Detailed information for compound 1400446

Basic information

Technical information
  • TDR Targets ID: 1400446
  • Name: 1,5-di(phenyl)-3,9-disulfanylidene-2,4,8,10-t etrazaspiro[5.5]undecane-7,11-dione
  • MW: 396.486 | Formula: C19H16N4O2S2
  • H donors: 3 H acceptors: 2 LogP: 2.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1NC(=O)C2(C(=O)N1)C(NC(=NC2c1ccccc1)S)c1ccccc1
  • InChi: 1S/C19H16N4O2S2/c24-15-19(16(25)23-18(27)22-15)13(11-7-3-1-4-8-11)20-17(26)21-14(19)12-9-5-2-6-10-12/h1-10,13-14H,(H2,20,21,26)(H2,22,23,24,25,27)
  • InChiKey: UPVOZJUUXROJCG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,5-di(phenyl)-3,9-dithioxo-2,4,8,10-tetrazaspiro[5.5]undecane-7,11-dione
  • 1,5-di(phenyl)-3,9-dithioxo-2,4,8,10-tetrazaspiro[5.5]undecane-7,11-quinone
  • ST5113410
  • 7,11-Diphenyl-3,9-dithioxo-2,4,8,10-tetraaza-spiro[5.5]undecane-1,5-dione
  • MLS000595246
  • SMR000149769

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens hepatocyte nuclear factor 4, alpha Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens perilipin 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Hepatocyte nuclear factor 4-beta, putative Get druggable targets OG5_131038 All targets in OG5_131038
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) Get druggable targets OG5_131038 All targets in OG5_131038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Nuclear hormone receptor family member nhr-49 Get druggable targets OG5_131038 All targets in OG5_131038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus hepatocyte nuclear factor 4 alpha Get druggable targets OG5_131038 All targets in OG5_131038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha Get druggable targets OG5_131038 All targets in OG5_131038
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 Get druggable targets OG5_131038 All targets in OG5_131038
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Transcription factor HNF-4 homolog, putative Get druggable targets OG5_131038 All targets in OG5_131038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0244 0.1677 0.2569
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2575 1
Entamoeba histolytica cyclin family protein 0.0156 0.0958 0.2383
Loa Loa (eye worm) hypothetical protein 0.0073 0.0277 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0034 0.0073
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0122 0.0682 0.1042
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0032 0.0062
Entamoeba histolytica cyclin, putative 0.0156 0.0958 0.2383
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0034 0.0061
Trichomonas vaginalis cyclins, putative 0.0302 0.2153 0.8349
Trypanosoma cruzi cyclin 6, putative 0.0302 0.2153 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0046 0.0052 0.0074
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0078 0.0315 0.139
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0158 0.097 0.097
Echinococcus multilocularis rac serine:threonine kinase 0.0086 0.0384 0.0583
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0052 0.0063
Loa Loa (eye worm) AGC/NDR protein kinase 0.0048 0.0073 0.0073
Onchocerca volvulus Tyrosine kinase homolog 0.0341 0.2481 0.494
Loa Loa (eye worm) TK/ROR protein kinase 0.004 0.0004 0.0004
Echinococcus multilocularis insulin receptor 0.0372 0.2733 0.4189
Trichomonas vaginalis cyclin D, putative 0.0156 0.0958 0.3676
Schistosoma mansoni tyrosine kinase 0.0268 0.1875 0.2857
Leishmania major cyclin 0.0302 0.2153 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0872 0.0872
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0134 0.0778 0.3559
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0302 0.2153 1
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0822 0.3144
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0315 0.0456
Trypanosoma cruzi cdc2-related kinase 1 0.0139 0.0822 0.3765
Loa Loa (eye worm) hypothetical protein 0.0255 0.1772 0.1772
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0078 0.0315 0.139
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0822 0.3144
Echinococcus granulosus protein kinase C gamma type 0.0048 0.0073 0.0091
Loa Loa (eye worm) AGC/AKT protein kinase 0.012 0.0662 0.0662
Loa Loa (eye worm) TK protein kinase 0.0231 0.1576 0.1576
Echinococcus granulosus cyclin b3 0.0156 0.0958 0.1253
Echinococcus granulosus epidermal growth factor receptor 0.0431 0.3213 0.4214
Entamoeba histolytica protein kinase, putative 0.0115 0.0618 0.1521
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0073 0.0084
Trypanosoma cruzi cdc2-related kinase 3 0.0139 0.0822 0.3765
Schistosoma mansoni protein kinase 0.0043 0.0032 0.002
Loa Loa (eye worm) hypothetical protein 0.0098 0.0482 0.0482
Trichomonas vaginalis cyclins, putative 0.0156 0.0958 0.3676
Trichomonas vaginalis cyclins, putative 0.0302 0.2153 0.8349
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0073 0.0084
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0018 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Schistosoma mansoni tyrosine kinase 0.0297 0.2112 0.322
Loa Loa (eye worm) hypothetical protein 0.0073 0.0277 0.0277
Echinococcus multilocularis cyclins 0.0156 0.0958 0.1465
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1126 0.1704
Schistosoma mansoni tyrosine kinase 0.0054 0.0119 0.0154
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0052 0.0074
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0134 0.0778 0.3559
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0117 0.0384
Echinococcus granulosus protein kinase 0.0194 0.1271 0.1664
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0176 0.1126 0.1126
Echinococcus multilocularis Immunoglobulin 0.0073 0.0277 0.0419
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0052 0.0074
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0158 0.097 1
Leishmania major protein kinase A catalytic subunit isoform 1 0.0134 0.0778 0.3559
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0034 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0073 0.0084
Echinococcus granulosus epidermal growth factor receptor 0.0297 0.2112 0.2768
Trichomonas vaginalis cyclins, putative 0.0302 0.2153 0.8349
Loa Loa (eye worm) hypothetical protein 0.0073 0.0277 0.0277
Echinococcus multilocularis rho associated protein kinase 0.0157 0.0965 0.1475
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0052 0.0063
Loa Loa (eye worm) hypothetical protein 0.0302 0.2153 0.2153
Toxoplasma gondii AGC kinase 0.0134 0.0778 0.7982
Loa Loa (eye worm) hypothetical protein 0.0266 0.1863 0.1863
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0158 0.097 0.4459
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2575 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0048 0.0073 0.0091
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0297 0.2112 0.2768
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.1677 0.649
Entamoeba histolytica cyclin family protein 0.0156 0.0958 0.2383
Trichomonas vaginalis esterase, putative 0.0043 0.0034 0.0061
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0122 0.0682 0.0891
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0372 0.2733 0.4189
Echinococcus granulosus nervana 2 0.0066 0.0222 0.0287
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0048 0.0073 0.0106
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0647 0.4987 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0032 0.0062
Schistosoma mansoni rap gtpase-activating protein 0.0075 0.0297 0.0428
Trypanosoma brucei mitotic cyclin 6 0.0302 0.2153 1
Schistosoma mansoni protein kinase 0.0194 0.1271 0.1926
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0043 0.0032 0.0037
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0522 0.3961 0.3961
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0142 0.0841 0.0824
Entamoeba histolytica protein kinase, putative 0.0158 0.097 0.2414
Mycobacterium ulcerans beta-lactamase 0.0043 0.0034 0.0145
Brugia malayi Protein kinase domain containing protein 0.0184 0.119 0.1174
Leishmania major hypothetical protein, conserved 0.0043 0.0034 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0073 0.0214
Echinococcus granulosus defective proboscis extension response 0.0073 0.0277 0.0359
Trichomonas vaginalis cyclin A, putative 0.0302 0.2153 0.8349
Brugia malayi Protein kinase domain containing protein 0.009 0.0415 0.0397
Trichomonas vaginalis cyclin B, putative 0.0302 0.2153 0.8349
Echinococcus multilocularis cyclin dependent kinase 5 0.0139 0.0822 0.1256
Brugia malayi cell division control protein 2 homolog 0.0139 0.0822 0.0805
Trichomonas vaginalis AGC family protein kinase 0.012 0.0662 0.2516
Schistosoma mansoni tyrosine kinase 0.0268 0.1875 0.2857
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0647 0.4987 0.4977
Schistosoma mansoni tyrosine kinase 0.0297 0.2112 0.322
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0142 0.0841 0.1285
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2575 0.6483
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0034 0.0145
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.009 0.0415 0.0631
Echinococcus multilocularis cyclin B 0.0302 0.2153 0.3299
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.1677 0.649
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0073 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0073 0.0214
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0052 0.0063
Schistosoma mansoni kinase 0.0261 0.1824 0.2777
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0081 0.034 0.3286
Onchocerca volvulus 0.0142 0.0847 0.1641
Brugia malayi Cyclin, N-terminal domain containing protein 0.0302 0.2153 0.2138
Trypanosoma cruzi cyclin, putative 0.0302 0.2153 1
Echinococcus multilocularis protein kinase shaggy 0.0158 0.097 0.1484
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0018 0.0019
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0115 0.0618 0.0618
Giardia lamblia Kinase, CDC7 0.0184 0.119 0.3872
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0139 0.0822 0.0822
Echinococcus granulosus Protein kinase C brain isozyme 0.0048 0.0073 0.0091
Plasmodium falciparum cyclin 0.0156 0.0958 0.9871
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0522 0.3961 0.395
Echinococcus multilocularis cyclins 0.0156 0.0958 0.1465
Trichomonas vaginalis cyclin B, putative 0.0302 0.2153 0.8349
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0075 0.0297 0.0385
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0139 0.0822 0.3765
Loa Loa (eye worm) inositol-1 0.0042 0.0018 0.0018
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0647 0.4987 0.6543
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0034 0.0047
Loa Loa (eye worm) CDC7 protein kinase 0.0184 0.119 0.119
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0255 0.1772 0.2322
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0536 0.2025
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0134 0.0778 0.7953
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1093 1
Trichomonas vaginalis cyclin B, putative 0.0302 0.2153 0.8349
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Brugia malayi beta-lactamase 0.0043 0.0034 0.0016
Plasmodium falciparum glycogen synthase kinase 3 0.0158 0.097 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0139 0.0822 0.2038
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0482 0.3635 0.4768
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0034 0.0034
Trypanosoma brucei cdc2-related kinase 3 0.0139 0.0822 0.3765
Giardia lamblia G2/mitotic-specific cyclin B 0.0302 0.2153 0.8133
Trichomonas vaginalis AGC family protein kinase 0.012 0.0662 0.2516
Schistosoma mansoni atypical protein kinase C 0.0048 0.0073 0.0084
Echinococcus multilocularis nervana 2 0.0066 0.0222 0.0335
Echinococcus multilocularis serine:threonine protein kinase N2 0.0048 0.0073 0.0106
Schistosoma mansoni tyrosine kinase 0.0268 0.1875 0.2857
Trypanosoma cruzi CYC2-like cyclin, putative 0.0302 0.2153 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0418 0.3105 0.3105
Trypanosoma brucei protein kinase, putative 0.0043 0.0032 0.0062
Trypanosoma brucei cdc2-related kinase 1 0.0139 0.0822 0.3765
Entamoeba histolytica protein kinase 2, putative 0.0081 0.034 0.0816
Schistosoma mansoni vam6/vps39 related 0.0075 0.0297 0.0428
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.0052 0.0074
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0048 0.0073 0.0073
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0075 0.0297 0.045
Echinococcus granulosus cyclins 0.0156 0.0958 0.1253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2575 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0139 0.0822 0.2037
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0244 0.1677 0.7773
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0277 0.0259
Echinococcus multilocularis 0.0194 0.1271 0.1945
Giardia lamblia Hypothetical protein 0.0156 0.0958 0.2846
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.097 0.3723
Loa Loa (eye worm) hypothetical protein 0.0073 0.0277 0.0277
Brugia malayi Immunoglobulin I-set domain containing protein 0.0418 0.3105 0.3093
Brugia malayi Protein kinase domain containing protein 0.0139 0.0822 0.0805
Echinococcus granulosus Glutaredoxin protein 5 0.0066 0.0222 0.0287
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0046 0.0052 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.0958 0.3676
Loa Loa (eye worm) TK/EGFR protein kinase 0.0431 0.3213 0.3213
Echinococcus multilocularis fibroblast growth factor receptor 4 0.022 0.1486 0.2276
Leishmania major protein kinase, putative 0.0043 0.0032 0.0062
Brugia malayi intracellular kinase 0.0158 0.097 0.0953
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.0073 0.0106
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0158 0.097 0.1269
Echinococcus granulosus roundabout 2 0.0098 0.0482 0.0628
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0046 0.0052 0.0074
Giardia lamblia Kinase, AGC PKA 0.0134 0.0778 0.2049
Brugia malayi Protein kinase domain containing protein 0.0372 0.2733 0.2719
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1958 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0134 0.0778 0.1189
Entamoeba histolytica protein kinase, putative 0.0048 0.0073 0.0138
Brugia malayi probable protein kinase 0.027 0.189 0.1875
Echinococcus multilocularis roundabout 2 0.0098 0.0482 0.0734
Toxoplasma gondii ABC1 family protein 0.0043 0.0034 0.0164
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.009 0.0415 0.0631
Echinococcus multilocularis cyclins 0.0156 0.0958 0.1465
Trichomonas vaginalis cyclins, putative 0.0302 0.2153 0.8349
Schistosoma mansoni serine/threonine kinase 0.0048 0.0073 0.0084
Echinococcus multilocularis cyclin B3 1 0.0156 0.0958 0.1465
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.1677 0.649
Schistosoma mansoni tyrosine kinase 0.0372 0.2733 0.4175
Leishmania major protein kinase A catalytic subunit isoform 2 0.0134 0.0778 0.3559
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.009 0.0415 0.0631
Brugia malayi protein kinase C II. 0.0048 0.0073 0.0055
Loa Loa (eye worm) cyclin domain-containing protein 0.0482 0.3635 0.3635
Schistosoma mansoni hypothetical protein 0.0054 0.0123 0.0161
Trichomonas vaginalis CMGC family protein kinase 0.0184 0.119 0.4583
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0134 0.0778 0.3559
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0018 0.0023
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0647 0.4987 0.4987
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.009 0.0415 0.054
Trichomonas vaginalis cyclin B, putative 0.0156 0.0958 0.3676
Brugia malayi Protein kinase domain containing protein 0.0048 0.0073 0.0055
Brugia malayi Protein kinase domain containing protein 0.0458 0.3434 0.3422
Entamoeba histolytica protein kinase domain containing protein 0.0522 0.3961 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0142 0.0841 0.0841
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.022 0.1486 0.1947
Echinococcus multilocularis epidermal growth factor receptor 0.0297 0.2112 0.3236
Echinococcus multilocularis 0.0063 0.0197 0.0297
Trichomonas vaginalis cyclin B3, putative 0.0156 0.0958 0.3676
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1093 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0075 0.0297 0.1304
Brugia malayi Fibronectin type III domain containing protein 0.0073 0.0277 0.0259
Schistosoma mansoni vesicular amine transporter 0.0073 0.0277 0.0398
Brugia malayi Protein kinase domain containing protein 0.012 0.0662 0.0644
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0078 0.0315 0.139
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0048 0.0073 0.0106
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1093 0.5503
Echinococcus granulosus dual specificity protein kinase clk2 0.0078 0.0315 0.0409
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0134 0.0778 0.7948
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0458 0.3434 0.3434
Echinococcus multilocularis Glutaredoxin protein 5 0.0066 0.0222 0.0335
Brugia malayi Temporarily assigned gene name protein 59 0.0075 0.0297 0.0279
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2575 1
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0522 0.3961 0.6075
Plasmodium vivax serine/threonine kinase-1, putative 0.0078 0.0315 0.3002
Trypanosoma brucei polo-like protein kinase 0.0244 0.1677 0.7773
Brugia malayi Cyclin, N-terminal domain containing protein 0.0302 0.2153 0.2138
Echinococcus multilocularis Immunoglobulin 0.0073 0.0277 0.0419
Echinococcus granulosus serine:threonine protein kinase N2 0.0048 0.0073 0.0091
Schistosoma mansoni tyrosine kinase 0.0046 0.0052 0.0051
Echinococcus multilocularis protein kinase c epsilon type 0.0048 0.0073 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0157 0.0965 0.1456
Echinococcus multilocularis cyclins 0.0156 0.0958 0.1465
Schistosoma mansoni tyrosine kinase 0.0046 0.0052 0.0051
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0134 0.0778 0.3559
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0244 0.1677 0.2198
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0034 0.0073
Echinococcus granulosus cyclins 0.0156 0.0958 0.1253
Brugia malayi beta-lactamase family protein 0.0043 0.0034 0.0016
Trichomonas vaginalis AGC family protein kinase 0.012 0.0662 0.2516
Echinococcus multilocularis cyclin b3 0.0156 0.0958 0.1465
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0134 0.0778 0.3559
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0046 0.0052 0.0074
Toxoplasma gondii hypothetical protein 0.0118 0.0649 0.6625
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0075 0.0297 0.0428
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.1677 0.649
Schistosoma mansoni cyclin B 0.0302 0.2153 0.3284
Onchocerca volvulus 0.0054 0.0123 0.0179
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0123 0.0105
Schistosoma mansoni cyclins 0.0156 0.0958 0.1446
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.119 0.1802
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2575 0.5
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.009 0.0415 0.054
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0066 0.0222 0.0335
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.1677 0.649
Plasmodium falciparum protein serine/threonine kinase-1 0.0078 0.0315 0.302
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.6519 1
Echinococcus granulosus serine/threonine protein kinase 0.0086 0.0384 0.0499
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.0033
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0075 0.0297 0.1304
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.009 0.0415 0.0415
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0034 0.004
Mycobacterium ulcerans lipase LipD 0.0043 0.0034 0.0145
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0139 0.0822 0.8443
Schistosoma mansoni hypothetical protein 0.0075 0.0297 0.0428
Toxoplasma gondii AGC kinase 0.0134 0.0778 0.7982
Trichomonas vaginalis CMGC family protein kinase 0.0184 0.119 0.4583
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.022 0.1486 0.2276
Giardia lamblia Kinase, CMGC CDK 0.0139 0.0822 0.2244
Schistosoma mansoni survival motor neuron protein 0.0054 0.0123 0.0161
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0522 0.3961 0.5197
Schistosoma mansoni tyrosine kinase 0.0372 0.2733 0.4175
Brugia malayi Tyrosine-protein kinase abl-1 0.0046 0.0052 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0073 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.1677 0.649
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0034 0.0073
Giardia lamblia Kinase, CMGC GSK 0.0158 0.097 0.2899
Echinococcus multilocularis survival motor neuron protein 1 0.0266 0.1863 0.2853
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0139 0.0822 0.0822
Entamoeba histolytica PH domain containing protein kinase, putative 0.0139 0.0822 0.2037
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0134 0.0778 0.0761
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0372 0.2733 0.3583
Echinococcus granulosus cyclins 0.0156 0.0958 0.1253
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0778 0.2972
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.1677 0.2552
Onchocerca volvulus 0.0302 0.2154 0.428
Loa Loa (eye worm) hypothetical protein 0.0302 0.2153 0.2153
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2575 0.6483
Brugia malayi Protein kinase domain containing protein 0.0257 0.179 0.1775
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0046 0.0052 0.0074
Schistosoma mansoni tyrosine kinase 0.022 0.1486 0.2258
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0073 0.0277 0.0398
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0134 0.0778 0.1017
Leishmania major protein kinase, putative 0.0078 0.0315 0.139
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0822 0.3144
Loa Loa (eye worm) hypothetical protein 0.0134 0.0778 0.0778
Trichomonas vaginalis AGC family protein kinase 0.012 0.0662 0.2516
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Trypanosoma cruzi cyclin, putative 0.0302 0.2153 1
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0315 0.0456
Echinococcus multilocularis epidermal growth factor receptor 0.0431 0.3213 0.4926
Echinococcus multilocularis neuroglian 0.0084 0.0367 0.0558
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0046 0.0052 0.0074
Echinococcus multilocularis cyclin dependent kinase 0.0139 0.0822 0.1256
Brugia malayi Protein kinase domain containing protein 0.0176 0.1126 0.111
Brugia malayi Cyclin, N-terminal domain containing protein 0.0482 0.3635 0.3623
Loa Loa (eye worm) hypothetical protein 0.0201 0.1328 0.1328
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0034 0.0061
Brugia malayi hypothetical protein 0.0073 0.0277 0.0259
Loa Loa (eye worm) SRC-1 0.0046 0.0052 0.0052
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0175 0.111 0.1452
Plasmodium vivax protein kinase Crk2 0.0139 0.0822 0.8417
Schistosoma mansoni nephrin 0.0084 0.0367 0.0536
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0134 0.0778 0.1017
Echinococcus granulosus CDC7 cell division cycle 7 0.0184 0.119 0.1558
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0967 0.7619 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0139 0.0822 0.1256
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0086 0.0384 0.1711
Echinococcus granulosus microtubule associated protein 2 0.0833 0.6519 0.8555
Trichomonas vaginalis AGC family protein kinase 0.012 0.0662 0.2516
Echinococcus granulosus activin receptor type 0.0043 0.0032 0.0037
Trypanosoma cruzi cdc2-related kinase 3 0.0139 0.0822 0.3765
Onchocerca volvulus 0.0158 0.097 0.189
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0048 0.0073 0.0091
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0081 0.034 0.1507
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0139 0.0822 0.1075
Echinococcus granulosus c src tyrosine kinase 0.0046 0.0052 0.0063
Echinococcus granulosus insulin receptor 0.0372 0.2733 0.3583
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0778 0.1169
Schistosoma mansoni protein kinase 0.0043 0.0032 0.002
Schistosoma mansoni tyrosine kinase 0.0165 0.1032 0.1559
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.0052 0.0063
Trypanosoma cruzi polo-like protein kinase, putative 0.0244 0.1677 0.7773
Echinococcus granulosus tyrosine protein kinase Src64B 0.0046 0.0052 0.0063
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0135 0.0788 0.1184
Entamoeba histolytica protein kinase, putative 0.012 0.0662 0.1631
Leishmania major protein kinase A catalytic subunit 0.0134 0.0778 0.3559
Giardia lamblia Kinase, PLK 0.0244 0.1677 0.6029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0142 0.0841 0.1099
Echinococcus granulosus NDR protein kinase 0.0048 0.0073 0.0091
Brugia malayi beta-lactamase family protein 0.0043 0.0034 0.0016
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.012 0.066 0.0862
Loa Loa (eye worm) hypothetical protein 0.0075 0.0297 0.0297
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.097 0.3723
Onchocerca volvulus Serine\/threonine kinase homolog 0.0244 0.1677 0.3318
Loa Loa (eye worm) hypothetical protein 0.0075 0.0297 0.0297
Echinococcus granulosus cyclin dependent kinase 0.0139 0.0822 0.1075
Trypanosoma brucei protein kinase, putative 0.0158 0.097 0.4459
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0073 0.0214
Echinococcus multilocularis 0.0123 0.0686 0.1048
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0482 0.3635 0.5573
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0134 0.0778 0.3559
Echinococcus granulosus rho-associated protein kinase 1 0.0157 0.0965 0.1262
Entamoeba histolytica cyclin, putative 0.0302 0.2153 0.5413
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0073 0.0277 0.0419
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0415 0.061
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0647 0.4987 0.4987
Entamoeba histolytica protein kinase, putative 0.012 0.0662 0.1631
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0078 0.0315 0.3116
Echinococcus granulosus hypothetical protein 0.0063 0.0197 0.0254
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0175 0.111 0.1698
Schistosoma mansoni tyrosine kinase 0.0431 0.3213 0.4914
Schistosoma mansoni cell adhesion molecule 0.0087 0.0392 0.0575
Echinococcus granulosus protein kinase c epsilon type 0.0048 0.0073 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0822 0.1236
Loa Loa (eye worm) hypothetical protein 0.0073 0.0277 0.0277
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0075 0.0297 0.1304
Brugia malayi Hr1 repeat family protein 0.0048 0.0073 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2575 1
Echinococcus granulosus cyclin B 0.0302 0.2153 0.2822
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0134 0.0778 0.3559
Echinococcus granulosus cyclin dependent kinase 1 0.0139 0.0822 0.1075
Brugia malayi hypothetical protein 0.0075 0.0297 0.0279
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0034 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0822 0.1236
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0081 0.034 0.3268
Echinococcus granulosus cyclins 0.0156 0.0958 0.1253
Trypanosoma cruzi Protein kinase B 0.0086 0.0384 0.1711
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0158 0.097 0.097
Onchocerca volvulus 0.0157 0.0965 0.1879
Echinococcus multilocularis cyclin dependent kinase 1 0.0139 0.0822 0.1256
Brugia malayi Protein kinase domain containing protein 0.0647 0.4987 0.4977
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0034 0.0024
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0066 0.0222 0.0287
Toxoplasma gondii AGC kinase 0.0115 0.0618 0.63
Entamoeba histolytica PH domain containing protein kinase, putative 0.0086 0.0384 0.0926
Giardia lamblia Kinase, CMGC GSK 0.0158 0.097 0.2899
Onchocerca volvulus 0.0184 0.119 0.2334
Entamoeba histolytica cell division protein kinase 2, putative 0.0139 0.0822 0.2038
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0647 0.4987 0.7649
Trichomonas vaginalis AGC family protein kinase 0.012 0.0662 0.2516
Trypanosoma cruzi polo-like protein kinase, putative 0.0244 0.1677 0.7773
Schistosoma mansoni serine/threonine-protein kinase 0.0086 0.0384 0.0562
Trichomonas vaginalis CMGC family protein kinase 0.0184 0.119 0.4583
Onchocerca volvulus 0.0302 0.2153 0.4278
Onchocerca volvulus 0.0075 0.0297 0.053
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0158 0.097 0.1464
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0139 0.0822 0.0822
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0078 0.0315 0.0315
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0778 0.1169
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0087 0.0392 0.051
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0043 0.0032 0.0138
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0046 0.0052 0.0074
Entamoeba histolytica protein kinase domain containing protein 0.0158 0.097 0.2414
Echinococcus multilocularis cyclins 0.0156 0.0958 0.1465
Echinococcus granulosus cyclins 0.0156 0.0958 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.0522 0.3961 0.6066
Echinococcus granulosus twitchin 0.0098 0.0485 0.0632
Loa Loa (eye worm) AGC/PKN protein kinase 0.0048 0.0073 0.0073
Brugia malayi p70 ribosomal S6 kinase beta 0.0115 0.0618 0.0601
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0034 0.0024
Brugia malayi SRC-1 0.0046 0.0052 0.0033
Echinococcus multilocularis serine:threonine protein kinase 38 0.0048 0.0073 0.0106
Giardia lamblia Kinase, AGC PKA 0.0081 0.034 0.0111
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0048 0.0073 0.0073
Leishmania major protein kinase, putative 0.0078 0.0315 0.139
Loa Loa (eye worm) TK/ALK protein kinase 0.0257 0.179 0.179
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0139 0.0822 0.3765
Schistosoma mansoni serine/threonine-protein kinase 0.0086 0.0384 0.0562
Echinococcus granulosus Immunoglobulin 0.0073 0.0277 0.0359
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0078 0.0315 0.139
Loa Loa (eye worm) hypothetical protein 0.0125 0.0704 0.0704
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0078 0.0315 0.139
Loa Loa (eye worm) hypothetical protein 0.0098 0.0482 0.0482
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0034 0.0061
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0046 0.0052 0.0063
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0158 0.097 0.1484
Echinococcus multilocularis dual specificity protein kinase clk2 0.0078 0.0315 0.0478
Entamoeba histolytica serine/threonine protein kinase, putative 0.0244 0.1677 0.4208
Echinococcus multilocularis c src tyrosine kinase 0.0046 0.0052 0.0074
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0048 0.0073 0.0073
Loa Loa (eye worm) beta-lactamase 0.0043 0.0034 0.0034
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.012 0.066 0.1008
Entamoeba histolytica protein kinase domain containing protein 0.0158 0.097 0.2414
Brugia malayi Immunoglobulin I-set domain containing protein 0.0231 0.1576 0.1561
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0034 0.0061
Echinococcus multilocularis activin receptor type 0.0043 0.0032 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2575 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0134 0.0778 0.1189
Brugia malayi hypothetical protein 0.0266 0.1863 0.1848
Loa Loa (eye worm) hypothetical protein 0.0087 0.0392 0.0392
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0046 0.0052 0.0051
Trichomonas vaginalis cyclin D, putative 0.0156 0.0958 0.3676
Trypanosoma brucei rac serine-threonine kinase, putative 0.012 0.0662 0.3014
Echinococcus granulosus survival motor neuron protein 1 0.0266 0.1863 0.2441
Brugia malayi Furin-like cysteine rich region family protein 0.0431 0.3213 0.32
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2575 1
Trichomonas vaginalis CAMK family protein kinase 0.0244 0.1677 0.649
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0073 0.0277 0.0398
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.6519 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0048 0.0073 0.0106
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0048 0.0073 0.0091
Echinococcus granulosus cyclin B3 1 0.0156 0.0958 0.1253
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0134 0.0778 0.1017
Trichomonas vaginalis cyclins, putative 0.0183 0.1181 0.4548
Plasmodium falciparum protein kinase 5 0.0139 0.0822 0.8422
Brugia malayi Protein kinase domain containing protein 0.0048 0.0073 0.0055
Brugia malayi Protein kinase domain containing protein 0.0078 0.0315 0.0297
Echinococcus granulosus neuroglian 0.0084 0.0367 0.0477
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0078 0.0315 0.139
Echinococcus granulosus tyrosine protein kinase Lyn 0.006 0.017 0.0218
Trichomonas vaginalis CMGC family protein kinase 0.0078 0.0315 0.116
Trichomonas vaginalis cyclin B, putative 0.0302 0.2153 0.8349
Loa Loa (eye worm) hypothetical protein 0.0073 0.0277 0.0277
Mycobacterium ulcerans hypothetical protein 0.0043 0.0034 0.0145
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0075 0.0297 0.0428
Echinococcus multilocularis CDC7 cell division cycle 7 0.0184 0.119 0.1821
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0081 0.034 0.0516
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0415 0.061
Schistosoma mansoni cyclin B3 0.0482 0.3635 0.5563
Giardia lamblia Kinase, CMGC CDK 0.0139 0.0822 0.2244
Echinococcus granulosus cyclin dependent kinase 5 0.0139 0.0822 0.1075
Echinococcus granulosus fibroblast growth factor receptor 4 0.022 0.1486 0.1947
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0778 0.1169
Echinococcus multilocularis protein kinase c iota type 0.0048 0.0073 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0647 0.4987 0.7643
Schistosoma mansoni protein kinase 0.027 0.189 0.288
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0244 0.1677 0.1677
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2575 1
Onchocerca volvulus 0.0184 0.119 0.2334
Loa Loa (eye worm) hypothetical protein 0.0139 0.0816 0.0816
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0194 0.1271 0.1271
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0073 0.0084
Loa Loa (eye worm) hypothetical protein 0.0048 0.0073 0.0073
Schistosoma mansoni tyrosine kinase 0.0046 0.0052 0.0051
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.009 0.0415 0.054
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0034 0.0016
Echinococcus multilocularis cyclins 0.0156 0.0958 0.1465
Schistosoma mansoni tyrosine kinase 0.0046 0.0052 0.0051
Echinococcus multilocularis nervana 2 0.0066 0.0222 0.0335
Loa Loa (eye worm) hypothetical protein 0.0075 0.0297 0.0297
Echinococcus multilocularis cyclins 0.0156 0.0958 0.1465
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0134 0.0778 0.7982
Echinococcus multilocularis serine:threonine protein kinase N2 0.0048 0.0073 0.0106
Schistosoma mansoni protein kinase 0.009 0.0415 0.061
Plasmodium vivax glycogen synthase kinase 3, putative 0.0158 0.097 1
Brugia malayi Protein kinase domain containing protein 0.0168 0.1052 0.1036
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0043 0.0032 0.0062
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0158 0.097 0.4459
Giardia lamblia Cyclin A 0.0156 0.0958 0.2846
Loa Loa (eye worm) hypothetical protein 0.0063 0.0197 0.0197
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0048 0.0073 0.0073
Trypanosoma cruzi cdc2-related kinase 1 0.0139 0.0822 0.3765
Echinococcus granulosus Vam6:Vps39 protein 0.0075 0.0297 0.0385
Loa Loa (eye worm) AGC/PKA protein kinase 0.0134 0.0778 0.0778
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0536 0.2025
Loa Loa (eye worm) AGC/PKA protein kinase 0.0134 0.0778 0.0778
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2575 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0134 0.0778 0.1189
Echinococcus granulosus nervana 2 0.0066 0.0222 0.0287
Trichomonas vaginalis AGC family protein kinase 0.012 0.0662 0.2516
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0134 0.0778 0.1189
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0052 0.0074
Brugia malayi serine/threonine-protein kinase plk-2 0.0244 0.1677 0.1662
Entamoeba histolytica PH domain containing protein kinase, putative 0.0086 0.0384 0.0926
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0048 0.0073 0.0106
Echinococcus granulosus protein kinase shaggy 0.0158 0.097 0.1269
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0081 0.034 0.0442
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0043 0.0032 0.0043
Echinococcus granulosus protein kinase c iota type 0.0048 0.0073 0.0091
Echinococcus granulosus serine threonine protein kinase nrc 0.0081 0.034 0.0442
Schistosoma mansoni protein kinase 0.0043 0.0032 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0073 0.0084
Loa Loa (eye worm) TK/INSR protein kinase 0.0372 0.2733 0.2733

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 4.337 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 5.814 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 69.38 uM PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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