tar DNA-binding protein 0.0254 0.0226 0.3508
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0002 0.0613
Schistosoma mansoni myelin transcription factor 1 myt1 0.0106 0.0083 0.1267
Onchocerca volvulus 0.007 0.0048 0.0681
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.0023 0.032
Trichomonas vaginalis glutaminase, putative 0.0273 0.0244 0.3604
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0021 0.0021
Echinococcus multilocularis snurportin 1 0.0621 0.0582 0.0582
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0002 0.0038
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0002 0.0118
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0036 0.5389
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0036 0.5389
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.0189 1
Loa Loa (eye worm) RNA binding protein 0.0254 0.0226 0.3835
Echinococcus granulosus Chromobox protein 3 0.0023 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0254 0.0226 0.3508
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.02 0.3102
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0006 0.0006
Echinococcus granulosus histone acetyltransferase MYST2 0.0106 0.0083 0.0083
Echinococcus granulosus zinc finger protein 0.0038 0.0017 0.0017
Trichomonas vaginalis ran, putative 0.0043 0.0021 0.0285
Loa Loa (eye worm) helicase 0.0023 0.0002 0.0038
Schistosoma mansoni hypothetical protein 0.0195 0.0169 0.2618
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0195 0.0169 0.2872
Brugia malayi mbt repeat family protein 0.0094 0.007 0.1196
Loa Loa (eye worm) hypothetical protein 0.0106 0.0083 0.1409
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0195 0.0169 0.0169
Brugia malayi Bromodomain containing protein 0.0075 0.0053 0.0893
Toxoplasma gondii ABC1 family protein 0.007 0.0048 0.7131
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.0189 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0006 0.0849
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0097
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0018 0.0307
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0094 0.007 0.107
Loa Loa (eye worm) mbt repeat family protein 0.0094 0.007 0.1196
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0026 0.0348
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0026 0.0348
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0006 0.0849
Loa Loa (eye worm) latrophilin receptor protein 2 0.0195 0.0169 0.2872
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0227 0.02 0.3396
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0036 0.1668
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0006 0.1576
Loa Loa (eye worm) glutaminase 2 0.0273 0.0244 0.4143
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0189 0.2777
Loa Loa (eye worm) hypothetical protein 0.0084 0.0061 0.1033
Entamoeba histolytica hypothetical protein 0.0023 0.0002 0.0118
Brugia malayi MH2 domain containing protein 0.0117 0.0093 0.1576
Leishmania major hypothetical protein, conserved 0.007 0.0048 0.2308
Brugia malayi mbt repeat family protein 0.0094 0.007 0.1196
Brugia malayi Bromodomain containing protein 0.0147 0.0122 0.2076
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0048 0.2308
Brugia malayi RNA recognition motif domain containing protein 0.0254 0.0226 0.3835

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) 0 uM In vitro inhibition of recombinant Mycobacterium smegmatis Arylamine N-Acetyltransferase (MSNAT) -catalyzed acetylation of isoniazid (INH); not active ChEMBL. 12852958
IC50 (binding) = 100 uM Inhibition of rabbit GSK3 ChEMBL. 16279768
IC50 (binding) = 100 uM Inhibition of rabbit GSK3 ChEMBL. 16279768
Inhibition (binding) Inhibition of bovine plasma thrombin using Boc-Val-Pro-Arg-AMC as substrate at 25 uM preincubated for 15 mins measured after 10 mins by fluorimetric assay ChEMBL. 22077389
IZ (functional) < 7 mm Antimicrobial activity against Escherichia coli UFPEDA 224 at 300 ug/disk after 24 hrs by disk diffusion method ChEMBL. 19027993
IZ (functional) < 7 mm Antimicrobial activity against Candida albicans UFPEDA 1007 at 300 ug/disk after 48 hrs by disk diffusion method ChEMBL. 19027993

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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