Detailed information for compound 1393979

Basic information

Technical information
  • TDR Targets ID: 1393979
  • Name: N-[4-(difluoromethylsulfanyl)phenyl]-9-oxo-2, 3-dihydro-1H-pyrrolo[2,1-b]quinazoline-6-carb oxamide
  • MW: 387.403 | Formula: C19H15F2N3O2S
  • H donors: 1 H acceptors: 2 LogP: 3.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(Sc1ccc(cc1)NC(=O)c1ccc2c(c1)nc1n(c2=O)CCC1)F
  • InChi: 1S/C19H15F2N3O2S/c20-19(21)27-13-6-4-12(5-7-13)22-17(25)11-3-8-14-15(10-11)23-16-2-1-9-24(16)18(14)26/h3-8,10,19H,1-2,9H2,(H,22,25)
  • InChiKey: ZVBWVJLHUWLTNP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[4-(difluoromethylthio)phenyl]-9-oxo-2,3-dihydro-1H-pyrrolo[2,1-b]quinazoline-6-carboxamide
  • N-[4-(difluoromethylthio)phenyl]-9-keto-2,3-dihydro-1H-pyrrolo[2,1-b]quinazoline-6-carboxamide
  • ZINC07779881
  • T5492718

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone receptor 2 No references
Homo sapiens corticotropin releasing hormone binding protein No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0066 0.0135
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0022 0.0094
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0128
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0739 0.2136 0.4494
Echinococcus granulosus microtubule associated protein 2 0.0677 0.1952 0.914
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0066 0.0301
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0357 0.0998 0.3712
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0115 1
Entamoeba histolytica protein kinase domain containing protein 0.0376 0.1054 0.4933
Echinococcus multilocularis protein kinase shaggy 0.0376 0.1054 0.2217
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0096 0.0223 0.083
Entamoeba histolytica hypothetical protein 0.0043 0.0066 0.0301
Brugia malayi hypothetical protein 0.0121 0.0297 0.0408
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0739 0.2136 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0096 0.0223 0.1037
Entamoeba histolytica hypothetical protein 0.0588 0.1687 0.7895
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0115 1
Brugia malayi PHD-finger family protein 0.0029 0.0022 0.0028
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0096 0.0223 0.1037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0022 1
Loa Loa (eye worm) hypothetical protein 0.026 0.0711 0.4217
Echinococcus multilocularis geminin 0.0205 0.0545 0.1145
Loa Loa (eye worm) hypothetical protein 0.0121 0.0297 0.1763
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0001 0.0005
Giardia lamblia Kinase, CMGC GSK 0.0376 0.1054 0.3923
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0262 0.1556
Schistosoma mansoni hypothetical protein 0.0035 0.004 0.0178
Entamoeba histolytica protein kinase, putative 0.0376 0.1054 0.4933
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0101 0.0209
Giardia lamblia Telomerase catalytic subunit 0.0924 0.2685 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0082 0.0488
Onchocerca volvulus 0.0439 0.1242 0.124
Loa Loa (eye worm) hypothetical protein 0.0439 0.1242 0.7362
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0717 0.2071 0.9695
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0128
Echinococcus granulosus geminin 0.0205 0.0545 0.2548
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0022 0.1868
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0022 0.1868
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.004 0.0052
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0285 0.169
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0739 0.2136 1
Echinococcus multilocularis peregrin 0.0029 0.0022 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0039 0.0234
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0215 0.045
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0039 0.0178
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.004 0.008
Schistosoma mansoni hypothetical protein 0.0043 0.0066 0.0301
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0376 0.1054 0.2217
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.022 0.0591 0.276
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0096 0.0223 0.0825
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0247 0.0672 0.2499
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0011 0.0034
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0115 0.024
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0022 0.0028
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0096 0.0223 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0101 0.0465
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0739 0.2136 0.7953
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0115 0.0424
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0039 0.008
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0001 0.0005
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0022 0.0001 0.0005
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0247 0.0672 0.3142
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0011 0.004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.004 0.0178
Echinococcus multilocularis Zinc finger, PHD finger 0.0096 0.0223 0.0466
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0022 0.1868
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.004 0.0234
Plasmodium falciparum glycogen synthase kinase 3 0.0376 0.1054 0.3926
Schistosoma mansoni hypothetical protein 0.0205 0.0545 0.2548
Brugia malayi intracellular kinase 0.0376 0.1054 0.1452
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0001 0.0009
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0247 0.0672 0.2499
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0739 0.2136 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0022 0.0028
Leishmania major hypothetical protein, conserved 0.0025 0.0011 0.0034
Onchocerca volvulus Alhambra homolog 0.0029 0.0022 0.002
Plasmodium vivax glycogen synthase kinase 3, putative 0.0376 0.1054 0.3926
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0112 0.0665
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0247 0.0672 0.3142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0101 0.0209
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0001 0.0127
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0096 0.0223 0.0466
Mycobacterium ulcerans hypothetical protein 0.0029 0.0022 0.1868
Loa Loa (eye worm) hypothetical protein 0.0295 0.0813 0.4823
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0096 0.0223 0.0825
Plasmodium falciparum telomerase reverse transcriptase 0.0924 0.2685 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0096 0.0223 0.1037
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0225 0.0607 0.2256
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0376 0.1054 0.3923
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0022 0.0128
Brugia malayi Bromodomain containing protein 0.0029 0.0022 0.0028
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0096 0.0223 0.1037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0101 0.0465
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0508 0.1447 0.6773
Onchocerca volvulus 0.0029 0.0022 0.002
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0011 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0035 0.004 0.0052
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0924 0.2685 1
Trichomonas vaginalis CMGC family protein kinase 0.0376 0.1054 0.4933
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0115 0.0533
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0101 0.0465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0101 0.0465
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0001 0.0009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0328 0.0912 0.4265
Loa Loa (eye worm) hypothetical protein 0.0439 0.1242 0.7362
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.1952 0.4107
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0063
Brugia malayi jmjC domain containing protein 0.0094 0.0215 0.0295
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0039 0.0178
Plasmodium vivax telomerase reverse transcriptase, putative 0.0924 0.2685 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0011 0.004
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0096 0.0223 0.0825
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0001 0.0009
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0022 0.0094
Schistosoma mansoni hypothetical protein 0.0035 0.004 0.0178
Entamoeba histolytica hypothetical protein 0.0043 0.0066 0.0301
Plasmodium vivax hypothetical protein 0.0022 0.0001 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0376 0.1054 0.4933
Entamoeba histolytica hypothetical protein 0.0043 0.0066 0.0301
Trypanosoma brucei telomerase reverse transcriptase 0.0924 0.2685 1
Leishmania major telomerase reverse transcriptase, putative 0.0924 0.2685 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0114 0.0528
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0096 0.0223 0.1037
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0262 0.036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0022 0.1868
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0234
Echinococcus granulosus jumonji domain containing protein 0.004 0.0055 0.025
Plasmodium falciparum phd finger protein, putative 0.0029 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0009
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0055 0.0112
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0215 0.1002
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0022 0.0028
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0739 0.2136 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0022 0.008
Trypanosoma brucei protein kinase, putative 0.0376 0.1054 0.3923
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0011 0.0034
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0011 0.004
Schistosoma mansoni hypothetical protein 0.0029 0.0022 0.0094
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0022 0.0042
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0115 0.0533
Loa Loa (eye worm) hypothetical protein 0.006 0.0114 0.0676
Echinococcus granulosus GPCR family 2 0.0035 0.004 0.0178
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0022 0.0094
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0022 0.0001 0.0005
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0376 0.1054 0.4933
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0096 0.0223 0.0825
Onchocerca volvulus 0.0376 0.1054 0.1053
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0096 0.0223 0.083
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0479 0.1361 0.6369
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0247 0.0672 0.3142
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0247 0.0672 0.3142
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0376 0.1054 0.6251
Loa Loa (eye worm) hypothetical protein 0.0121 0.0297 0.1763
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0739 0.2136 0.7953
Loa Loa (eye worm) hypothetical protein 0.0479 0.1361 0.8069
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0158 0.0733
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0159 0.0218
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0022 0.0075
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0022 0.0001 0.0005
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0096 0.0223 0.1037
Loa Loa (eye worm) phosphatidylinositol kinase 0.0022 0.0001 0.0009
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0479 0.1361 0.2862
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0001 0.0009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.022 0.0591 0.124
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0009
Loa Loa (eye worm) phosphatidylinositol 3 0.0588 0.1687 1
Onchocerca volvulus 0.006 0.0114 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0001 0.0005
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0247 0.0672 0.3142
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0128
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0479 0.1361 0.1875
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0128
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0022 0.0094
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0022 0.0075
Brugia malayi MH2 domain containing protein 0.0117 0.0285 0.0391
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0376 0.1054 0.4933
Echinococcus multilocularis tumor protein p63 0.0408 0.1151 0.2419
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0022 0.1868
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0376 0.1054 0.6251
Brugia malayi hypothetical protein 0.0043 0.0066 0.0089
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0096 0.0223 0.1037
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0247 0.0672 0.3142
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0376 0.1054 0.3923
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0096 0.0223 0.1321
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0022 0.0075
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0022 0.0094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0295 0.0813 0.112
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0247 0.0672 0.0925
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0096 0.0223 0.0825
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0115 0.0424
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0739 0.2136 1
Schistosoma mansoni hypothetical protein 0.0075 0.0159 0.0739
Loa Loa (eye worm) runx1 0.0055 0.01 0.0593
Onchocerca volvulus Huntingtin homolog 0.0121 0.0297 0.0296
Schistosoma mansoni lozenge 0.0055 0.01 0.0462
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0066 0.0301
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0022 0.1868
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0022 0.1868
Giardia lamblia Kinase, CMGC GSK 0.0376 0.1054 0.3923
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0022 0.1868
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0115 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0285 0.169
Echinococcus granulosus protein kinase shaggy 0.0376 0.1054 0.4933
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0022 1
Brugia malayi hypothetical protein 0.0439 0.1242 0.1711
Brugia malayi jmjC domain containing protein 0.0035 0.0039 0.0052
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0508 0.1447 0.6773
Entamoeba histolytica hypothetical protein 0.0043 0.0066 0.0301
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0039 0.0178
Onchocerca volvulus Huntingtin homolog 0.0121 0.0297 0.0296
Brugia malayi hypothetical protein 0.0025 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0205 0.0545 0.2548
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0376 0.1054 0.3923
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0096 0.0223 0.0825
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.1952 0.914
Giardia lamblia PHD finger protein 15 0.0029 0.0022 0.0075
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1618 0.4751 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0011 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0022 0.0075
Echinococcus multilocularis Protein lozenge 0.0055 0.01 0.0208
Brugia malayi Telomerase reverse transcriptase 0.2458 0.7251 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0022 0.0075
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0173 0.0451 0.1674
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0607 0.3599
Schistosoma mansoni hypothetical protein 0.0035 0.004 0.0178
Echinococcus granulosus peregrin 0.0029 0.0022 0.0094
Loa Loa (eye worm) hypothetical protein 0.0075 0.0159 0.0944
Echinococcus multilocularis GPCR, family 2 0.0035 0.004 0.008
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0001 0.0009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0739 0.2136 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0096 0.0223 0.0825
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0001 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0739 0.2136 0.2944
Schistosoma mansoni hypothetical protein 0.0035 0.004 0.0178
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0101 0.0597
Echinococcus granulosus tumor protein p63 0.0408 0.1151 0.5384
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0115 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0588 0.1687 0.7895
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0096 0.0223 0.1037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0101 0.0137
Entamoeba histolytica protein kinase domain containing protein 0.0376 0.1054 0.4933
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0096 0.0223 0.1037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0022 0.1868
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0101 0.0465
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0924 0.2685 1
Toxoplasma gondii RNA-directed DNA polymerase 0.0924 0.2685 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0115 0.0533

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.4 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0588 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3934 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 47.7548 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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