Detailed information for compound 1400033

Basic information

Technical information
  • TDR Targets ID: 1400033
  • Name: (4-ethoxy-3-nitrophenyl)methylsulfanylmethani midamide hydrochloride
  • MW: 291.754 | Formula: C10H14ClN3O3S
  • H donors: 1 H acceptors: 2 LogP: 2.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1[N+](=O)[O-])CSC(=N)N.Cl
  • InChi: 1S/C10H13N3O3S.ClH/c1-2-16-9-4-3-7(6-17-10(11)12)5-8(9)13(14)15;/h3-5H,2,6H2,1H3,(H3,11,12);1H
  • InChiKey: FVVJLPABEVIZDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-ethoxy-3-nitro-phenyl)methylsulfanylformamidine hydrochloride
  • [(4-ethoxy-3-nitrophenyl)methylthio]formamidine hydrochloride
  • [(4-ethoxy-3-nitro-benzyl)thio]formamidine hydrochloride
  • (4-ethoxy-3-nitro-phenyl)methylsulfanylmethanimidamide hydrochloride
  • SMR000137444
  • 4-ethoxy-3-nitrobenzyl imidothiocarbamate hydrochloride
  • MLS000532505

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0041 0.0333 0.0378
Onchocerca volvulus 0.0047 0.0401 1
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.0401 0.039
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0401 0.0449
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0376 0.041
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0401 0.0462
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0401 0.039
Brugia malayi GnHR receptor homolog 0.0047 0.0401 0.0449
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0021 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0728 0.0838
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Schistosoma mansoni hypothetical protein 0.0034 0.0242 0.0279
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0112 0.0206
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0401 0.039
Schistosoma mansoni biogenic amine receptor 0.0047 0.0401 0.0462
Echinococcus granulosus g protein coupled receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis sex peptide receptor 0.0047 0.0401 0.039
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0401 0.0449
Schistosoma mansoni zinc finger protein 0.0019 0.0052 0.006
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0401 0.0457
Schistosoma mansoni neuropeptide receptor 0.0047 0.0401 0.0462
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.107 0.1232
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.0705 0.8685 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.061 0.0702
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.054 0.0529
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0009
Echinococcus granulosus allatostatin A receptor 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Brugia malayi RE15519p 0.0047 0.0401 0.0449
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0401 0.0449
Schistosoma mansoni hypothetical protein 0.0041 0.0325 0.0375
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0401 0.0449
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0317 0.0807
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0401 0.0449
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0401 0.0449
Brugia malayi PHD-finger family protein 0.0024 0.0117 0.0121
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0036 0.0043
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0401 0.0449
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1631 0.1621
Brugia malayi Dopamine receptor 0.0047 0.0401 0.0449
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0345 0.0384
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0052 0.0464 0.053
Brugia malayi Serotonin receptor 0.0047 0.0401 0.0449
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis protein patched 0.0042 0.0345 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0063 0.061 0.0702
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus granulosus expressed conserved protein 0.0092 0.0976 0.1111
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Echinococcus multilocularis expressed conserved protein 0.0092 0.0976 0.0965
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.0401 0.039
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Brugia malayi RNA binding protein 0.0063 0.061 0.0689
Brugia malayi Melatonin receptor type 1A 0.0047 0.0401 0.0449
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0401 0.039
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0401 0.0449
Entamoeba histolytica hypothetical protein 0.0073 0.0728 0.0719
Loa Loa (eye worm) hypothetical protein 0.005 0.044 0.0502
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0401 0.039
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0401 0.039
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0401 0.039
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0308 0.3687 1
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0401 0.039
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0036 0.0018
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0144 0.1631 0.1874
Loa Loa (eye worm) inositol-1 0.0045 0.0376 0.0428
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0401 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.061 0.0689
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Schistosoma mansoni hypothetical protein 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0032 0.0216 0.0244
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0401 0.039
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0705 0.8685 1
Brugia malayi neuropeptide F receptor 0.0047 0.0401 0.0449
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0401 0.0449
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0376 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0112 0.0206
Echinococcus multilocularis 0.0705 0.8685 0.8684
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus granulosus zinc finger protein 0.0019 0.0052 0.0046
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0401 0.0449
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0112 0.0129
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0401 0.039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0401 0.039
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0401 0.039
Onchocerca volvulus 0.0047 0.0401 1
Onchocerca volvulus 0.0033 0.0224 0.3878
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0401 0.0449
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0376 0.0308
Schistosoma mansoni opsin-like receptor 0.0047 0.0401 0.0462
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.0401 0.039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0021 0.0025
Brugia malayi TAR-binding protein 0.0063 0.061 0.0689
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0401 0.039
Echinococcus granulosus lamin 0.0033 0.0224 0.0245
Onchocerca volvulus 0.0047 0.0401 1
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.0705 0.8685 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.0401 0.039
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Onchocerca volvulus 0.0047 0.0401 1
Schistosoma mansoni neuropeptide receptor 0.0047 0.0401 0.0462
Echinococcus granulosus sex peptide receptor 0.0047 0.0401 0.0449
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0021 0.0024
Entamoeba histolytica hypothetical protein 0.0073 0.0728 0.0719
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Loa Loa (eye worm) RNA binding protein 0.0063 0.061 0.0697
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0376 0.0432
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.0401 0.0449
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0401 0.0449
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0401 0.0449
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0401 0.0457
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0401 0.0449
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0401 0.039
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1051 0.1198
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0401 0.0449
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1051 0.1095
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0088 0.0088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0021 0.0009
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0705 0.8685 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.0705 0.8685 1
Onchocerca volvulus 0.0047 0.0401 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0401 0.0449
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0401 0.039
Schistosoma mansoni hypothetical protein 0.0205 0.2391 0.2752
Brugia malayi hypothetical protein 0.0073 0.0728 0.0826
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0401 0.0462
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0401 0.0457
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0401 0.039
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0112 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0401 0.0449
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0021 0.0019
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0014
Echinococcus multilocularis serotonin receptor 0.0047 0.0401 0.039
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0224 0.0244
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0401 0.0449
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0401 0.0449
Schistosoma mansoni lamin 0.0033 0.0224 0.0258
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0401 0.0462
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.044 0.0494
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0401 0.0462
Echinococcus granulosus serotonin receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis protein dispatched 1 0.0048 0.042 0.0408
Brugia malayi Dopamine receptor protein 2 0.0047 0.0401 0.0449
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0112 0.0248
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Brugia malayi Bromodomain containing protein 0.0072 0.0726 0.0823
Onchocerca volvulus 0.0047 0.0401 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.002
Echinococcus granulosus intermediate filament protein 0.0033 0.0224 0.0245
Echinococcus granulosus fmrfamide receptor 0.0047 0.0401 0.0449
Schistosoma mansoni bromodomain containing protein 0.0061 0.0584 0.0672
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0401 0.0462
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.0401 0.039
Loa Loa (eye worm) hypothetical protein 0.0034 0.0242 0.0274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0401 0.0462
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Schistosoma mansoni biogenic amine receptor 0.0047 0.0401 0.0462
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0401 0.039
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.0705 0.8685 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.061 0.0702
Brugia malayi G-protein coupled receptor 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0009
Schistosoma mansoni neuropeptide receptor 0.0047 0.0401 0.0462
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0021 0.0024
Echinococcus granulosus somatostatin receptor 0.0047 0.0401 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0112 0.0206
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus granulosus histone lysine methyltransferase setb 0.0016 0.0021 0.0011
Schistosoma mansoni hypothetical protein 0.0041 0.0325 0.0375
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.0705 0.8685 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0401 0.0449
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0065 0.007
Brugia malayi Muscleblind-like protein 0.0144 0.1631 0.1867
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0401 0.039
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0012 0.0009
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0376 0.5
Schistosoma mansoni histamine h1 receptor 0.0047 0.0401 0.0462
Echinococcus granulosus hypothetical protein 0.0047 0.0401 0.0449
Brugia malayi putative neuropeptide receptor 0.0047 0.0401 0.0449
Onchocerca volvulus 0.0047 0.0401 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0401 0.039
Echinococcus granulosus tar DNA binding protein 0.0063 0.061 0.0689
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0401 0.0462
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0401 0.0457
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.0705 0.8685 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0376 0.0432
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0401 0.0457
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0401 0.0449
Schistosoma mansoni hypothetical protein 0.0047 0.0401 0.0462
Schistosoma mansoni hypothetical protein 0.0205 0.2391 0.2752
Schistosoma mansoni lamin 0.0033 0.0224 0.0258
Echinococcus multilocularis tar DNA binding protein 0.0063 0.061 0.0599
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0401 0.0462
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0401 0.039
Schistosoma mansoni tar DNA-binding protein 0.0063 0.061 0.0702
Schistosoma mansoni amine GPCR 0.0047 0.0401 0.0462
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0376 0.0419
Brugia malayi sulfakinin receptor protein 0.0047 0.0401 0.0449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0401 0.039
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0376 0.0432
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus multilocularis lamin 0.0033 0.0224 0.0212
Schistosoma mansoni biogenic amine receptor 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.0705 0.8685 0.5
Echinococcus granulosus g protein coupled receptor 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0401 0.039
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0705 0.8685 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0401 0.0462
Schistosoma mansoni amine GPCR 0.0047 0.0401 0.0462
Echinococcus granulosus g protein coupled receptor 0.0047 0.0401 0.0449
Onchocerca volvulus 0.0047 0.0401 1
Echinococcus granulosus neuropeptide receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0401 0.039
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0376 0.0364
Echinococcus multilocularis lamin dm0 0.0033 0.0224 0.0212
Brugia malayi Serotonin receptor 0.0047 0.0401 0.0449
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0021 0.001
Echinococcus multilocularis somatostatin receptor 0.0047 0.0401 0.039
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0251 0.0276
Loa Loa (eye worm) TAR-binding protein 0.0063 0.061 0.0697
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.0705 0.8685 1
Brugia malayi larval opioid receptor 0.0047 0.0401 0.0449
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.061 0.0697
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0401 0.0449
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0345 0.0384
Mycobacterium ulcerans hypothetical protein 0.0024 0.0112 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0034 0.0025
Schistosoma mansoni hypothetical protein 0.0047 0.0401 0.0462
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0401 0.0462
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.044 0.0494
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1581 0.181
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0112 0.0206
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0401 0.0462
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1581 0.1571
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0376 0.0432
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0112 0.0129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0401 0.0462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0112 0.0248
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0042 0.0345 0.0392
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0401 0.039
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0401 0.0462
Brugia malayi Bromodomain containing protein 0.0037 0.028 0.0309
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0144 0.1631 0.1874
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0021 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.001
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0112 0.0115
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0376 0.0432
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0401 0.039
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0014
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0401 0.039
Echinococcus granulosus neuropeptide receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0251 0.0239
Onchocerca volvulus 0.0047 0.0401 1
Onchocerca volvulus 0.0047 0.0401 1
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0401 0.0457
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0401 0.0462
Brugia malayi neuropeptide F receptor 0.0047 0.0401 0.0449
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0401 0.0457
Entamoeba histolytica hypothetical protein 0.0073 0.0728 0.0719
Schistosoma mansoni hypothetical protein 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0401 0.0462
Schistosoma mansoni tar DNA-binding protein 0.0063 0.061 0.0702
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Onchocerca volvulus 0.0047 0.0401 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0034 0.0034
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0401 1
Onchocerca volvulus 0.0047 0.0401 1
Schistosoma mansoni adenoreceptor 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0098 0.1051 0.1205
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0345 0.0392
Brugia malayi Dopamine receptor protein 1 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0021 0.0011
Echinococcus granulosus orexin receptor type 2 0.0047 0.0401 0.0449
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0016 0.0021 0.001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0401 0.0457
Brugia malayi G-protein coupled receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0401 0.039
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0401 0.0449
Brugia malayi isocitrate dehydrogenase 0.0016 0.0021 0.001
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0401 0.039
Echinococcus granulosus geminin 0.0205 0.2391 0.2743
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.0705 0.8685 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Schistosoma mansoni neuropeptide receptor 0.0047 0.0401 0.0462
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0021 0.0024
Schistosoma mansoni patched 1 0.0042 0.0345 0.0397
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0401 0.0449
Schistosoma mansoni hypothetical protein 0.0073 0.0728 0.0838
Brugia malayi AKH receptor 0.0047 0.0401 0.0449
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis muscleblind protein 0.0144 0.1631 0.1621
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1051 0.1197
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0014
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Mycobacterium ulcerans hypothetical protein 0.0308 0.3687 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0112 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0401 0.0449
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0401 0.0462
Echinococcus multilocularis serotonin receptor 0.0047 0.0401 0.039
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0705 0.8685 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0037
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0021 0.0024
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0705 0.8685 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0037
Schistosoma mansoni amine GPCR 0.0047 0.0401 0.0462
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0112 0.0206
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0401 0.0449
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0112 0.0115
Brugia malayi ORL1-like opioid receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis geminin 0.0205 0.2391 0.2382
Loa Loa (eye worm) hypothetical protein 0.0037 0.0281 0.0318
Schistosoma mansoni inositol monophosphatase 0.0045 0.0376 0.0432
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0021 0.0009
Schistosoma mansoni amine GPCR 0.0047 0.0401 0.0462
Schistosoma mansoni hypothetical protein 0.0041 0.0325 0.0375
Onchocerca volvulus 0.0047 0.0401 1
Brugia malayi G protein-coupled receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0401 0.039
Echinococcus granulosus muscleblind protein 0.0144 0.1631 0.1867
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0401 0.0462
Brugia malayi intermediate filament protein 0.0033 0.0224 0.0244
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0705 0.8685 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0124
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0021 0.0024
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0401 0.0457
Loa Loa (eye worm) hypothetical protein 0.0068 0.0674 0.0772
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0728 0.0826
Loa Loa (eye worm) hypothetical protein 0.0039 0.0309 0.0352
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0376 0.0037
Schistosoma mansoni hypothetical protein 0.0041 0.0325 0.0375
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Schistosoma mansoni hypothetical protein 0.002 0.0065 0.0075
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.054 0.0609
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0401 0.0457
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0088 0.0076
Schistosoma mansoni intermediate filament proteins 0.0033 0.0224 0.0258
Echinococcus granulosus lamin dm0 0.0033 0.0224 0.0245
Onchocerca volvulus 0.0047 0.0401 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0401 0.039
Echinococcus multilocularis musashi 0.0033 0.0224 0.0212
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0401 0.0457
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0224 0.0253
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0112 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0401 0.039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.001
Schistosoma mansoni opsin-like receptor 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Onchocerca volvulus 0.0047 0.0401 1
Echinococcus granulosus neuropeptide s receptor 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Onchocerca volvulus 0.0047 0.0401 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0345 0.0333
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.0705 0.8685 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0401 0.039
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0021 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0401 0.039
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Onchocerca volvulus 0.0033 0.0224 0.3878
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0021 0.0025
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0029 0.0028
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0036 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0401 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0124
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0401 0.0449
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0401 0.0449
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0728 0.0717
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0401 0.0462
Schistosoma mansoni amine GPCR 0.0047 0.0401 0.0462
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0401 0.039
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0401 0.0449
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0401 0.0449
Loa Loa (eye worm) hypothetical protein 0.0033 0.0224 0.0253
Schistosoma mansoni opsin-like receptor 0.0047 0.0401 0.0462
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0401 0.039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0037
Echinococcus multilocularis zinc finger protein 0.0019 0.0052 0.004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.044 0.0502
Loa Loa (eye worm) hypothetical protein 0.0047 0.0401 0.0457
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0401 0.039
Entamoeba histolytica hypothetical protein 0.0073 0.0728 0.0719
Brugia malayi hypothetical protein 0.0047 0.0401 0.0449
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0401 0.039
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0088 0.0101
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0401 0.0462
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0242 0.0265
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0021 0.0009
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0401 0.039
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0401 0.0462
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0401 0.0449
Schistosoma mansoni myosin xvIII 0.0047 0.0401 0.0462
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0224 0.0253
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0401 0.0462
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1051 0.104
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0021 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0401 0.0462
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0376 0.0037
Onchocerca volvulus 0.0047 0.0401 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0112 0.0129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0024 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0401 0.0449
Brugia malayi Inositol-1 0.0045 0.0376 0.0419
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0317 1
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0705 0.8685 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0376 0.0929
Brugia malayi CHE-14 protein 0.0042 0.0345 0.0383
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0037

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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