Detailed information for compound 1395246

Basic information

Technical information
  • TDR Targets ID: 1395246
  • Name: 2-[[4-[(4-chlorophenyl)amino]-6-ethoxy-1,3,5- triazin-2-yl]amino]ethanol
  • MW: 309.751 | Formula: C13H16ClN5O2
  • H donors: 3 H acceptors: 4 LogP: 2.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNc1nc(Nc2ccc(cc2)Cl)nc(n1)OCC
  • InChi: 1S/C13H16ClN5O2/c1-2-21-13-18-11(15-7-8-20)17-12(19-13)16-10-5-3-9(14)4-6-10/h3-6,20H,2,7-8H2,1H3,(H2,15,16,17,18,19)
  • InChiKey: SMMCQSAJDJGYAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[4-[(4-chlorophenyl)amino]-6-ethoxy-s-triazin-2-yl]amino]ethanol
  • MLS000521259
  • SMR000131667
  • Oprea1_696732

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0648 0.106
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0128 0.147 0.2026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Onchocerca volvulus 0.0038 0.0356 0.1814
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.074 0.1021
Loa Loa (eye worm) hypothetical protein 0.0152 0.1774 0.2445
Leishmania major cathepsin L-like protease 0.0175 0.2062 0.7928
Onchocerca volvulus Cathepsin L homolog 0.0128 0.147 0.8244
Brugia malayi Cathepsin L-like precursor 0.0128 0.147 0.2027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.147 0.5682
Echinococcus multilocularis cathepsin L cysteine protease 0.0128 0.147 0.1469
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0429 0.0592
Brugia malayi Cathepsin L-like precursor 0.0128 0.147 0.2027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0356 0.0489
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0429 0.059
Echinococcus multilocularis cpg binding protein 0.0031 0.0269 0.0268
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.013 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0356 0.096
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0128 0.147 1
Brugia malayi hypothetical protein 0.0019 0.013 0.0179
Leishmania major cathepsin L-like protease 0.0128 0.147 0.5054
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0042 0.0056
Schistosoma mansoni hypothetical protein 0.0043 0.0429 0.0537
Echinococcus granulosus cathepsin l1 0.0128 0.147 0.2026
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0128 0.147 0.1469
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0284 0.039
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0429 0.0428
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0356 0.0436
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0369 0.0367
Loa Loa (eye worm) fibroinase 0.0128 0.147 0.2026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0284 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0808 0.1838
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.2489 0.3394
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0038 0.0356 0.0436
Loa Loa (eye worm) hypothetical protein 0.0038 0.0356 0.0489
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0042 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0429 0.127
Loa Loa (eye worm) hypothetical protein 0.0032 0.0284 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0038 0.0356 0.096
Onchocerca volvulus Cathepsin L homolog 0.0128 0.147 0.8244
Loa Loa (eye worm) hypothetical protein 0.01 0.1134 0.1561
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0356 0.0489
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0056
Entamoeba histolytica hypothetical protein 0.0043 0.0429 0.2232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0808 0.1838
Onchocerca volvulus 0.0128 0.147 0.8244
Schistosoma mansoni cpg binding protein 0.0029 0.0249 0.0287
Leishmania major cathepsin L-like protease 0.0175 0.2062 0.7928
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0648 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0038 0.0356 0.096
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.013 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.013 0.0177
Entamoeba histolytica cysteine proteinase, putative 0.0128 0.147 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0042 0.0058
Echinococcus granulosus dnaJ subfamily B 0.0412 0.499 0.688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0139 0.161 0.1835
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0056
Plasmodium vivax vivapain-3 0.0074 0.0808 0.4126
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0074 0.0808 0.1062
Brugia malayi cathepsin F-like cysteine proteinase 0.0038 0.0356 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0042 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.147 0.5682
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0284 0.039
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0356 0.0489
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0042 0.0056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0429 0.0428
Entamoeba histolytica hypothetical protein 0.0043 0.0429 0.2232
Echinococcus multilocularis lamin dm0 0.0027 0.0227 0.0225
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0056
Trypanosoma cruzi major cysteine proteinase, putative 0.0085 0.0948 0.0876
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0808 0.2874
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0356 0.096
Schistosoma mansoni inositol transporter 0.0039 0.0369 0.0453
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.013 0.0128
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0356 0.0489
Schistosoma mansoni regulator of G protein signaling 0.0019 0.013 0.0122
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1134 0.1563
Brugia malayi Cathepsin L-like precursor 0.0091 0.1019 0.1404
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0056
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0369 0.0506
Loa Loa (eye worm) hypothetical protein 0.0091 0.1019 0.1403
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0042 0.0056
Entamoeba histolytica cysteine protease, putative 0.0038 0.0356 0.1689
Echinococcus granulosus cathepsin b 0.0594 0.7252 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.013 0.0128
Entamoeba histolytica cysteine protease, putative 0.0038 0.0356 0.1689
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0038 0.0356 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0594 0.7252 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.059
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0042 0.0058
Entamoeba histolytica cysteine proteinase 1, putative 0.0074 0.0808 0.5058
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.013 0.0122
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0429 0.059
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0342 0.0472
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0429 0.0771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0042 0.0056
Plasmodium vivax serine-repeat antigen (SERA) 0.0038 0.0356 0.0122
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.021 0.2489 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0429 0.059
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.013 0.0179
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.013 0.0122
Toxoplasma gondii cathepsin CPL 0.0128 0.147 0.5224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Schistosoma mansoni high-affinity choline transporter 0.035 0.4224 0.58
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0648 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0091 0.1019 0.1404
Brugia malayi Cathepsin L-like precursor 0.0091 0.1019 0.1404
Schistosoma mansoni regulator of G protein signaling 0.0019 0.013 0.0122
Leishmania major cathepsin L-like protease 0.0128 0.147 0.5054
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0042 0.0058
Mycobacterium leprae Probable lipase LipE 0.0043 0.0429 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Loa Loa (eye worm) RGS-3 protein 0.0019 0.013 0.0177
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0038 0.0356 0.0436
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0227 0.0311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1019 0.3768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0356 0.096
Onchocerca volvulus 0.0128 0.147 0.8244
Brugia malayi ecdysteroid receptor 0.0012 0.0042 0.0058
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.013 0.0128
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0429 0.127
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0356 0.0436
Echinococcus granulosus cathepsin L 0.0074 0.0808 0.1112
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0227 0.0311
Entamoeba histolytica cysteine protease, putative 0.0038 0.0356 0.1689
Onchocerca volvulus 0.0128 0.147 0.8244
Echinococcus granulosus cathepsin L cysteine proteinase 0.0128 0.147 0.2026
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0429 0.127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0429 0.0537
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0356 0.0489
Brugia malayi GH02984p 0.035 0.4224 0.5825
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0429 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.147 0.5682
Schistosoma mansoni hypothetical protein 0.0412 0.499 0.6862
Loa Loa (eye worm) cysteine protease 0.0128 0.147 0.2026
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0074 0.0808 0.0674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0369 0.0506
Plasmodium vivax vivapain-1 0.0074 0.0808 0.4126
Brugia malayi Cathepsin L-like precursor 0.0128 0.147 0.2027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0042 0.0058
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.059
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.147 0.5682
Entamoeba histolytica hypothetical protein 0.0043 0.0429 0.2232
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0038 0.0356 0.096
Schistosoma mansoni cathepsin F (C01 family) 0.0128 0.147 0.1981
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.013 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.013 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0356 0.096
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.013 0.0177
Echinococcus multilocularis cathepsin b 0.0594 0.7252 0.7252
Echinococcus multilocularis cathepsin L 0.0038 0.0356 0.0355
Trypanosoma cruzi cysteine peptidase, putative 0.0175 0.2062 0.2489
Trypanosoma cruzi cruzipain precursor, putative 0.0175 0.2062 0.2489
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0429 0.127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0042 0.004
Echinococcus granulosus lamin 0.0027 0.0227 0.0311
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.147 0.5682
Onchocerca volvulus 0.0128 0.147 0.8244
Echinococcus multilocularis expressed protein 0.0376 0.4544 0.4543
Entamoeba histolytica cysteine proteinase 2 0.0074 0.0808 0.5058
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.0808 0.5058
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0369 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0356 0.096
Entamoeba histolytica cysteine proteinase, putative 0.0128 0.147 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0042 0.0056
Schistosoma mansoni intermediate filament proteins 0.0027 0.0227 0.0257
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0429 0.0537
Trypanosoma cruzi cysteine protease, putative 0.0074 0.0808 0.0674
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0356 0.0491
Brugia malayi Papain family cysteine protease containing protein 0.0074 0.0808 0.1114
Brugia malayi cathepsin B-like cysteine proteinase 0.0594 0.7252 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0042 0.004
Brugia malayi beta-lactamase 0.0043 0.0429 0.0592
Entamoeba histolytica hypothetical protein 0.0043 0.0429 0.2232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.147 0.5682
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.047
Brugia malayi fibroinase precursor 0.0038 0.0356 0.0491
Plasmodium vivax unspecified product 0.0038 0.0356 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0356 0.096
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.0808 0.5058
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0594 0.7252 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1019 0.3768
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.013 0.0177
Onchocerca volvulus 0.0128 0.147 0.8244
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0038 0.0356 0.0436
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.0808 0.5058
Loa Loa (eye worm) hypothetical protein 0.0594 0.7252 1
Onchocerca volvulus 0.0043 0.0429 0.2236
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1134 0.1561
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3332 1
Echinococcus granulosus cathepsin l1 0.0091 0.1019 0.1403
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0369 0.0367
Echinococcus multilocularis musashi 0.0027 0.0227 0.0225
Loa Loa (eye worm) ctsf protein 0.0128 0.147 0.2026
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0038 0.0356 0.0122
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0128 0.147 0.1469
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0356 0.1814
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0429 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0128 0.147 0.5682
Onchocerca volvulus Cathepsin F homolog 0.0128 0.147 0.8244
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.013 0.0128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0356 0.0436
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0284 0.0283
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0038 0.0356 0.0489
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0594 0.7252 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0042 0.0056
Entamoeba histolytica cysteine protease, putative 0.0038 0.0356 0.1689
Echinococcus granulosus cathepsin l cysteine peptidase 0.0128 0.147 0.2026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0038 0.0356 0.1689
Schistosoma mansoni axis inhibition protein axin 0.0019 0.013 0.0122
Brugia malayi Cathepsin L-like precursor 0.0036 0.0342 0.0472
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.059
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0177
Trypanosoma cruzi cysteine proteinase, putative 0.0074 0.0808 0.0674
Giardia lamblia Cathepsin B precursor 0.021 0.2489 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0042 0.0058
Echinococcus granulosus lamin dm0 0.0027 0.0227 0.0311
Trypanosoma cruzi cysteine proteinase, putative 0.0074 0.0808 0.0674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Trichomonas vaginalis esterase, putative 0.0043 0.0429 0.127
Plasmodium vivax vivapain-2 0.0128 0.147 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Brugia malayi PXA domain containing protein 0.0019 0.013 0.0179
Onchocerca volvulus 0.0043 0.0429 0.2236
Echinococcus granulosus cathepsin L cysteine protease 0.0074 0.0808 0.1112
Echinococcus granulosus axis inhibition protein axin 0.0019 0.013 0.0177
Echinococcus granulosus high affinity choline transporter 1 0.035 0.4224 0.5824
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.059
Entamoeba histolytica cysteine protease, putative 0.0128 0.147 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0356 0.0436
Brugia malayi beta-lactamase family protein 0.0043 0.0429 0.0592
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0227 0.0313
Loa Loa (eye worm) hypothetical protein 0.0091 0.1019 0.1403
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0369 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0177
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0036 0.0342 0.0472
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0071 0.0098
Brugia malayi cathepsin Z-like cysteine proteinase 0.0038 0.0356 0.0491
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0042 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0042 0.0058
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.013 0.0122
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0249 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Plasmodium falciparum cysteine proteinase falcipain 1 0.0074 0.0808 0.4054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0042 0.0058
Brugia malayi Cathepsin L-like precursor 0.0128 0.147 0.2027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0648 0.0646
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0429 0.0537
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.013 0.0179
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0284 0.0392
Brugia malayi hypothetical protein 0.0019 0.013 0.0179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0356 0.0489
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0429 0.059
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.013 0.0177
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0038 0.0356 0.0122
Toxoplasma gondii cathepsin B 0.021 0.2489 1
Giardia lamblia Cathepsin B precursor 0.021 0.2489 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0128 0.147 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0042 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0042 0.0056
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0042 0.0056
Schistosoma mansoni cpg binding protein 0.0031 0.0269 0.0315
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0038 0.0356 0.0122
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0569 0.0998
Schistosoma mansoni hypothetical protein 0.0032 0.0284 0.0336
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0042 0.0056
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.013 0.0128
Brugia malayi Papain family cysteine protease containing protein 0.0128 0.147 0.2027
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0074 0.0808 0.1062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0038 0.0356 0.0436
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0429 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.147 0.5682
Trypanosoma brucei cysteine peptidase C (CPC) 0.021 0.2489 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0042 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0038 0.0356 0.096
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.013 0.0177
Trypanosoma cruzi major cysteine proteinase, putative 0.0038 0.0356 0.002
Schistosoma mansoni hypothetical protein 0.0069 0.074 0.0969
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0042 0.0056
Brugia malayi nuclear receptor NHR-88 0.0012 0.0042 0.0058
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0648 0.0891
Brugia malayi CXXC zinc finger family protein 0.0029 0.0249 0.0343
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0042 0.004
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0074 0.0808 0.1062
Echinococcus multilocularis solute carrier family 5 0.0039 0.0369 0.0367
Schistosoma mansoni lamin 0.0027 0.0227 0.0257
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.047
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.065 0.0844
Echinococcus multilocularis high affinity choline transporter 1 0.035 0.4224 0.4223
Brugia malayi hypothetical protein 0.0152 0.1774 0.2447
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.059
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0038 0.0356 0.0122
Echinococcus multilocularis cathepsin L cysteine protease 0.0128 0.147 0.1469
Brugia malayi cathepsin L precursor 0.0038 0.0356 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0042 0.0058
Brugia malayi Cathepsin L-like precursor 0.0128 0.147 0.2027
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.013 0.0128
Loa Loa (eye worm) hypothetical protein 0.035 0.4224 0.5824
Schistosoma mansoni cathepsin B (C01 family) 0.0038 0.0356 0.0436
Echinococcus granulosus cysteine protease 0.0074 0.0808 0.1112
Echinococcus multilocularis cysteine protease 0.0128 0.147 0.1469
Leishmania major cathepsin L-like protease 0.0175 0.2062 0.7928
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.021 0.2489 0.3107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0038 0.0356 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Echinococcus granulosus cathepsin b 0.0594 0.7252 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.013 0.0177
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0038 0.0356 0.0122
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.013 0.0177
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0369 0.0506
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0594 0.7252 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.1019 0.1403
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.013 0.0177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.059
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0053 0.0071
Giardia lamblia Cathepsin B precursor 0.021 0.2489 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.074 0.1019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0038 0.0356 0.096
Brugia malayi cathepsin L-like precursor 0.0091 0.1019 0.1404
Brugia malayi hypothetical protein 0.0043 0.0429 0.0591
Brugia malayi beta-lactamase family protein 0.0043 0.0429 0.0592
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0063
Echinococcus multilocularis GPCR, family 2 0.0032 0.0284 0.0283
Leishmania major cathepsin L-like protease 0.0128 0.147 0.5054
Echinococcus granulosus expressed protein 0.0376 0.4544 0.6265
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0038 0.0356 0.0122
Entamoeba histolytica cysteine proteinase, putative 0.0074 0.0808 0.5058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0042 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0356 0.096
Trypanosoma cruzi cysteine peptidase, putative 0.0175 0.2062 0.2489
Schistosoma mansoni hypothetical protein 0.0032 0.0284 0.0336
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.013 0.0177
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.147 0.5682
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0056
Echinococcus granulosus solute carrier family 5 0.0039 0.0369 0.0506
Echinococcus granulosus axis inhibition protein axin 0.0019 0.013 0.0177
Schistosoma mansoni cathepsin C 0.0038 0.0356 0.0436
Onchocerca volvulus 0.0128 0.147 0.8244
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0056
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0042 0.004
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0038 0.0356 0.0122
Leishmania major cathepsin L-like protease 0.0128 0.147 0.5054
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0038 0.0356 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0074 0.0808 0.2874
Loa Loa (eye worm) hypothetical protein 0.0128 0.147 0.2026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0042 0.0058
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0042 0.0056
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0808 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0038 0.0356 0.096
Plasmodium vivax vivapain-2 0.0128 0.147 1
Echinococcus granulosus cathepsin L 0.0038 0.0356 0.0489
Onchocerca volvulus 0.0043 0.0429 0.2236
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1134 0.1563
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0042 0.0056
Echinococcus multilocularis cysteine protease 0.0128 0.147 0.1469
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0128 0.147 0.5682
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.499 0.4989
Schistosoma mansoni hypothetical protein 0.0032 0.0284 0.0336
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.1019 0.1355
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0356 0.0491
Brugia malayi nuclear hormone receptor 0.0012 0.0042 0.0058
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0221 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0042 0.0058
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.013 0.0122
Schistosoma mansoni regulator of G protein signaling 0.0019 0.013 0.0122
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0042 0.004
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0648 0.084
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0042 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0356 0.096
Schistosoma mansoni regulator of G protein signaling 0.0019 0.013 0.0122
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Brugia malayi steroid hormone receptor 0.0012 0.0042 0.0058
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.013 0.0179
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0311
Brugia malayi Papain family cysteine protease containing protein 0.0074 0.0808 0.1114
Leishmania major cathepsin L-like protease 0.0128 0.147 0.5054
Brugia malayi cathepsin Z-like cysteine proteinase 0.0038 0.0356 0.0491
Loa Loa (eye worm) hypothetical protein 0.0038 0.0356 0.0489
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.013 0.0179
Schistosoma mansoni cathepsin F (C01 family) 0.0128 0.147 0.1981
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0429 0.127
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0038 0.0356 0.1689
Schistosoma mansoni cpg binding protein 0.0031 0.0269 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.147 0.5682
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0177
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0284 0.039
Entamoeba histolytica cysteine protease, putative 0.0074 0.0808 0.5058
Echinococcus multilocularis lamin 0.0027 0.0227 0.0225
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1019 0.6631
Brugia malayi intermediate filament protein 0.0027 0.0227 0.0313
Onchocerca volvulus 0.0027 0.0227 0.1068
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.013 0.0177
Toxoplasma gondii ABC1 family protein 0.0043 0.0429 0.0343
Echinococcus multilocularis cathepsin L 0.0074 0.0808 0.0806
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0284 0.0392
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0369 0.0508
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.013 0.0179
Schistosoma mansoni cathepsin S (C01 family) 0.0038 0.0356 0.0436
Brugia malayi PXA domain containing protein 0.0019 0.013 0.0179
Echinococcus granulosus cpg binding protein 0.0031 0.0269 0.0369
Schistosoma mansoni cathepsin s 0.0036 0.0342 0.0417
Loa Loa (eye worm) cathepsin B 0.021 0.2489 0.3431
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0356 0.0491
Onchocerca volvulus 0.0152 0.1774 1
Onchocerca volvulus 0.0128 0.147 0.8244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Onchocerca volvulus 0.0039 0.0369 0.1886
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.021 0.2489 1
Leishmania major cysteine peptidase A (CPA) 0.0128 0.147 0.5054
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0038 0.0356 0.096
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0071 0.0096
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.013 0.0128
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0128 0.147 0.2026
Echinococcus multilocularis cathepsin b 0.0594 0.7252 0.7252
Echinococcus granulosus intermediate filament protein 0.0027 0.0227 0.0311
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0128 0.147 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0342 0.047
Entamoeba histolytica hypothetical protein 0.0038 0.0356 0.1689
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.013 0.0179
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.013 0.0122
Plasmodium vivax unspecified product 0.0074 0.0808 0.4126
Entamoeba histolytica cysteine protease, putative 0.0038 0.0356 0.1689
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0177
Echinococcus granulosus GPCR family 2 0.0032 0.0284 0.039
Schistosoma mansoni hypothetical protein 0.0032 0.0284 0.0336
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0594 0.7252 1
Onchocerca volvulus 0.0027 0.0227 0.1068
Schistosoma mansoni axis inhibition protein axin 0.0019 0.013 0.0122
Trypanosoma cruzi cysteine peptidase, putative 0.0175 0.2062 0.2489
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0369 0.0059
Plasmodium vivax serine-repeat antigen (SERA) 0.0038 0.0356 0.0122
Loa Loa (eye worm) hypothetical protein 0.0039 0.0369 0.0506
Onchocerca volvulus 0.0029 0.0249 0.1194
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0042 0.0056
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0648 0.1367
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0056
Schistosoma mansoni regulator of G protein signaling 0.0019 0.013 0.0122
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0038 0.0356 0.0122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0356 0.096
Schistosoma mansoni sodium/solute symporter 0.0039 0.0369 0.0453
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0648 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0648 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0356 0.096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0042 0.0056
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0042 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0356 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0038 0.0356 0.0491
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.013 0.0128
Brugia malayi cathepsin L-like cysteine proteinase 0.0038 0.0356 0.0491
Schistosoma mansoni inositol transporter 0.0039 0.0369 0.0453
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0175 0.2062 0.7928
Onchocerca volvulus 0.0091 0.1019 0.5637
Entamoeba histolytica cysteine protease, putative 0.0038 0.0356 0.1689
Schistosoma mansoni lamin 0.0027 0.0227 0.0257
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0038 0.0356 0.0436
Brugia malayi Cathepsin L-like precursor 0.0128 0.147 0.2027
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.013 0.0122
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.147 0.1632
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0128 0.147 0.5682
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0648 0.084

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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