Detailed information for compound 1389985

Basic information

Technical information
  • TDR Targets ID: 1389985
  • Name: 1-(2,1,3-benzoxadiazol-7-yloxy)-3,3-dimethyl- 1-(1,2,4-triazol-1-yl)butan-2-one
  • MW: 301.301 | Formula: C14H15N5O3
  • H donors: 0 H acceptors: 5 LogP: 2.31 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C)(C)C)C(n1cncn1)Oc1cccc2c1non2
  • InChi: 1S/C14H15N5O3/c1-14(2,3)12(20)13(19-8-15-7-16-19)21-10-6-4-5-9-11(10)18-22-17-9/h4-8,13H,1-3H3
  • InChiKey: PODIEYIBRDGSNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-benzofurazan-4-yloxy-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one
  • MLS000080929
  • SMR000044873

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0034 0.0097 0.0196
Entamoeba histolytica hypothetical protein 0.003 0.0067 0.0702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0078 0.0425 0.1202
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0268 0.0758
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0039 0.0132 0.0259
Schistosoma mansoni alpha-1 adrenergic receptor 0.0057 0.0268 0.0758
Plasmodium vivax hypothetical protein, conserved 0.0031 0.007 0.0064
Schistosoma mansoni biogenic amine receptor 0.0057 0.0268 0.0758
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0576 0.6029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0067 0.0189
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) integrin alpha pat-2 0.0499 0.3589 0.7444
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0268 0.0758
Echinococcus granulosus peptide allatostatin:somatostatin 0.0057 0.0268 0.0758
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0057 0.0268 0.0267
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0235
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0576 0.6029
Schistosoma mansoni chromatin regulatory protein sir2 0.0031 0.007 0.0106
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0031 0.007 0.0069
Echinococcus multilocularis protein patched 0.0035 0.0107 0.0106
Echinococcus multilocularis serotonin receptor 0.0057 0.0268 0.0267
Echinococcus multilocularis mitogen activated protein kinase 0.0039 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.043 0.3077 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0268 0.0267
Schistosoma mansoni neuropeptide f receptor 76f 0.0057 0.0268 0.0758
Leishmania major polypeptide deformylase-like protein, putative 0.0267 0.1844 1
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0268 0.0267
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0281 0.1949 0.4042
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0147 0.0942 0.2668
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Schistosoma mansoni myosin xvIII 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0268 0.0267
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0031 0.007 0.0196
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0148 0.0955 1
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0268 0.0555
Schistosoma mansoni neuropeptide receptor 0.0057 0.0268 0.0758
Toxoplasma gondii histone deacetylase SIR2-like 0.0031 0.007 0.0136
Echinococcus granulosus g protein coupled receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0031 0.007 0.0377
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Brugia malayi Kelch motif family protein 0.0101 0.0597 0.1237
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0268 0.0758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0268 0.0758
Loa Loa (eye worm) sirtuin 4 0.0031 0.007 0.0144
Echinococcus multilocularis chromatin regulatory protein sir2 0.0148 0.0955 0.0955
Onchocerca volvulus 0.0057 0.0268 1
Schistosoma mansoni hypothetical protein 0.0057 0.0268 0.0758
Echinococcus granulosus sterol regulatory element binding protein 0.0035 0.0107 0.0301
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Schistosoma mansoni chromatin regulatory protein sir2 0.0148 0.0955 0.3019
Loa Loa (eye worm) integrin beta-2 0.0663 0.4822 1
Schistosoma mansoni integrin alpha-ps 0.0145 0.093 0.2937
Onchocerca volvulus 0.0057 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0268 0.0758
Schistosoma mansoni integrin alpha 0.0323 0.2272 0.7352
Loa Loa (eye worm) hypothetical protein 0.0245 0.168 0.3483
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0148 0.0955 0.5177
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.007 0.0362 0.0751
Trichomonas vaginalis hypothetical protein 0.0021 0 0.0004
Plasmodium vivax peptide deformylase, putative 0.0699 0.5093 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0031 0.007 0.0377
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0067 0.0098
Brugia malayi sulfakinin receptor protein 0.0057 0.0268 0.0555
Brugia malayi Integrin alpha pat-2 precursor 0.0323 0.2272 0.4712
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0031 0.007 0.0196
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0078 0.0425 0.088
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0057 0.0268 0.0758
Echinococcus granulosus chromatin regulatory protein sir2 0.0148 0.0955 0.2704
Brugia malayi G-protein coupled receptor 0.0057 0.0268 0.0555
Schistosoma mansoni chromatin regulatory protein sir2 0.0031 0.007 0.0106
Loa Loa (eye worm) hypothetical protein 0.0178 0.1182 0.245
Echinococcus granulosus g protein coupled receptor 0.0057 0.0268 0.0758
Brugia malayi putative neuropeptide receptor 0.0057 0.0268 0.0555
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0268 0.0758
Echinococcus multilocularis Niemann Pick C1 protein 0.0118 0.0729 0.0728
Echinococcus granulosus snurportin 1 0.0281 0.1949 0.5521
Loa Loa (eye worm) transcriptional regulator 0.0031 0.007 0.0144
Echinococcus granulosus neuropeptide FF receptor 2 0.0057 0.0268 0.0758
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0267 0.1844 1
Loa Loa (eye worm) hypothetical protein 0.021 0.1418 0.2941
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0268 0.0758
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Toxoplasma gondii histone deacetylase SIR2 0.0031 0.007 0.0136
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0098 0.0576 0.163
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Trypanosoma brucei SIR2-like protein 4, putative 0.0031 0.007 0.0178
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0139
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0057 0.0268 0.0555
Echinococcus granulosus integrin alpha ps 0.007 0.0362 0.1026
Plasmodium vivax hypothetical protein, conserved 0.003 0.0067 0.0059
Onchocerca volvulus 0.0057 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0057 0.0268 0.0267
Plasmodium falciparum peptide deformylase 0.0699 0.5093 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0039 0.0132 0.0717
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus granulosus neuropeptide receptor 0.0057 0.0268 0.0758
Onchocerca volvulus 0.0057 0.0268 1
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0031 0.007 0.0005
Onchocerca volvulus 0.0057 0.0268 1
Echinococcus granulosus integrin beta 2 0.0491 0.353 1
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0339 0.0703
Onchocerca volvulus 0.0041 0.0144 0.5388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0078 0.0425 0.1274
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0268 0.0267
Schistosoma mansoni hypothetical protein 0.0034 0.0097 0.0196
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0268 0.0267
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0699 0.5093 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0132 0.0312
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0139
Brugia malayi larval opioid receptor 0.0057 0.0268 0.0555
Entamoeba histolytica hypothetical protein 0.003 0.0067 0.0702
Echinococcus multilocularis sex peptide receptor 0.0057 0.0268 0.0267
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0039 0.0132 0.0525
Schistosoma mansoni amine GPCR 0.0057 0.0268 0.0758
Echinococcus granulosus allatostatin A receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) RNA binding protein 0.005 0.0219 0.0453
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Echinococcus multilocularis integrin alpha ps 0.0145 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0139
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.003 0.0067 0.0139
Schistosoma mansoni neuropeptide receptor 0.0057 0.0268 0.0758
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0067 0.0704
Schistosoma mansoni neuropeptide receptor 0.0057 0.0268 0.0758
Onchocerca volvulus 0.0057 0.0268 1
Toxoplasma gondii HEAT repeat-containing protein 0.0026 0.0037 0.0073
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0268 0.0758
Treponema pallidum polypeptide deformylase (def) 0.0699 0.5093 0.5
Echinococcus granulosus Protein patched homolog 1 0.0035 0.0107 0.0301
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0267 0.1844 1
Echinococcus granulosus fmrfamide receptor 0.0057 0.0268 0.0758
Echinococcus multilocularis serotonin receptor 0.0057 0.0268 0.0267
Brugia malayi hypothetical protein 0.0101 0.0597 0.1237
Echinococcus multilocularis integrin beta 2 0.0491 0.353 0.353
Echinococcus multilocularis snurportin 1 0.0281 0.1949 0.1949
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0107 0.1117
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0268 0.0758
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0031 0.007 0.0064
Schistosoma mansoni amine GPCR 0.0057 0.0268 0.0758
Onchocerca volvulus 0.003 0.0067 0.25
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0067 0.0165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0268 0.0758
Echinococcus multilocularis integrin alpha 3 0.0248 0.1704 0.1704
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0035 0.0107 0.0221
Schistosoma mansoni patched 1 0.0035 0.0107 0.0228
Echinococcus granulosus G protein coupled receptor 139 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0256
Loa Loa (eye worm) hypothetical protein 0.0083 0.0462 0.0957
Onchocerca volvulus 0.0057 0.0268 1
Brugia malayi hypothetical protein 0.003 0.0067 0.0138
Echinococcus multilocularis survival motor neuron protein 1 0.0199 0.1334 0.1333
Echinococcus multilocularis tumor protein p63 0.0258 0.1779 0.1779
Loa Loa (eye worm) beta-lactamase 0.003 0.0067 0.0139
Loa Loa (eye worm) hypothetical protein 0.0101 0.0597 0.1237
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0268 0.0267
Loa Loa (eye worm) TYRA-2 protein 0.0057 0.0268 0.0555
Brugia malayi transcriptional regulator, Sir2 family protein 0.0148 0.0955 0.198
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0132 0.1385
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus granulosus mitogen activated protein kinase 3 0.0039 0.0132 0.0374
Schistosoma mansoni amine GPCR 0.0057 0.0268 0.0758
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0057 0.0268 0.0267
Schistosoma mansoni hypothetical protein 0.0057 0.0268 0.0758
Trypanosoma brucei protein kinase, putative 0.0039 0.0132 0.0525
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0339 0.0703
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0031 0.007 0.0064
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0057 0.0268 0.0555
Leishmania major hypothetical protein, conserved 0.003 0.0067 0.0364
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0268 0.0758
Schistosoma mansoni chromatin regulatory protein sir2 0.0148 0.0955 0.3019
Schistosoma mansoni opsin-like receptor 0.0057 0.0268 0.0758
Brugia malayi hypothetical protein 0.0199 0.1334 0.2765
Schistosoma mansoni tar DNA-binding protein 0.005 0.0219 0.0597
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0143 0.0919 0.1905
Schistosoma mansoni hypothetical protein 0.0224 0.1528 0.4903
Echinococcus granulosus geminin 0.043 0.3077 0.8715
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus granulosus tumor protein p63 0.0258 0.1779 0.5039
Schistosoma mansoni hypothetical protein 0.0057 0.0268 0.0758
Schistosoma mansoni biogenic amine receptor 0.0057 0.0268 0.0758
Schistosoma mansoni hypothetical protein 0.0066 0.0339 0.0993
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0268 0.0758
Echinococcus granulosus 7TM GPCR rhodopsin 0.0057 0.0268 0.0758
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0057 0.0268 0.0555
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0031 0.007 0.0729
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0268 0.0267
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0021 0 0.0004
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0075 0.0408 0.0845
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0148 0.0955 0.0955
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Brugia malayi GnHR receptor homolog 0.0057 0.0268 0.0555
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0057 0.0268 0.0267
Echinococcus multilocularis neuropeptide s receptor 0.0057 0.0268 0.0267
Brugia malayi RNA recognition motif domain containing protein 0.005 0.0219 0.0453
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0268 0.0758
Trypanosoma cruzi Peptide deformylase 2, putative 0.0267 0.1844 1
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0268 0.0758
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0339 0.096
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0339 0.0339
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0057 0.0268 0.0758
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0268 0.0267
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0057 0.0268 0.0555
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0268 0.0758
Echinococcus multilocularis dro:myosuppressin receptor 0.0057 0.0268 0.0267
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0139
Loa Loa (eye worm) melatonin receptor type 1A 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Onchocerca volvulus 0.0057 0.0268 1
Echinococcus granulosus integrin alpha ps 0.0145 0.093 0.2634
Loa Loa (eye worm) TAR-binding protein 0.005 0.0219 0.0453
Onchocerca volvulus 0.0057 0.0268 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0268 0.0267
Echinococcus granulosus g-protein coupled receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0031 0.007 0.0729
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0031 0.007 0.0729
Echinococcus granulosus beta LACTamase domain containing family member 0.003 0.0067 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0268 0.0758
Brugia malayi RNA, U transporter 1 0.0075 0.0402 0.0832
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0268 0.0758
Brugia malayi neuropeptide F receptor 0.0057 0.0268 0.0555
Onchocerca volvulus 0.003 0.0067 0.25
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0339 0.0339
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0067 0.0704
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0041 0.0151 0.0151
Schistosoma mansoni sex comb on midleg homolog 0.0036 0.0114 0.0251
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0268 0.0555
Echinococcus granulosus importin subunit beta 1 0.0026 0.0037 0.0105
Schistosoma mansoni survival motor neuron protein 0.0041 0.0144 0.0352
Brugia malayi CHE-14 protein 0.0035 0.0107 0.0221
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Toxoplasma gondii hypothetical protein 0.0699 0.5093 1
Echinococcus multilocularis polycomb protein SCMH1 0.0036 0.0114 0.0113
Onchocerca volvulus 0.0057 0.0268 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0132 0.0717
Schistosoma mansoni amine GPCR 0.0057 0.0268 0.0758
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0041 0.0151 0.0428
Loa Loa (eye worm) hypothetical protein 0.0199 0.1334 0.2765
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0268 0.0267
Brugia malayi Importin beta-1 subunit 0.0026 0.0037 0.0077
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0268 0.0267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0268 0.0758
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0148 0.0955 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0221
Giardia lamblia Kinase, CMGC MAPK 0.0039 0.0132 0.1382
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0067 0.0704
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0057 0.0268 0.0267
Echinococcus multilocularis sterol regulatory element binding protein 0.0035 0.0107 0.0106
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0268 0.0758
Brugia malayi Dopamine receptor 0.0057 0.0268 0.0555
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0067 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0268 0.0758
Echinococcus granulosus integrin alpha 3 0.0248 0.1704 0.4827
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0132 0.1385
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0268 0.0758
Onchocerca volvulus 0.0057 0.0268 1
Onchocerca volvulus 0.0057 0.0268 1
Loa Loa (eye worm) transcriptional regulator 0.0031 0.007 0.0144
Schistosoma mansoni amine GPCR 0.0057 0.0268 0.0758
Echinococcus multilocularis expressed conserved protein 0.0078 0.0424 0.0424
Schistosoma mansoni growth hormone secretagogue receptor 0.0057 0.0268 0.0758
Schistosoma mansoni sex comb on midleg homolog 0.0036 0.0114 0.0251
Echinococcus multilocularis importin subunit beta 1 0.0026 0.0037 0.0037
Echinococcus multilocularis somatostatin receptor 0.0057 0.0268 0.0267
Brugia malayi mbt repeat family protein 0.0036 0.0114 0.0235
Echinococcus granulosus g protein coupled receptor 0.0057 0.0268 0.0758
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0031 0.007 0.0729
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0057 0.0268 0.0555
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Mycobacterium ulcerans NAD-dependent deacetylase 0.0031 0.007 0.0005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0031 0.007 0.0729
Brugia malayi follicle stimulating hormone receptor 0.025 0.1721 0.3569
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Onchocerca volvulus 0.0057 0.0268 1
Echinococcus granulosus sex peptide receptor 0.0057 0.0268 0.0758
Brugia malayi transcriptional regulator, Sir2 family protein 0.0031 0.007 0.0144
Schistosoma mansoni integrin alpha-ps 0.0075 0.0408 0.1218
Brugia malayi TAR-binding protein 0.005 0.0219 0.0453
Onchocerca volvulus 0.0057 0.0268 1
Echinococcus granulosus neuropeptide receptor A26 0.0057 0.0268 0.0758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0078 0.0425 0.0424
Echinococcus multilocularis histone acetyltransferase MYST2 0.0041 0.0151 0.0151
Echinococcus multilocularis orexin receptor type 2 0.0057 0.0268 0.0267
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0078 0.0425 0.0424
Onchocerca volvulus 0.0036 0.0114 0.4233
Schistosoma mansoni hypothetical protein 0.007 0.0362 0.107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0078 0.0425 0.1274
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0268 0.0758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0098 0.0576 0.1193
Brugia malayi RNA binding protein 0.005 0.0219 0.0453
Loa Loa (eye worm) hypothetical protein 0.0043 0.0167 0.0345
Brugia malayi beta-lactamase 0.003 0.0067 0.0139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0268 0.0267
Schistosoma mansoni integrin beta subunit 0.039 0.2773 0.9002
Schistosoma mansoni neuropeptide receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0066 0.0339 0.0703
Echinococcus granulosus neuropeptide receptor 0.0057 0.0268 0.0758
Echinococcus granulosus tachykinin peptides receptor 99D 0.0057 0.0268 0.0758
Brugia malayi Dopamine receptor protein 2 0.0057 0.0268 0.0555
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0132 0.1385
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0039 0.0132 0.0274
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus granulosus histone acetyltransferase MYST2 0.0041 0.0151 0.0428
Brugia malayi G-protein coupled receptor 0.0057 0.0268 0.0555
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.003 0.0067 0.0139
Schistosoma mansoni hypothetical protein 0.0281 0.1949 0.629
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus granulosus dro:myosuppressin receptor 0.0057 0.0268 0.0758
Leishmania major silent information regulator 2, putative 0.0148 0.0955 0.5177
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0268 0.0267
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0268 0.0758
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0057 0.0268 0.0758
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0268 0.0267
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0268 0.0758
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.1721 0.3569
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0268 0.0267
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0699 0.5093 1
Brugia malayi G protein-coupled receptor 0.0057 0.0268 0.0555
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0057 0.0268 0.0758
Schistosoma mansoni hypothetical protein 0.043 0.3077 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0031 0.007 0.0144
Plasmodium vivax NAD-dependent deacetylase, putative 0.0031 0.007 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.003 0.0067 0.0067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0268 0.0758
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0098 0.0576 0.0575
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0268 0.0267
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Schistosoma mansoni hypothetical protein 0.0066 0.0339 0.0993
Schistosoma mansoni tar DNA-binding protein 0.005 0.0219 0.0597
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0339 0.096
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0057 0.0268 0.0758
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0057 0.0268 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0268 0.0267
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0036 0.0114 0.4233
Trypanosoma cruzi Peptide deformylase 2, putative 0.0267 0.1844 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus multilocularis SAM and MBT domain containing protein 0.0036 0.0114 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0067 0.0364
Brugia malayi beta-lactamase family protein 0.003 0.0067 0.0139
Echinococcus multilocularis tar DNA binding protein 0.005 0.0219 0.0218
Onchocerca volvulus Neuropeptide F receptor homolog 0.0057 0.0268 1
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0268 0.0555
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0268 0.0758
Echinococcus multilocularis Niemann Pick C1 protein 0.0083 0.0462 0.0461
Entamoeba histolytica hypothetical protein 0.003 0.0067 0.0702
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0139
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0057 0.0268 1
Brugia malayi Melatonin receptor type 1A 0.0057 0.0268 0.0555
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0031 0.007 0.0729
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Schistosoma mansoni cellular tumor antigen P53 0.0038 0.0124 0.0284
Trypanosoma brucei Polypeptide deformylase 1 0.0267 0.1844 1
Brugia malayi MAP kinase sur-1 0.0039 0.0132 0.0274
Schistosoma mansoni hypothetical protein 0.0034 0.0097 0.0196
Echinococcus multilocularis integrin alpha ps 0.007 0.0362 0.0362
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0193 0.1293 0.2438
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0147 0.0942 0.0942
Brugia malayi RE15519p 0.0057 0.0268 0.0555
Giardia lamblia Hypothetical protein 0.0148 0.0955 1
Echinococcus granulosus survival motor neuron protein 1 0.0199 0.1334 0.3777
Echinococcus granulosus somatostatin receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Mycobacterium ulcerans Sir2-like regulatory protein 0.0031 0.007 0.0005
Echinococcus multilocularis g-protein coupled receptor 0.0057 0.0268 0.0267
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0098 0.0576 0.6028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0078 0.0425 0.1202
Schistosoma mansoni opsin-like receptor 0.0057 0.0268 0.0758
Echinococcus multilocularis G protein coupled receptor 139 0.0057 0.0268 0.0267
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0148 0.0955 1
Echinococcus multilocularis protein dispatched 1 0.0041 0.0144 0.0144
Toxoplasma gondii ABC1 family protein 0.003 0.0067 0.0131
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0699 0.5093 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0039 0.0132 0.0717
Schistosoma mansoni chromatin regulatory protein sir2 0.0098 0.0576 0.1771
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0576 0.6029
Echinococcus multilocularis integrin alpha ps 0.0145 0.093 0.093
Brugia malayi hypothetical protein 0.0057 0.0268 0.0555
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0268 0.0267
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0078 0.0425 0.088
Echinococcus multilocularis neuropeptide FF receptor 2 0.0057 0.0268 0.0267
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0057 0.0268 0.0267
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0268 0.0267
Echinococcus granulosus neuropeptide s receptor 0.0057 0.0268 0.0758
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0067 0.0704
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0132 0.1385
Schistosoma mansoni hypothetical protein 0.0143 0.0919 0.29
Schistosoma mansoni chromatin regulatory protein sir2 0.0148 0.0955 0.3019
Trypanosoma brucei Peptide deformylase 2 0.0267 0.1844 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Leishmania major sir2-family protein-like protein 0.0031 0.007 0.0377
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0057 0.0268 0.0758
Schistosoma mansoni myelin transcription factor 1 myt1 0.0041 0.0151 0.0375
Echinococcus granulosus serotonin receptor 0.0057 0.0268 0.0758
Schistosoma mansoni hypothetical protein 0.003 0.0067 0.0098
Giardia lamblia Transcriptional regulator, Sir2 family 0.0031 0.007 0.0726
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Brugia malayi ORL1-like opioid receptor 0.0057 0.0268 0.0555
Brugia malayi Serotonin receptor 0.0057 0.0268 0.0555
Echinococcus granulosus mitogen activated protein kinase 0.0039 0.0132 0.0374
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0057 0.0268 0.0267
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0339 0.0703
Loa Loa (eye worm) MBCTL1 0.0041 0.0151 0.0313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0268 0.0758
Brugia malayi putative neuropeptide receptor NPR1 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0057 0.0268 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0268 0.0267
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0084 0.0471 0.1428
Schistosoma mansoni tar DNA-binding protein 0.005 0.0219 0.0597
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0268 0.0267
Schistosoma mansoni hypothetical protein 0.0034 0.0097 0.0196
Echinococcus multilocularis mitogen activated protein kinase 3 0.0039 0.0132 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0067 0.0364
Brugia malayi Serotonin receptor 0.0057 0.0268 0.0555
Brugia malayi AKH receptor 0.0057 0.0268 0.0555
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0101 0.0597 0.1237
Echinococcus granulosus hypothetical protein 0.0057 0.0268 0.0758
Echinococcus granulosus alpha 1A adrenergic receptor 0.0057 0.0268 0.0758
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0083 0.0462 0.4835
Brugia malayi NAD-dependent deacetylase SIRT1 0.0098 0.0576 0.1193
Echinococcus granulosus tar DNA binding protein 0.005 0.0219 0.0619
Schistosoma mansoni hypothetical protein 0.0066 0.0339 0.0993
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0576 0.6029
Schistosoma mansoni adenoreceptor 0.0057 0.0268 0.0758
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0031 0.007 0.0377
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0031 0.007 0.0729
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0057 0.0268 0.0555
Brugia malayi beta-lactamase family protein 0.003 0.0067 0.0139
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0313
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.1418 0.2941
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.0144 0.0299
Echinococcus granulosus 7tm_1 domain containing protein 0.0057 0.0268 0.0758
Schistosoma mansoni hypothetical protein 0.0066 0.0339 0.0993
Brugia malayi neuropeptide F receptor 0.0057 0.0268 0.0555
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0132 0.0717
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0139
Onchocerca volvulus 0.003 0.0067 0.25
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0067 0.0067
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0031 0.007 0.0069
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0041 0.0151 0.0313
Echinococcus multilocularis allatostatin A receptor 0.0057 0.0268 0.0267
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0148 0.0955 0.5177
Onchocerca volvulus 0.0057 0.0268 1
Schistosoma mansoni hypothetical protein 0.0041 0.0144 0.0352
Echinococcus multilocularis geminin 0.043 0.3077 0.3077
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0148 0.0955 1
Schistosoma mansoni hypothetical protein 0.0057 0.0268 0.0758
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0268 0.0555
Echinococcus multilocularis GPCR, family 2 0.0066 0.0339 0.0339
Echinococcus granulosus polycomb protein SCMH1 0.0036 0.0114 0.0321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0078 0.0425 0.1274
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0245 0.168 0.3483
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0057 0.0268 0.0267
Echinococcus granulosus SAM and MBT domain containing protein 0.0036 0.0114 0.0321
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Trichomonas vaginalis esterase, putative 0.003 0.0067 0.0704
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.007 0.0729
Schistosoma mansoni histamine h1 receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0057 0.0268 0.0555
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0268 0.0758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0039 0.0132 0.0717
Schistosoma mansoni tar DNA-binding protein 0.005 0.0219 0.0597
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0067 0.0098
Onchocerca volvulus 0.0057 0.0268 1
Brugia malayi Integrin beta pat-3 precursor 0.0663 0.4822 1
Schistosoma mansoni opsin-like receptor 0.0057 0.0268 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0268 0.0267
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0717
Echinococcus granulosus GPCR family 2 0.0066 0.0339 0.096
Echinococcus multilocularis G-protein coupled receptor, putative 0.0057 0.0268 0.0267
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0067 0.0704
Onchocerca volvulus 0.0038 0.0124 0.461
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.0919 0.1905
Brugia malayi G protein-coupled receptor F59B2.13 0.0057 0.0268 0.0555
Brugia malayi mbt repeat family protein 0.0036 0.0114 0.0235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0268 0.0758
Entamoeba histolytica hypothetical protein 0.003 0.0067 0.0702
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0268 0.0758
Echinococcus granulosus Niemann Pick C1 protein 0.0118 0.0729 0.2063
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0268 0.0758
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0148 0.0955 0.5078
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0254 0.1749 0.3628
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0268 0.0758
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0036 0.0114 0.0251
Echinococcus granulosus Niemann Pick C1 protein 0.0083 0.0462 0.1307
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0268 0.0267
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) mbt repeat family protein 0.0036 0.0114 0.0235
Brugia malayi Tachykinin-like peptides receptor 99D 0.0057 0.0268 0.0555
Chlamydia trachomatis peptide deformylase 0.0699 0.5093 0.5
Mycobacterium ulcerans peptide deformylase 0.0699 0.5093 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Loa Loa (eye worm) transcriptional regulator 0.0148 0.0955 0.198
Echinococcus granulosus expressed conserved protein 0.0078 0.0424 0.12
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.005 0.0219 0.0453
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0148 0.0955 0.2704
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0057 0.0268 0.0555
Schistosoma mansoni chromatin regulatory protein sir2 0.0031 0.007 0.0106
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.1418 0.2941
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Schistosoma mansoni tar DNA-binding protein 0.005 0.0219 0.0597
Echinococcus granulosus orexin receptor type 2 0.0057 0.0268 0.0758
Brugia malayi Dopamine receptor protein 1 0.0057 0.0268 0.0555
Schistosoma mansoni biogenic amine receptor 0.0057 0.0268 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0268 0.0267
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0268 0.0758
Onchocerca volvulus 0.0057 0.0268 1
Giardia lamblia Sirtuin type 2 0.0031 0.007 0.0726
Echinococcus multilocularis neuropeptide receptor A26 0.0057 0.0268 0.0267
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0039 0.0132 0.0717
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0268 0.0267
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.1418 0.2941
Brugia malayi Niemann-Pick C1 protein precursor 0.0083 0.0462 0.0957
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0031 0.007 0.0178
Loa Loa (eye worm) hypothetical protein 0.0057 0.0268 0.0555

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 22.3872 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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